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Protein

Olfactory receptor 52I1

Gene

OR52I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32131-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52I1
Alternative name(s):
Olfactory receptor OR11-13
Gene namesi
Name:OR52I1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15220. OR52I1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 103ExtracellularSequence analysisAdd BLAST24
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 200ExtracellularSequence analysisAdd BLAST36
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 241CytoplasmicSequence analysisAdd BLAST20
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 278ExtracellularSequence analysisAdd BLAST16
Transmembranei279 – 299Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini300 – 324CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi390037.
OpenTargetsiENSG00000232268.
PharmGKBiPA32412.

Polymorphism and mutation databases

BioMutaiOR52I1.
DMDMi38372717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507781 – 324Olfactory receptor 52I1Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGK6.
PRIDEiQ8NGK6.

PTM databases

iPTMnetiQ8NGK6.
PhosphoSitePlusiQ8NGK6.

Expressioni

Gene expression databases

CleanExiHS_OR52I1.
ExpressionAtlasiQ8NGK6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000409094.

Structurei

3D structure databases

ProteinModelPortaliQ8NGK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIRM. Eukaryota.
ENOG41114NG. LUCA.
GeneTreeiENSGT00810000125507.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK6.
KOiK04257.
PhylomeDBiQ8NGK6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGPAYNHTM ETPASFLLVG IPGLQSSHLW LAISLSAMYI TALLGNTLIV
60 70 80 90 100
TAIWMDSTRH EPMYCFLCVL AAVDIVMASS VVPKMVSIFC SGDSSISFSA
110 120 130 140 150
CFTQMFFVHL ATAVETGLLL TMAFDRYVAI CKPLHYKRIL TPQVMLGMSM
160 170 180 190 200
AVTIRAVTFM TPLSWMMNHL PFCGSNVVVH SYCKHIALAR LACADPVPSS
210 220 230 240 250
LYSLIGSSLM VGSDVAFIAA SYILILRAVF DLSSKTAQLK ALSTCGSHVG
260 270 280 290 300
VMALYYLPGM ASIYAAWLGQ DIVPLHTQVL LADLYVIIPA TLNPIIYGMR
310 320
TKQLLEGIWS YLMHFLFDHS NLGS
Length:324
Mass (Da):35,386
Last modified:October 10, 2003 - v2
Checksum:i460E0FCF43844960
GO

Sequence cautioni

The sequence BAC06007 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03434241T → I.Corresponds to variant rs2010722dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065788 Genomic DNA. Translation: BAC06007.1. Different initiation.
BK004371 Genomic DNA. Translation: DAA04769.1.
CCDSiCCDS59223.1.
RefSeqiNP_001005169.1. NM_001005169.1.
UniGeneiHs.553727.

Genome annotation databases

EnsembliENST00000530443; ENSP00000436453; ENSG00000232268.
GeneIDi390037.
KEGGihsa:390037.
UCSCiuc010qyi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065788 Genomic DNA. Translation: BAC06007.1. Different initiation.
BK004371 Genomic DNA. Translation: DAA04769.1.
CCDSiCCDS59223.1.
RefSeqiNP_001005169.1. NM_001005169.1.
UniGeneiHs.553727.

3D structure databases

ProteinModelPortaliQ8NGK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000409094.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGK6.
PhosphoSitePlusiQ8NGK6.

Polymorphism and mutation databases

BioMutaiOR52I1.
DMDMi38372717.

Proteomic databases

PaxDbiQ8NGK6.
PRIDEiQ8NGK6.

Protocols and materials databases

DNASUi390037.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000530443; ENSP00000436453; ENSG00000232268.
GeneIDi390037.
KEGGihsa:390037.
UCSCiuc010qyi.2. human.

Organism-specific databases

CTDi390037.
DisGeNETi390037.
GeneCardsiOR52I1.
HGNCiHGNC:15220. OR52I1.
neXtProtiNX_Q8NGK6.
OpenTargetsiENSG00000232268.
PharmGKBiPA32412.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIRM. Eukaryota.
ENOG41114NG. LUCA.
GeneTreeiENSGT00810000125507.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK6.
KOiK04257.
PhylomeDBiQ8NGK6.

Enzyme and pathway databases

BioCyciZFISH:G66-32131-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52I1.
GenomeRNAii390037.
PROiQ8NGK6.

Gene expression databases

CleanExiHS_OR52I1.
ExpressionAtlasiQ8NGK6. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52I1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK6
Secondary accession number(s): Q6IF91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.