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Q8NGK5

- O52M1_HUMAN

UniProt

Q8NGK5 - O52M1_HUMAN

Protein

Olfactory receptor 52M1

Gene

OR52M1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 52M1
    Alternative name(s):
    Olfactory receptor OR11-11
    Gene namesi
    Name:OR52M1
    Synonyms:OR52M1P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15225. OR52M1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32422.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Olfactory receptor 52M1PRO_0000150785Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi99 ↔ 192PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ8NGK5.
    PRIDEiQ8NGK5.

    PTM databases

    PhosphoSiteiQ8NGK5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8NGK5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000353343.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGK5.
    SMRiQ8NGK5. Positions 27-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19937ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 24020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 27615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 31720CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG81318.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NGK5.
    KOiK04257.
    OMAiHPTHILL.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ8NGK5.
    TreeFamiTF343679.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTFHNVCSV PSSFWLTGIP GLESLHVWLS IPFGSMYLVA VVGNVTILAV    50
    VKIERSLHQP MYFFLCMLAA IDLVLSTSTI PKLLGIFWFG ACDIGLDACL 100
    GQMFLIHCFA TVESGIFLAM AFDRYVAICN PLRHSMVLTY TVVGRLGLVS 150
    LLRGVLYIGP LPLMIRLRLP LYKTHVISHS YCEHMAVVAL TCGDSRVNNV 200
    YGLSIGFLVL ILDSVAIAAS YVMIFRAVMG LATPEARLKT LGTCASHLCA 250
    ILIFYVPIAV SSLIHRFGQC VPPPVHTLLA NFYLLIPPIL NPIVYAVRTK 300
    QIRESLLQIP RIEMKIR 317
    Length:317
    Mass (Da):35,037
    Last modified:October 1, 2002 - v1
    Checksum:iB09AD144D01F104F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91S → L.
    Corresponds to variant rs7112010 [ dbSNP | Ensembl ].
    VAR_034349
    Natural varianti305 – 3051S → R.
    Corresponds to variant rs2657167 [ dbSNP | Ensembl ].
    VAR_034350

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065789 Genomic DNA. Translation: BAC06008.1.
    BK004372 Genomic DNA. Translation: DAA04770.1.
    CCDSiCCDS31353.1.
    RefSeqiNP_001004137.1. NM_001004137.1.
    UniGeneiHs.553567.

    Genome annotation databases

    EnsembliENST00000360213; ENSP00000353343; ENSG00000197790.
    GeneIDi119772.
    KEGGihsa:119772.
    UCSCiuc010qyf.2. human.

    Polymorphism databases

    DMDMi74762580.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065789 Genomic DNA. Translation: BAC06008.1 .
    BK004372 Genomic DNA. Translation: DAA04770.1 .
    CCDSi CCDS31353.1.
    RefSeqi NP_001004137.1. NM_001004137.1.
    UniGenei Hs.553567.

    3D structure databases

    ProteinModelPortali Q8NGK5.
    SMRi Q8NGK5. Positions 27-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000353343.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGK5.

    Polymorphism databases

    DMDMi 74762580.

    Proteomic databases

    PaxDbi Q8NGK5.
    PRIDEi Q8NGK5.

    Protocols and materials databases

    DNASUi 119772.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360213 ; ENSP00000353343 ; ENSG00000197790 .
    GeneIDi 119772.
    KEGGi hsa:119772.
    UCSCi uc010qyf.2. human.

    Organism-specific databases

    CTDi 119772.
    GeneCardsi GC11P004523.
    HGNCi HGNC:15225. OR52M1.
    neXtProti NX_Q8NGK5.
    PharmGKBi PA32422.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81318.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NGK5.
    KOi K04257.
    OMAi HPTHILL.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q8NGK5.
    TreeFami TF343679.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR52M1.
    GenomeRNAii 119772.
    NextBioi 80498.
    PROi Q8NGK5.

    Gene expression databases

    Genevestigatori Q8NGK5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    Pfami PF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO52M1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3