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Q8NGK5 (O52M1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 52M1
Alternative name(s):
Olfactory receptor OR11-11
Gene names
Name:OR52M1
Synonyms:OR52M1P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Olfactory receptor 52M1
PRO_0000150785

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 4821Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 10124Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 14119Cytoplasmic Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Topological domain163 – 19937Extracellular Potential
Transmembrane200 – 22021Helical; Name=5; Potential
Topological domain221 – 24020Cytoplasmic Potential
Transmembrane241 – 26121Helical; Name=6; Potential
Topological domain262 – 27615Extracellular Potential
Transmembrane277 – 29721Helical; Name=7; Potential
Topological domain298 – 31720Cytoplasmic Potential

Amino acid modifications

Disulfide bond99 ↔ 192 By similarity

Natural variations

Natural variant91S → L.
Corresponds to variant rs7112010 [ dbSNP | Ensembl ].
VAR_034349
Natural variant3051S → R.
Corresponds to variant rs2657167 [ dbSNP | Ensembl ].
VAR_034350

Sequences

Sequence LengthMass (Da)Tools
Q8NGK5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: B09AD144D01F104F

FASTA31735,037
        10         20         30         40         50         60 
MLTFHNVCSV PSSFWLTGIP GLESLHVWLS IPFGSMYLVA VVGNVTILAV VKIERSLHQP 

        70         80         90        100        110        120 
MYFFLCMLAA IDLVLSTSTI PKLLGIFWFG ACDIGLDACL GQMFLIHCFA TVESGIFLAM 

       130        140        150        160        170        180 
AFDRYVAICN PLRHSMVLTY TVVGRLGLVS LLRGVLYIGP LPLMIRLRLP LYKTHVISHS 

       190        200        210        220        230        240 
YCEHMAVVAL TCGDSRVNNV YGLSIGFLVL ILDSVAIAAS YVMIFRAVMG LATPEARLKT 

       250        260        270        280        290        300 
LGTCASHLCA ILIFYVPIAV SSLIHRFGQC VPPPVHTLLA NFYLLIPPIL NPIVYAVRTK 

       310 
QIRESLLQIP RIEMKIR 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065789 Genomic DNA. Translation: BAC06008.1.
BK004372 Genomic DNA. Translation: DAA04770.1.
CCDSCCDS31353.1.
RefSeqNP_001004137.1. NM_001004137.1.
UniGeneHs.553567.

3D structure databases

ProteinModelPortalQ8NGK5.
SMRQ8NGK5. Positions 27-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000353343.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGK5.

Polymorphism databases

DMDM74762580.

Proteomic databases

PaxDbQ8NGK5.
PRIDEQ8NGK5.

Protocols and materials databases

DNASU119772.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360213; ENSP00000353343; ENSG00000197790.
GeneID119772.
KEGGhsa:119772.
UCSCuc010qyf.2. human.

Organism-specific databases

CTD119772.
GeneCardsGC11P004523.
HGNCHGNC:15225. OR52M1.
neXtProtNX_Q8NGK5.
PharmGKBPA32422.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81318.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ8NGK5.
KOK04257.
OMAHPTHILL.
OrthoDBEOG754HPV.
PhylomeDBQ8NGK5.
TreeFamTF343679.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

GenevestigatorQ8NGK5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR52M1.
GenomeRNAi119772.
NextBio80498.
PROQ8NGK5.

Entry information

Entry nameO52M1_HUMAN
AccessionPrimary (citable) accession number: Q8NGK5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries