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Protein

Olfactory receptor 52M1

Gene

OR52M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-30715-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52M1
Alternative name(s):
Olfactory receptor OR11-11
Gene namesi
Name:OR52M1
Synonyms:OR52M1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15225. OR52M1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 199ExtracellularSequence analysisAdd BLAST37
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 240CytoplasmicSequence analysisAdd BLAST20
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 276ExtracellularSequence analysisAdd BLAST15
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 317CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi119772.
OpenTargetsiENSG00000197790.
PharmGKBiPA32422.

Polymorphism and mutation databases

BioMutaiOR52M1.
DMDMi74762580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507851 – 317Olfactory receptor 52M1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NGK5.
PRIDEiQ8NGK5.

PTM databases

iPTMnetiQ8NGK5.
PhosphoSitePlusiQ8NGK5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353343.

Structurei

3D structure databases

ProteinModelPortaliQ8NGK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IITR. Eukaryota.
ENOG410YEKD. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK5.
KOiK04257.
OMAiCLGQMFL.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGK5.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTFHNVCSV PSSFWLTGIP GLESLHVWLS IPFGSMYLVA VVGNVTILAV
60 70 80 90 100
VKIERSLHQP MYFFLCMLAA IDLVLSTSTI PKLLGIFWFG ACDIGLDACL
110 120 130 140 150
GQMFLIHCFA TVESGIFLAM AFDRYVAICN PLRHSMVLTY TVVGRLGLVS
160 170 180 190 200
LLRGVLYIGP LPLMIRLRLP LYKTHVISHS YCEHMAVVAL TCGDSRVNNV
210 220 230 240 250
YGLSIGFLVL ILDSVAIAAS YVMIFRAVMG LATPEARLKT LGTCASHLCA
260 270 280 290 300
ILIFYVPIAV SSLIHRFGQC VPPPVHTLLA NFYLLIPPIL NPIVYAVRTK
310
QIRESLLQIP RIEMKIR
Length:317
Mass (Da):35,037
Last modified:October 1, 2002 - v1
Checksum:iB09AD144D01F104F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0343499S → L.Corresponds to variant rs7112010dbSNPEnsembl.1
Natural variantiVAR_034350305S → R.Corresponds to variant rs2657167dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065789 Genomic DNA. Translation: BAC06008.1.
BK004372 Genomic DNA. Translation: DAA04770.1.
CCDSiCCDS31353.1.
RefSeqiNP_001004137.1. NM_001004137.1.
UniGeneiHs.553567.

Genome annotation databases

EnsembliENST00000360213; ENSP00000353343; ENSG00000197790.
GeneIDi119772.
KEGGihsa:119772.
UCSCiuc010qyf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065789 Genomic DNA. Translation: BAC06008.1.
BK004372 Genomic DNA. Translation: DAA04770.1.
CCDSiCCDS31353.1.
RefSeqiNP_001004137.1. NM_001004137.1.
UniGeneiHs.553567.

3D structure databases

ProteinModelPortaliQ8NGK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353343.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGK5.
PhosphoSitePlusiQ8NGK5.

Polymorphism and mutation databases

BioMutaiOR52M1.
DMDMi74762580.

Proteomic databases

PaxDbiQ8NGK5.
PRIDEiQ8NGK5.

Protocols and materials databases

DNASUi119772.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360213; ENSP00000353343; ENSG00000197790.
GeneIDi119772.
KEGGihsa:119772.
UCSCiuc010qyf.2. human.

Organism-specific databases

CTDi119772.
DisGeNETi119772.
GeneCardsiOR52M1.
HGNCiHGNC:15225. OR52M1.
neXtProtiNX_Q8NGK5.
OpenTargetsiENSG00000197790.
PharmGKBiPA32422.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IITR. Eukaryota.
ENOG410YEKD. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK5.
KOiK04257.
OMAiCLGQMFL.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGK5.
TreeFamiTF343679.

Enzyme and pathway databases

BioCyciZFISH:G66-30715-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52M1.
GenomeRNAii119772.
PROiQ8NGK5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52M1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.