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Protein

Olfactory receptor 52M1

Gene

OR52M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52M1
Alternative name(s):
Olfactory receptor OR11-11
Gene namesi
Name:OR52M1
Synonyms:OR52M1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15225. OR52M1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19937ExtracellularSequence AnalysisAdd
BLAST
Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 24020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini262 – 27615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini298 – 31720CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32422.

Polymorphism and mutation databases

BioMutaiOR52M1.
DMDMi74762580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Olfactory receptor 52M1PRO_0000150785Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi99 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NGK5.
PRIDEiQ8NGK5.

PTM databases

PhosphoSiteiQ8NGK5.

Expressioni

Gene expression databases

GenevestigatoriQ8NGK5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353343.

Structurei

3D structure databases

ProteinModelPortaliQ8NGK5.
SMRiQ8NGK5. Positions 27-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG81318.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK5.
KOiK04257.
OMAiHPTHILL.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGK5.
TreeFamiTF343679.

Family and domain databases

InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTFHNVCSV PSSFWLTGIP GLESLHVWLS IPFGSMYLVA VVGNVTILAV
60 70 80 90 100
VKIERSLHQP MYFFLCMLAA IDLVLSTSTI PKLLGIFWFG ACDIGLDACL
110 120 130 140 150
GQMFLIHCFA TVESGIFLAM AFDRYVAICN PLRHSMVLTY TVVGRLGLVS
160 170 180 190 200
LLRGVLYIGP LPLMIRLRLP LYKTHVISHS YCEHMAVVAL TCGDSRVNNV
210 220 230 240 250
YGLSIGFLVL ILDSVAIAAS YVMIFRAVMG LATPEARLKT LGTCASHLCA
260 270 280 290 300
ILIFYVPIAV SSLIHRFGQC VPPPVHTLLA NFYLLIPPIL NPIVYAVRTK
310
QIRESLLQIP RIEMKIR
Length:317
Mass (Da):35,037
Last modified:October 1, 2002 - v1
Checksum:iB09AD144D01F104F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91S → L.
Corresponds to variant rs7112010 [ dbSNP | Ensembl ].
VAR_034349
Natural varianti305 – 3051S → R.
Corresponds to variant rs2657167 [ dbSNP | Ensembl ].
VAR_034350

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065789 Genomic DNA. Translation: BAC06008.1.
BK004372 Genomic DNA. Translation: DAA04770.1.
CCDSiCCDS31353.1.
RefSeqiNP_001004137.1. NM_001004137.1.
UniGeneiHs.553567.

Genome annotation databases

EnsembliENST00000360213; ENSP00000353343; ENSG00000197790.
GeneIDi119772.
KEGGihsa:119772.
UCSCiuc010qyf.2. human.

Polymorphism and mutation databases

BioMutaiOR52M1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065789 Genomic DNA. Translation: BAC06008.1.
BK004372 Genomic DNA. Translation: DAA04770.1.
CCDSiCCDS31353.1.
RefSeqiNP_001004137.1. NM_001004137.1.
UniGeneiHs.553567.

3D structure databases

ProteinModelPortaliQ8NGK5.
SMRiQ8NGK5. Positions 27-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353343.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGK5.

Polymorphism and mutation databases

BioMutaiOR52M1.
DMDMi74762580.

Proteomic databases

PaxDbiQ8NGK5.
PRIDEiQ8NGK5.

Protocols and materials databases

DNASUi119772.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360213; ENSP00000353343; ENSG00000197790.
GeneIDi119772.
KEGGihsa:119772.
UCSCiuc010qyf.2. human.

Organism-specific databases

CTDi119772.
GeneCardsiGC11P004523.
HGNCiHGNC:15225. OR52M1.
neXtProtiNX_Q8NGK5.
PharmGKBiPA32422.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG81318.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK5.
KOiK04257.
OMAiHPTHILL.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGK5.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52M1.
GenomeRNAii119772.
NextBioi80498.
PROiQ8NGK5.

Gene expression databases

GenevestigatoriQ8NGK5.

Family and domain databases

InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52M1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.