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Protein

Olfactory receptor 52K2

Gene

OR52K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52K2
Alternative name(s):
Olfactory receptor OR11-7
Gene namesi
Name:OR52K2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15223. OR52K2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27515ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini297 – 31418CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32418.

Polymorphism and mutation databases

BioMutaiOR52K2.
DMDMi218511725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 52K2PRO_0000150782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGK3.
PRIDEiQ8NGK3.

Expressioni

Gene expression databases

CleanExiHS_OR52K2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000318956.

Structurei

3D structure databases

ProteinModelPortaliQ8NGK3.
SMRiQ8NGK3. Positions 112-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUGV. Eukaryota.
ENOG410YB92. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK3.
KOiK04257.
OMAiNITLTHP.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGK3.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASNITLTH PTAFLLVGIP GLEHLHIWIS IPFCLAYTLA LLGNCTLLLI
60 70 80 90 100
IQADAALHEP MYLFLAMLAA IDLVLSSSAL PKMLAIFWFR DREINFFACL
110 120 130 140 150
AQMFFLHSFS IMESAVLLAM AFDRYVAICK PLHYTKVLTG SLITKIGMAA
160 170 180 190 200
VARAVTLMTP LPFLLRCFHY CRGPVIAHCY CEHMAVVRLA CGDTSFNNIY
210 220 230 240 250
GIAVAMFIVV LDLLLVILSY IFILQAVLLL ASQEARYKAF GTCVSHIGAI
260 270 280 290 300
LAFYTTVVIS SVMHRVARHA APHVHILLAN FYLLFPPMVN PIIYGVKTKQ
310
IRESILGVFP RKDM
Length:314
Mass (Da):34,926
Last modified:December 16, 2008 - v2
Checksum:iCCA5A033E904A0B6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241R → C.
Corresponds to variant rs11032296 [ dbSNP | Ensembl ].
VAR_034347
Natural varianti236 – 2361R → H.1 Publication
Corresponds to variant rs331537 [ dbSNP | Ensembl ].
VAR_047827
Natural varianti302 – 3021R → C.
Corresponds to variant rs7934336 [ dbSNP | Ensembl ].
VAR_034348

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065791 Genomic DNA. Translation: BAC06010.1.
AC010930 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68843.1.
BC137247 mRNA. Translation: AAI37248.1.
BC137248 mRNA. Translation: AAI37249.1.
BK004258 Genomic DNA. Translation: DAA04656.1.
CCDSiCCDS31351.1.
RefSeqiNP_001005172.2. NM_001005172.2.
UniGeneiHs.553568.

Genome annotation databases

EnsembliENST00000325719; ENSP00000318956; ENSG00000181963.
GeneIDi119774.
KEGGihsa:119774.
UCSCiuc001lyz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065791 Genomic DNA. Translation: BAC06010.1.
AC010930 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68843.1.
BC137247 mRNA. Translation: AAI37248.1.
BC137248 mRNA. Translation: AAI37249.1.
BK004258 Genomic DNA. Translation: DAA04656.1.
CCDSiCCDS31351.1.
RefSeqiNP_001005172.2. NM_001005172.2.
UniGeneiHs.553568.

3D structure databases

ProteinModelPortaliQ8NGK3.
SMRiQ8NGK3. Positions 112-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318956.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR52K2.
DMDMi218511725.

Proteomic databases

PaxDbiQ8NGK3.
PRIDEiQ8NGK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325719; ENSP00000318956; ENSG00000181963.
GeneIDi119774.
KEGGihsa:119774.
UCSCiuc001lyz.2. human.

Organism-specific databases

CTDi119774.
GeneCardsiOR52K2.
H-InvDBHIX0036146.
HGNCiHGNC:15223. OR52K2.
neXtProtiNX_Q8NGK3.
PharmGKBiPA32418.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUGV. Eukaryota.
ENOG410YB92. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK3.
KOiK04257.
OMAiNITLTHP.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGK3.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52K2.
GenomeRNAii119774.
NextBioi80502.
PROiQ8NGK3.

Gene expression databases

CleanExiHS_OR52K2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-236.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52K2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK3
Secondary accession number(s): A8MUY8, B2RP35, Q6IFK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: May 11, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.