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Protein

Olfactory receptor 52B4

Gene

OR52B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • cognition Source: UniProtKB
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174541-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52B4
Alternative name(s):
Olfactory receptor OR11-3
Gene namesi
Name:OR52B4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15209. OR52B4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 275ExtracellularSequence analysisAdd BLAST15
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 314CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi143496.
OpenTargetsiENSG00000221996.
PharmGKBiPA32398.

Polymorphism and mutation databases

BioMutaiOR52B4.
DMDMi68600998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507681 – 314Olfactory receptor 52B4Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGK2.
PRIDEiQ8NGK2.

PTM databases

iPTMnetiQ8NGK2.
PhosphoSitePlusiQ8NGK2.

Expressioni

Gene expression databases

CleanExiHS_OR52B4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386160.

Structurei

3D structure databases

ProteinModelPortaliQ8NGK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFD8. Eukaryota.
ENOG41115T2. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK2.
KOiK04257.
OMAiHAVFHMS.
PhylomeDBiQ8NGK2.
TreeFamiTF352745.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTVNHSGTS HTVFHLLGIP GLQDQHMWIS IPFFISYVTA LLGNSLLIFI
60 70 80 90 100
ILTKRSLHEP MYLFLCMLAG ADIVLSTCTI PQALAIFWFR AGDISLDRCI
110 120 130 140 150
TQLFFIHSTF ISESGILLVM AFDHYIAICY PLRYTTILTN ALIKKICVTV
160 170 180 190 200
SLRSYGTIFP IIFLLKRLTF CQNNIIPHTF CEHIGLAKYA CNDIRINIWY
210 220 230 240 250
GFSILMSTVV LDVVLIFISY MLILHAVFHM PSPDACHKAL NTFGSHVCII
260 270 280 290 300
ILFYGSGIFT ILTQRFGRHI PPCIHIPLAN VCILAPPMLN PIIYGIKTKQ
310
IQEQVVQFLF IKQK
Length:314
Mass (Da):35,584
Last modified:July 5, 2005 - v2
Checksum:i001831EAE8314474
GO

Polymorphismi

A stop codon at position Ala-40 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037834139T → I.Corresponds to variant rs11031961dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065792 Genomic DNA. Translation: BAC06011.1.
AC009758 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68847.1.
BK004256 Genomic DNA. Translation: DAA04654.1.
RefSeqiNP_001005161.2. NM_001005161.3.
UniGeneiHs.447463.

Genome annotation databases

EnsembliENST00000624801; ENSP00000485530; ENSG00000221996.
GeneIDi143496.
KEGGihsa:143496.
UCSCiuc010qye.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065792 Genomic DNA. Translation: BAC06011.1.
AC009758 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68847.1.
BK004256 Genomic DNA. Translation: DAA04654.1.
RefSeqiNP_001005161.2. NM_001005161.3.
UniGeneiHs.447463.

3D structure databases

ProteinModelPortaliQ8NGK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386160.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGK2.
PhosphoSitePlusiQ8NGK2.

Polymorphism and mutation databases

BioMutaiOR52B4.
DMDMi68600998.

Proteomic databases

PaxDbiQ8NGK2.
PRIDEiQ8NGK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624801; ENSP00000485530; ENSG00000221996.
GeneIDi143496.
KEGGihsa:143496.
UCSCiuc010qye.2. human.

Organism-specific databases

CTDi143496.
DisGeNETi143496.
GeneCardsiOR52B4.
HGNCiHGNC:15209. OR52B4.
neXtProtiNX_Q8NGK2.
OpenTargetsiENSG00000221996.
PharmGKBiPA32398.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFD8. Eukaryota.
ENOG41115T2. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK2.
KOiK04257.
OMAiHAVFHMS.
PhylomeDBiQ8NGK2.
TreeFamiTF352745.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174541-MONOMER.

Miscellaneous databases

GeneWikiiOR52B4.
GenomeRNAii143496.
PROiQ8NGK2.

Gene expression databases

CleanExiHS_OR52B4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52B4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK2
Secondary accession number(s): A6NP68, Q6IFK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.