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Protein

Olfactory receptor 52B4

Gene

OR52B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • cognition Source: UniProtKB
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52B4
Alternative name(s):
Olfactory receptor OR11-3
Gene namesi
Name:OR52B4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15209. OR52B4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27515ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini297 – 31418CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32398.

Polymorphism and mutation databases

BioMutaiOR52B4.
DMDMi68600998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 52B4PRO_0000150768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGK2.
PRIDEiQ8NGK2.

PTM databases

iPTMnetiQ8NGK2.
PhosphoSiteiQ8NGK2.

Expressioni

Gene expression databases

CleanExiHS_OR52B4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386160.

Structurei

3D structure databases

ProteinModelPortaliQ8NGK2.
SMRiQ8NGK2. Positions 18-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFD8. Eukaryota.
ENOG41115T2. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK2.
KOiK04257.
OMAiHAVFHMS.
PhylomeDBiQ8NGK2.
TreeFamiTF352745.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTVNHSGTS HTVFHLLGIP GLQDQHMWIS IPFFISYVTA LLGNSLLIFI
60 70 80 90 100
ILTKRSLHEP MYLFLCMLAG ADIVLSTCTI PQALAIFWFR AGDISLDRCI
110 120 130 140 150
TQLFFIHSTF ISESGILLVM AFDHYIAICY PLRYTTILTN ALIKKICVTV
160 170 180 190 200
SLRSYGTIFP IIFLLKRLTF CQNNIIPHTF CEHIGLAKYA CNDIRINIWY
210 220 230 240 250
GFSILMSTVV LDVVLIFISY MLILHAVFHM PSPDACHKAL NTFGSHVCII
260 270 280 290 300
ILFYGSGIFT ILTQRFGRHI PPCIHIPLAN VCILAPPMLN PIIYGIKTKQ
310
IQEQVVQFLF IKQK
Length:314
Mass (Da):35,584
Last modified:July 5, 2005 - v2
Checksum:i001831EAE8314474
GO

Polymorphismi

A stop codon at position Ala-40 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti139 – 1391T → I.
Corresponds to variant rs11031961 [ dbSNP | Ensembl ].
VAR_037834

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065792 Genomic DNA. Translation: BAC06011.1.
AC009758 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68847.1.
BK004256 Genomic DNA. Translation: DAA04654.1.
CCDSiCCDS41609.1.
RefSeqiNP_001005161.2. NM_001005161.3.
UniGeneiHs.447463.

Genome annotation databases

EnsembliENST00000408920; ENSP00000386160; ENSG00000221996.
ENST00000624801; ENSP00000485530; ENSG00000221996.
GeneIDi143496.
KEGGihsa:143496.
UCSCiuc010qye.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065792 Genomic DNA. Translation: BAC06011.1.
AC009758 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68847.1.
BK004256 Genomic DNA. Translation: DAA04654.1.
CCDSiCCDS41609.1.
RefSeqiNP_001005161.2. NM_001005161.3.
UniGeneiHs.447463.

3D structure databases

ProteinModelPortaliQ8NGK2.
SMRiQ8NGK2. Positions 18-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386160.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGK2.
PhosphoSiteiQ8NGK2.

Polymorphism and mutation databases

BioMutaiOR52B4.
DMDMi68600998.

Proteomic databases

PaxDbiQ8NGK2.
PRIDEiQ8NGK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408920; ENSP00000386160; ENSG00000221996.
ENST00000624801; ENSP00000485530; ENSG00000221996.
GeneIDi143496.
KEGGihsa:143496.
UCSCiuc010qye.2. human.

Organism-specific databases

CTDi143496.
GeneCardsiOR52B4.
HGNCiHGNC:15209. OR52B4.
neXtProtiNX_Q8NGK2.
PharmGKBiPA32398.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFD8. Eukaryota.
ENOG41115T2. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK2.
KOiK04257.
OMAiHAVFHMS.
PhylomeDBiQ8NGK2.
TreeFamiTF352745.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52B4.
GenomeRNAii143496.
PROiQ8NGK2.

Gene expression databases

CleanExiHS_OR52B4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52B4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK2
Secondary accession number(s): A6NP68, Q6IFK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.