UniProtKB - Q8NGK1 (O51G1_HUMAN)
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Protein
Olfactory receptor 51G1
Gene
OR51G1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G-protein coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
GO - Biological processi
- signal transduction Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 51G1Alternative name(s): Olfactory receptor 51G3 Olfactory receptor OR11-29 |
Gene namesi | Name:OR51G1 Synonyms:OR51G3P |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000176879.3 |
HGNCi | HGNC:14738 OR51G1 |
neXtProti | NX_Q8NGK1 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 56 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 57 – 77 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 101 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 102 – 122 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 123 – 141 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 142 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 198 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 199 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 239 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 240 – 260 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 261 – 275 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 276 – 296 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 321 | CytoplasmicSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79324 |
PharmGKBi | PA32376 |
Polymorphism and mutation databases
BioMutai | OR51G1 |
DMDMi | 38372713 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150754 | 1 – 321 | Olfactory receptor 51G1Add BLAST | 321 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 99 ↔ 191 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGK1 |
PRIDEi | Q8NGK1 |
PTM databases
iPTMneti | Q8NGK1 |
PhosphoSitePlusi | Q8NGK1 |
Expressioni
Gene expression databases
CleanExi | HS_OR51G1 |
ExpressionAtlasi | Q8NGK1 baseline |
Organism-specific databases
HPAi | HPA050482 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IVBQ Eukaryota ENOG411182A LUCA |
GeneTreei | ENSGT00890000139335 |
HOGENOMi | HOG000041363 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGK1 |
KOi | K04257 |
OMAi | DLHGWIS |
OrthoDBi | EOG091G0AZH |
PhylomeDBi | Q8NGK1 |
TreeFami | TF342735 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGK1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTILLNSSLQ RATFFLTGFQ GLEGLHGWIS IPFCFIYLTV ILGNLTILHV
60 70 80 90 100
ICTDATLHGP MYYFLGMLAV TDLGLCLSTL PTVLGIFWFD TREIGIPACF
110 120 130 140 150
TQLFFIHTLS SMESSVLLSM SIDRYVAVCN PLHDSTVLTP ACIVKMGLSS
160 170 180 190 200
VLRSALLILP LPFLLKRFQY CHSHVLAHAY CLHLEIMKLA CSSIIVNHIY
210 220 230 240 250
GLFVVACTVG VDSLLIFLSY ALILRTVLSI ASHQERLRAL NTCVSHICAV
260 270 280 290 300
LLFYIPMIGL SLVHRFGEHL PRVVHLFMSY VYLLVPPLMN PIIYSIKTKQ
310 320
IRQRIIKKFQ FIKSLRCFWK D
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053324 | 114 | S → L. Corresponds to variant dbSNP:rs10836954Ensembl. | 1 | |
Natural variantiVAR_053325 | 124 | R → H. Corresponds to variant dbSNP:rs34742470Ensembl. | 1 | |
Natural variantiVAR_034318 | 125 | Y → S1 PublicationCorresponds to variant dbSNP:rs1378739Ensembl. | 1 | |
Natural variantiVAR_053326 | 195 | I → T. Corresponds to variant dbSNP:rs12796015Ensembl. | 1 | |
Natural variantiVAR_062080 | 303 | Q → H. Corresponds to variant dbSNP:rs57920748Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065793 Genomic DNA Translation: BAC06012.1 BC136852 mRNA Translation: AAI36853.1 BC136861 mRNA Translation: AAI36862.1 BK004286 Genomic DNA Translation: DAA04684.1 |
RefSeqi | NP_001005237.1, NM_001005237.1 |
UniGenei | Hs.554541 |
Genome annotation databases
Ensembli | ENST00000623849; ENSP00000485612; ENSG00000278870 |
GeneIDi | 79324 |
KEGGi | hsa:79324 |
UCSCi | uc010qyr.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | O51G1_HUMAN | |
Accessioni | Q8NGK1Primary (citable) accession number: Q8NGK1 Secondary accession number(s): B9EGW8, Q6IFH6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 28, 2018 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |