OR51G1

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

signal transduction Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 51G1 Alternative name(s): Olfactory receptor 51G3 Olfactory receptor OR11-29
Gene namesⁱ	Name:OR51G1 Synonyms:OR51G3P
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000176879.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14738 OR51G1
neXtProtⁱ	NX_Q8NGK1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 27	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	28 – 48	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	49 – 56	CytoplasmicSequence analysis	8
Transmembraneⁱ	57 – 77	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	78 – 101	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	102 – 122	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	123 – 141	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	142 – 162	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	163 – 198	ExtracellularSequence analysisAdd BLAST	36
Transmembraneⁱ	199 – 219	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	220 – 239	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	240 – 260	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	261 – 275	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	276 – 296	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	297 – 321	CytoplasmicSequence analysisAdd BLAST	25

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79324
PharmGKBⁱ	PA32376

Polymorphism and mutation databases

BioMutaⁱ	OR51G1
DMDMⁱ	38372713

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150754	1 – 321	Olfactory receptor 51G1Add BLAST		321

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	6	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	99 ↔ 191	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGK1
PRIDEⁱ	Q8NGK1

PTM databases

iPTMnetⁱ	Q8NGK1
PhosphoSitePlusⁱ	Q8NGK1

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_OR51G1
ExpressionAtlasⁱ	Q8NGK1 differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA050482

HPAⁱ

HPA050482

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000322546

STRINGⁱ

9606.ENSP00000322546

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGK1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IVBQ Eukaryota ENOG411182A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139335
HOGENOMⁱ	HOG000041363
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGK1
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	DLHGWIS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH
PhylomeDBⁱ	Q8NGK1
TreeFamⁱ	TF342735

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGK1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTILLNSSLQ RATFFLTGFQ GLEGLHGWIS IPFCFIYLTV ILGNLTILHV 
        60         70         80         90        100
ICTDATLHGP MYYFLGMLAV TDLGLCLSTL PTVLGIFWFD TREIGIPACF 
       110        120        130        140        150
TQLFFIHTLS SMESSVLLSM SIDRYVAVCN PLHDSTVLTP ACIVKMGLSS 
       160        170        180        190        200
VLRSALLILP LPFLLKRFQY CHSHVLAHAY CLHLEIMKLA CSSIIVNHIY 
       210        220        230        240        250
GLFVVACTVG VDSLLIFLSY ALILRTVLSI ASHQERLRAL NTCVSHICAV 
       260        270        280        290        300
LLFYIPMIGL SLVHRFGEHL PRVVHLFMSY VYLLVPPLMN PIIYSIKTKQ 
       310        320 
IRQRIIKKFQ FIKSLRCFWK D

Length:321

Mass (Da):36,290

Last modified:October 1, 2002 - v1

Checksum:ⁱEDDEECD9FD1005C5

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_053324	114	S → L. Corresponds to variant dbSNP:rs10836954Ensembl.	1
Natural variantⁱVAR_053325	124	R → H. Corresponds to variant dbSNP:rs34742470Ensembl.	1
Natural variantⁱVAR_034318	125	Y → S1 PublicationCorresponds to variant dbSNP:rs1378739Ensembl.	1
Natural variantⁱVAR_053326	195	I → T. Corresponds to variant dbSNP:rs12796015Ensembl.	1
Natural variantⁱVAR_062080	303	Q → H. Corresponds to variant dbSNP:rs57920748Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065793 Genomic DNA Translation: BAC06012.1 BC136852 mRNA Translation: AAI36853.1 BC136861 mRNA Translation: AAI36862.1 BK004286 Genomic DNA Translation: DAA04684.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001005237.1, NM_001005237.1
UniGeneⁱ	Hs.554541

Genome annotation databases

Ensemblⁱ	ENST00000623849; ENSP00000485612; ENSG00000278870
GeneIDⁱ	79324
KEGGⁱ	hsa:79324
UCSC genome browser More...UCSCⁱ	uc010qyr.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8NGK1	Olfactory receptor		HUMAN		321
Olfactory receptor		PANTR		321
Olfactory receptor		Cebus capucinus imitator		321
Olfactory receptor		GORGO		321
UPI0004F4AF40		PONAB		321
+2

Protein	Similar proteins		Species	Score	Length
Q8NGK1	Olfactory receptor 51F1		HUMAN		319
UPI0004F0C115		PANPA		319
Olfactory receptor		GORGO		319
OR51F1 isoform 1		PANTR		319
Olfactory receptor		CALJA		319
+1724

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065793 Genomic DNA Translation: BAC06012.1 BC136852 mRNA Translation: AAI36853.1 BC136861 mRNA Translation: AAI36862.1 BK004286 Genomic DNA Translation: DAA04684.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001005237.1, NM_001005237.1
UniGeneⁱ	Hs.554541

3D structure databases

ProteinModelPortalⁱ	Q8NGK1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000322546

STRINGⁱ

9606.ENSP00000322546

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q8NGK1
PhosphoSitePlusⁱ	Q8NGK1

Polymorphism and mutation databases

BioMutaⁱ	OR51G1
DMDMⁱ	38372713

Proteomic databases

PaxDbⁱ	Q8NGK1
PRIDEⁱ	Q8NGK1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000623849; ENSP00000485612; ENSG00000278870
GeneIDⁱ	79324
KEGGⁱ	hsa:79324
UCSC genome browser More...UCSCⁱ	uc010qyr.2 human

Organism-specific databases

CTDⁱ	79324
DisGeNET More...DisGeNETⁱ	79324
EuPathDBⁱ	HostDB:ENSG00000176879.3
GeneCardsⁱ	OR51G1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14738 OR51G1
Human Protein Atlas More...HPAⁱ	HPA050482
neXtProtⁱ	NX_Q8NGK1
PharmGKBⁱ	PA32376
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVBQ Eukaryota ENOG411182A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139335
HOGENOMⁱ	HOG000041363
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGK1
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	DLHGWIS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH
PhylomeDBⁱ	Q8NGK1
TreeFamⁱ	TF342735

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiⁱ	OR51G1
GenomeRNAiⁱ	79324
Protein Ontology More...PROⁱ	PR:Q8NGK1

Gene expression databases

CleanExⁱ	HS_OR51G1
ExpressionAtlasⁱ	Q8NGK1 differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O51G1_HUMAN
Accessionⁱ	Q8NGK1Primary (citable) accession number: Q8NGK1 Secondary accession number(s): B9EGW8, Q6IFH6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	October 1, 2002
	Last modified:	May 23, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q8NGK1 (O51G1_HUMAN)

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Olfactory receptor 51G1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ