OR51G1

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

signal transduction Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 51G1 Alternative name(s): Olfactory receptor 51G3 Olfactory receptor OR11-29
Gene namesⁱ	Name:OR51G1 Synonyms:OR51G3P
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14738. OR51G1.

HGNCⁱ

HGNC:14738. OR51G1.

Subcellular locationⁱ

Cell membrane; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 27	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	28 – 48	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	49 – 56	CytoplasmicSequence analysis	8
Transmembraneⁱ	57 – 77	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	78 – 101	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	102 – 122	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	123 – 141	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	142 – 162	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	163 – 198	ExtracellularSequence analysisAdd BLAST	36
Transmembraneⁱ	199 – 219	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	220 – 239	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	240 – 260	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	261 – 275	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	276 – 296	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	297 – 321	CytoplasmicSequence analysisAdd BLAST	25

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: GO_Central

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79324.
PharmGKBⁱ	PA32376.

Polymorphism and mutation databases

BioMutaⁱ	OR51G1.
DMDMⁱ	38372713.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150754	1 – 321	Olfactory receptor 51G1Add BLAST		321

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	6	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	99 ↔ 191	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGK1.
PRIDEⁱ	Q8NGK1.

PTM databases

iPTMnetⁱ	Q8NGK1.
PhosphoSitePlusⁱ	Q8NGK1.

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_OR51G1.
ExpressionAtlasⁱ	Q8NGK1. baseline.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA050482.

HPAⁱ

HPA050482.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000322546.

STRINGⁱ

9606.ENSP00000322546.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGK1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IVBQ. Eukaryota. ENOG411182A. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129672.
HOGENOMⁱ	HOG000041363.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	Q8NGK1.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	DLHGWIS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH.
PhylomeDBⁱ	Q8NGK1.
TreeFamⁱ	TF342735.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGK1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTILLNSSLQ RATFFLTGFQ GLEGLHGWIS IPFCFIYLTV ILGNLTILHV 
        60         70         80         90        100
ICTDATLHGP MYYFLGMLAV TDLGLCLSTL PTVLGIFWFD TREIGIPACF 
       110        120        130        140        150
TQLFFIHTLS SMESSVLLSM SIDRYVAVCN PLHDSTVLTP ACIVKMGLSS 
       160        170        180        190        200
VLRSALLILP LPFLLKRFQY CHSHVLAHAY CLHLEIMKLA CSSIIVNHIY 
       210        220        230        240        250
GLFVVACTVG VDSLLIFLSY ALILRTVLSI ASHQERLRAL NTCVSHICAV 
       260        270        280        290        300
LLFYIPMIGL SLVHRFGEHL PRVVHLFMSY VYLLVPPLMN PIIYSIKTKQ 
       310        320 
IRQRIIKKFQ FIKSLRCFWK D

Length:321

Mass (Da):36,290

Last modified:October 1, 2002 - v1

Checksum:ⁱEDDEECD9FD1005C5

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_053324	114	S → L. Corresponds to variant dbSNP:rs10836954Ensembl.	1
Natural variantⁱVAR_053325	124	R → H. Corresponds to variant dbSNP:rs34742470Ensembl.	1
Natural variantⁱVAR_034318	125	Y → S1 PublicationCorresponds to variant dbSNP:rs1378739Ensembl.	1
Natural variantⁱVAR_053326	195	I → T. Corresponds to variant dbSNP:rs12796015Ensembl.	1
Natural variantⁱVAR_062080	303	Q → H. Corresponds to variant dbSNP:rs57920748Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065793 Genomic DNA. Translation: BAC06012.1. BC136852 mRNA. Translation: AAI36853.1. BC136861 mRNA. Translation: AAI36862.1. BK004286 Genomic DNA. Translation: DAA04684.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001005237.1. NM_001005237.1.
UniGeneⁱ	Hs.554541.

Genome annotation databases

Ensemblⁱ	ENST00000623849; ENSP00000485612; ENSG00000278870.
GeneIDⁱ	79324.
KEGGⁱ	hsa:79324.
UCSC genome browser More...UCSCⁱ	uc010qyr.2. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065793 Genomic DNA. Translation: BAC06012.1. BC136852 mRNA. Translation: AAI36853.1. BC136861 mRNA. Translation: AAI36862.1. BK004286 Genomic DNA. Translation: DAA04684.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001005237.1. NM_001005237.1.
UniGeneⁱ	Hs.554541.

3D structure databases

ProteinModelPortalⁱ	Q8NGK1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000322546.

STRINGⁱ

9606.ENSP00000322546.

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q8NGK1.
PhosphoSitePlusⁱ	Q8NGK1.

Polymorphism and mutation databases

BioMutaⁱ	OR51G1.
DMDMⁱ	38372713.

Proteomic databases

PaxDbⁱ	Q8NGK1.
PRIDEⁱ	Q8NGK1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000623849; ENSP00000485612; ENSG00000278870.
GeneIDⁱ	79324.
KEGGⁱ	hsa:79324.
UCSC genome browser More...UCSCⁱ	uc010qyr.2. human.

Organism-specific databases

CTDⁱ	79324.
DisGeNET More...DisGeNETⁱ	79324.
GeneCardsⁱ	OR51G1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14738. OR51G1.
Human Protein Atlas More...HPAⁱ	HPA050482.
neXtProtⁱ	NX_Q8NGK1.
PharmGKBⁱ	PA32376.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVBQ. Eukaryota. ENOG411182A. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129672.
HOGENOMⁱ	HOG000041363.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	Q8NGK1.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	DLHGWIS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH.
PhylomeDBⁱ	Q8NGK1.
TreeFamⁱ	TF342735.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiⁱ	OR51G1.
GenomeRNAiⁱ	79324.
Protein Ontology More...PROⁱ	PR:Q8NGK1.

Gene expression databases

CleanExⁱ	HS_OR51G1.
ExpressionAtlasⁱ	Q8NGK1. baseline.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O51G1_HUMAN
Accessionⁱ	Q8NGK1Primary (citable) accession number: Q8NGK1 Secondary accession number(s): B9EGW8, Q6IFH6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	October 1, 2002
	Last modified:	June 7, 2017
	This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NGK1 (O51G1_HUMAN)

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Olfactory receptor 51G1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ