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Protein

Olfactory receptor 51G1

Gene

OR51G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51G1
Alternative name(s):
Olfactory receptor 51G3
Olfactory receptor OR11-29
Gene namesi
Name:OR51G1
Synonyms:OR51G3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14738. OR51G1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27515ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini297 – 32125CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32376.

Polymorphism and mutation databases

BioMutaiOR51G1.
DMDMi38372713.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Olfactory receptor 51G1PRO_0000150754Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGK1.
PRIDEiQ8NGK1.

PTM databases

iPTMnetiQ8NGK1.

Expressioni

Gene expression databases

CleanExiHS_OR51G1.

Organism-specific databases

HPAiHPA050482.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322546.

Structurei

3D structure databases

ProteinModelPortaliQ8NGK1.
SMRiQ8NGK1. Positions 111-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVBQ. Eukaryota.
ENOG411182A. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK1.
KOiK04257.
OMAiARIIKMG.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGK1.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILLNSSLQ RATFFLTGFQ GLEGLHGWIS IPFCFIYLTV ILGNLTILHV
60 70 80 90 100
ICTDATLHGP MYYFLGMLAV TDLGLCLSTL PTVLGIFWFD TREIGIPACF
110 120 130 140 150
TQLFFIHTLS SMESSVLLSM SIDRYVAVCN PLHDSTVLTP ACIVKMGLSS
160 170 180 190 200
VLRSALLILP LPFLLKRFQY CHSHVLAHAY CLHLEIMKLA CSSIIVNHIY
210 220 230 240 250
GLFVVACTVG VDSLLIFLSY ALILRTVLSI ASHQERLRAL NTCVSHICAV
260 270 280 290 300
LLFYIPMIGL SLVHRFGEHL PRVVHLFMSY VYLLVPPLMN PIIYSIKTKQ
310 320
IRQRIIKKFQ FIKSLRCFWK D
Length:321
Mass (Da):36,290
Last modified:October 1, 2002 - v1
Checksum:iEDDEECD9FD1005C5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti114 – 1141S → L.
Corresponds to variant rs10836954 [ dbSNP | Ensembl ].
VAR_053324
Natural varianti124 – 1241R → H.
Corresponds to variant rs34742470 [ dbSNP | Ensembl ].
VAR_053325
Natural varianti125 – 1251Y → S.1 Publication
Corresponds to variant rs1378739 [ dbSNP | Ensembl ].
VAR_034318
Natural varianti195 – 1951I → T.
Corresponds to variant rs12796015 [ dbSNP | Ensembl ].
VAR_053326
Natural varianti303 – 3031Q → H.
Corresponds to variant rs57920748 [ dbSNP | Ensembl ].
VAR_062080

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065793 Genomic DNA. Translation: BAC06012.1.
BC136852 mRNA. Translation: AAI36853.1.
BC136861 mRNA. Translation: AAI36862.1.
BK004286 Genomic DNA. Translation: DAA04684.1.
CCDSiCCDS31366.1.
RefSeqiNP_001005237.1. NM_001005237.1.
UniGeneiHs.554541.

Genome annotation databases

EnsembliENST00000321961; ENSP00000322546; ENSG00000176879.
GeneIDi79324.
KEGGihsa:79324.
UCSCiuc010qyr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065793 Genomic DNA. Translation: BAC06012.1.
BC136852 mRNA. Translation: AAI36853.1.
BC136861 mRNA. Translation: AAI36862.1.
BK004286 Genomic DNA. Translation: DAA04684.1.
CCDSiCCDS31366.1.
RefSeqiNP_001005237.1. NM_001005237.1.
UniGeneiHs.554541.

3D structure databases

ProteinModelPortaliQ8NGK1.
SMRiQ8NGK1. Positions 111-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322546.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGK1.

Polymorphism and mutation databases

BioMutaiOR51G1.
DMDMi38372713.

Proteomic databases

PaxDbiQ8NGK1.
PRIDEiQ8NGK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321961; ENSP00000322546; ENSG00000176879.
GeneIDi79324.
KEGGihsa:79324.
UCSCiuc010qyr.2. human.

Organism-specific databases

CTDi79324.
GeneCardsiOR51G1.
HGNCiHGNC:14738. OR51G1.
HPAiHPA050482.
neXtProtiNX_Q8NGK1.
PharmGKBiPA32376.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVBQ. Eukaryota.
ENOG411182A. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK1.
KOiK04257.
OMAiARIIKMG.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGK1.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51G1.
GenomeRNAii79324.
PROiQ8NGK1.

Gene expression databases

CleanExiHS_OR51G1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-125.
    Tissue: Testis.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO51G1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK1
Secondary accession number(s): B9EGW8, Q6IFH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.