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Protein

Olfactory receptor 51G1

Gene

OR51G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51G1
Alternative name(s):
Olfactory receptor 51G3
Olfactory receptor OR11-29
Gene namesi
Name:OR51G1
Synonyms:OR51G3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176879.3
HGNCiHGNC:14738 OR51G1
neXtProtiNX_Q8NGK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 275ExtracellularSequence analysisAdd BLAST15
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 321CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79324
PharmGKBiPA32376

Polymorphism and mutation databases

BioMutaiOR51G1
DMDMi38372713

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507541 – 321Olfactory receptor 51G1Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGK1
PRIDEiQ8NGK1

PTM databases

iPTMnetiQ8NGK1
PhosphoSitePlusiQ8NGK1

Expressioni

Gene expression databases

CleanExiHS_OR51G1
ExpressionAtlasiQ8NGK1 differential

Organism-specific databases

HPAiHPA050482

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322546

Structurei

3D structure databases

ProteinModelPortaliQ8NGK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVBQ Eukaryota
ENOG411182A LUCA
GeneTreeiENSGT00890000139335
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NGK1
KOiK04257
OMAiDLHGWIS
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGK1
TreeFamiTF342735

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILLNSSLQ RATFFLTGFQ GLEGLHGWIS IPFCFIYLTV ILGNLTILHV
60 70 80 90 100
ICTDATLHGP MYYFLGMLAV TDLGLCLSTL PTVLGIFWFD TREIGIPACF
110 120 130 140 150
TQLFFIHTLS SMESSVLLSM SIDRYVAVCN PLHDSTVLTP ACIVKMGLSS
160 170 180 190 200
VLRSALLILP LPFLLKRFQY CHSHVLAHAY CLHLEIMKLA CSSIIVNHIY
210 220 230 240 250
GLFVVACTVG VDSLLIFLSY ALILRTVLSI ASHQERLRAL NTCVSHICAV
260 270 280 290 300
LLFYIPMIGL SLVHRFGEHL PRVVHLFMSY VYLLVPPLMN PIIYSIKTKQ
310 320
IRQRIIKKFQ FIKSLRCFWK D
Length:321
Mass (Da):36,290
Last modified:October 1, 2002 - v1
Checksum:iEDDEECD9FD1005C5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053324114S → L. Corresponds to variant dbSNP:rs10836954Ensembl.1
Natural variantiVAR_053325124R → H. Corresponds to variant dbSNP:rs34742470Ensembl.1
Natural variantiVAR_034318125Y → S1 PublicationCorresponds to variant dbSNP:rs1378739Ensembl.1
Natural variantiVAR_053326195I → T. Corresponds to variant dbSNP:rs12796015Ensembl.1
Natural variantiVAR_062080303Q → H. Corresponds to variant dbSNP:rs57920748Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065793 Genomic DNA Translation: BAC06012.1
BC136852 mRNA Translation: AAI36853.1
BC136861 mRNA Translation: AAI36862.1
BK004286 Genomic DNA Translation: DAA04684.1
RefSeqiNP_001005237.1, NM_001005237.1
UniGeneiHs.554541

Genome annotation databases

EnsembliENST00000623849; ENSP00000485612; ENSG00000278870
GeneIDi79324
KEGGihsa:79324
UCSCiuc010qyr.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO51G1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK1
Secondary accession number(s): B9EGW8, Q6IFH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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