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Protein

Olfactory receptor 51G2

Gene

OR51G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51G2
Alternative name(s):
Olfactory receptor OR11-28
Gene namesi
Name:OR51G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15198. OR51G2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence analysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini52 – 598CytoplasmicSequence analysis
Transmembranei60 – 8021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 10424ExtracellularSequence analysisAdd
BLAST
Transmembranei105 – 12521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini126 – 14419CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini166 – 20136ExtracellularSequence analysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini223 – 24220CytoplasmicSequence analysisAdd
BLAST
Transmembranei243 – 26321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini264 – 27815ExtracellularSequence analysisAdd
BLAST
Transmembranei279 – 29921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini300 – 31415CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32377.

Polymorphism and mutation databases

BioMutaiOR51G2.
DMDMi38372712.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 51G2PRO_0000150755Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Disulfide bondi102 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGK0.
PRIDEiQ8NGK0.

PTM databases

iPTMnetiQ8NGK0.

Expressioni

Gene expression databases

CleanExiHS_OR51G2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322593.

Structurei

3D structure databases

ProteinModelPortaliQ8NGK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIE4. Eukaryota.
ENOG4111C5A. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK0.
KOiK04257.
OMAiGIFWIGA.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGK0.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLGSLGNSS SSVSATFLLS GIPGLERMHI WISIPLCFMY LVSIPGNCTI
60 70 80 90 100
LFIIKTERSL HEPMYLFLSM LALIDLGLSL CTLPTVLGIF WVGAREISHD
110 120 130 140 150
ACFAQLFFIH CFSFLESSVL LSMAFDRFVA ICHPLHYVSI LTNTVIGRIG
160 170 180 190 200
LVSLGRSVAL IFPLPFMLKR FPYCGSPVLS HSYCLHQEVM KLACADMKAN
210 220 230 240 250
SIYGMFVIVS TVGIDSLLIL FSYALILRTV LSIASRAERF KALNTCVSHI
260 270 280 290 300
CAVLLFYTPM IGLSVIHRFG KQAPHLVQVV MGFMYLLFPP VMNPIVYSVK
310
TKQIRDRVTH AFCY
Length:314
Mass (Da):35,012
Last modified:October 1, 2002 - v1
Checksum:i97DD37E1F38E976C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941A → E.
Corresponds to variant rs16907312 [ dbSNP | Ensembl ].
VAR_053327
Natural varianti96 – 961E → Q.
Corresponds to variant rs12419598 [ dbSNP | Ensembl ].
VAR_034319

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065794 Genomic DNA. Translation: BAC06013.1.
CH471064 Genomic DNA. Translation: EAW68821.1.
BC136830 mRNA. Translation: AAI36831.1.
BC136831 mRNA. Translation: AAI36832.1.
BK004285 Genomic DNA. Translation: DAA04683.1.
CCDSiCCDS31365.1.
RefSeqiNP_001005238.1. NM_001005238.1.
UniGeneiHs.542302.

Genome annotation databases

EnsembliENST00000322013; ENSP00000322593; ENSG00000176893.
GeneIDi81282.
KEGGihsa:81282.
UCSCiuc001lzr.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065794 Genomic DNA. Translation: BAC06013.1.
CH471064 Genomic DNA. Translation: EAW68821.1.
BC136830 mRNA. Translation: AAI36831.1.
BC136831 mRNA. Translation: AAI36832.1.
BK004285 Genomic DNA. Translation: DAA04683.1.
CCDSiCCDS31365.1.
RefSeqiNP_001005238.1. NM_001005238.1.
UniGeneiHs.542302.

3D structure databases

ProteinModelPortaliQ8NGK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322593.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGK0.

Polymorphism and mutation databases

BioMutaiOR51G2.
DMDMi38372712.

Proteomic databases

PaxDbiQ8NGK0.
PRIDEiQ8NGK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322013; ENSP00000322593; ENSG00000176893.
GeneIDi81282.
KEGGihsa:81282.
UCSCiuc001lzr.1. human.

Organism-specific databases

CTDi81282.
GeneCardsiOR51G2.
HGNCiHGNC:15198. OR51G2.
neXtProtiNX_Q8NGK0.
PharmGKBiPA32377.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIE4. Eukaryota.
ENOG4111C5A. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGK0.
KOiK04257.
OMAiGIFWIGA.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGK0.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51G2.
GenomeRNAii81282.
PROiQ8NGK0.

Gene expression databases

CleanExiHS_OR51G2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO51G2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK0
Secondary accession number(s): Q6IFH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.