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Protein

Olfactory receptor 51S1

Gene

OR51S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51S1
Alternative name(s):
Olfactory receptor OR11-24
Gene namesi
Name:OR51S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15204. OR51S1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini55 – 628CytoplasmicSequence Analysis
Transmembranei63 – 8321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini84 – 10724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei108 – 12821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini129 – 14719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini169 – 20335ExtracellularSequence AnalysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini225 – 24420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini266 – 28015ExtracellularSequence AnalysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini302 – 32322CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Olfactory receptor 51S1PRO_0000150762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi105 ↔ 197PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGJ8.

Expressioni

Gene expression databases

CleanExiHS_OR51S1.
GenevestigatoriQ8NGJ8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322754.

Structurei

3D structure databases

ProteinModelPortaliQ8NGJ8.
SMRiQ8NGJ8. Positions 24-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40020.
GeneTreeiENSGT00780000122068.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGJ8.
KOiK04257.
OMAiNNTSMAP.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGJ8.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLPTQIAP NSSTSMAPTF LLVGMPGLSG APSWWTLPLI AVYLLSALGN
60 70 80 90 100
GTILWIIALQ PALHRPMHFF LFLLSVSDIG LVTALMPTLL GIALAGAHTV
110 120 130 140 150
PASACLLQMV FIHVFSVMES SVLLAMSIDR ALAICRPLHY PALLTNGVIS
160 170 180 190 200
KISLAISFRC LGLHLPLPFL LAYMPYCLPQ VLTHSYCLHP DVARLACPEA
210 220 230 240 250
WGAAYSLFVV LSAMGLDPLL IFFSYGLIGK VLQGVESRED RWKAGQTCAA
260 270 280 290 300
HLSAVLLFYI PMILLALINH PELPITQHTH TLLSYVHFLL PPLINPILYS
310 320
VKMKEIRKRI LNRLQPRKVG GAQ
Length:323
Mass (Da):35,313
Last modified:September 30, 2002 - v1
Checksum:i366318DDE5CE6D73
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571I → N.
Corresponds to variant rs12417164 [ dbSNP | Ensembl ].
VAR_034329
Natural varianti60 – 601Q → E.
Corresponds to variant rs11602499 [ dbSNP | Ensembl ].
VAR_034330
Natural varianti178 – 1781L → R.
Corresponds to variant rs7117260 [ dbSNP | Ensembl ].
VAR_024145
Natural varianti264 – 2641L → F.
Corresponds to variant rs12361955 [ dbSNP | Ensembl ].
VAR_053331

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065796 Genomic DNA. Translation: BAC06015.1.
BC136932 mRNA. Translation: AAI36933.1.
BC136934 mRNA. Translation: AAI36935.1.
BK004280 Genomic DNA. Translation: DAA04678.1.
CCDSiCCDS31362.1.
RefSeqiNP_001004758.1. NM_001004758.1.
UniGeneiHs.553561.

Genome annotation databases

EnsembliENST00000322101; ENSP00000322754; ENSG00000176922.
GeneIDi119692.
KEGGihsa:119692.
UCSCiuc010qyo.2. human.

Polymorphism databases

DMDMi38372710.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065796 Genomic DNA. Translation: BAC06015.1.
BC136932 mRNA. Translation: AAI36933.1.
BC136934 mRNA. Translation: AAI36935.1.
BK004280 Genomic DNA. Translation: DAA04678.1.
CCDSiCCDS31362.1.
RefSeqiNP_001004758.1. NM_001004758.1.
UniGeneiHs.553561.

3D structure databases

ProteinModelPortaliQ8NGJ8.
SMRiQ8NGJ8. Positions 24-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322754.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi38372710.

Proteomic databases

PRIDEiQ8NGJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322101; ENSP00000322754; ENSG00000176922.
GeneIDi119692.
KEGGihsa:119692.
UCSCiuc010qyo.2. human.

Organism-specific databases

CTDi119692.
GeneCardsiGC11M004870.
HGNCiHGNC:15204. OR51S1.
neXtProtiNX_Q8NGJ8.
PharmGKBiPA32390.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40020.
GeneTreeiENSGT00780000122068.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGJ8.
KOiK04257.
OMAiNNTSMAP.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGJ8.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51S1.
GenomeRNAii119692.
NextBioi80461.
PROiQ8NGJ8.

Gene expression databases

CleanExiHS_OR51S1.
GenevestigatoriQ8NGJ8.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiO51S1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGJ8
Secondary accession number(s): B9EGZ1, Q6IFI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 9, 2003
Last sequence update: September 30, 2002
Last modified: February 3, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.