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Q8NGJ8

- O51S1_HUMAN

UniProt

Q8NGJ8 - O51S1_HUMAN

Protein

Olfactory receptor 51S1

Gene

OR51S1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 51S1
    Alternative name(s):
    Olfactory receptor OR11-24
    Gene namesi
    Name:OR51S1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15204. OR51S1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32390.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Olfactory receptor 51S1PRO_0000150762Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi105 ↔ 197PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGJ8.

    Expressioni

    Gene expression databases

    CleanExiHS_OR51S1.
    GenevestigatoriQ8NGJ8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000322754.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGJ8.
    SMRiQ8NGJ8. Positions 24-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini55 – 628CytoplasmicSequence Analysis
    Topological domaini84 – 10724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini129 – 14719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 20335ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 24420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 28015ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini302 – 32322CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40020.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NGJ8.
    KOiK04257.
    OMAiPFLLAYM.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ8NGJ8.
    TreeFamiTF342735.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTLPTQIAP NSSTSMAPTF LLVGMPGLSG APSWWTLPLI AVYLLSALGN    50
    GTILWIIALQ PALHRPMHFF LFLLSVSDIG LVTALMPTLL GIALAGAHTV 100
    PASACLLQMV FIHVFSVMES SVLLAMSIDR ALAICRPLHY PALLTNGVIS 150
    KISLAISFRC LGLHLPLPFL LAYMPYCLPQ VLTHSYCLHP DVARLACPEA 200
    WGAAYSLFVV LSAMGLDPLL IFFSYGLIGK VLQGVESRED RWKAGQTCAA 250
    HLSAVLLFYI PMILLALINH PELPITQHTH TLLSYVHFLL PPLINPILYS 300
    VKMKEIRKRI LNRLQPRKVG GAQ 323
    Length:323
    Mass (Da):35,313
    Last modified:October 1, 2002 - v1
    Checksum:i366318DDE5CE6D73
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571I → N.
    Corresponds to variant rs12417164 [ dbSNP | Ensembl ].
    VAR_034329
    Natural varianti60 – 601Q → E.
    Corresponds to variant rs11602499 [ dbSNP | Ensembl ].
    VAR_034330
    Natural varianti178 – 1781L → R.
    Corresponds to variant rs7117260 [ dbSNP | Ensembl ].
    VAR_024145
    Natural varianti264 – 2641L → F.
    Corresponds to variant rs12361955 [ dbSNP | Ensembl ].
    VAR_053331

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065796 Genomic DNA. Translation: BAC06015.1.
    BC136932 mRNA. Translation: AAI36933.1.
    BC136934 mRNA. Translation: AAI36935.1.
    BK004280 Genomic DNA. Translation: DAA04678.1.
    CCDSiCCDS31362.1.
    RefSeqiNP_001004758.1. NM_001004758.1.
    UniGeneiHs.553561.

    Genome annotation databases

    EnsembliENST00000322101; ENSP00000322754; ENSG00000176922.
    GeneIDi119692.
    KEGGihsa:119692.
    UCSCiuc010qyo.2. human.

    Polymorphism databases

    DMDMi38372710.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065796 Genomic DNA. Translation: BAC06015.1 .
    BC136932 mRNA. Translation: AAI36933.1 .
    BC136934 mRNA. Translation: AAI36935.1 .
    BK004280 Genomic DNA. Translation: DAA04678.1 .
    CCDSi CCDS31362.1.
    RefSeqi NP_001004758.1. NM_001004758.1.
    UniGenei Hs.553561.

    3D structure databases

    ProteinModelPortali Q8NGJ8.
    SMRi Q8NGJ8. Positions 24-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000322754.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372710.

    Proteomic databases

    PRIDEi Q8NGJ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322101 ; ENSP00000322754 ; ENSG00000176922 .
    GeneIDi 119692.
    KEGGi hsa:119692.
    UCSCi uc010qyo.2. human.

    Organism-specific databases

    CTDi 119692.
    GeneCardsi GC11M004870.
    HGNCi HGNC:15204. OR51S1.
    neXtProti NX_Q8NGJ8.
    PharmGKBi PA32390.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40020.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NGJ8.
    KOi K04257.
    OMAi PFLLAYM.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q8NGJ8.
    TreeFami TF342735.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR51S1.
    GenomeRNAii 119692.
    NextBioi 80461.
    PROi Q8NGJ8.

    Gene expression databases

    CleanExi HS_OR51S1.
    Genevestigatori Q8NGJ8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO51S1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGJ8
    Secondary accession number(s): B9EGZ1, Q6IFI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3