UniProtKB - Q8NGJ8 (O51S1_HUMAN)
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Protein
Olfactory receptor 51S1
Gene
OR51S1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G-protein coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
GO - Biological processi
- signal transduction Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753. Olfactory Signaling Pathway. |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 51S1Alternative name(s): Olfactory receptor OR11-24 |
Gene namesi | Name:OR51S1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000176922.3. |
HGNCi | HGNC:15204. OR51S1. |
neXtProti | NX_Q8NGJ8. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 33 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 34 – 54 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 55 – 62 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 63 – 83 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 84 – 107 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 108 – 128 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 147 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 148 – 168 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 169 – 203 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 204 – 224 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 225 – 244 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 245 – 265 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 266 – 280 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 281 – 301 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 302 – 323 | CytoplasmicSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000176922. |
PharmGKBi | PA32390. |
Polymorphism and mutation databases
BioMutai | OR51S1. |
DMDMi | 38372710. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150762 | 1 – 323 | Olfactory receptor 51S1Add BLAST | 323 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 105 ↔ 197 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGJ8. |
PeptideAtlasi | Q8NGJ8. |
PRIDEi | Q8NGJ8. |
Expressioni
Gene expression databases
Bgeei | ENSG00000176922. |
CleanExi | HS_OR51S1. |
ExpressionAtlasi | Q8NGJ8. baseline and differential. |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410J941. Eukaryota. ENOG4111BEU. LUCA. |
GeneTreei | ENSGT00890000139587. |
HOGENOMi | HOG000041363. |
HOVERGENi | HBG017625. |
InParanoidi | Q8NGJ8. |
KOi | K04257. |
OMAi | TILWIIA. |
OrthoDBi | EOG091G0AZH. |
PhylomeDBi | Q8NGJ8. |
TreeFami | TF342735. |
Family and domain databases
InterProi | View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. |
Pfami | View protein in Pfam PF13853. 7tm_4. 1 hit. |
PRINTSi | PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR. |
PROSITEi | View protein in PROSITE PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8NGJ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTLPTQIAP NSSTSMAPTF LLVGMPGLSG APSWWTLPLI AVYLLSALGN
60 70 80 90 100
GTILWIIALQ PALHRPMHFF LFLLSVSDIG LVTALMPTLL GIALAGAHTV
110 120 130 140 150
PASACLLQMV FIHVFSVMES SVLLAMSIDR ALAICRPLHY PALLTNGVIS
160 170 180 190 200
KISLAISFRC LGLHLPLPFL LAYMPYCLPQ VLTHSYCLHP DVARLACPEA
210 220 230 240 250
WGAAYSLFVV LSAMGLDPLL IFFSYGLIGK VLQGVESRED RWKAGQTCAA
260 270 280 290 300
HLSAVLLFYI PMILLALINH PELPITQHTH TLLSYVHFLL PPLINPILYS
310 320
VKMKEIRKRI LNRLQPRKVG GAQ
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034329 | 57 | I → N. Corresponds to variant dbSNP:rs12417164Ensembl. | 1 | |
Natural variantiVAR_034330 | 60 | Q → E. Corresponds to variant dbSNP:rs11602499Ensembl. | 1 | |
Natural variantiVAR_024145 | 178 | L → R. Corresponds to variant dbSNP:rs7117260Ensembl. | 1 | |
Natural variantiVAR_053331 | 264 | L → F. Corresponds to variant dbSNP:rs12361955Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065796 Genomic DNA. Translation: BAC06015.1. BC136932 mRNA. Translation: AAI36933.1. BC136934 mRNA. Translation: AAI36935.1. BK004280 Genomic DNA. Translation: DAA04678.1. |
CCDSi | CCDS31362.1. |
RefSeqi | NP_001004758.1. NM_001004758.1. |
UniGenei | Hs.553561. |
Genome annotation databases
Ensembli | ENST00000322101; ENSP00000322754; ENSG00000176922. |
GeneIDi | 119692. |
KEGGi | hsa:119692. |
UCSCi | uc010qyo.2. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | O51S1_HUMAN | |
Accessioni | Q8NGJ8Primary (citable) accession number: Q8NGJ8 Secondary accession number(s): B9EGZ1, Q6IFI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 28, 2018 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |