Q8NGJ8 (O51S1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 51S1

Alternative name(s):
Olfactory receptor OR11-24

Gene names

Name:

OR51S1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Olfactory receptor 51S1		PRO_0000150762
Regions
	Topological domain	1 – 33	33	Extracellular Potential
	Transmembrane	34 – 54	21	Helical; Name=1; Potential
	Topological domain	55 – 62	8	Cytoplasmic Potential
	Transmembrane	63 – 83	21	Helical; Name=2; Potential
	Topological domain	84 – 107	24	Extracellular Potential
	Transmembrane	108 – 128	21	Helical; Name=3; Potential
	Topological domain	129 – 147	19	Cytoplasmic Potential
	Transmembrane	148 – 168	21	Helical; Name=4; Potential
	Topological domain	169 – 203	35	Extracellular Potential
	Transmembrane	204 – 224	21	Helical; Name=5; Potential
	Topological domain	225 – 244	20	Cytoplasmic Potential
	Transmembrane	245 – 265	21	Helical; Name=6; Potential
	Topological domain	266 – 280	15	Extracellular Potential
	Transmembrane	281 – 301	21	Helical; Name=7; Potential
	Topological domain	302 – 323	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	11	1	N-linked (GlcNAc...) Potential
	Disulfide bond	105 ↔ 197		By similarity
Natural variations
	Natural variant	57	1	I → N. Corresponds to variant rs12417164 [ dbSNP | Ensembl ].		VAR_034329
	Natural variant	60	1	Q → E. Corresponds to variant rs11602499 [ dbSNP | Ensembl ].		VAR_034330
	Natural variant	178	1	L → R. Corresponds to variant rs7117260 [ dbSNP | Ensembl ].		VAR_024145
	Natural variant	264	1	L → F. Corresponds to variant rs12361955 [ dbSNP | Ensembl ].		VAR_053331

Sequences

	Sequence		Length	Mass (Da)
	Q8NGJ8 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 366318DDE5CE6D73	FASTA	323	35,313
	10 20 30 40 50 60 MSTLPTQIAP NSSTSMAPTF LLVGMPGLSG APSWWTLPLI AVYLLSALGN GTILWIIALQ 70 80 90 100 110 120 PALHRPMHFF LFLLSVSDIG LVTALMPTLL GIALAGAHTV PASACLLQMV FIHVFSVMES 130 140 150 160 170 180 SVLLAMSIDR ALAICRPLHY PALLTNGVIS KISLAISFRC LGLHLPLPFL LAYMPYCLPQ 190 200 210 220 230 240 VLTHSYCLHP DVARLACPEA WGAAYSLFVV LSAMGLDPLL IFFSYGLIGK VLQGVESRED 250 260 270 280 290 300 RWKAGQTCAA HLSAVLLFYI PMILLALINH PELPITQHTH TLLSYVHFLL PPLINPILYS 310 320 VKMKEIRKRI LNRLQPRKVG GAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065796 Genomic DNA. Translation: BAC06015.1. BC136932 mRNA. Translation: AAI36933.1. BC136934 mRNA. Translation: AAI36935.1. BK004280 Genomic DNA. Translation: DAA04678.1.
IPI	IPI00169040.
RefSeq	NP_001004758.1. NM_001004758.1.
UniGene	Hs.553561.
3D structure databases
ProteinModelPortal	Q8NGJ8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000322754.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38372710.
Proteomic databases
PRIDE	Q8NGJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322101; ENSP00000322754; ENSG00000176922.
GeneID	119692.
KEGG	hsa:119692.
UCSC	uc010qyo.2. human.
Organism-specific databases
CTD	119692.
GeneCards	GC11M004826.
HGNC	HGNC:15204. OR51S1.
neXtProt	NX_Q8NGJ8.
PharmGKB	PA32390.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40020.
HOGENOM	HOG000041363.
HOVERGEN	HBG017625.
InParanoid	Q8NGJ8.
KO	K04257.
OMA	FIHVFSV.
OrthoDB	EOG4Z36F8.
PhylomeDB	Q8NGJ8.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR51S1.
Genevestigator	Q8NGJ8.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	119692.
NextBio	80461.

Entry information

Entry name

O51S1_HUMAN

Accession

Primary (citable) accession number: Q8NGJ8
Secondary accession number(s): B9EGZ1, Q6IFI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.