OR51S1

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

signal transduction Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 51S1 Alternative name(s): Olfactory receptor OR11-24
Gene namesⁱ	Name:OR51S1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000176922.3.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15204. OR51S1.
neXtProtⁱ	NX_Q8NGJ8.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 33	ExtracellularSequence analysisAdd BLAST	33
Transmembraneⁱ	34 – 54	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	55 – 62	CytoplasmicSequence analysis	8
Transmembraneⁱ	63 – 83	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	84 – 107	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	108 – 128	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	129 – 147	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	148 – 168	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	169 – 203	ExtracellularSequence analysisAdd BLAST	35
Transmembraneⁱ	204 – 224	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	225 – 244	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	245 – 265	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	266 – 280	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	281 – 301	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	302 – 323	CytoplasmicSequence analysisAdd BLAST	22

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000176922.
PharmGKBⁱ	PA32390.

Polymorphism and mutation databases

BioMutaⁱ	OR51S1.
DMDMⁱ	38372710.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150762	1 – 323	Olfactory receptor 51S1Add BLAST		323

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	11	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	105 ↔ 197	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGJ8.
PeptideAtlas More...PeptideAtlasⁱ	Q8NGJ8.
PRIDEⁱ	Q8NGJ8.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000176922.
CleanExⁱ	HS_OR51S1.
ExpressionAtlasⁱ	Q8NGJ8. baseline and differential.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000322754.

STRINGⁱ

9606.ENSP00000322754.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGJ8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J941. Eukaryota. ENOG4111BEU. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139587.
HOGENOMⁱ	HOG000041363.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	Q8NGJ8.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	TILWIIA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH.
PhylomeDBⁱ	Q8NGJ8.
TreeFamⁱ	TF342735.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853. 7tm_4. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGJ8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTLPTQIAP NSSTSMAPTF LLVGMPGLSG APSWWTLPLI AVYLLSALGN 
        60         70         80         90        100
GTILWIIALQ PALHRPMHFF LFLLSVSDIG LVTALMPTLL GIALAGAHTV 
       110        120        130        140        150
PASACLLQMV FIHVFSVMES SVLLAMSIDR ALAICRPLHY PALLTNGVIS 
       160        170        180        190        200
KISLAISFRC LGLHLPLPFL LAYMPYCLPQ VLTHSYCLHP DVARLACPEA 
       210        220        230        240        250
WGAAYSLFVV LSAMGLDPLL IFFSYGLIGK VLQGVESRED RWKAGQTCAA 
       260        270        280        290        300
HLSAVLLFYI PMILLALINH PELPITQHTH TLLSYVHFLL PPLINPILYS 
       310        320 
VKMKEIRKRI LNRLQPRKVG GAQ

Length:323

Mass (Da):35,313

Last modified:October 1, 2002 - v1

Checksum:ⁱ366318DDE5CE6D73

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034329	57	I → N. Corresponds to variant dbSNP:rs12417164Ensembl.	1
Natural variantⁱVAR_034330	60	Q → E. Corresponds to variant dbSNP:rs11602499Ensembl.	1
Natural variantⁱVAR_024145	178	L → R. Corresponds to variant dbSNP:rs7117260Ensembl.	1
Natural variantⁱVAR_053331	264	L → F. Corresponds to variant dbSNP:rs12361955Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065796 Genomic DNA. Translation: BAC06015.1. BC136932 mRNA. Translation: AAI36933.1. BC136934 mRNA. Translation: AAI36935.1. BK004280 Genomic DNA. Translation: DAA04678.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31362.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001004758.1. NM_001004758.1.
UniGeneⁱ	Hs.553561.

Genome annotation databases

Ensemblⁱ	ENST00000322101; ENSP00000322754; ENSG00000176922.
GeneIDⁱ	119692.
KEGGⁱ	hsa:119692.
UCSC genome browser More...UCSCⁱ	uc010qyo.2. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8NGJ8	A0A126GWN3	Homo sapiens (Human)	323	UniRef100_Q8NGJ8	Cluster: Olfactory receptor 51S1	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8NGJ8	A0A126GWN3 B0VX95 A0A2I3RK46 H2NEG0 G7N838 G3RDN2 G7P0E5 A0A0D9SDC6 A9L8V8 UPI00020AA351 +8	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Macaca mulatta (Rhesus macaque) Gorilla gorilla gorilla (Western lowland gorilla) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Papio anubis (Olive baboon) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) And more	323	UniRef90_Q8NGJ8	Cluster: Olfactory receptor 51S1	19

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8NGJ8	A0A126GWN3 UPI0005333BFC UPI00020AA351 G7P0E5 G3RDN2 G7N838 A9L8V8 UPI000C295D9F UPI0005F4CEB4 H2NEG0 +104	Homo sapiens (Human) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Gorilla gorilla gorilla (Western lowland gorilla) Macaca mulatta (Rhesus macaque) Papio anubis (Olive baboon) Piliocolobus tephrosceles (Ugandan red Colobus) Macaca nemestrina (Pig-tailed macaque) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) And more	323	UniRef50_Q8NGJ8	Cluster: Olfactory receptor 51S1	115

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065796 Genomic DNA. Translation: BAC06015.1. BC136932 mRNA. Translation: AAI36933.1. BC136934 mRNA. Translation: AAI36935.1. BK004280 Genomic DNA. Translation: DAA04678.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31362.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001004758.1. NM_001004758.1.
UniGeneⁱ	Hs.553561.

3D structure databases

ProteinModelPortalⁱ	Q8NGJ8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000322754.

STRINGⁱ

9606.ENSP00000322754.

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Polymorphism and mutation databases

BioMutaⁱ	OR51S1.
DMDMⁱ	38372710.

Proteomic databases

PaxDbⁱ	Q8NGJ8.
PeptideAtlas More...PeptideAtlasⁱ	Q8NGJ8.
PRIDEⁱ	Q8NGJ8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000322101; ENSP00000322754; ENSG00000176922.
GeneIDⁱ	119692.
KEGGⁱ	hsa:119692.
UCSC genome browser More...UCSCⁱ	uc010qyo.2. human.

Organism-specific databases

CTDⁱ	119692.
EuPathDBⁱ	HostDB:ENSG00000176922.3.
GeneCardsⁱ	OR51S1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15204. OR51S1.
neXtProtⁱ	NX_Q8NGJ8.
Open Targets More...OpenTargetsⁱ	ENSG00000176922.
PharmGKBⁱ	PA32390.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J941. Eukaryota. ENOG4111BEU. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139587.
HOGENOMⁱ	HOG000041363.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	Q8NGJ8.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	TILWIIA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH.
PhylomeDBⁱ	Q8NGJ8.
TreeFamⁱ	TF342735.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiⁱ	OR51S1.
GenomeRNAiⁱ	119692.
Protein Ontology More...PROⁱ	PR:Q8NGJ8.

Gene expression databases

Bgeeⁱ	ENSG00000176922.
CleanExⁱ	HS_OR51S1.
ExpressionAtlasⁱ	Q8NGJ8. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853. 7tm_4. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O51S1_HUMAN
Accessionⁱ	Q8NGJ8Primary (citable) accession number: Q8NGJ8 Secondary accession number(s): B9EGZ1, Q6IFI2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	October 1, 2002
	Last modified:	February 28, 2018
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NGJ8 (O51S1_HUMAN)

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Olfactory receptor 51S1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ