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Protein

Olfactory receptor 51L1

Gene

OR51L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51L1
Alternative name(s):
Olfactory receptor OR11-31
Gene namesi
Name:OR51L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176798.1
HGNCiHGNC:14759 OR51L1
neXtProtiNX_Q8NGJ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 275ExtracellularSequence analysisAdd BLAST15
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 315CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176798
PharmGKBiPA32384

Polymorphism and mutation databases

BioMutaiOR51L1
DMDMi38372707

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507591 – 315Olfactory receptor 51L1Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGJ5
PRIDEiQ8NGJ5
ProteomicsDBi73531

Expressioni

Gene expression databases

CleanExiHS_OR51L1
ExpressionAtlasiQ8NGJ5 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322156

Structurei

3D structure databases

ProteinModelPortaliQ8NGJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIE4 Eukaryota
ENOG4111C5A LUCA
GeneTreeiENSGT00920000149018
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NGJ5
KOiK04257
OMAiIWIESSL
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGJ5
TreeFamiTF342735

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWNNSDAV EPIFILRGFP GLEYVHSWLS ILFCLAYLVA FMGNVTILSV
60 70 80 90 100
IWIESSLHQP MYYFISILAV NDLGMSLSTL PTMLAVLWLD APEIQASACY
110 120 130 140 150
AQLFFIHTFT FLESSVLLAM AFDRFVAICH PLHYPTILTN SVIGKIGLAC
160 170 180 190 200
LLRSLGVVLP TPLLLRHYHY CHGNALSHAF CLHQDVLRLS CTDARTNSIY
210 220 230 240 250
GLCVVIATLG VDSIFILLSY VLILNTVLDI ASREEQLKAL NTCVSHICVV
260 270 280 290 300
LIFFVPVIGV SMVHRFGKHL SPIVHILMAD IYLLLPPVLN PIVYSVRTKQ
310
IRLGILHKFV LRRRF
Length:315
Mass (Da):35,369
Last modified:October 1, 2002 - v1
Checksum:i2F85D0A03440813D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034324196T → I. Corresponds to variant dbSNP:rs10768448Ensembl.1
Natural variantiVAR_034325207A → V. Corresponds to variant dbSNP:rs10768450Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065799 Genomic DNA Translation: BAC06018.1
CH471064 Genomic DNA Translation: EAW68816.1
BK004317 Genomic DNA Translation: DAA04715.1
CCDSiCCDS31369.1
RefSeqiNP_001004755.1, NM_001004755.1
UniGeneiHs.553559

Genome annotation databases

EnsembliENST00000321543; ENSP00000322156; ENSG00000176798
ENST00000641819; ENSP00000493015; ENSG00000176798
GeneIDi119682
KEGGihsa:119682
UCSCiuc010qyu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO51L1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGJ5
Secondary accession number(s): Q6IFE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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