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Protein

Olfactory receptor 52E2

Gene

OR52E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52E2
Gene namesi
Name:OR52E2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14769. OR52E2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21820Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence analysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 27415ExtracellularSequence analysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini296 – 32530CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32403.

Polymorphism and mutation databases

BioMutaiOR52E2.
DMDMi296439248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Olfactory receptor 52E2PRO_0000150772Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGJ4.
PeptideAtlasiQ8NGJ4.
PRIDEiQ8NGJ4.

PTM databases

PhosphoSiteiQ8NGJ4.

Expressioni

Gene expression databases

CleanExiHS_OR52E2.

Organism-specific databases

HPAiHPA045748.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322088.

Structurei

3D structure databases

ProteinModelPortaliQ8NGJ4.
SMRiQ8NGJ4. Positions 35-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIR5. Eukaryota.
ENOG411157P. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGJ4.
KOiK04257.
OMAiPTHEARL.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGJ4.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLPNDTQFH PSSFLLLGIP GLETLHIWIG FPFCAVYMIA LIGNFTILLV
60 70 80 90 100
IKTDSSLHQP MFYFLAMLAT TDVGLSTATI PKMLGIFWIN LRGIIFEACL
110 120 130 140 150
TQMFFIHNFT LMESAVLVAM AYDSYVAICN PLQYSAILTN KVVSVIGLGV
160 170 180 190 200
FVRALIFVIP SILLILRLPF CGNHVIPHTY CEHMGLAHLS CASIKINIIY
210 220 230 240 250
GLCAICNLVF DITVIALSYV HILCAVFRLP THEARLKSLS TCGSHVCVIL
260 270 280 290 300
AFYTPALFSF MTHRFGRNVP RYIHILLANL YVVVPPMLNP VIYGVRTKQI
310 320
YKCVKKILLQ EQGMEKEEYL IHTRF
Length:325
Mass (Da):36,630
Last modified:May 18, 2010 - v2
Checksum:i96F7CD13A53148BA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51N → S.
Corresponds to variant rs16909440 [ dbSNP | Ensembl ].
VAR_053332
Natural varianti167 – 1671R → W.
Corresponds to variant rs11035396 [ dbSNP | Ensembl ].
VAR_053333
Natural varianti264 – 2641R → C.1 Publication
Corresponds to variant rs2500052 [ dbSNP | Ensembl ].
VAR_053334

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065800 Genomic DNA. Translation: BAC06019.1.
AC113331 Genomic DNA. No translation available.
CCDSiCCDS31371.1.
RefSeqiNP_001005164.2. NM_001005164.2.
UniGeneiHs.553557.

Genome annotation databases

EnsembliENST00000321522; ENSP00000322088; ENSG00000176787.
GeneIDi119678.
KEGGihsa:119678.
UCSCiuc010qyw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065800 Genomic DNA. Translation: BAC06019.1.
AC113331 Genomic DNA. No translation available.
CCDSiCCDS31371.1.
RefSeqiNP_001005164.2. NM_001005164.2.
UniGeneiHs.553557.

3D structure databases

ProteinModelPortaliQ8NGJ4.
SMRiQ8NGJ4. Positions 35-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322088.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGJ4.

Polymorphism and mutation databases

BioMutaiOR52E2.
DMDMi296439248.

Proteomic databases

PaxDbiQ8NGJ4.
PeptideAtlasiQ8NGJ4.
PRIDEiQ8NGJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321522; ENSP00000322088; ENSG00000176787.
GeneIDi119678.
KEGGihsa:119678.
UCSCiuc010qyw.2. human.

Organism-specific databases

CTDi119678.
GeneCardsiOR52E2.
HGNCiHGNC:14769. OR52E2.
HPAiHPA045748.
neXtProtiNX_Q8NGJ4.
PharmGKBiPA32403.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIR5. Eukaryota.
ENOG411157P. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGJ4.
KOiK04257.
OMAiPTHEARL.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGJ4.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52E2.
GenomeRNAii119678.
PROiQ8NGJ4.

Gene expression databases

CleanExiHS_OR52E2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52E2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.