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Protein

Olfactory receptor 52H1

Gene

OR52H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181616-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52H1
Alternative name(s):
Olfactory receptor OR11-45
Gene namesi
Name:OR52H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15218. OR52H1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 62CytoplasmicSequence analysis8
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 107ExtracellularSequence analysisAdd BLAST24
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 147CytoplasmicSequence analysisAdd BLAST19
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 204ExtracellularSequence analysisAdd BLAST36
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 245CytoplasmicSequence analysisAdd BLAST20
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 281ExtracellularSequence analysisAdd BLAST15
Transmembranei282 – 302Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini303 – 320CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181616.
PharmGKBiPA32410.

Polymorphism and mutation databases

BioMutaiOR52H1.
DMDMi223590251.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507771 – 320Olfactory receptor 52H1Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi105 ↔ 197PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGJ2.
PRIDEiQ8NGJ2.

PTM databases

iPTMnetiQ8NGJ2.
PhosphoSitePlusiQ8NGJ2.

Expressioni

Gene expression databases

CleanExiHS_OR52H1.

Organism-specific databases

HPAiCAB046467.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326259.

Structurei

3D structure databases

ProteinModelPortaliQ8NGJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFSE. Eukaryota.
ENOG4111586. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGJ2.
KOiK04257.
OMAiVSHTFHI.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGJ2.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSASAMIIF NLSSYNPGPF ILVGIPGLEQ FHVWIGIPFC IIYIVAVVGN
60 70 80 90 100
CILLYLIVVE HSLHEPMFFF LSMLAMTDLI LSTAGVPKAL SIFWLGAREI
110 120 130 140 150
TFPGCLTQMF FLHYNFVLDS AILMAMAFDH YVAICSPLRY TTILTPKTII
160 170 180 190 200
KSAMGISFRS FCIILPDVFL LTCLPFCRTR IIPHTYCEHI GVAQLACADI
210 220 230 240 250
SINFWYGFCV PIMTVISDVI LIAVSYAHIL CAVFGLPSQD ACQKALGTCG
260 270 280 290 300
SHVCVILMFY TPAFFSILAH RFGHNVSRTF HIMFANLYIV IPPALNPMVY
310 320
GVKTKQIRDK VILLFSKGTG
Length:320
Mass (Da):35,592
Last modified:February 10, 2009 - v3
Checksum:i71E26A745498018D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06208345V → A.Corresponds to variant rs56291963dbSNPEnsembl.1
Natural variantiVAR_05436147V → I.Corresponds to variant rs2254076dbSNPEnsembl.1
Natural variantiVAR_05436289A → T.Corresponds to variant rs10769054dbSNPEnsembl.1
Natural variantiVAR_054363130H → R.Corresponds to variant rs1566275dbSNPEnsembl.1
Natural variantiVAR_054364235G → C.Corresponds to variant rs1995157dbSNPEnsembl.1
Natural variantiVAR_054365242C → R.Corresponds to variant rs1995158dbSNPEnsembl.1
Natural variantiVAR_054366283M → T.Corresponds to variant rs7934354dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065802 Genomic DNA. Translation: BAC06021.1.
BC136998 mRNA. Translation: AAI36999.1.
BK004383 Genomic DNA. Translation: DAA04781.1.
CCDSiCCDS31386.1.
RefSeqiNP_001005289.1. NM_001005289.1.
UniGeneiHs.554540.

Genome annotation databases

EnsembliENST00000322653; ENSP00000326259; ENSG00000181616.
GeneIDi390067.
KEGGihsa:390067.
UCSCiuc010qzh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065802 Genomic DNA. Translation: BAC06021.1.
BC136998 mRNA. Translation: AAI36999.1.
BK004383 Genomic DNA. Translation: DAA04781.1.
CCDSiCCDS31386.1.
RefSeqiNP_001005289.1. NM_001005289.1.
UniGeneiHs.554540.

3D structure databases

ProteinModelPortaliQ8NGJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326259.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGJ2.
PhosphoSitePlusiQ8NGJ2.

Polymorphism and mutation databases

BioMutaiOR52H1.
DMDMi223590251.

Proteomic databases

PaxDbiQ8NGJ2.
PRIDEiQ8NGJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322653; ENSP00000326259; ENSG00000181616.
GeneIDi390067.
KEGGihsa:390067.
UCSCiuc010qzh.2. human.

Organism-specific databases

CTDi390067.
GeneCardsiOR52H1.
HGNCiHGNC:15218. OR52H1.
HPAiCAB046467.
neXtProtiNX_Q8NGJ2.
OpenTargetsiENSG00000181616.
PharmGKBiPA32410.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFSE. Eukaryota.
ENOG4111586. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGJ2.
KOiK04257.
OMAiVSHTFHI.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGJ2.
TreeFamiTF343679.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181616-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52H1.
GenomeRNAii390067.
PROiQ8NGJ2.

Gene expression databases

CleanExiHS_OR52H1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52H1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGJ2
Secondary accession number(s): B9EH26, Q6IF79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: November 2, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.