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Protein

Olfactory receptor 52H1

Gene

OR52H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52H1
Alternative name(s):
Olfactory receptor OR11-45
Gene namesi
Name:OR52H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15218. OR52H1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 628CytoplasmicSequence analysis
Transmembranei63 – 8321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini84 – 10724ExtracellularSequence analysisAdd
BLAST
Transmembranei108 – 12821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini129 – 14719CytoplasmicSequence analysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini169 – 20436ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini226 – 24520CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini267 – 28115ExtracellularSequence analysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini303 – 32018CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32410.

Polymorphism and mutation databases

BioMutaiOR52H1.
DMDMi223590251.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 52H1PRO_0000150777Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi105 ↔ 197PROSITE-ProRule annotation
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGJ2.
PRIDEiQ8NGJ2.

PTM databases

iPTMnetiQ8NGJ2.
PhosphoSiteiQ8NGJ2.

Expressioni

Gene expression databases

CleanExiHS_OR52H1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326259.

Structurei

3D structure databases

ProteinModelPortaliQ8NGJ2.
SMRiQ8NGJ2. Positions 33-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFSE. Eukaryota.
ENOG4111586. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGJ2.
KOiK04257.
OMAiVSHTFHI.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGJ2.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSASAMIIF NLSSYNPGPF ILVGIPGLEQ FHVWIGIPFC IIYIVAVVGN
60 70 80 90 100
CILLYLIVVE HSLHEPMFFF LSMLAMTDLI LSTAGVPKAL SIFWLGAREI
110 120 130 140 150
TFPGCLTQMF FLHYNFVLDS AILMAMAFDH YVAICSPLRY TTILTPKTII
160 170 180 190 200
KSAMGISFRS FCIILPDVFL LTCLPFCRTR IIPHTYCEHI GVAQLACADI
210 220 230 240 250
SINFWYGFCV PIMTVISDVI LIAVSYAHIL CAVFGLPSQD ACQKALGTCG
260 270 280 290 300
SHVCVILMFY TPAFFSILAH RFGHNVSRTF HIMFANLYIV IPPALNPMVY
310 320
GVKTKQIRDK VILLFSKGTG
Length:320
Mass (Da):35,592
Last modified:February 10, 2009 - v3
Checksum:i71E26A745498018D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451V → A.
Corresponds to variant rs56291963 [ dbSNP | Ensembl ].
VAR_062083
Natural varianti47 – 471V → I.
Corresponds to variant rs2254076 [ dbSNP | Ensembl ].
VAR_054361
Natural varianti89 – 891A → T.
Corresponds to variant rs10769054 [ dbSNP | Ensembl ].
VAR_054362
Natural varianti130 – 1301H → R.
Corresponds to variant rs1566275 [ dbSNP | Ensembl ].
VAR_054363
Natural varianti235 – 2351G → C.
Corresponds to variant rs1995157 [ dbSNP | Ensembl ].
VAR_054364
Natural varianti242 – 2421C → R.
Corresponds to variant rs1995158 [ dbSNP | Ensembl ].
VAR_054365
Natural varianti283 – 2831M → T.
Corresponds to variant rs7934354 [ dbSNP | Ensembl ].
VAR_054366

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065802 Genomic DNA. Translation: BAC06021.1.
BC136998 mRNA. Translation: AAI36999.1.
BK004383 Genomic DNA. Translation: DAA04781.1.
CCDSiCCDS31386.1.
RefSeqiNP_001005289.1. NM_001005289.1.
UniGeneiHs.554540.

Genome annotation databases

EnsembliENST00000322653; ENSP00000326259; ENSG00000181616.
GeneIDi390067.
KEGGihsa:390067.
UCSCiuc010qzh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065802 Genomic DNA. Translation: BAC06021.1.
BC136998 mRNA. Translation: AAI36999.1.
BK004383 Genomic DNA. Translation: DAA04781.1.
CCDSiCCDS31386.1.
RefSeqiNP_001005289.1. NM_001005289.1.
UniGeneiHs.554540.

3D structure databases

ProteinModelPortaliQ8NGJ2.
SMRiQ8NGJ2. Positions 33-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326259.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGJ2.
PhosphoSiteiQ8NGJ2.

Polymorphism and mutation databases

BioMutaiOR52H1.
DMDMi223590251.

Proteomic databases

PaxDbiQ8NGJ2.
PRIDEiQ8NGJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322653; ENSP00000326259; ENSG00000181616.
GeneIDi390067.
KEGGihsa:390067.
UCSCiuc010qzh.2. human.

Organism-specific databases

CTDi390067.
GeneCardsiOR52H1.
HGNCiHGNC:15218. OR52H1.
neXtProtiNX_Q8NGJ2.
PharmGKBiPA32410.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFSE. Eukaryota.
ENOG4111586. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGJ2.
KOiK04257.
OMAiVSHTFHI.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGJ2.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52H1.
GenomeRNAii390067.
PROiQ8NGJ2.

Gene expression databases

CleanExiHS_OR52H1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52H1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGJ2
Secondary accession number(s): B9EH26, Q6IF79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: June 8, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.