ID   OR4D6_HUMAN             Reviewed;         314 AA.
AC   Q8NGJ1; B2RNP7; Q6IFF5; Q96R74;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 156.
DE   RecName: Full=Olfactory receptor 4D6;
DE   AltName: Full=Olfactory receptor OR11-250;
GN   Name=OR4D6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLY-96.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-96.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4D6";
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DR   EMBL; AB065803; BAC06022.1; -; Genomic_DNA.
DR   EMBL; CH471076; EAW73845.1; -; Genomic_DNA.
DR   EMBL; BC137028; AAI37029.1; -; mRNA.
DR   EMBL; BC137029; AAI37030.1; -; mRNA.
DR   EMBL; AF399569; AAK95054.1; -; Genomic_DNA.
DR   EMBL; BK004307; DAA04705.1; -; Genomic_DNA.
DR   CCDS; CCDS31562.1; -.
DR   RefSeq; NP_001004708.1; NM_001004708.1.
DR   AlphaFoldDB; Q8NGJ1; -.
DR   SMR; Q8NGJ1; -.
DR   BioGRID; 128611; 16.
DR   IntAct; Q8NGJ1; 1.
DR   MINT; Q8NGJ1; -.
DR   STRING; 9606.ENSP00000300127; -.
DR   GlyCosmos; Q8NGJ1; 1 site, No reported glycans.
DR   GlyGen; Q8NGJ1; 2 sites, 1 O-linked glycan (1 site).
DR   PhosphoSitePlus; Q8NGJ1; -.
DR   BioMuta; OR4D6; -.
DR   DMDM; 38372703; -.
DR   MassIVE; Q8NGJ1; -.
DR   PaxDb; 9606-ENSP00000300127; -.
DR   PeptideAtlas; Q8NGJ1; -.
DR   ProteomicsDB; 73527; -.
DR   Antibodypedia; 27754; 106 antibodies from 20 providers.
DR   DNASU; 219983; -.
DR   Ensembl; ENST00000300127.3; ENSP00000300127.2; ENSG00000166884.3.
DR   GeneID; 219983; -.
DR   KEGG; hsa:219983; -.
DR   MANE-Select; ENST00000300127.3; ENSP00000300127.2; NM_001004708.1; NP_001004708.1.
DR   UCSC; uc010rku.3; human.
DR   AGR; HGNC:15175; -.
DR   CTD; 219983; -.
DR   DisGeNET; 219983; -.
DR   GeneCards; OR4D6; -.
DR   HGNC; HGNC:15175; OR4D6.
DR   HPA; ENSG00000166884; Not detected.
DR   neXtProt; NX_Q8NGJ1; -.
DR   OpenTargets; ENSG00000166884; -.
DR   PharmGKB; PA32273; -.
DR   VEuPathDB; HostDB:ENSG00000166884; -.
DR   eggNOG; ENOG502RCKG; Eukaryota.
DR   GeneTree; ENSGT00940000163118; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q8NGJ1; -.
DR   OMA; TITCESH; -.
DR   OrthoDB; 4634745at2759; -.
DR   PhylomeDB; Q8NGJ1; -.
DR   TreeFam; TF352732; -.
DR   PathwayCommons; Q8NGJ1; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q8NGJ1; -.
DR   BioGRID-ORCS; 219983; 8 hits in 741 CRISPR screens.
DR   GeneWiki; OR4D6; -.
DR   GenomeRNAi; 219983; -.
DR   Pharos; Q8NGJ1; Tdark.
DR   PRO; PR:Q8NGJ1; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGJ1; Protein.
DR   Bgee; ENSG00000166884; Expressed in vermiform appendix and 4 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15936; 7tmA_OR4D-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48002:SF23; OLFACTORY RECEPTOR 4D6; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 4D6"
FT                   /id="PRO_0000150540"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..289
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         11
FT                   /note="E -> Q (in dbSNP:rs17153766)"
FT                   /id="VAR_034194"
FT   VARIANT         59
FT                   /note="M -> V (in dbSNP:rs1453544)"
FT                   /id="VAR_053169"
FT   VARIANT         96
FT                   /note="D -> G (in dbSNP:rs1453543)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT                   /id="VAR_024091"
FT   VARIANT         102
FT                   /note="F -> S (in dbSNP:rs17153770)"
FT                   /id="VAR_034195"
FT   VARIANT         111
FT                   /note="D -> A (in dbSNP:rs17500380)"
FT                   /id="VAR_034196"
FT   VARIANT         151
FT                   /note="S -> T (in dbSNP:rs1453542)"
FT                   /id="VAR_024092"
FT   VARIANT         263
FT                   /note="M -> T (in dbSNP:rs1453541)"
FT                   /id="VAR_024093"
SQ   SEQUENCE   314 AA;  35954 MW;  FA70D423F278502E CRC64;
     MDQINHTNVK EFFFLELTRS RELEFFLFVV FFAVYVATVL GNALIVVTIT CESRLHTPMY
     FLLRNKSVLD IVFSSITVPK FLVDLLSDRK TISYNDCMAQ IFFFHFAGGA DIFFLSVMAY
     DRYLAIAKPL HYVTMMRKEV WVALVVASWV SGGLHSIIQV ILMLPFPFCG PNTLDAFYCY
     VLQVVKLACT DTFALELFMI SNNGLVTLLW FLLLLGSYTV ILVMLRSHSG EGRNKALSTC
     TSHMLVVTLH FVPCVYIYCR PFMTLPMDTT ISINNTVITP MLNPIIYSLR NQEMKSAMQR
     LQRRLGPSES RKWG
//