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Q8NGJ1

- OR4D6_HUMAN

UniProt

Q8NGJ1 - OR4D6_HUMAN

Protein

Olfactory receptor 4D6

Gene

OR4D6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 4D6
    Alternative name(s):
    Olfactory receptor OR11-250
    Gene namesi
    Name:OR4D6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15175. OR4D6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32273.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 4D6PRO_0000150540Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGJ1.
    PRIDEiQ8NGJ1.

    Expressioni

    Gene expression databases

    CleanExiHS_OR4D6.
    GenevestigatoriQ8NGJ1.

    Interactioni

    Protein-protein interaction databases

    BioGridi128611. 1 interaction.
    IntActiQ8NGJ1. 1 interaction.
    MINTiMINT-8201775.
    STRINGi9606.ENSP00000300127.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGJ1.
    SMRiQ8NGJ1. Positions 27-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23516CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 26911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31425CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148673.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGJ1.
    KOiK04257.
    OMAiCTSHMLV.
    OrthoDBiEOG7KSX95.
    PhylomeDBiQ8NGJ1.
    TreeFamiTF352732.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGJ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQINHTNVK EFFFLELTRS RELEFFLFVV FFAVYVATVL GNALIVVTIT    50
    CESRLHTPMY FLLRNKSVLD IVFSSITVPK FLVDLLSDRK TISYNDCMAQ 100
    IFFFHFAGGA DIFFLSVMAY DRYLAIAKPL HYVTMMRKEV WVALVVASWV 150
    SGGLHSIIQV ILMLPFPFCG PNTLDAFYCY VLQVVKLACT DTFALELFMI 200
    SNNGLVTLLW FLLLLGSYTV ILVMLRSHSG EGRNKALSTC TSHMLVVTLH 250
    FVPCVYIYCR PFMTLPMDTT ISINNTVITP MLNPIIYSLR NQEMKSAMQR 300
    LQRRLGPSES RKWG 314
    Length:314
    Mass (Da):35,954
    Last modified:October 1, 2002 - v1
    Checksum:iFA70D423F278502E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111E → Q.
    Corresponds to variant rs17153766 [ dbSNP | Ensembl ].
    VAR_034194
    Natural varianti59 – 591M → V.
    Corresponds to variant rs1453544 [ dbSNP | Ensembl ].
    VAR_053169
    Natural varianti96 – 961D → G.2 Publications
    Corresponds to variant rs1453543 [ dbSNP | Ensembl ].
    VAR_024091
    Natural varianti102 – 1021F → S.
    Corresponds to variant rs17153770 [ dbSNP | Ensembl ].
    VAR_034195
    Natural varianti111 – 1111D → A.
    Corresponds to variant rs17500380 [ dbSNP | Ensembl ].
    VAR_034196
    Natural varianti151 – 1511S → T.
    Corresponds to variant rs1453542 [ dbSNP | Ensembl ].
    VAR_024092
    Natural varianti263 – 2631M → T.
    Corresponds to variant rs1453541 [ dbSNP | Ensembl ].
    VAR_024093

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065803 Genomic DNA. Translation: BAC06022.1.
    CH471076 Genomic DNA. Translation: EAW73845.1.
    BC137028 mRNA. Translation: AAI37029.1.
    BC137029 mRNA. Translation: AAI37030.1.
    AF399569 Genomic DNA. Translation: AAK95054.1.
    BK004307 Genomic DNA. Translation: DAA04705.1.
    CCDSiCCDS31562.1.
    RefSeqiNP_001004708.1. NM_001004708.1.
    UniGeneiHs.553650.

    Genome annotation databases

    EnsembliENST00000300127; ENSP00000300127; ENSG00000166884.
    GeneIDi219983.
    KEGGihsa:219983.
    UCSCiuc010rku.2. human.

    Polymorphism databases

    DMDMi38372703.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065803 Genomic DNA. Translation: BAC06022.1 .
    CH471076 Genomic DNA. Translation: EAW73845.1 .
    BC137028 mRNA. Translation: AAI37029.1 .
    BC137029 mRNA. Translation: AAI37030.1 .
    AF399569 Genomic DNA. Translation: AAK95054.1 .
    BK004307 Genomic DNA. Translation: DAA04705.1 .
    CCDSi CCDS31562.1.
    RefSeqi NP_001004708.1. NM_001004708.1.
    UniGenei Hs.553650.

    3D structure databases

    ProteinModelPortali Q8NGJ1.
    SMRi Q8NGJ1. Positions 27-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128611. 1 interaction.
    IntActi Q8NGJ1. 1 interaction.
    MINTi MINT-8201775.
    STRINGi 9606.ENSP00000300127.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372703.

    Proteomic databases

    PaxDbi Q8NGJ1.
    PRIDEi Q8NGJ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300127 ; ENSP00000300127 ; ENSG00000166884 .
    GeneIDi 219983.
    KEGGi hsa:219983.
    UCSCi uc010rku.2. human.

    Organism-specific databases

    CTDi 219983.
    GeneCardsi GC11P059224.
    HGNCi HGNC:15175. OR4D6.
    neXtProti NX_Q8NGJ1.
    PharmGKBi PA32273.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148673.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGJ1.
    KOi K04257.
    OMAi CTSHMLV.
    OrthoDBi EOG7KSX95.
    PhylomeDBi Q8NGJ1.
    TreeFami TF352732.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR4D6.
    NextBioi 90921.
    PROi Q8NGJ1.

    Gene expression databases

    CleanExi HS_OR4D6.
    Genevestigatori Q8NGJ1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-96.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-96.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR4D6_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGJ1
    Secondary accession number(s): B2RNP7, Q6IFF5, Q96R74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3