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Q8NGJ1 (OR4D6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4D6
Alternative name(s):
Olfactory receptor OR11-250
Gene names
Name:OR4D6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Olfactory receptor 4D6
PRO_0000150540

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23516Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 26911Extracellular Potential
Transmembrane270 – 28920Helical; Name=7; Potential
Topological domain290 – 31425Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant111E → Q.
Corresponds to variant rs17153766 [ dbSNP | Ensembl ].
VAR_034194
Natural variant591M → V.
Corresponds to variant rs1453544 [ dbSNP | Ensembl ].
VAR_053169
Natural variant961D → G. Ref.2 Ref.3
Corresponds to variant rs1453543 [ dbSNP | Ensembl ].
VAR_024091
Natural variant1021F → S.
Corresponds to variant rs17153770 [ dbSNP | Ensembl ].
VAR_034195
Natural variant1111D → A.
Corresponds to variant rs17500380 [ dbSNP | Ensembl ].
VAR_034196
Natural variant1511S → T.
Corresponds to variant rs1453542 [ dbSNP | Ensembl ].
VAR_024092
Natural variant2631M → T.
Corresponds to variant rs1453541 [ dbSNP | Ensembl ].
VAR_024093

Sequences

Sequence LengthMass (Da)Tools
Q8NGJ1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: FA70D423F278502E

FASTA31435,954
        10         20         30         40         50         60 
MDQINHTNVK EFFFLELTRS RELEFFLFVV FFAVYVATVL GNALIVVTIT CESRLHTPMY 

        70         80         90        100        110        120 
FLLRNKSVLD IVFSSITVPK FLVDLLSDRK TISYNDCMAQ IFFFHFAGGA DIFFLSVMAY 

       130        140        150        160        170        180 
DRYLAIAKPL HYVTMMRKEV WVALVVASWV SGGLHSIIQV ILMLPFPFCG PNTLDAFYCY 

       190        200        210        220        230        240 
VLQVVKLACT DTFALELFMI SNNGLVTLLW FLLLLGSYTV ILVMLRSHSG EGRNKALSTC 

       250        260        270        280        290        300 
TSHMLVVTLH FVPCVYIYCR PFMTLPMDTT ISINNTVITP MLNPIIYSLR NQEMKSAMQR 

       310 
LQRRLGPSES RKWG 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-96.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-96.
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065803 Genomic DNA. Translation: BAC06022.1.
CH471076 Genomic DNA. Translation: EAW73845.1.
BC137028 mRNA. Translation: AAI37029.1.
BC137029 mRNA. Translation: AAI37030.1.
AF399569 Genomic DNA. Translation: AAK95054.1.
BK004307 Genomic DNA. Translation: DAA04705.1.
RefSeqNP_001004708.1. NM_001004708.1.
UniGeneHs.553650.

3D structure databases

ProteinModelPortalQ8NGJ1.
SMRQ8NGJ1. Positions 27-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128611. 1 interaction.
IntActQ8NGJ1. 1 interaction.
MINTMINT-8201775.
STRING9606.ENSP00000300127.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372703.

Proteomic databases

PaxDbQ8NGJ1.
PRIDEQ8NGJ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300127; ENSP00000300127; ENSG00000166884.
GeneID219983.
KEGGhsa:219983.
UCSCuc010rku.2. human.

Organism-specific databases

CTD219983.
GeneCardsGC11P059224.
HGNCHGNC:15175. OR4D6.
neXtProtNX_Q8NGJ1.
PharmGKBPA32273.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148673.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGJ1.
KOK04257.
OMACTSHMLV.
OrthoDBEOG7KSX95.
PhylomeDBQ8NGJ1.
TreeFamTF352732.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR4D6.
GenevestigatorQ8NGJ1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR4D6.
NextBio90921.
PROQ8NGJ1.

Entry information

Entry nameOR4D6_HUMAN
AccessionPrimary (citable) accession number: Q8NGJ1
Secondary accession number(s): B2RNP7, Q6IFF5, Q96R74
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries