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Q8NGJ1

- OR4D6_HUMAN

UniProt

Q8NGJ1 - OR4D6_HUMAN

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Protein

Olfactory receptor 4D6

Gene
OR4D6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4D6
Alternative name(s):
Olfactory receptor OR11-250
Gene namesi
Name:OR4D6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15175. OR4D6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4924Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini50 – 578Cytoplasmic Reviewed prediction
Transmembranei58 – 7922Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini80 – 10021Extracellular Reviewed predictionAdd
BLAST
Transmembranei101 – 12020Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 15819Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini159 – 19537Extracellular Reviewed predictionAdd
BLAST
Transmembranei196 – 21924Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini220 – 23516Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei236 – 25823Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini259 – 26911Extracellular Reviewed predictionAdd
BLAST
Transmembranei270 – 28920Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini290 – 31425Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32273.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 4D6PRO_0000150540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGJ1.
PRIDEiQ8NGJ1.

Expressioni

Gene expression databases

CleanExiHS_OR4D6.
GenevestigatoriQ8NGJ1.

Interactioni

Protein-protein interaction databases

BioGridi128611. 1 interaction.
IntActiQ8NGJ1. 1 interaction.
MINTiMINT-8201775.
STRINGi9606.ENSP00000300127.

Structurei

3D structure databases

ProteinModelPortaliQ8NGJ1.
SMRiQ8NGJ1. Positions 27-303.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148673.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGJ1.
KOiK04257.
OMAiCTSHMLV.
OrthoDBiEOG7KSX95.
PhylomeDBiQ8NGJ1.
TreeFamiTF352732.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGJ1-1 [UniParc]FASTAAdd to Basket

« Hide

MDQINHTNVK EFFFLELTRS RELEFFLFVV FFAVYVATVL GNALIVVTIT    50
CESRLHTPMY FLLRNKSVLD IVFSSITVPK FLVDLLSDRK TISYNDCMAQ 100
IFFFHFAGGA DIFFLSVMAY DRYLAIAKPL HYVTMMRKEV WVALVVASWV 150
SGGLHSIIQV ILMLPFPFCG PNTLDAFYCY VLQVVKLACT DTFALELFMI 200
SNNGLVTLLW FLLLLGSYTV ILVMLRSHSG EGRNKALSTC TSHMLVVTLH 250
FVPCVYIYCR PFMTLPMDTT ISINNTVITP MLNPIIYSLR NQEMKSAMQR 300
LQRRLGPSES RKWG 314
Length:314
Mass (Da):35,954
Last modified:October 1, 2002 - v1
Checksum:iFA70D423F278502E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111E → Q.
Corresponds to variant rs17153766 [ dbSNP | Ensembl ].
VAR_034194
Natural varianti59 – 591M → V.
Corresponds to variant rs1453544 [ dbSNP | Ensembl ].
VAR_053169
Natural varianti96 – 961D → G.2 Publications
Corresponds to variant rs1453543 [ dbSNP | Ensembl ].
VAR_024091
Natural varianti102 – 1021F → S.
Corresponds to variant rs17153770 [ dbSNP | Ensembl ].
VAR_034195
Natural varianti111 – 1111D → A.
Corresponds to variant rs17500380 [ dbSNP | Ensembl ].
VAR_034196
Natural varianti151 – 1511S → T.
Corresponds to variant rs1453542 [ dbSNP | Ensembl ].
VAR_024092
Natural varianti263 – 2631M → T.
Corresponds to variant rs1453541 [ dbSNP | Ensembl ].
VAR_024093

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065803 Genomic DNA. Translation: BAC06022.1.
CH471076 Genomic DNA. Translation: EAW73845.1.
BC137028 mRNA. Translation: AAI37029.1.
BC137029 mRNA. Translation: AAI37030.1.
AF399569 Genomic DNA. Translation: AAK95054.1.
BK004307 Genomic DNA. Translation: DAA04705.1.
CCDSiCCDS31562.1.
RefSeqiNP_001004708.1. NM_001004708.1.
UniGeneiHs.553650.

Genome annotation databases

EnsembliENST00000300127; ENSP00000300127; ENSG00000166884.
GeneIDi219983.
KEGGihsa:219983.
UCSCiuc010rku.2. human.

Polymorphism databases

DMDMi38372703.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065803 Genomic DNA. Translation: BAC06022.1 .
CH471076 Genomic DNA. Translation: EAW73845.1 .
BC137028 mRNA. Translation: AAI37029.1 .
BC137029 mRNA. Translation: AAI37030.1 .
AF399569 Genomic DNA. Translation: AAK95054.1 .
BK004307 Genomic DNA. Translation: DAA04705.1 .
CCDSi CCDS31562.1.
RefSeqi NP_001004708.1. NM_001004708.1.
UniGenei Hs.553650.

3D structure databases

ProteinModelPortali Q8NGJ1.
SMRi Q8NGJ1. Positions 27-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128611. 1 interaction.
IntActi Q8NGJ1. 1 interaction.
MINTi MINT-8201775.
STRINGi 9606.ENSP00000300127.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372703.

Proteomic databases

PaxDbi Q8NGJ1.
PRIDEi Q8NGJ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300127 ; ENSP00000300127 ; ENSG00000166884 .
GeneIDi 219983.
KEGGi hsa:219983.
UCSCi uc010rku.2. human.

Organism-specific databases

CTDi 219983.
GeneCardsi GC11P059224.
HGNCi HGNC:15175. OR4D6.
neXtProti NX_Q8NGJ1.
PharmGKBi PA32273.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148673.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGJ1.
KOi K04257.
OMAi CTSHMLV.
OrthoDBi EOG7KSX95.
PhylomeDBi Q8NGJ1.
TreeFami TF352732.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR4D6.
NextBioi 90921.
PROi Q8NGJ1.

Gene expression databases

CleanExi HS_OR4D6.
Genevestigatori Q8NGJ1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-96.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-96.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4D6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGJ1
Secondary accession number(s): B2RNP7, Q6IFF5, Q96R74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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