ID   O5AN1_HUMAN             Reviewed;         311 AA.
AC   Q8NGI8; B9EIS2; Q6IEV4;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 163.
DE   RecName: Full=Olfactory receptor 5AN1;
DE   AltName: Full=Olfactory receptor OR11-244;
GN   Name=OR5AN1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-289.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN   [5]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=24361078; DOI=10.1016/j.neuron.2013.10.021;
RA   Shirasu M., Yoshikawa K., Takai Y., Nakashima A., Takeuchi H., Sakano H.,
RA   Touhara K.;
RT   "Olfactory receptor and neural pathway responsible for highly selective
RT   sensing of musk odors.";
RL   Neuron 81:165-178(2014).
RN   [6]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=25901328; DOI=10.1073/pnas.1503054112;
RA   Block E., Jang S., Matsunami H., Sekharan S., Dethier B., Ertem M.Z.,
RA   Gundala S., Pan Y., Li S., Li Z., Lodge S.N., Ozbil M., Jiang H.,
RA   Penalba S.F., Batista V.S., Zhuang H.;
RT   "Implausibility of the vibrational theory of olfaction.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:E2766-E2774(2015).
CC   -!- FUNCTION: Odorant receptor involved in the detection of muscone,
CC       cyclopentadecanone, cyclopentadecanol, and omega-pentadecalactone
CC       (PubMed:24361078, PubMed:25901328). The activity of this receptor is
CC       mediated by G proteins which activate adenylyl cyclase (Probable).
CC       {ECO:0000269|PubMed:24361078, ECO:0000269|PubMed:25901328,
CC       ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:24361078,
CC       ECO:0000305|PubMed:25901328}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5AN1";
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DR   EMBL; AB065806; BAC06025.1; -; Genomic_DNA.
DR   EMBL; BC140917; AAI40918.1; -; mRNA.
DR   EMBL; BK004508; DAA04906.1; -; Genomic_DNA.
DR   CCDS; CCDS31559.1; -.
DR   RefSeq; NP_001004729.1; NM_001004729.1.
DR   AlphaFoldDB; Q8NGI8; -.
DR   SMR; Q8NGI8; -.
DR   STRING; 9606.ENSP00000492957; -.
DR   GlyCosmos; Q8NGI8; 1 site, No reported glycans.
DR   GlyGen; Q8NGI8; 1 site.
DR   BioMuta; OR5AN1; -.
DR   DMDM; 38372701; -.
DR   MassIVE; Q8NGI8; -.
DR   PaxDb; 9606-ENSP00000320302; -.
DR   PeptideAtlas; Q8NGI8; -.
DR   Antibodypedia; 58819; 85 antibodies from 20 providers.
DR   DNASU; 390195; -.
DR   Ensembl; ENST00000313940.2; ENSP00000320302.2; ENSG00000176495.3.
DR   Ensembl; ENST00000641850.1; ENSP00000492957.1; ENSG00000176495.3.
DR   Ensembl; ENST00000641998.1; ENSP00000493250.1; ENSG00000176495.3.
DR   GeneID; 390195; -.
DR   KEGG; hsa:390195; -.
DR   MANE-Select; ENST00000641998.1; ENSP00000493250.1; NM_001004729.2; NP_001004729.1.
DR   UCSC; uc010rks.3; human.
DR   AGR; HGNC:15255; -.
DR   CTD; 390195; -.
DR   DisGeNET; 390195; -.
DR   GeneCards; OR5AN1; -.
DR   HGNC; HGNC:15255; OR5AN1.
DR   HPA; ENSG00000176495; Not detected.
DR   MIM; 615702; gene.
DR   neXtProt; NX_Q8NGI8; -.
DR   OpenTargets; ENSG00000176495; -.
DR   PharmGKB; PA32466; -.
DR   VEuPathDB; HostDB:ENSG00000176495; -.
DR   eggNOG; ENOG502TM2A; Eukaryota.
DR   GeneTree; ENSGT01100000263499; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGI8; -.
DR   OMA; YITSLTW; -.
DR   OrthoDB; 5262319at2759; -.
DR   PhylomeDB; Q8NGI8; -.
DR   TreeFam; TF352755; -.
DR   PathwayCommons; Q8NGI8; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390195; 15 hits in 747 CRISPR screens.
DR   GeneWiki; OR5AN1; -.
DR   GenomeRNAi; 390195; -.
DR   Pharos; Q8NGI8; Tbio.
DR   PRO; PR:Q8NGI8; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGI8; Protein.
DR   Bgee; ENSG00000176495; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 1 other cell type or tissue.
DR   ExpressionAtlas; Q8NGI8; baseline and differential.
DR   GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IDA:UniProtKB.
DR   GO; GO:0004984; F:olfactory receptor activity; IDA:UniProtKB.
DR   GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IDA:UniProtKB.
DR   CDD; cd15417; 7tmA_OR5A1-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26452; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26452:SF262; OLFACTORY RECEPTOR 5AN1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Olfactory receptor 5AN1"
FT                   /id="PRO_0000150577"
FT   TOPO_DOM        1..26
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         289
FT                   /note="L -> F (in dbSNP:rs7941190)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_024098"
SQ   SEQUENCE   311 AA;  34789 MW;  31F86526CC4C869B CRC64;
     MTGGGNITEI TYFILLGFSD FPRIIKVLFT IFLVIYITSL AWNLSLIVLI RMDSHLHTPM
     YFFLSNLSFI DVCYISSTVP KMLSNLLQEQ QTITFVGCII QYFIFSTMGL SESCLMTAMA
     YDRYAAICNP LLYSSIMSPT LCVWMVLGAY MTGLTASLFQ IGALLQLHFC GSNVIRHFFC
     DMPQLLILSC TDTFFVQVMT AILTMFFGIA SALVIMISYG YIGISIMKIT SAKGRSKAFN
     TCASHLTAVS LFYTSGIFVY LSSSSGGSSS FDRFASVFYT VVIPMLNPLI YSLRNKEIKD
     ALKRLQKRKC C
//