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Q8NGI8

- O5AN1_HUMAN

UniProt

Q8NGI8 - O5AN1_HUMAN

Protein

Olfactory receptor 5AN1

Gene

OR5AN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor involved in the detection of muscone.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5AN1
    Alternative name(s):
    Olfactory receptor OR11-244
    Gene namesi
    Name:OR5AN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15255. OR5AN1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32466.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 5AN1PRO_0000150577Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGI8.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5AN1.
    GenevestigatoriQ8NGI8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000320302.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGI8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 13413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini156 – 19742ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 31118CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG127675.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGI8.
    KOiK04257.
    OMAiFVQVMTA.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGI8.
    TreeFamiTF352755.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGGGNITEI TYFILLGFSD FPRIIKVLFT IFLVIYITSL AWNLSLIVLI    50
    RMDSHLHTPM YFFLSNLSFI DVCYISSTVP KMLSNLLQEQ QTITFVGCII 100
    QYFIFSTMGL SESCLMTAMA YDRYAAICNP LLYSSIMSPT LCVWMVLGAY 150
    MTGLTASLFQ IGALLQLHFC GSNVIRHFFC DMPQLLILSC TDTFFVQVMT 200
    AILTMFFGIA SALVIMISYG YIGISIMKIT SAKGRSKAFN TCASHLTAVS 250
    LFYTSGIFVY LSSSSGGSSS FDRFASVFYT VVIPMLNPLI YSLRNKEIKD 300
    ALKRLQKRKC C 311
    Length:311
    Mass (Da):34,789
    Last modified:October 1, 2002 - v1
    Checksum:i31F86526CC4C869B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti289 – 2891L → F.1 Publication
    Corresponds to variant rs7941190 [ dbSNP | Ensembl ].
    VAR_024098

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065806 Genomic DNA. Translation: BAC06025.1.
    BC140917 mRNA. Translation: AAI40918.1.
    BK004508 Genomic DNA. Translation: DAA04906.1.
    CCDSiCCDS31559.1.
    RefSeqiNP_001004729.1. NM_001004729.1.
    UniGeneiHs.553755.

    Genome annotation databases

    EnsembliENST00000313940; ENSP00000320302; ENSG00000176495.
    GeneIDi390195.
    KEGGihsa:390195.
    UCSCiuc010rks.2. human.

    Polymorphism databases

    DMDMi38372701.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065806 Genomic DNA. Translation: BAC06025.1 .
    BC140917 mRNA. Translation: AAI40918.1 .
    BK004508 Genomic DNA. Translation: DAA04906.1 .
    CCDSi CCDS31559.1.
    RefSeqi NP_001004729.1. NM_001004729.1.
    UniGenei Hs.553755.

    3D structure databases

    ProteinModelPortali Q8NGI8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000320302.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372701.

    Proteomic databases

    PRIDEi Q8NGI8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313940 ; ENSP00000320302 ; ENSG00000176495 .
    GeneIDi 390195.
    KEGGi hsa:390195.
    UCSCi uc010rks.2. human.

    Organism-specific databases

    CTDi 390195.
    GeneCardsi GC11P059131.
    HGNCi HGNC:15255. OR5AN1.
    MIMi 615702. gene.
    neXtProti NX_Q8NGI8.
    PharmGKBi PA32466.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG127675.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGI8.
    KOi K04257.
    OMAi FVQVMTA.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGI8.
    TreeFami TF352755.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5AN1.
    NextBioi 103503.
    PROi Q8NGI8.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_OR5AN1.
    Genevestigatori Q8NGI8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-289.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
    5. "Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors."
      Shirasu M., Yoshikawa K., Takai Y., Nakashima A., Takeuchi H., Sakano H., Touhara K.
      Neuron 81:165-178(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiO5AN1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGI8
    Secondary accession number(s): B9EIS2, Q6IEV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3