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Protein

Olfactory receptor 5AN1

Gene

OR5AN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor involved in the detection of muscone.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AN1
Alternative name(s):
Olfactory receptor OR11-244
Gene namesi
Name:OR5AN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15255. OR5AN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 13413CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei135 – 15521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini156 – 19742ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 31118CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32466.

Polymorphism and mutation databases

BioMutaiOR5AN1.
DMDMi38372701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 5AN1PRO_0000150577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGI8.

Expressioni

Gene expression databases

CleanExiHS_OR5AN1.
GenevestigatoriQ8NGI8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320302.

Structurei

3D structure databases

ProteinModelPortaliQ8NGI8.
SMRiQ8NGI8. Positions 110-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG127675.
GeneTreeiENSGT00440000033435.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGI8.
KOiK04257.
OMAiFVQVMTA.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGI8.
TreeFamiTF352755.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGGGNITEI TYFILLGFSD FPRIIKVLFT IFLVIYITSL AWNLSLIVLI
60 70 80 90 100
RMDSHLHTPM YFFLSNLSFI DVCYISSTVP KMLSNLLQEQ QTITFVGCII
110 120 130 140 150
QYFIFSTMGL SESCLMTAMA YDRYAAICNP LLYSSIMSPT LCVWMVLGAY
160 170 180 190 200
MTGLTASLFQ IGALLQLHFC GSNVIRHFFC DMPQLLILSC TDTFFVQVMT
210 220 230 240 250
AILTMFFGIA SALVIMISYG YIGISIMKIT SAKGRSKAFN TCASHLTAVS
260 270 280 290 300
LFYTSGIFVY LSSSSGGSSS FDRFASVFYT VVIPMLNPLI YSLRNKEIKD
310
ALKRLQKRKC C
Length:311
Mass (Da):34,789
Last modified:October 1, 2002 - v1
Checksum:i31F86526CC4C869B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti289 – 2891L → F.1 Publication
Corresponds to variant rs7941190 [ dbSNP | Ensembl ].
VAR_024098

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065806 Genomic DNA. Translation: BAC06025.1.
BC140917 mRNA. Translation: AAI40918.1.
BK004508 Genomic DNA. Translation: DAA04906.1.
CCDSiCCDS31559.1.
RefSeqiNP_001004729.1. NM_001004729.1.
UniGeneiHs.553755.

Genome annotation databases

EnsembliENST00000313940; ENSP00000320302; ENSG00000176495.
GeneIDi390195.
KEGGihsa:390195.
UCSCiuc010rks.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065806 Genomic DNA. Translation: BAC06025.1.
BC140917 mRNA. Translation: AAI40918.1.
BK004508 Genomic DNA. Translation: DAA04906.1.
CCDSiCCDS31559.1.
RefSeqiNP_001004729.1. NM_001004729.1.
UniGeneiHs.553755.

3D structure databases

ProteinModelPortaliQ8NGI8.
SMRiQ8NGI8. Positions 110-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000320302.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5AN1.
DMDMi38372701.

Proteomic databases

PRIDEiQ8NGI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313940; ENSP00000320302; ENSG00000176495.
GeneIDi390195.
KEGGihsa:390195.
UCSCiuc010rks.2. human.

Organism-specific databases

CTDi390195.
GeneCardsiGC11P059131.
HGNCiHGNC:15255. OR5AN1.
MIMi615702. gene.
neXtProtiNX_Q8NGI8.
PharmGKBiPA32466.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG127675.
GeneTreeiENSGT00440000033435.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGI8.
KOiK04257.
OMAiFVQVMTA.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGI8.
TreeFamiTF352755.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5AN1.
GenomeRNAii390195.
NextBioi103503.
PROiQ8NGI8.
SOURCEiSearch...

Gene expression databases

CleanExiHS_OR5AN1.
GenevestigatoriQ8NGI8.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-289.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  5. "Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors."
    Shirasu M., Yoshikawa K., Takai Y., Nakashima A., Takeuchi H., Sakano H., Touhara K.
    Neuron 81:165-178(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiO5AN1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI8
Secondary accession number(s): B9EIS2, Q6IEV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: May 27, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.