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Q8NGI8

- O5AN1_HUMAN

UniProt

Q8NGI8 - O5AN1_HUMAN

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Protein

Olfactory receptor 5AN1

Gene

OR5AN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor involved in the detection of muscone.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AN1
Alternative name(s):
Olfactory receptor OR11-244
Gene namesi
Name:OR5AN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15255. OR5AN1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 5AN1PRO_0000150577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGI8.

Expressioni

Gene expression databases

CleanExiHS_OR5AN1.
GenevestigatoriQ8NGI8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320302.

Structurei

3D structure databases

ProteinModelPortaliQ8NGI8.
SMRiQ8NGI8. Positions 110-141.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
BLAST
Topological domaini122 – 13413CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini156 – 19742ExtracellularSequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Topological domaini294 – 31118CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei135 – 15521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG127675.
GeneTreeiENSGT00440000033435.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGI8.
KOiK04257.
OMAiFVQVMTA.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGI8.
TreeFamiTF352755.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGI8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGGGNITEI TYFILLGFSD FPRIIKVLFT IFLVIYITSL AWNLSLIVLI
60 70 80 90 100
RMDSHLHTPM YFFLSNLSFI DVCYISSTVP KMLSNLLQEQ QTITFVGCII
110 120 130 140 150
QYFIFSTMGL SESCLMTAMA YDRYAAICNP LLYSSIMSPT LCVWMVLGAY
160 170 180 190 200
MTGLTASLFQ IGALLQLHFC GSNVIRHFFC DMPQLLILSC TDTFFVQVMT
210 220 230 240 250
AILTMFFGIA SALVIMISYG YIGISIMKIT SAKGRSKAFN TCASHLTAVS
260 270 280 290 300
LFYTSGIFVY LSSSSGGSSS FDRFASVFYT VVIPMLNPLI YSLRNKEIKD
310
ALKRLQKRKC C
Length:311
Mass (Da):34,789
Last modified:October 1, 2002 - v1
Checksum:i31F86526CC4C869B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti289 – 2891L → F.1 Publication
Corresponds to variant rs7941190 [ dbSNP | Ensembl ].
VAR_024098

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065806 Genomic DNA. Translation: BAC06025.1.
BC140917 mRNA. Translation: AAI40918.1.
BK004508 Genomic DNA. Translation: DAA04906.1.
CCDSiCCDS31559.1.
RefSeqiNP_001004729.1. NM_001004729.1.
UniGeneiHs.553755.

Genome annotation databases

EnsembliENST00000313940; ENSP00000320302; ENSG00000176495.
GeneIDi390195.
KEGGihsa:390195.
UCSCiuc010rks.2. human.

Polymorphism databases

DMDMi38372701.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065806 Genomic DNA. Translation: BAC06025.1 .
BC140917 mRNA. Translation: AAI40918.1 .
BK004508 Genomic DNA. Translation: DAA04906.1 .
CCDSi CCDS31559.1.
RefSeqi NP_001004729.1. NM_001004729.1.
UniGenei Hs.553755.

3D structure databases

ProteinModelPortali Q8NGI8.
SMRi Q8NGI8. Positions 110-141.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000320302.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372701.

Proteomic databases

PRIDEi Q8NGI8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313940 ; ENSP00000320302 ; ENSG00000176495 .
GeneIDi 390195.
KEGGi hsa:390195.
UCSCi uc010rks.2. human.

Organism-specific databases

CTDi 390195.
GeneCardsi GC11P059131.
HGNCi HGNC:15255. OR5AN1.
MIMi 615702. gene.
neXtProti NX_Q8NGI8.
PharmGKBi PA32466.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG127675.
GeneTreei ENSGT00440000033435.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGI8.
KOi K04257.
OMAi FVQVMTA.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGI8.
TreeFami TF352755.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR5AN1.
GenomeRNAii 390195.
NextBioi 103503.
PROi Q8NGI8.
SOURCEi Search...

Gene expression databases

CleanExi HS_OR5AN1.
Genevestigatori Q8NGI8.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-289.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  5. "Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors."
    Shirasu M., Yoshikawa K., Takai Y., Nakashima A., Takeuchi H., Sakano H., Touhara K.
    Neuron 81:165-178(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiO5AN1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI8
Secondary accession number(s): B9EIS2, Q6IEV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3