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Q8NGI8 (O5AN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5AN1
Alternative name(s):
Olfactory receptor OR11-244
Gene names
Name:OR5AN1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Olfactory receptor 5AN1
PRO_0000150577

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 4721Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 10024Extracellular Potential
Transmembrane101 – 12121Helical; Name=3; Potential
Topological domain122 – 13413Cytoplasmic Potential
Transmembrane135 – 15521Helical; Name=4; Potential
Topological domain156 – 19742Extracellular Potential
Transmembrane198 – 21821Helical; Name=5; Potential
Topological domain219 – 23820Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29321Helical; Name=7; Potential
Topological domain294 – 31118Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant2891L → F. Ref.2
Corresponds to variant rs7941190 [ dbSNP | Ensembl ].
VAR_024098

Sequences

Sequence LengthMass (Da)Tools
Q8NGI8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 31F86526CC4C869B

FASTA31134,789
        10         20         30         40         50         60 
MTGGGNITEI TYFILLGFSD FPRIIKVLFT IFLVIYITSL AWNLSLIVLI RMDSHLHTPM 

        70         80         90        100        110        120 
YFFLSNLSFI DVCYISSTVP KMLSNLLQEQ QTITFVGCII QYFIFSTMGL SESCLMTAMA 

       130        140        150        160        170        180 
YDRYAAICNP LLYSSIMSPT LCVWMVLGAY MTGLTASLFQ IGALLQLHFC GSNVIRHFFC 

       190        200        210        220        230        240 
DMPQLLILSC TDTFFVQVMT AILTMFFGIA SALVIMISYG YIGISIMKIT SAKGRSKAFN 

       250        260        270        280        290        300 
TCASHLTAVS LFYTSGIFVY LSSSSGGSSS FDRFASVFYT VVIPMLNPLI YSLRNKEIKD 

       310 
ALKRLQKRKC C 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-289.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065806 Genomic DNA. Translation: BAC06025.1.
BC140917 mRNA. Translation: AAI40918.1.
BK004508 Genomic DNA. Translation: DAA04906.1.
RefSeqNP_001004729.1. NM_001004729.1.
UniGeneHs.553755.

3D structure databases

ProteinModelPortalQ8NGI8.
SMRQ8NGI8. Positions 110-141, 279-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000320302.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372701.

Proteomic databases

PRIDEQ8NGI8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313940; ENSP00000320302; ENSG00000176495.
GeneID390195.
KEGGhsa:390195.
UCSCuc010rks.2. human.

Organism-specific databases

CTD390195.
GeneCardsGC11P059131.
HGNCHGNC:15255. OR5AN1.
neXtProtNX_Q8NGI8.
PharmGKBPA32466.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG127675.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGI8.
KOK04257.
OMAFVQVMTA.
OrthoDBEOG71K63J.
PhylomeDBQ8NGI8.
TreeFamTF352755.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5AN1.
GenevestigatorQ8NGI8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR5AN1.
NextBio103503.
PROQ8NGI8.

Entry information

Entry nameO5AN1_HUMAN
AccessionPrimary (citable) accession number: Q8NGI8
Secondary accession number(s): B9EIS2, Q6IEV4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries