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Protein

Olfactory receptor 10V1

Gene

OR10V1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10V1
Alternative name(s):
Olfactory receptor OR11-256
Gene namesi
Name:OR10V1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15136. OR10V1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 10025ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 30916CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 10V1PRO_0000150718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGI7.

Expressioni

Gene expression databases

CleanExiHS_OR10V1.
GenevestigatoriQ8NGI7.

Organism-specific databases

HPAiHPA060076.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302199.

Structurei

3D structure databases

ProteinModelPortaliQ8NGI7.
SMRiQ8NGI7. Positions 29-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47552.
GeneTreeiENSGT00710000106401.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGI7.
KOiK04257.
OMAiSPEMGRV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGI7.
TreeFamiTF352734.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGI7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGINKTAKM QFFFRPFSPD PEVQMLIFVV FLMMYLTSLG GNATIAVIVQ
60 70 80 90 100
INHSLHTPMY FFLANLAVLE IFYTSSITPL ALANLLSMGK TPVSITGCGT
110 120 130 140 150
QMFFFVFLGG ADCVLLVVMA YDQFIAICHP LRYRLIMSWS LCVELLVGSL
160 170 180 190 200
VLGFLLSLPL TILIFHLPFC HNDEIYHFYC DMPAVMRLAC ADTRVHKTAL
210 220 230 240 250
YIISFIVLSI PLSLISISYV FIVVAILRIR SAEGRQQAYS TCSSHILVVL
260 270 280 290 300
LQYGCTSFIY LSPSSSYSPE MGRVVSVAYT FITPILNPLI YSLRNKELKD

ALRKALRKF
Length:309
Mass (Da):34,746
Last modified:October 17, 2006 - v3
Checksum:iBF43CCF7C95284EC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171V → A.
Corresponds to variant rs472177 [ dbSNP | Ensembl ].
VAR_048065
Natural varianti123 – 1231Q → R.2 Publications
Corresponds to variant rs499033 [ dbSNP | Ensembl ].
VAR_034296

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065807 Genomic DNA. Translation: BAC06026.1.
CH471076 Genomic DNA. Translation: EAW73852.1.
AF399593 Genomic DNA. Translation: AAK95078.1.
BK004323 Genomic DNA. Translation: DAA04721.1.
CCDSiCCDS31565.1.
RefSeqiNP_001005324.1. NM_001005324.1.
UniGeneiHs.589001.

Genome annotation databases

EnsembliENST00000307552; ENSP00000302199; ENSG00000172289.
GeneIDi390201.
KEGGihsa:390201.
UCSCiuc001nof.1. human.

Polymorphism databases

DMDMi116242686.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065807 Genomic DNA. Translation: BAC06026.1.
CH471076 Genomic DNA. Translation: EAW73852.1.
AF399593 Genomic DNA. Translation: AAK95078.1.
BK004323 Genomic DNA. Translation: DAA04721.1.
CCDSiCCDS31565.1.
RefSeqiNP_001005324.1. NM_001005324.1.
UniGeneiHs.589001.

3D structure databases

ProteinModelPortaliQ8NGI7.
SMRiQ8NGI7. Positions 29-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302199.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi116242686.

Proteomic databases

PRIDEiQ8NGI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307552; ENSP00000302199; ENSG00000172289.
GeneIDi390201.
KEGGihsa:390201.
UCSCiuc001nof.1. human.

Organism-specific databases

CTDi390201.
GeneCardsiGC11M059480.
HGNCiHGNC:15136. OR10V1.
HPAiHPA060076.
neXtProtiNX_Q8NGI7.
PharmGKBiPA32003.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47552.
GeneTreeiENSGT00710000106401.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGI7.
KOiK04257.
OMAiSPEMGRV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGI7.
TreeFamiTF352734.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10V1.
GenomeRNAii390201.
NextBioi103515.
PROiQ8NGI7.

Gene expression databases

CleanExiHS_OR10V1.
GenevestigatoriQ8NGI7.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-123.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284, VARIANT ARG-123.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10V1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI7
Secondary accession number(s): Q6IFD9, Q96R50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 17, 2006
Last modified: January 7, 2015
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.