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Q8NGI7

- O10V1_HUMAN

UniProt

Q8NGI7 - O10V1_HUMAN

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Protein
Olfactory receptor 10V1
Gene
OR10V1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10V1
    Alternative name(s):
    Olfactory receptor OR11-256
    Gene namesi
    Name:OR10V1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15136. OR10V1.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei26 – 4621Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini47 – 548Cytoplasmic Reviewed prediction
    Transmembranei55 – 7521Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini76 – 10025Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei101 – 12121Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini122 – 14019Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei141 – 16121Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini162 – 19837Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei199 – 21820Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini219 – 23820Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei239 – 25921Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini260 – 27213Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei273 – 29321Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini294 – 30916Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32003.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Olfactory receptor 10V1
    PRO_0000150718Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi98 ↔ 190 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGI7.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10V1.
    GenevestigatoriQ8NGI7.

    Organism-specific databases

    HPAiHPA060076.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000302199.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGI7.
    SMRiQ8NGI7. Positions 29-307.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47552.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGI7.
    KOiK04257.
    OMAiSPEMGRV.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGI7.
    TreeFamiTF352734.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGI7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGINKTAKM QFFFRPFSPD PEVQMLIFVV FLMMYLTSLG GNATIAVIVQ    50
    INHSLHTPMY FFLANLAVLE IFYTSSITPL ALANLLSMGK TPVSITGCGT 100
    QMFFFVFLGG ADCVLLVVMA YDQFIAICHP LRYRLIMSWS LCVELLVGSL 150
    VLGFLLSLPL TILIFHLPFC HNDEIYHFYC DMPAVMRLAC ADTRVHKTAL 200
    YIISFIVLSI PLSLISISYV FIVVAILRIR SAEGRQQAYS TCSSHILVVL 250
    LQYGCTSFIY LSPSSSYSPE MGRVVSVAYT FITPILNPLI YSLRNKELKD 300
    ALRKALRKF 309
    Length:309
    Mass (Da):34,746
    Last modified:October 17, 2006 - v3
    Checksum:iBF43CCF7C95284EC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti117 – 1171V → A.
    Corresponds to variant rs472177 [ dbSNP | Ensembl ].
    VAR_048065
    Natural varianti123 – 1231Q → R.2 Publications
    Corresponds to variant rs499033 [ dbSNP | Ensembl ].
    VAR_034296

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065807 Genomic DNA. Translation: BAC06026.1.
    CH471076 Genomic DNA. Translation: EAW73852.1.
    AF399593 Genomic DNA. Translation: AAK95078.1.
    BK004323 Genomic DNA. Translation: DAA04721.1.
    CCDSiCCDS31565.1.
    RefSeqiNP_001005324.1. NM_001005324.1.
    UniGeneiHs.589001.

    Genome annotation databases

    EnsembliENST00000307552; ENSP00000302199; ENSG00000172289.
    GeneIDi390201.
    KEGGihsa:390201.
    UCSCiuc001nof.1. human.

    Polymorphism databases

    DMDMi116242686.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065807 Genomic DNA. Translation: BAC06026.1 .
    CH471076 Genomic DNA. Translation: EAW73852.1 .
    AF399593 Genomic DNA. Translation: AAK95078.1 .
    BK004323 Genomic DNA. Translation: DAA04721.1 .
    CCDSi CCDS31565.1.
    RefSeqi NP_001005324.1. NM_001005324.1.
    UniGenei Hs.589001.

    3D structure databases

    ProteinModelPortali Q8NGI7.
    SMRi Q8NGI7. Positions 29-307.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000302199.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 116242686.

    Proteomic databases

    PRIDEi Q8NGI7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307552 ; ENSP00000302199 ; ENSG00000172289 .
    GeneIDi 390201.
    KEGGi hsa:390201.
    UCSCi uc001nof.1. human.

    Organism-specific databases

    CTDi 390201.
    GeneCardsi GC11M059480.
    HGNCi HGNC:15136. OR10V1.
    HPAi HPA060076.
    neXtProti NX_Q8NGI7.
    PharmGKBi PA32003.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47552.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGI7.
    KOi K04257.
    OMAi SPEMGRV.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGI7.
    TreeFami TF352734.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10V1.
    GenomeRNAii 390201.
    NextBioi 103515.
    PROi Q8NGI7.

    Gene expression databases

    CleanExi HS_OR10V1.
    Genevestigatori Q8NGI7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-123.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284, VARIANT ARG-123.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10V1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGI7
    Secondary accession number(s): Q6IFD9, Q96R50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: October 17, 2006
    Last modified: September 3, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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