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Protein

Olfactory receptor 10V1

Gene

OR10V1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10V1
Alternative name(s):
Olfactory receptor OR11-256
Gene namesi
Name:OR10V1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172289.2
HGNCiHGNC:15136 OR10V1
neXtProtiNX_Q8NGI7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 100ExtracellularSequence analysisAdd BLAST25
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 309CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32003

Polymorphism and mutation databases

BioMutaiOR10V1
DMDMi116242686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507181 – 309Olfactory receptor 10V1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGI7
PRIDEiQ8NGI7

Expressioni

Gene expression databases

BgeeiENSG00000172289
CleanExiHS_OR10V1

Organism-specific databases

HPAiHPA060076

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302199

Structurei

3D structure databases

ProteinModelPortaliQ8NGI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMIJ Eukaryota
ENOG411141U LUCA
GeneTreeiENSGT00710000106401
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGI7
KOiK04257
OMAiSPEMGRV
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGI7
TreeFamiTF352734

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGINKTAKM QFFFRPFSPD PEVQMLIFVV FLMMYLTSLG GNATIAVIVQ
60 70 80 90 100
INHSLHTPMY FFLANLAVLE IFYTSSITPL ALANLLSMGK TPVSITGCGT
110 120 130 140 150
QMFFFVFLGG ADCVLLVVMA YDQFIAICHP LRYRLIMSWS LCVELLVGSL
160 170 180 190 200
VLGFLLSLPL TILIFHLPFC HNDEIYHFYC DMPAVMRLAC ADTRVHKTAL
210 220 230 240 250
YIISFIVLSI PLSLISISYV FIVVAILRIR SAEGRQQAYS TCSSHILVVL
260 270 280 290 300
LQYGCTSFIY LSPSSSYSPE MGRVVSVAYT FITPILNPLI YSLRNKELKD

ALRKALRKF
Length:309
Mass (Da):34,746
Last modified:October 17, 2006 - v3
Checksum:iBF43CCF7C95284EC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048065117V → A. Corresponds to variant dbSNP:rs472177Ensembl.1
Natural variantiVAR_034296123Q → R2 PublicationsCorresponds to variant dbSNP:rs499033Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065807 Genomic DNA Translation: BAC06026.1
CH471076 Genomic DNA Translation: EAW73852.1
AF399593 Genomic DNA Translation: AAK95078.1
BK004323 Genomic DNA Translation: DAA04721.1
CCDSiCCDS31565.1
RefSeqiNP_001005324.1, NM_001005324.1
UniGeneiHs.589001

Genome annotation databases

EnsembliENST00000307552; ENSP00000302199; ENSG00000172289
GeneIDi390201
KEGGihsa:390201
UCSCiuc001nof.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO10V1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI7
Secondary accession number(s): Q6IFD9, Q96R50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 17, 2006
Last modified: December 20, 2017
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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