ID OR4DB_HUMAN Reviewed; 311 AA. AC Q8NGI4; DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 24-JAN-2024, entry version 142. DE RecName: Full=Olfactory receptor 4D11; GN Name=OR4D11; Synonyms=OR4D11P; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4D11"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065810; BAC06029.1; -; Genomic_DNA. DR CCDS; CCDS31563.1; -. DR RefSeq; NP_001004706.1; NM_001004706.1. DR AlphaFoldDB; Q8NGI4; -. DR SMR; Q8NGI4; -. DR STRING; 9606.ENSP00000320077; -. DR GlyCosmos; Q8NGI4; 1 site, No reported glycans. DR GlyGen; Q8NGI4; 1 site. DR PhosphoSitePlus; Q8NGI4; -. DR BioMuta; OR4D11; -. DR DMDM; 71153030; -. DR MassIVE; Q8NGI4; -. DR PaxDb; 9606-ENSP00000320077; -. DR PeptideAtlas; Q8NGI4; -. DR Antibodypedia; 65199; 66 antibodies from 19 providers. DR DNASU; 219986; -. DR Ensembl; ENST00000313253.1; ENSP00000320077.1; ENSG00000176200.1. DR GeneID; 219986; -. DR KEGG; hsa:219986; -. DR MANE-Select; ENST00000313253.1; ENSP00000320077.1; NM_001004706.1; NP_001004706.1. DR UCSC; uc001noa.1; human. DR AGR; HGNC:15174; -. DR CTD; 219986; -. DR GeneCards; OR4D11; -. DR HGNC; HGNC:15174; OR4D11. DR HPA; ENSG00000176200; Not detected. DR neXtProt; NX_Q8NGI4; -. DR OpenTargets; ENSG00000176200; -. DR PharmGKB; PA32269; -. DR VEuPathDB; HostDB:ENSG00000176200; -. DR eggNOG; ENOG502SIBY; Eukaryota. DR GeneTree; ENSGT00940000163523; -. DR HOGENOM; CLU_012526_8_1_1; -. DR InParanoid; Q8NGI4; -. DR OMA; CYMAISK; -. DR OrthoDB; 4634745at2759; -. DR PhylomeDB; Q8NGI4; -. DR TreeFam; TF352732; -. DR PathwayCommons; Q8NGI4; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR SignaLink; Q8NGI4; -. DR BioGRID-ORCS; 219986; 15 hits in 742 CRISPR screens. DR GeneWiki; OR4D11; -. DR GenomeRNAi; 219986; -. DR Pharos; Q8NGI4; Tdark. DR PRO; PR:Q8NGI4; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q8NGI4; Protein. DR ExpressionAtlas; Q8NGI4; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR CDD; cd15936; 7tmA_OR4D-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR48002:SF89; OLFACTORY RECEPTOR 4D11; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..311 FT /note="Olfactory receptor 4D11" FT /id="PRO_0000150543" FT TOPO_DOM 1..25 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 26..49 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 50..57 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 58..79 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 80..100 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 101..120 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 121..139 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 140..158 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 159..195 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 196..219 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 220..235 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 236..258 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 259..269 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 270..289 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 290..311 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 5 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 97..189 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 197 FT /note="F -> L (in dbSNP:rs7120079)" FT /id="VAR_034197" SQ SEQUENCE 311 AA; 34969 MW; 503FDDBFCACABC61 CRC64; MELGNVTRVK EFIFLGLTQS QDQSLVLFLF LCLVYMTTLL GNLLIMVTVT CESRLHTPMY FLLRNLAILD ICFSSTTAPK VLLDLLSKKK TISYTSCMTQ IFLFHLLGGA DIFSLSVMAF DCYMAISKPL HYVTIMSRGQ CTALISASWM GGFVHSIVQI SLLLPLPFCG PNVLDTFYCD VPQVLKLTCT DTFALEFLMI SNNGLVTTLW FIFLLVSYTV ILMTLRSQAG GGRRKAISTC TSHITVVTLH FVPCIYVYAR PFTALPTEKA ISVTFTVISP LLNPLIYTLR NQEMKSAMRR LKRRLVPSER E //