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Q8NGI4

- OR4DB_HUMAN

UniProt

Q8NGI4 - OR4DB_HUMAN

Protein

Olfactory receptor 4D11

Gene

OR4D11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 4D11
    Gene namesi
    Name:OR4D11
    Synonyms:OR4D11P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15174. OR4D11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32269.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 4D11PRO_0000150543Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGI4.
    PRIDEiQ8NGI4.

    Expressioni

    Gene expression databases

    CleanExiHS_OR4D11.
    GenevestigatoriQ8NGI4.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000320077.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGI4.
    SMRiQ8NGI4. Positions 25-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23516CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 26911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31122CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47369.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGI4.
    KOiK04257.
    OMAiLISASWM.
    OrthoDBiEOG7KSX95.
    PhylomeDBiQ8NGI4.
    TreeFamiTF352732.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELGNVTRVK EFIFLGLTQS QDQSLVLFLF LCLVYMTTLL GNLLIMVTVT    50
    CESRLHTPMY FLLRNLAILD ICFSSTTAPK VLLDLLSKKK TISYTSCMTQ 100
    IFLFHLLGGA DIFSLSVMAF DCYMAISKPL HYVTIMSRGQ CTALISASWM 150
    GGFVHSIVQI SLLLPLPFCG PNVLDTFYCD VPQVLKLTCT DTFALEFLMI 200
    SNNGLVTTLW FIFLLVSYTV ILMTLRSQAG GGRRKAISTC TSHITVVTLH 250
    FVPCIYVYAR PFTALPTEKA ISVTFTVISP LLNPLIYTLR NQEMKSAMRR 300
    LKRRLVPSER E 311
    Length:311
    Mass (Da):34,969
    Last modified:October 1, 2002 - v1
    Checksum:i503FDDBFCACABC61
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti197 – 1971F → L.
    Corresponds to variant rs7120079 [ dbSNP | Ensembl ].
    VAR_034197

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065810 Genomic DNA. Translation: BAC06029.1.
    CCDSiCCDS31563.1.
    RefSeqiNP_001004706.1. NM_001004706.1.
    UniGeneiHs.553651.

    Genome annotation databases

    EnsembliENST00000313253; ENSP00000320077; ENSG00000176200.
    GeneIDi219986.
    KEGGihsa:219986.
    UCSCiuc001noa.1. human.

    Polymorphism databases

    DMDMi71153030.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065810 Genomic DNA. Translation: BAC06029.1 .
    CCDSi CCDS31563.1.
    RefSeqi NP_001004706.1. NM_001004706.1.
    UniGenei Hs.553651.

    3D structure databases

    ProteinModelPortali Q8NGI4.
    SMRi Q8NGI4. Positions 25-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000320077.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 71153030.

    Proteomic databases

    PaxDbi Q8NGI4.
    PRIDEi Q8NGI4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313253 ; ENSP00000320077 ; ENSG00000176200 .
    GeneIDi 219986.
    KEGGi hsa:219986.
    UCSCi uc001noa.1. human.

    Organism-specific databases

    CTDi 219986.
    GeneCardsi GC11P059271.
    HGNCi HGNC:15174. OR4D11.
    neXtProti NX_Q8NGI4.
    PharmGKBi PA32269.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47369.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGI4.
    KOi K04257.
    OMAi LISASWM.
    OrthoDBi EOG7KSX95.
    PhylomeDBi Q8NGI4.
    TreeFami TF352732.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR4D11.
    NextBioi 90925.
    PROi Q8NGI4.

    Gene expression databases

    CleanExi HS_OR4D11.
    Genevestigatori Q8NGI4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiOR4DB_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3