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Protein

Olfactory receptor 4D11

Gene

OR4D11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
  3. transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4D11
Gene namesi
Name:OR4D11
Synonyms:OR4D11P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15174. OR4D11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23516CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence AnalysisAdd
BLAST
Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 31122CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32269.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 4D11PRO_0000150543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGI4.
PRIDEiQ8NGI4.

Expressioni

Gene expression databases

CleanExiHS_OR4D11.
GenevestigatoriQ8NGI4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320077.

Structurei

3D structure databases

ProteinModelPortaliQ8NGI4.
SMRiQ8NGI4. Positions 25-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47369.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGI4.
KOiK04257.
OMAiLISASWM.
OrthoDBiEOG7KSX95.
PhylomeDBiQ8NGI4.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELGNVTRVK EFIFLGLTQS QDQSLVLFLF LCLVYMTTLL GNLLIMVTVT
60 70 80 90 100
CESRLHTPMY FLLRNLAILD ICFSSTTAPK VLLDLLSKKK TISYTSCMTQ
110 120 130 140 150
IFLFHLLGGA DIFSLSVMAF DCYMAISKPL HYVTIMSRGQ CTALISASWM
160 170 180 190 200
GGFVHSIVQI SLLLPLPFCG PNVLDTFYCD VPQVLKLTCT DTFALEFLMI
210 220 230 240 250
SNNGLVTTLW FIFLLVSYTV ILMTLRSQAG GGRRKAISTC TSHITVVTLH
260 270 280 290 300
FVPCIYVYAR PFTALPTEKA ISVTFTVISP LLNPLIYTLR NQEMKSAMRR
310
LKRRLVPSER E
Length:311
Mass (Da):34,969
Last modified:October 1, 2002 - v1
Checksum:i503FDDBFCACABC61
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti197 – 1971F → L.
Corresponds to variant rs7120079 [ dbSNP | Ensembl ].
VAR_034197

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065810 Genomic DNA. Translation: BAC06029.1.
CCDSiCCDS31563.1.
RefSeqiNP_001004706.1. NM_001004706.1.
UniGeneiHs.553651.

Genome annotation databases

EnsembliENST00000313253; ENSP00000320077; ENSG00000176200.
GeneIDi219986.
KEGGihsa:219986.
UCSCiuc001noa.1. human.

Polymorphism databases

DMDMi71153030.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065810 Genomic DNA. Translation: BAC06029.1.
CCDSiCCDS31563.1.
RefSeqiNP_001004706.1. NM_001004706.1.
UniGeneiHs.553651.

3D structure databases

ProteinModelPortaliQ8NGI4.
SMRiQ8NGI4. Positions 25-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000320077.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi71153030.

Proteomic databases

PaxDbiQ8NGI4.
PRIDEiQ8NGI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313253; ENSP00000320077; ENSG00000176200.
GeneIDi219986.
KEGGihsa:219986.
UCSCiuc001noa.1. human.

Organism-specific databases

CTDi219986.
GeneCardsiGC11P059271.
HGNCiHGNC:15174. OR4D11.
neXtProtiNX_Q8NGI4.
PharmGKBiPA32269.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47369.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGI4.
KOiK04257.
OMAiLISASWM.
OrthoDBiEOG7KSX95.
PhylomeDBiQ8NGI4.
TreeFamiTF352732.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4D11.
GenomeRNAii219986.
NextBioi90925.
PROiQ8NGI4.

Gene expression databases

CleanExiHS_OR4D11.
GenevestigatoriQ8NGI4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiOR4DB_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.