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Q8NGI4 (OR4DB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4D11
Gene names
Name:OR4D11
Synonyms:OR4D11P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Olfactory receptor 4D11
PRO_0000150543

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23516Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 26911Extracellular Potential
Transmembrane270 – 28920Helical; Name=7; Potential
Topological domain290 – 31122Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant1971F → L.
Corresponds to variant rs7120079 [ dbSNP | Ensembl ].
VAR_034197

Sequences

Sequence LengthMass (Da)Tools
Q8NGI4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 503FDDBFCACABC61

FASTA31134,969
        10         20         30         40         50         60 
MELGNVTRVK EFIFLGLTQS QDQSLVLFLF LCLVYMTTLL GNLLIMVTVT CESRLHTPMY 

        70         80         90        100        110        120 
FLLRNLAILD ICFSSTTAPK VLLDLLSKKK TISYTSCMTQ IFLFHLLGGA DIFSLSVMAF 

       130        140        150        160        170        180 
DCYMAISKPL HYVTIMSRGQ CTALISASWM GGFVHSIVQI SLLLPLPFCG PNVLDTFYCD 

       190        200        210        220        230        240 
VPQVLKLTCT DTFALEFLMI SNNGLVTTLW FIFLLVSYTV ILMTLRSQAG GGRRKAISTC 

       250        260        270        280        290        300 
TSHITVVTLH FVPCIYVYAR PFTALPTEKA ISVTFTVISP LLNPLIYTLR NQEMKSAMRR 

       310 
LKRRLVPSER E 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065810 Genomic DNA. Translation: BAC06029.1.
RefSeqNP_001004706.1. NM_001004706.1.
UniGeneHs.553651.

3D structure databases

ProteinModelPortalQ8NGI4.
SMRQ8NGI4. Positions 25-227, 274-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000320077.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM71153030.

Proteomic databases

PaxDbQ8NGI4.
PRIDEQ8NGI4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313253; ENSP00000320077; ENSG00000176200.
GeneID219986.
KEGGhsa:219986.
UCSCuc001noa.1. human.

Organism-specific databases

CTD219986.
GeneCardsGC11P059271.
HGNCHGNC:15174. OR4D11.
neXtProtNX_Q8NGI4.
PharmGKBPA32269.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47369.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGI4.
KOK04257.
OMALISASWM.
OrthoDBEOG7KSX95.
PhylomeDBQ8NGI4.
TreeFamTF352732.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR4D11.
GenevestigatorQ8NGI4.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR4D11.
NextBio90925.
PROQ8NGI4.

Entry information

Entry nameOR4DB_HUMAN
AccessionPrimary (citable) accession number: Q8NGI4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries