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Q8NGI3

- O56B1_HUMAN

UniProt

Q8NGI3 - O56B1_HUMAN

Protein

Olfactory receptor 56B1

Gene

OR56B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 56B1
    Alternative name(s):
    Olfactory receptor OR11-65
    Gene namesi
    Name:OR56B1
    Synonyms:OR56B1P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15245. OR56B1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32450.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Olfactory receptor 56B1PRO_0000150796Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 198PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGI3.
    PRIDEiQ8NGI3.

    Expressioni

    Gene expression databases

    CleanExiHS_OR56B1.
    GenevestigatoriQ8NGI3.

    Organism-specific databases

    HPAiHPA045043.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000322939.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGI3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini56 – 638CytoplasmicSequence Analysis
    Topological domaini85 – 10824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 14819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini170 – 20536ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 24620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 28114ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini303 – 32220CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei64 – 8421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40164.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NGI3.
    KOiK04257.
    OMAiICQDPAL.
    OrthoDBiEOG7QK0CJ.
    PhylomeDBiQ8NGI3.
    TreeFamiTF344049.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGI3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHMSASLKI SNSSKFQVSE FILLGFPGIH SWQHWLSLPL ALLYLSALAA    50
    NTLILIIIWQ NPSLQQPMYI FLGILCMVDM GLATTIIPKI LAIFWFDAKV 100
    ISLPECFAQI YAIHFFVGME SGILLCMAFD RYVAICHPLR YPSIVTSSLI 150
    LKATLFMVLR NGLFVTPVPV LAAQRDYCSK NEIEHCLCSN LGVTSLACDD 200
    RRPNSICQLV LAWLGMGSDL SLIILSYILI LYSVLRLNSA EAAAKALSTC 250
    SSHLTLILFF YTIVVVISVT HLTEMKATLI PVLLNVLHNI IPPSLNPTVY 300
    ALQTKELRAA FQKVLFALTK EIRS 324
    Length:324
    Mass (Da):36,050
    Last modified:May 5, 2009 - v2
    Checksum:i2174312B66363017
    GO

    Sequence cautioni

    The sequence BAC06031.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti181 – 1811N → S in BAG53654. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061C → R.1 Publication
    Corresponds to variant rs7397032 [ dbSNP | Ensembl ].
    VAR_055055

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065812 Genomic DNA. Translation: BAC06031.1. Different initiation.
    AK122668 mRNA. Translation: BAG53654.1.
    AC131574 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68765.1.
    BC137184 mRNA. Translation: AAI37185.1.
    BC137185 mRNA. Translation: AAI37186.1.
    BK004386 Genomic DNA. Translation: DAA04784.1.
    CCDSiCCDS31395.1.
    RefSeqiNP_001005180.1. NM_001005180.2.
    UniGeneiHs.689609.

    Genome annotation databases

    EnsembliENST00000317121; ENSP00000322939; ENSG00000181023.
    GeneIDi387748.
    KEGGihsa:387748.
    UCSCiuc001mbs.1. human.

    Polymorphism databases

    DMDMi229462916.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065812 Genomic DNA. Translation: BAC06031.1 . Different initiation.
    AK122668 mRNA. Translation: BAG53654.1 .
    AC131574 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68765.1 .
    BC137184 mRNA. Translation: AAI37185.1 .
    BC137185 mRNA. Translation: AAI37186.1 .
    BK004386 Genomic DNA. Translation: DAA04784.1 .
    CCDSi CCDS31395.1.
    RefSeqi NP_001005180.1. NM_001005180.2.
    UniGenei Hs.689609.

    3D structure databases

    ProteinModelPortali Q8NGI3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000322939.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 229462916.

    Proteomic databases

    PaxDbi Q8NGI3.
    PRIDEi Q8NGI3.

    Protocols and materials databases

    DNASUi 387748.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317121 ; ENSP00000322939 ; ENSG00000181023 .
    GeneIDi 387748.
    KEGGi hsa:387748.
    UCSCi uc001mbs.1. human.

    Organism-specific databases

    CTDi 387748.
    GeneCardsi GC11P005715.
    HGNCi HGNC:15245. OR56B1.
    HPAi HPA045043.
    neXtProti NX_Q8NGI3.
    PharmGKBi PA32450.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40164.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NGI3.
    KOi K04257.
    OMAi ICQDPAL.
    OrthoDBi EOG7QK0CJ.
    PhylomeDBi Q8NGI3.
    TreeFami TF344049.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    ChiTaRSi OR56B1. human.
    GeneWikii OR56B1.
    GenomeRNAii 387748.
    NextBioi 101573.
    PROi Q8NGI3.

    Gene expression databases

    CleanExi HS_OR56B1.
    Genevestigatori Q8NGI3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-106.
      Tissue: Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: IDENTIFICATION.
    7. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO56B1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGI3
    Secondary accession number(s): B2RNY6, B3KV42, Q6IF76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-4 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3