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Protein

Olfactory receptor 56B1

Gene

OR56B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56B1
Alternative name(s):
Olfactory receptor OR11-65
Gene namesi
Name:OR56B1
Synonyms:OR56B1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000181023.6.
HGNCiHGNC:15245. OR56B1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini56 – 63CytoplasmicSequence analysis8
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 108ExtracellularSequence analysisAdd BLAST24
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 148CytoplasmicSequence analysisAdd BLAST19
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 205ExtracellularSequence analysisAdd BLAST36
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 246CytoplasmicSequence analysisAdd BLAST20
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 281ExtracellularSequence analysisAdd BLAST14
Transmembranei282 – 302Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini303 – 322CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32450.

Polymorphism and mutation databases

BioMutaiOR56B1.
DMDMi229462916.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507961 – 324Olfactory receptor 56B1Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 198

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGI3.
PRIDEiQ8NGI3.

Expressioni

Gene expression databases

BgeeiENSG00000181023.
CleanExiHS_OR56B1.

Organism-specific databases

HPAiHPA045043.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322939.

Structurei

3D structure databases

ProteinModelPortaliQ8NGI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDZQ. Eukaryota.
ENOG4111EHJ. LUCA.
GeneTreeiENSGT00550000074576.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGI3.
KOiK04257.
OMAiWLGMGSD.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGI3.
TreeFamiTF344049.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NGI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHMSASLKI SNSSKFQVSE FILLGFPGIH SWQHWLSLPL ALLYLSALAA
60 70 80 90 100
NTLILIIIWQ NPSLQQPMYI FLGILCMVDM GLATTIIPKI LAIFWFDAKV
110 120 130 140 150
ISLPECFAQI YAIHFFVGME SGILLCMAFD RYVAICHPLR YPSIVTSSLI
160 170 180 190 200
LKATLFMVLR NGLFVTPVPV LAAQRDYCSK NEIEHCLCSN LGVTSLACDD
210 220 230 240 250
RRPNSICQLV LAWLGMGSDL SLIILSYILI LYSVLRLNSA EAAAKALSTC
260 270 280 290 300
SSHLTLILFF YTIVVVISVT HLTEMKATLI PVLLNVLHNI IPPSLNPTVY
310 320
ALQTKELRAA FQKVLFALTK EIRS
Length:324
Mass (Da):36,050
Last modified:May 5, 2009 - v2
Checksum:i2174312B66363017
GO

Sequence cautioni

The sequence BAC06031 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181N → S in BAG53654 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055055106C → R1 PublicationCorresponds to variant dbSNP:rs7397032Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065812 Genomic DNA. Translation: BAC06031.1. Different initiation.
AK122668 mRNA. Translation: BAG53654.1.
AC131574 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68765.1.
BC137184 mRNA. Translation: AAI37185.1.
BC137185 mRNA. Translation: AAI37186.1.
BK004386 Genomic DNA. Translation: DAA04784.1.
CCDSiCCDS31395.1.
RefSeqiNP_001005180.1. NM_001005180.2.
UniGeneiHs.689609.

Genome annotation databases

EnsembliENST00000317121; ENSP00000322939; ENSG00000181023.
GeneIDi387748.
KEGGihsa:387748.
UCSCiuc001mbt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO56B1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI3
Secondary accession number(s): B2RNY6, B3KV42, Q6IF76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 5, 2009
Last modified: September 27, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families