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Q8NGI3

- O56B1_HUMAN

UniProt

Q8NGI3 - O56B1_HUMAN

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Protein

Olfactory receptor 56B1

Gene

OR56B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56B1
Alternative name(s):
Olfactory receptor OR11-65
Gene namesi
Name:OR56B1
Synonyms:OR56B1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15245. OR56B1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Olfactory receptor 56B1PRO_0000150796Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGI3.
PRIDEiQ8NGI3.

Expressioni

Gene expression databases

CleanExiHS_OR56B1.
GenevestigatoriQ8NGI3.

Organism-specific databases

HPAiHPA045043.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322939.

Structurei

3D structure databases

ProteinModelPortaliQ8NGI3.
SMRiQ8NGI3. Positions 118-149.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
BLAST
Topological domaini56 – 638CytoplasmicSequence Analysis
Topological domaini85 – 10824ExtracellularSequence AnalysisAdd
BLAST
Topological domaini130 – 14819CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini170 – 20536ExtracellularSequence AnalysisAdd
BLAST
Topological domaini227 – 24620CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini268 – 28114ExtracellularSequence AnalysisAdd
BLAST
Topological domaini303 – 32220CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei64 – 8421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei247 – 26721Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40164.
GeneTreeiENSGT00550000074576.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGI3.
KOiK04257.
OMAiICQDPAL.
OrthoDBiEOG7QK0CJ.
PhylomeDBiQ8NGI3.
TreeFamiTF344049.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGI3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNHMSASLKI SNSSKFQVSE FILLGFPGIH SWQHWLSLPL ALLYLSALAA
60 70 80 90 100
NTLILIIIWQ NPSLQQPMYI FLGILCMVDM GLATTIIPKI LAIFWFDAKV
110 120 130 140 150
ISLPECFAQI YAIHFFVGME SGILLCMAFD RYVAICHPLR YPSIVTSSLI
160 170 180 190 200
LKATLFMVLR NGLFVTPVPV LAAQRDYCSK NEIEHCLCSN LGVTSLACDD
210 220 230 240 250
RRPNSICQLV LAWLGMGSDL SLIILSYILI LYSVLRLNSA EAAAKALSTC
260 270 280 290 300
SSHLTLILFF YTIVVVISVT HLTEMKATLI PVLLNVLHNI IPPSLNPTVY
310 320
ALQTKELRAA FQKVLFALTK EIRS
Length:324
Mass (Da):36,050
Last modified:May 5, 2009 - v2
Checksum:i2174312B66363017
GO

Sequence cautioni

The sequence BAC06031.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811N → S in BAG53654. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061C → R.1 Publication
Corresponds to variant rs7397032 [ dbSNP | Ensembl ].
VAR_055055

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065812 Genomic DNA. Translation: BAC06031.1. Different initiation.
AK122668 mRNA. Translation: BAG53654.1.
AC131574 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68765.1.
BC137184 mRNA. Translation: AAI37185.1.
BC137185 mRNA. Translation: AAI37186.1.
BK004386 Genomic DNA. Translation: DAA04784.1.
CCDSiCCDS31395.1.
RefSeqiNP_001005180.1. NM_001005180.2.
UniGeneiHs.689609.

Genome annotation databases

EnsembliENST00000317121; ENSP00000322939; ENSG00000181023.
GeneIDi387748.
KEGGihsa:387748.
UCSCiuc001mbs.1. human.

Polymorphism databases

DMDMi229462916.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065812 Genomic DNA. Translation: BAC06031.1 . Different initiation.
AK122668 mRNA. Translation: BAG53654.1 .
AC131574 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68765.1 .
BC137184 mRNA. Translation: AAI37185.1 .
BC137185 mRNA. Translation: AAI37186.1 .
BK004386 Genomic DNA. Translation: DAA04784.1 .
CCDSi CCDS31395.1.
RefSeqi NP_001005180.1. NM_001005180.2.
UniGenei Hs.689609.

3D structure databases

ProteinModelPortali Q8NGI3.
SMRi Q8NGI3. Positions 118-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000322939.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 229462916.

Proteomic databases

PaxDbi Q8NGI3.
PRIDEi Q8NGI3.

Protocols and materials databases

DNASUi 387748.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317121 ; ENSP00000322939 ; ENSG00000181023 .
GeneIDi 387748.
KEGGi hsa:387748.
UCSCi uc001mbs.1. human.

Organism-specific databases

CTDi 387748.
GeneCardsi GC11P005715.
HGNCi HGNC:15245. OR56B1.
HPAi HPA045043.
neXtProti NX_Q8NGI3.
PharmGKBi PA32450.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40164.
GeneTreei ENSGT00550000074576.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q8NGI3.
KOi K04257.
OMAi ICQDPAL.
OrthoDBi EOG7QK0CJ.
PhylomeDBi Q8NGI3.
TreeFami TF344049.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

ChiTaRSi OR56B1. human.
GeneWikii OR56B1.
GenomeRNAii 387748.
NextBioi 101573.
PROi Q8NGI3.

Gene expression databases

CleanExi HS_OR56B1.
Genevestigatori Q8NGI3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-106.
    Tissue: Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO56B1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI3
Secondary accession number(s): B2RNY6, B3KV42, Q6IF76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3