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Q8NGI3 (O56B1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 56B1
Alternative name(s):
Olfactory receptor OR11-65
Gene names
Name:OR56B1
Synonyms:OR56B1P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.

Sequence caution

The sequence BAC06031.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Olfactory receptor 56B1
PRO_0000150796

Regions

Topological domain1 – 3434Extracellular Potential
Transmembrane35 – 5521Helical; Name=1; Potential
Topological domain56 – 638Cytoplasmic Potential
Transmembrane64 – 8421Helical; Name=2; Potential
Topological domain85 – 10824Extracellular Potential
Transmembrane109 – 12921Helical; Name=3; Potential
Topological domain130 – 14819Cytoplasmic Potential
Transmembrane149 – 16921Helical; Name=4; Potential
Topological domain170 – 20536Extracellular Potential
Transmembrane206 – 22621Helical; Name=5; Potential
Topological domain227 – 24620Cytoplasmic Potential
Transmembrane247 – 26721Helical; Name=6; Potential
Topological domain268 – 28114Extracellular Potential
Transmembrane282 – 30221Helical; Name=7; Potential
Topological domain303 – 32220Cytoplasmic Potential

Amino acid modifications

Glycosylation121N-linked (GlcNAc...) Potential
Disulfide bond106 ↔ 198 By similarity

Natural variations

Natural variant1061C → R. Ref.2
Corresponds to variant rs7397032 [ dbSNP | Ensembl ].
VAR_055055

Experimental info

Sequence conflict1811N → S in BAG53654. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8NGI3 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 2174312B66363017

FASTA32436,050
        10         20         30         40         50         60 
MNHMSASLKI SNSSKFQVSE FILLGFPGIH SWQHWLSLPL ALLYLSALAA NTLILIIIWQ 

        70         80         90        100        110        120 
NPSLQQPMYI FLGILCMVDM GLATTIIPKI LAIFWFDAKV ISLPECFAQI YAIHFFVGME 

       130        140        150        160        170        180 
SGILLCMAFD RYVAICHPLR YPSIVTSSLI LKATLFMVLR NGLFVTPVPV LAAQRDYCSK 

       190        200        210        220        230        240 
NEIEHCLCSN LGVTSLACDD RRPNSICQLV LAWLGMGSDL SLIILSYILI LYSVLRLNSA 

       250        260        270        280        290        300 
EAAAKALSTC SSHLTLILFF YTIVVVISVT HLTEMKATLI PVLLNVLHNI IPPSLNPTVY 

       310        320 
ALQTKELRAA FQKVLFALTK EIRS 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-106.
Tissue: Thymus.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065812 Genomic DNA. Translation: BAC06031.1. Different initiation.
AK122668 mRNA. Translation: BAG53654.1.
AC131574 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68765.1.
BC137184 mRNA. Translation: AAI37185.1.
BC137185 mRNA. Translation: AAI37186.1.
BK004386 Genomic DNA. Translation: DAA04784.1.
CCDSCCDS31395.1.
RefSeqNP_001005180.1. NM_001005180.2.
UniGeneHs.689609.

3D structure databases

ProteinModelPortalQ8NGI3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000322939.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM229462916.

Proteomic databases

PaxDbQ8NGI3.
PRIDEQ8NGI3.

Protocols and materials databases

DNASU387748.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317121; ENSP00000322939; ENSG00000181023.
GeneID387748.
KEGGhsa:387748.
UCSCuc001mbs.1. human.

Organism-specific databases

CTD387748.
GeneCardsGC11P005715.
HGNCHGNC:15245. OR56B1.
HPAHPA045043.
neXtProtNX_Q8NGI3.
PharmGKBPA32450.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40164.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ8NGI3.
KOK04257.
OMAICQDPAL.
OrthoDBEOG7QK0CJ.
PhylomeDBQ8NGI3.
TreeFamTF344049.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR56B1.
GenevestigatorQ8NGI3.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSOR56B1. human.
GeneWikiOR56B1.
GenomeRNAi387748.
NextBio101573.
PROQ8NGI3.

Entry information

Entry nameO56B1_HUMAN
AccessionPrimary (citable) accession number: Q8NGI3
Secondary accession number(s): B2RNY6, B3KV42, Q6IF76
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries