Q8NGI3 (O56B1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 56B1

Alternative name(s):
Olfactory receptor OR11-65

Gene names

Name:	OR56B1
Synonyms:	OR56B1P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	It is uncertain whether Met-1 or Met-4 is the initiator.
Sequence caution	The sequence BAC06031.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Olfactory receptor 56B1		PRO_0000150796
Regions
	Topological domain	1 – 34	34	Extracellular Potential
	Transmembrane	35 – 55	21	Helical; Name=1; Potential
	Topological domain	56 – 63	8	Cytoplasmic Potential
	Transmembrane	64 – 84	21	Helical; Name=2; Potential
	Topological domain	85 – 108	24	Extracellular Potential
	Transmembrane	109 – 129	21	Helical; Name=3; Potential
	Topological domain	130 – 148	19	Cytoplasmic Potential
	Transmembrane	149 – 169	21	Helical; Name=4; Potential
	Topological domain	170 – 205	36	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Name=5; Potential
	Topological domain	227 – 246	20	Cytoplasmic Potential
	Transmembrane	247 – 267	21	Helical; Name=6; Potential
	Topological domain	268 – 281	14	Extracellular Potential
	Transmembrane	282 – 302	21	Helical; Name=7; Potential
	Topological domain	303 – 322	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 198		By similarity
Natural variations
	Natural variant	106	1	C → R. Ref.2 Corresponds to variant rs7397032 [ dbSNP | Ensembl ].		VAR_055055
Experimental info
	Sequence conflict	181	1	N → S in BAG53654. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8NGI3 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 2174312B66363017	FASTA	324	36,050
	10 20 30 40 50 60 MNHMSASLKI SNSSKFQVSE FILLGFPGIH SWQHWLSLPL ALLYLSALAA NTLILIIIWQ 70 80 90 100 110 120 NPSLQQPMYI FLGILCMVDM GLATTIIPKI LAIFWFDAKV ISLPECFAQI YAIHFFVGME 130 140 150 160 170 180 SGILLCMAFD RYVAICHPLR YPSIVTSSLI LKATLFMVLR NGLFVTPVPV LAAQRDYCSK 190 200 210 220 230 240 NEIEHCLCSN LGVTSLACDD RRPNSICQLV LAWLGMGSDL SLIILSYILI LYSVLRLNSA 250 260 270 280 290 300 EAAAKALSTC SSHLTLILFF YTIVVVISVT HLTEMKATLI PVLLNVLHNI IPPSLNPTVY 310 320 ALQTKELRAA FQKVLFALTK EIRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-106. Tissue: Thymus.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065812 Genomic DNA. Translation: BAC06031.1. Different initiation. AK122668 mRNA. Translation: BAG53654.1. AC131574 Genomic DNA. No translation available. CH471064 Genomic DNA. Translation: EAW68765.1. BC137184 mRNA. Translation: AAI37185.1. BC137185 mRNA. Translation: AAI37186.1. BK004386 Genomic DNA. Translation: DAA04784.1.
IPI	IPI00375706.
RefSeq	NP_001005180.1. NM_001005180.2.
UniGene	Hs.689609.
3D structure databases
ProteinModelPortal	Q8NGI3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000322939.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	229462916.
Proteomic databases
PaxDb	Q8NGI3.
PRIDE	Q8NGI3.
Protocols and materials databases
DNASU	387748.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317121; ENSP00000322939; ENSG00000181023.
GeneID	387748.
KEGG	hsa:387748.
UCSC	uc001mbs.1. human.
Organism-specific databases
CTD	387748.
GeneCards	GC11P005715.
HGNC	HGNC:15245. OR56B1.
HPA	HPA045043.
neXtProt	NX_Q8NGI3.
PharmGKB	PA32450.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40164.
HOGENOM	HOG000041363.
HOVERGEN	HBG017625.
InParanoid	Q8NGI3.
KO	K04257.
OMA	AWLGMGS.
OrthoDB	EOG4FXR83.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR56B1.
Genevestigator	Q8NGI3.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	OR56B1. human.
GenomeRNAi	387748.
NextBio	101573.

Entry information

Entry name

O56B1_HUMAN

Accession

Primary (citable) accession number: Q8NGI3
Secondary accession number(s): B2RNY6, B3KV42, Q6IF76

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.