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Q8NGI2 (O52N4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 52N4
Alternative name(s):
Olfactory receptor OR11-64
Gene names
Name:OR52N4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Polymorphism

A stop codon at position Arg-172 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Olfactory receptor 52N4
PRO_0000150788

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 4821Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 10124Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 14119Cytoplasmic Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Topological domain163 – 19836Extracellular Potential
Transmembrane199 – 21921Helical; Name=5; Potential
Topological domain220 – 23920Cytoplasmic Potential
Transmembrane240 – 26021Helical; Name=6; Potential
Topological domain261 – 27616Extracellular Potential
Transmembrane277 – 29721Helical; Name=7; Potential
Topological domain298 – 32124Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 191 By similarity

Natural variations

Natural variant1061T → I. Ref.1 Ref.3 Ref.4 Ref.5
Corresponds to variant rs7936512 [ dbSNP | Ensembl ].
VAR_034352
Natural variant1671L → R. Ref.1 Ref.3 Ref.4 Ref.5
Corresponds to variant rs7394584 [ dbSNP | Ensembl ].
VAR_053338
Natural variant2091W → G. Ref.1 Ref.5
Corresponds to variant rs12363178 [ dbSNP | Ensembl ].
VAR_053339
Natural variant2181N → I. Ref.1 Ref.3 Ref.4 Ref.5
Corresponds to variant rs7396938 [ dbSNP | Ensembl ].
VAR_034353

Sequences

Sequence LengthMass (Da)Tools
Q8NGI2 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 756230B548736347

FASTA32136,080
        10         20         30         40         50         60 
MLTLNKTDLI PASFILNGVP GLEDTQLWIS FPFCSMYVVA MVGNCGLLYL IHYEDALHKP 

        70         80         90        100        110        120 
MYYFLAMLSF TDLVMCSSTI PKALCIFWFH LKDIGFDECL VQMFFTHTFT GMESGVLMLM 

       130        140        150        160        170        180 
ALDRYVAICY PLRYSTILTN PVIAKVGTAT FLRGVLLIIP FTFLTKLLPY CRGNILPHTY 

       190        200        210        220        230        240 
CDHMSVAKLS CGNVKVNAIY GLMVALLIWG FDILCITNSY TMILRAVVSL SSADARQKAF 

       250        260        270        280        290        300 
NTCTAHICAI VFSYTPAFFS FFSHRFGEHI IPPSCHIIVA NIYLLLPPTM NPIVYGVKTK 

       310        320 
QIRDCVIRIL SGSKDTKSYS M 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-106; ARG-167; GLY-209 AND ILE-218.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-106; ARG-167 AND ILE-218.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-106; ARG-167 AND ILE-218.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, VARIANTS ILE-106; ARG-167; GLY-209 AND ILE-218.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[7]"Different noses for different people."
Menashe I., Man O., Lancet D., Gilad Y.
Nat. Genet. 34:143-144(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065813 Genomic DNA. Translation: BAC06032.1.
AC131574 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68764.1.
BC137035 mRNA. Translation: AAI37036.1.
BC137036 mRNA. Translation: AAI37037.1.
BK004385 Genomic DNA. Translation: DAA04783.1.
CCDSCCDS44528.1.
RefSeqNP_001005175.3. NM_001005175.3.
XP_005252969.1. XM_005252912.2.
XP_005252970.1. XM_005252913.1.
UniGeneHs.553735.

3D structure databases

ProteinModelPortalQ8NGI2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000323224.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM296439252.

Proteomic databases

PaxDbQ8NGI2.
PRIDEQ8NGI2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317254; ENSP00000323224; ENSG00000181074.
GeneID390072.
KEGGhsa:390072.
UCSCuc001mbu.3. human.

Organism-specific databases

CTD390072.
GeneCardsGC11P005732.
HGNCHGNC:15230. OR52N4.
neXtProtNX_Q8NGI2.
PharmGKBPA32428.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44192.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ8NGI2.
KOK04257.
OMAFSHRFGE.
OrthoDBEOG7327P6.
PhylomeDBQ8NGI2.
TreeFamTF343679.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR52N4.
GenevestigatorQ8NGI2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR52N4.
GenomeRNAi390072.
NextBio103349.
PROQ8NGI2.

Entry information

Entry nameO52N4_HUMAN
AccessionPrimary (citable) accession number: Q8NGI2
Secondary accession number(s): B2RNP8, Q6IF77
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries