Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8NGI2

- O52N4_HUMAN

UniProt

Q8NGI2 - O52N4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Olfactory receptor 52N4

Gene

OR52N4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52N4
Alternative name(s):
Olfactory receptor OR11-64
Gene namesi
Name:OR52N4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15230. OR52N4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini298 – 32124CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Olfactory receptor 52N4PRO_0000150788Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGI2.
PRIDEiQ8NGI2.

Expressioni

Gene expression databases

CleanExiHS_OR52N4.
GenevestigatoriQ8NGI2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323224.

Structurei

3D structure databases

ProteinModelPortaliQ8NGI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44192.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGI2.
KOiK04257.
OMAiFSHRFGE.
OrthoDBiEOG7327P6.
PhylomeDBiQ8NGI2.
TreeFamiTF343679.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTLNKTDLI PASFILNGVP GLEDTQLWIS FPFCSMYVVA MVGNCGLLYL
60 70 80 90 100
IHYEDALHKP MYYFLAMLSF TDLVMCSSTI PKALCIFWFH LKDIGFDECL
110 120 130 140 150
VQMFFTHTFT GMESGVLMLM ALDRYVAICY PLRYSTILTN PVIAKVGTAT
160 170 180 190 200
FLRGVLLIIP FTFLTKLLPY CRGNILPHTY CDHMSVAKLS CGNVKVNAIY
210 220 230 240 250
GLMVALLIWG FDILCITNSY TMILRAVVSL SSADARQKAF NTCTAHICAI
260 270 280 290 300
VFSYTPAFFS FFSHRFGEHI IPPSCHIIVA NIYLLLPPTM NPIVYGVKTK
310 320
QIRDCVIRIL SGSKDTKSYS M
Length:321
Mass (Da):36,080
Last modified:May 18, 2010 - v2
Checksum:i756230B548736347
GO

Polymorphismi

A stop codon at position Arg-172 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061T → I.4 Publications
Corresponds to variant rs7936512 [ dbSNP | Ensembl ].
VAR_034352
Natural varianti167 – 1671L → R.4 Publications
Corresponds to variant rs7394584 [ dbSNP | Ensembl ].
VAR_053338
Natural varianti209 – 2091W → G.2 Publications
Corresponds to variant rs12363178 [ dbSNP | Ensembl ].
VAR_053339
Natural varianti218 – 2181N → I.4 Publications
Corresponds to variant rs7396938 [ dbSNP | Ensembl ].
VAR_034353

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065813 Genomic DNA. Translation: BAC06032.1.
AC131574 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68764.1.
BC137035 mRNA. Translation: AAI37036.1.
BC137036 mRNA. Translation: AAI37037.1.
BK004385 Genomic DNA. Translation: DAA04783.1.
CCDSiCCDS44528.1.
RefSeqiNP_001005175.3. NM_001005175.3.
XP_005252969.1. XM_005252912.2.
XP_005252970.1. XM_005252913.1.
UniGeneiHs.553735.

Genome annotation databases

EnsembliENST00000317254; ENSP00000323224; ENSG00000181074.
GeneIDi390072.
KEGGihsa:390072.
UCSCiuc001mbu.3. human.

Polymorphism databases

DMDMi296439252.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065813 Genomic DNA. Translation: BAC06032.1 .
AC131574 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68764.1 .
BC137035 mRNA. Translation: AAI37036.1 .
BC137036 mRNA. Translation: AAI37037.1 .
BK004385 Genomic DNA. Translation: DAA04783.1 .
CCDSi CCDS44528.1.
RefSeqi NP_001005175.3. NM_001005175.3.
XP_005252969.1. XM_005252912.2.
XP_005252970.1. XM_005252913.1.
UniGenei Hs.553735.

3D structure databases

ProteinModelPortali Q8NGI2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000323224.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 296439252.

Proteomic databases

PaxDbi Q8NGI2.
PRIDEi Q8NGI2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317254 ; ENSP00000323224 ; ENSG00000181074 .
GeneIDi 390072.
KEGGi hsa:390072.
UCSCi uc001mbu.3. human.

Organism-specific databases

CTDi 390072.
GeneCardsi GC11P005732.
HGNCi HGNC:15230. OR52N4.
neXtProti NX_Q8NGI2.
PharmGKBi PA32428.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44192.
GeneTreei ENSGT00760000118843.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q8NGI2.
KOi K04257.
OMAi FSHRFGE.
OrthoDBi EOG7327P6.
PhylomeDBi Q8NGI2.
TreeFami TF343679.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR52N4.
GenomeRNAii 390072.
NextBioi 103349.
PROi Q8NGI2.

Gene expression databases

CleanExi HS_OR52N4.
Genevestigatori Q8NGI2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-106; ARG-167; GLY-209 AND ILE-218.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-106; ARG-167 AND ILE-218.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-106; ARG-167 AND ILE-218.
  5. Cited for: IDENTIFICATION, VARIANTS ILE-106; ARG-167; GLY-209 AND ILE-218.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  7. Cited for: POLYMORPHISM.

Entry informationi

Entry nameiO52N4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI2
Secondary accession number(s): B2RNP8, Q6IF77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3