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Protein

Olfactory receptor 52N4

Gene

OR52N4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52N4
Alternative name(s):
Olfactory receptor OR11-64
Gene namesi
Name:OR52N4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000181074.3
HGNCiHGNC:15230 OR52N4
neXtProtiNX_Q8NGI2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 276ExtracellularSequence analysisAdd BLAST16
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 321CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181074
PharmGKBiPA32428

Polymorphism and mutation databases

DMDMi296439252

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507881 – 321Olfactory receptor 52N4Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGI2
PeptideAtlasiQ8NGI2
PRIDEiQ8NGI2

PTM databases

iPTMnetiQ8NGI2
PhosphoSitePlusiQ8NGI2

Expressioni

Gene expression databases

BgeeiENSG00000181074
CleanExiHS_OR52N4

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323224

Structurei

3D structure databases

ProteinModelPortaliQ8NGI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVDV Eukaryota
ENOG410YASE LUCA
GeneTreeiENSGT00900000140922
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NGI2
KOiK04257
OMAiFSHRFGE
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGI2
TreeFamiTF343679

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLNKTDLI PASFILNGVP GLEDTQLWIS FPFCSMYVVA MVGNCGLLYL
60 70 80 90 100
IHYEDALHKP MYYFLAMLSF TDLVMCSSTI PKALCIFWFH LKDIGFDECL
110 120 130 140 150
VQMFFTHTFT GMESGVLMLM ALDRYVAICY PLRYSTILTN PVIAKVGTAT
160 170 180 190 200
FLRGVLLIIP FTFLTKLLPY CRGNILPHTY CDHMSVAKLS CGNVKVNAIY
210 220 230 240 250
GLMVALLIWG FDILCITNSY TMILRAVVSL SSADARQKAF NTCTAHICAI
260 270 280 290 300
VFSYTPAFFS FFSHRFGEHI IPPSCHIIVA NIYLLLPPTM NPIVYGVKTK
310 320
QIRDCVIRIL SGSKDTKSYS M
Length:321
Mass (Da):36,080
Last modified:May 18, 2010 - v2
Checksum:i756230B548736347
GO

Polymorphismi

A stop codon at position Arg-172 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034352106T → I4 PublicationsCorresponds to variant dbSNP:rs7936512Ensembl.1
Natural variantiVAR_053338167L → R4 PublicationsCorresponds to variant dbSNP:rs7394584Ensembl.1
Natural variantiVAR_053339209W → G2 PublicationsCorresponds to variant dbSNP:rs12363178Ensembl.1
Natural variantiVAR_034353218N → I4 PublicationsCorresponds to variant dbSNP:rs7396938Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065813 Genomic DNA Translation: BAC06032.1
AC131574 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68764.1
BC137035 mRNA Translation: AAI37036.1
BC137036 mRNA Translation: AAI37037.1
BK004385 Genomic DNA Translation: DAA04783.1
CCDSiCCDS44528.1
RefSeqiNP_001005175.3, NM_001005175.3
XP_016873200.1, XM_017017711.1
XP_016873201.1, XM_017017712.1
XP_016873202.1, XM_017017713.1
UniGeneiHs.553735

Genome annotation databases

EnsembliENST00000317254; ENSP00000323224; ENSG00000181074
ENST00000641350; ENSP00000493338; ENSG00000181074
GeneIDi390072
KEGGihsa:390072
UCSCiuc001mbu.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO52N4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI2
Secondary accession number(s): B2RNP8, Q6IF77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: February 28, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome