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Q8NGI2

- O52N4_HUMAN

UniProt

Q8NGI2 - O52N4_HUMAN

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Protein
Olfactory receptor 52N4
Gene
OR52N4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 52N4
    Alternative name(s):
    Olfactory receptor OR11-64
    Gene namesi
    Name:OR52N4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15230. OR52N4.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei28 – 4821Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini49 – 568Cytoplasmic Reviewed prediction
    Transmembranei57 – 7721Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini78 – 10124Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei102 – 12221Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini123 – 14119Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei142 – 16221Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini163 – 19836Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei199 – 21921Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini220 – 23920Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei240 – 26021Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini261 – 27616Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei277 – 29721Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini298 – 32124Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32428.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Olfactory receptor 52N4
    PRO_0000150788Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi99 ↔ 191 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGI2.
    PRIDEiQ8NGI2.

    Expressioni

    Gene expression databases

    CleanExiHS_OR52N4.
    GenevestigatoriQ8NGI2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000323224.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGI2.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44192.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NGI2.
    KOiK04257.
    OMAiFSHRFGE.
    OrthoDBiEOG7327P6.
    PhylomeDBiQ8NGI2.
    TreeFamiTF343679.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTLNKTDLI PASFILNGVP GLEDTQLWIS FPFCSMYVVA MVGNCGLLYL    50
    IHYEDALHKP MYYFLAMLSF TDLVMCSSTI PKALCIFWFH LKDIGFDECL 100
    VQMFFTHTFT GMESGVLMLM ALDRYVAICY PLRYSTILTN PVIAKVGTAT 150
    FLRGVLLIIP FTFLTKLLPY CRGNILPHTY CDHMSVAKLS CGNVKVNAIY 200
    GLMVALLIWG FDILCITNSY TMILRAVVSL SSADARQKAF NTCTAHICAI 250
    VFSYTPAFFS FFSHRFGEHI IPPSCHIIVA NIYLLLPPTM NPIVYGVKTK 300
    QIRDCVIRIL SGSKDTKSYS M 321
    Length:321
    Mass (Da):36,080
    Last modified:May 18, 2010 - v2
    Checksum:i756230B548736347
    GO

    Polymorphismi

    A stop codon at position Arg-172 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061T → I.4 Publications
    Corresponds to variant rs7936512 [ dbSNP | Ensembl ].
    VAR_034352
    Natural varianti167 – 1671L → R.4 Publications
    Corresponds to variant rs7394584 [ dbSNP | Ensembl ].
    VAR_053338
    Natural varianti209 – 2091W → G.2 Publications
    Corresponds to variant rs12363178 [ dbSNP | Ensembl ].
    VAR_053339
    Natural varianti218 – 2181N → I.4 Publications
    Corresponds to variant rs7396938 [ dbSNP | Ensembl ].
    VAR_034353

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065813 Genomic DNA. Translation: BAC06032.1.
    AC131574 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68764.1.
    BC137035 mRNA. Translation: AAI37036.1.
    BC137036 mRNA. Translation: AAI37037.1.
    BK004385 Genomic DNA. Translation: DAA04783.1.
    CCDSiCCDS44528.1.
    RefSeqiNP_001005175.3. NM_001005175.3.
    XP_005252969.1. XM_005252912.2.
    XP_005252970.1. XM_005252913.1.
    UniGeneiHs.553735.

    Genome annotation databases

    EnsembliENST00000317254; ENSP00000323224; ENSG00000181074.
    GeneIDi390072.
    KEGGihsa:390072.
    UCSCiuc001mbu.3. human.

    Polymorphism databases

    DMDMi296439252.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065813 Genomic DNA. Translation: BAC06032.1 .
    AC131574 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68764.1 .
    BC137035 mRNA. Translation: AAI37036.1 .
    BC137036 mRNA. Translation: AAI37037.1 .
    BK004385 Genomic DNA. Translation: DAA04783.1 .
    CCDSi CCDS44528.1.
    RefSeqi NP_001005175.3. NM_001005175.3.
    XP_005252969.1. XM_005252912.2.
    XP_005252970.1. XM_005252913.1.
    UniGenei Hs.553735.

    3D structure databases

    ProteinModelPortali Q8NGI2.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000323224.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 296439252.

    Proteomic databases

    PaxDbi Q8NGI2.
    PRIDEi Q8NGI2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317254 ; ENSP00000323224 ; ENSG00000181074 .
    GeneIDi 390072.
    KEGGi hsa:390072.
    UCSCi uc001mbu.3. human.

    Organism-specific databases

    CTDi 390072.
    GeneCardsi GC11P005732.
    HGNCi HGNC:15230. OR52N4.
    neXtProti NX_Q8NGI2.
    PharmGKBi PA32428.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44192.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NGI2.
    KOi K04257.
    OMAi FSHRFGE.
    OrthoDBi EOG7327P6.
    PhylomeDBi Q8NGI2.
    TreeFami TF343679.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR52N4.
    GenomeRNAii 390072.
    NextBioi 103349.
    PROi Q8NGI2.

    Gene expression databases

    CleanExi HS_OR52N4.
    Genevestigatori Q8NGI2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-106; ARG-167; GLY-209 AND ILE-218.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-106; ARG-167 AND ILE-218.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-106; ARG-167 AND ILE-218.
    5. Cited for: IDENTIFICATION, VARIANTS ILE-106; ARG-167; GLY-209 AND ILE-218.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
    7. Cited for: POLYMORPHISM.

    Entry informationi

    Entry nameiO52N4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGI2
    Secondary accession number(s): B2RNP8, Q6IF77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: May 18, 2010
    Last modified: September 3, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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