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Protein

Olfactory receptor 52N2

Gene

OR52N2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52N2
Alternative name(s):
Olfactory receptor OR11-57
Gene namesi
Name:OR52N2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15228. OR52N2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini298 – 32124CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Olfactory receptor 52N2PRO_0000150787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGI0.
PRIDEiQ8NGI0.

PTM databases

PhosphoSiteiQ8NGI0.

Expressioni

Gene expression databases

CleanExiHS_OR52N2.
GenevestigatoriQ8NGI0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322801.

Structurei

3D structure databases

ProteinModelPortaliQ8NGI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG48028.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGI0.
KOiK04257.
OMAiGHNIPHH.
OrthoDBiEOG7327P6.
PhylomeDBiQ8NGI0.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDNSSSLT PGFFILNGVP GLEATHIWIS LPFCFMYIIA VVGNCGLICL
60 70 80 90 100
ISHEEALHRP MYYFLALLSF TDVTLCTTMV PNMLCIFWFN LKEIDFNACL
110 120 130 140 150
AQMFFVHMLT GMESGVLMLM ALDRYVAICY PLRYATILTN PVIAKAGLAT
160 170 180 190 200
FLRNVMLIIP FTLLTKRLPY CRGNFIPHTY CDHMSVAKVS CGNFKVNAIY
210 220 230 240 250
GLMVALLIGV FDICCISVSY TMILQAVMSL SSADARHKAF STCTSHMCSI
260 270 280 290 300
VITYVAAFFT FFTHRFVGHN IPNHIHIIVA NLYLLLPPTM NPIVYGVKTK
310 320
QIQEGVIKFL LGDKVSFTYD K
Length:321
Mass (Da):35,940
Last modified:October 1, 2002 - v1
Checksum:iA08A2658BD26477C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491S → A.
Corresponds to variant rs8181529 [ dbSNP | Ensembl ].
VAR_024150
Natural varianti264 – 2641H → R.
Corresponds to variant rs8181512 [ dbSNP | Ensembl ].
VAR_024151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065816 Genomic DNA. Translation: BAC06035.1.
CH471064 Genomic DNA. Translation: EAW68759.1.
BK004303 Genomic DNA. Translation: DAA04701.1.
CCDSiCCDS31399.1.
RefSeqiNP_001005174.1. NM_001005174.1.
UniGeneiHs.553737.

Genome annotation databases

EnsembliENST00000317037; ENSP00000322801; ENSG00000180988.
GeneIDi390077.
KEGGihsa:390077.
UCSCiuc010qzp.2. human.

Polymorphism databases

DMDMi38372698.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065816 Genomic DNA. Translation: BAC06035.1.
CH471064 Genomic DNA. Translation: EAW68759.1.
BK004303 Genomic DNA. Translation: DAA04701.1.
CCDSiCCDS31399.1.
RefSeqiNP_001005174.1. NM_001005174.1.
UniGeneiHs.553737.

3D structure databases

ProteinModelPortaliQ8NGI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322801.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGI0.

Polymorphism databases

DMDMi38372698.

Proteomic databases

PaxDbiQ8NGI0.
PRIDEiQ8NGI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317037; ENSP00000322801; ENSG00000180988.
GeneIDi390077.
KEGGihsa:390077.
UCSCiuc010qzp.2. human.

Organism-specific databases

CTDi390077.
GeneCardsiGC11P005798.
HGNCiHGNC:15228. OR52N2.
neXtProtiNX_Q8NGI0.
PharmGKBiPA32426.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG48028.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGI0.
KOiK04257.
OMAiGHNIPHH.
OrthoDBiEOG7327P6.
PhylomeDBiQ8NGI0.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52N2.
GenomeRNAii390077.
NextBioi103359.
PROiQ8NGI0.

Gene expression databases

CleanExiHS_OR52N2.
GenevestigatoriQ8NGI0.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52N2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI0
Secondary accession number(s): Q6IFF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.