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Protein

Olfactory receptor 52N2

Gene

OR52N2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180988-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52N2
Alternative name(s):
Olfactory receptor OR11-57
Gene namesi
Name:OR52N2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15228. OR52N2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 276ExtracellularSequence analysisAdd BLAST16
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 321CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180988.
PharmGKBiPA32426.

Polymorphism and mutation databases

BioMutaiOR52N2.
DMDMi38372698.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507871 – 321Olfactory receptor 52N2Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGI0.
PRIDEiQ8NGI0.

PTM databases

PhosphoSitePlusiQ8NGI0.

Expressioni

Gene expression databases

CleanExiHS_OR52N2.

Organism-specific databases

HPAiCAB017459.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322801.

Structurei

3D structure databases

ProteinModelPortaliQ8NGI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVDV. Eukaryota.
ENOG410YASE. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGI0.
KOiK04257.
OMAiGHNIPHH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGI0.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDNSSSLT PGFFILNGVP GLEATHIWIS LPFCFMYIIA VVGNCGLICL
60 70 80 90 100
ISHEEALHRP MYYFLALLSF TDVTLCTTMV PNMLCIFWFN LKEIDFNACL
110 120 130 140 150
AQMFFVHMLT GMESGVLMLM ALDRYVAICY PLRYATILTN PVIAKAGLAT
160 170 180 190 200
FLRNVMLIIP FTLLTKRLPY CRGNFIPHTY CDHMSVAKVS CGNFKVNAIY
210 220 230 240 250
GLMVALLIGV FDICCISVSY TMILQAVMSL SSADARHKAF STCTSHMCSI
260 270 280 290 300
VITYVAAFFT FFTHRFVGHN IPNHIHIIVA NLYLLLPPTM NPIVYGVKTK
310 320
QIQEGVIKFL LGDKVSFTYD K
Length:321
Mass (Da):35,940
Last modified:October 1, 2002 - v1
Checksum:iA08A2658BD26477C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024150249S → A.Corresponds to variant rs8181529dbSNPEnsembl.1
Natural variantiVAR_024151264H → R.Corresponds to variant rs8181512dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065816 Genomic DNA. Translation: BAC06035.1.
CH471064 Genomic DNA. Translation: EAW68759.1.
BK004303 Genomic DNA. Translation: DAA04701.1.
CCDSiCCDS31399.1.
RefSeqiNP_001005174.1. NM_001005174.1.
XP_011518392.1. XM_011520090.2.
UniGeneiHs.553737.

Genome annotation databases

EnsembliENST00000317037; ENSP00000322801; ENSG00000180988.
GeneIDi390077.
KEGGihsa:390077.
UCSCiuc010qzp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065816 Genomic DNA. Translation: BAC06035.1.
CH471064 Genomic DNA. Translation: EAW68759.1.
BK004303 Genomic DNA. Translation: DAA04701.1.
CCDSiCCDS31399.1.
RefSeqiNP_001005174.1. NM_001005174.1.
XP_011518392.1. XM_011520090.2.
UniGeneiHs.553737.

3D structure databases

ProteinModelPortaliQ8NGI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322801.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8NGI0.

Polymorphism and mutation databases

BioMutaiOR52N2.
DMDMi38372698.

Proteomic databases

PaxDbiQ8NGI0.
PRIDEiQ8NGI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317037; ENSP00000322801; ENSG00000180988.
GeneIDi390077.
KEGGihsa:390077.
UCSCiuc010qzp.3. human.

Organism-specific databases

CTDi390077.
GeneCardsiOR52N2.
HGNCiHGNC:15228. OR52N2.
HPAiCAB017459.
neXtProtiNX_Q8NGI0.
OpenTargetsiENSG00000180988.
PharmGKBiPA32426.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVDV. Eukaryota.
ENOG410YASE. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGI0.
KOiK04257.
OMAiGHNIPHH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGI0.
TreeFamiTF343679.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180988-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52N2.
GenomeRNAii390077.
PROiQ8NGI0.

Gene expression databases

CleanExiHS_OR52N2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52N2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI0
Secondary accession number(s): Q6IFF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.