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Q8NGI0

- O52N2_HUMAN

UniProt

Q8NGI0 - O52N2_HUMAN

Protein

Olfactory receptor 52N2

Gene

OR52N2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 52N2
    Alternative name(s):
    Olfactory receptor OR11-57
    Gene namesi
    Name:OR52N2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15228. OR52N2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32426.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Olfactory receptor 52N2PRO_0000150787Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGI0.
    PRIDEiQ8NGI0.

    PTM databases

    PhosphoSiteiQ8NGI0.

    Expressioni

    Gene expression databases

    CleanExiHS_OR52N2.
    GenevestigatoriQ8NGI0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000322801.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGI0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19836ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 32124CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG48028.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NGI0.
    KOiK04257.
    OMAiGHNIPHH.
    OrthoDBiEOG7327P6.
    PhylomeDBiQ8NGI0.
    TreeFamiTF343679.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGI0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGDNSSSLT PGFFILNGVP GLEATHIWIS LPFCFMYIIA VVGNCGLICL    50
    ISHEEALHRP MYYFLALLSF TDVTLCTTMV PNMLCIFWFN LKEIDFNACL 100
    AQMFFVHMLT GMESGVLMLM ALDRYVAICY PLRYATILTN PVIAKAGLAT 150
    FLRNVMLIIP FTLLTKRLPY CRGNFIPHTY CDHMSVAKVS CGNFKVNAIY 200
    GLMVALLIGV FDICCISVSY TMILQAVMSL SSADARHKAF STCTSHMCSI 250
    VITYVAAFFT FFTHRFVGHN IPNHIHIIVA NLYLLLPPTM NPIVYGVKTK 300
    QIQEGVIKFL LGDKVSFTYD K 321
    Length:321
    Mass (Da):35,940
    Last modified:October 1, 2002 - v1
    Checksum:iA08A2658BD26477C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti249 – 2491S → A.
    Corresponds to variant rs8181529 [ dbSNP | Ensembl ].
    VAR_024150
    Natural varianti264 – 2641H → R.
    Corresponds to variant rs8181512 [ dbSNP | Ensembl ].
    VAR_024151

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065816 Genomic DNA. Translation: BAC06035.1.
    CH471064 Genomic DNA. Translation: EAW68759.1.
    BK004303 Genomic DNA. Translation: DAA04701.1.
    CCDSiCCDS31399.1.
    RefSeqiNP_001005174.1. NM_001005174.1.
    UniGeneiHs.553737.

    Genome annotation databases

    EnsembliENST00000317037; ENSP00000322801; ENSG00000180988.
    GeneIDi390077.
    KEGGihsa:390077.
    UCSCiuc010qzp.2. human.

    Polymorphism databases

    DMDMi38372698.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065816 Genomic DNA. Translation: BAC06035.1 .
    CH471064 Genomic DNA. Translation: EAW68759.1 .
    BK004303 Genomic DNA. Translation: DAA04701.1 .
    CCDSi CCDS31399.1.
    RefSeqi NP_001005174.1. NM_001005174.1.
    UniGenei Hs.553737.

    3D structure databases

    ProteinModelPortali Q8NGI0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000322801.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGI0.

    Polymorphism databases

    DMDMi 38372698.

    Proteomic databases

    PaxDbi Q8NGI0.
    PRIDEi Q8NGI0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317037 ; ENSP00000322801 ; ENSG00000180988 .
    GeneIDi 390077.
    KEGGi hsa:390077.
    UCSCi uc010qzp.2. human.

    Organism-specific databases

    CTDi 390077.
    GeneCardsi GC11P005798.
    HGNCi HGNC:15228. OR52N2.
    neXtProti NX_Q8NGI0.
    PharmGKBi PA32426.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG48028.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NGI0.
    KOi K04257.
    OMAi GHNIPHH.
    OrthoDBi EOG7327P6.
    PhylomeDBi Q8NGI0.
    TreeFami TF343679.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR52N2.
    GenomeRNAii 390077.
    NextBioi 103359.
    PROi Q8NGI0.

    Gene expression databases

    CleanExi HS_OR52N2.
    Genevestigatori Q8NGI0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO52N2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGI0
    Secondary accession number(s): Q6IFF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3