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Q8NGI0

- O52N2_HUMAN

UniProt

Q8NGI0 - O52N2_HUMAN

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Protein

Olfactory receptor 52N2

Gene

OR52N2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52N2
Alternative name(s):
Olfactory receptor OR11-57
Gene namesi
Name:OR52N2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15228. OR52N2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Olfactory receptor 52N2PRO_0000150787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGI0.
PRIDEiQ8NGI0.

PTM databases

PhosphoSiteiQ8NGI0.

Expressioni

Gene expression databases

CleanExiHS_OR52N2.
GenevestigatoriQ8NGI0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322801.

Structurei

3D structure databases

ProteinModelPortaliQ8NGI0.
SMRiQ8NGI0. Positions 111-142.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence AnalysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini261 – 27616ExtracellularSequence AnalysisAdd
BLAST
Topological domaini298 – 32124CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG48028.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGI0.
KOiK04257.
OMAiGHNIPHH.
OrthoDBiEOG7327P6.
PhylomeDBiQ8NGI0.
TreeFamiTF343679.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGI0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGDNSSSLT PGFFILNGVP GLEATHIWIS LPFCFMYIIA VVGNCGLICL
60 70 80 90 100
ISHEEALHRP MYYFLALLSF TDVTLCTTMV PNMLCIFWFN LKEIDFNACL
110 120 130 140 150
AQMFFVHMLT GMESGVLMLM ALDRYVAICY PLRYATILTN PVIAKAGLAT
160 170 180 190 200
FLRNVMLIIP FTLLTKRLPY CRGNFIPHTY CDHMSVAKVS CGNFKVNAIY
210 220 230 240 250
GLMVALLIGV FDICCISVSY TMILQAVMSL SSADARHKAF STCTSHMCSI
260 270 280 290 300
VITYVAAFFT FFTHRFVGHN IPNHIHIIVA NLYLLLPPTM NPIVYGVKTK
310 320
QIQEGVIKFL LGDKVSFTYD K
Length:321
Mass (Da):35,940
Last modified:October 1, 2002 - v1
Checksum:iA08A2658BD26477C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491S → A.
Corresponds to variant rs8181529 [ dbSNP | Ensembl ].
VAR_024150
Natural varianti264 – 2641H → R.
Corresponds to variant rs8181512 [ dbSNP | Ensembl ].
VAR_024151

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065816 Genomic DNA. Translation: BAC06035.1.
CH471064 Genomic DNA. Translation: EAW68759.1.
BK004303 Genomic DNA. Translation: DAA04701.1.
CCDSiCCDS31399.1.
RefSeqiNP_001005174.1. NM_001005174.1.
UniGeneiHs.553737.

Genome annotation databases

EnsembliENST00000317037; ENSP00000322801; ENSG00000180988.
GeneIDi390077.
KEGGihsa:390077.
UCSCiuc010qzp.2. human.

Polymorphism databases

DMDMi38372698.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065816 Genomic DNA. Translation: BAC06035.1 .
CH471064 Genomic DNA. Translation: EAW68759.1 .
BK004303 Genomic DNA. Translation: DAA04701.1 .
CCDSi CCDS31399.1.
RefSeqi NP_001005174.1. NM_001005174.1.
UniGenei Hs.553737.

3D structure databases

ProteinModelPortali Q8NGI0.
SMRi Q8NGI0. Positions 111-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000322801.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGI0.

Polymorphism databases

DMDMi 38372698.

Proteomic databases

PaxDbi Q8NGI0.
PRIDEi Q8NGI0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317037 ; ENSP00000322801 ; ENSG00000180988 .
GeneIDi 390077.
KEGGi hsa:390077.
UCSCi uc010qzp.2. human.

Organism-specific databases

CTDi 390077.
GeneCardsi GC11P005798.
HGNCi HGNC:15228. OR52N2.
neXtProti NX_Q8NGI0.
PharmGKBi PA32426.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG48028.
GeneTreei ENSGT00760000118843.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q8NGI0.
KOi K04257.
OMAi GHNIPHH.
OrthoDBi EOG7327P6.
PhylomeDBi Q8NGI0.
TreeFami TF343679.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR52N2.
GenomeRNAii 390077.
NextBioi 103359.
PROi Q8NGI0.

Gene expression databases

CleanExi HS_OR52N2.
Genevestigatori Q8NGI0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52N2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI0
Secondary accession number(s): Q6IFF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3