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Protein

Olfactory receptor 52E4

Gene

OR52E4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52E4
Alternative name(s):
Olfactory receptor OR11-55
Gene namesi
Name:OR52E4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15213. OR52E4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21820Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence analysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 27415ExtracellularSequence analysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini296 – 31217CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32405.

Polymorphism and mutation databases

BioMutaiOR52E4.
DMDMi38372697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 52E4PRO_0000150773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGH9.
PRIDEiQ8NGH9.

Expressioni

Gene expression databases

CleanExiHS_OR52E4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321426.

Structurei

3D structure databases

ProteinModelPortaliQ8NGH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIR5. Eukaryota.
ENOG411157P. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGH9.
KOiK04257.
OMAiCAPIKIN.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGH9.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSINDTHFY PPFFLLLGIP GLDTLHIWIS FPFCIVYLIA IVGNMTILFV
60 70 80 90 100
IKTEHSLHQP MFYFLAMLSM IDLGLSTSTI PKMLGIFWFN LQEISFGGCL
110 120 130 140 150
LQMFFIHMFT GMETVLLVVM AYDRFVAICN PLQYTMILTN KTISILASVV
160 170 180 190 200
VGRNLVLVTP FVFLILRLPF CGHNIVPHTY CEHRGLAGLA CAPIKINIIY
210 220 230 240 250
GLMVISYIIV DVILIASSYV LILRAVFRLP SQDVRLKAFN TCGSHVCVML
260 270 280 290 300
CFYTPAFFSF MTHRFGQNIP HYIHILLANL YVVVPPALNP VIYGVRTKQI
310
REQIVKIFVQ KE
Length:312
Mass (Da):35,480
Last modified:October 1, 2002 - v1
Checksum:iEBB273B03A05149A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491F → L.
Corresponds to variant rs16914094 [ dbSNP | Ensembl ].
VAR_034335
Natural varianti176 – 1761V → I.
Corresponds to variant rs4758168 [ dbSNP | Ensembl ].
VAR_024147
Natural varianti184 – 1841R → M.
Corresponds to variant rs4757986 [ dbSNP | Ensembl ].
VAR_024148
Natural varianti227 – 2271F → L.
Corresponds to variant rs11823828 [ dbSNP | Ensembl ].
VAR_062082
Natural varianti228 – 2281R → H.
Corresponds to variant rs4757987 [ dbSNP | Ensembl ].
VAR_034336
Natural varianti257 – 2571F → L.
Corresponds to variant rs11823842 [ dbSNP | Ensembl ].
VAR_034337

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065817 Genomic DNA. Translation: BAC06036.1.
BK004302 Genomic DNA. Translation: DAA04700.1.
CCDSiCCDS31401.1.
RefSeqiNP_001005165.1. NM_001005165.1.
XP_011518394.1. XM_011520092.1.
UniGeneiHs.553739.

Genome annotation databases

EnsembliENST00000316987; ENSP00000321426; ENSG00000180974.
GeneIDi390081.
KEGGihsa:390081.
UCSCiuc010qzs.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065817 Genomic DNA. Translation: BAC06036.1.
BK004302 Genomic DNA. Translation: DAA04700.1.
CCDSiCCDS31401.1.
RefSeqiNP_001005165.1. NM_001005165.1.
XP_011518394.1. XM_011520092.1.
UniGeneiHs.553739.

3D structure databases

ProteinModelPortaliQ8NGH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321426.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR52E4.
DMDMi38372697.

Proteomic databases

PaxDbiQ8NGH9.
PRIDEiQ8NGH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316987; ENSP00000321426; ENSG00000180974.
GeneIDi390081.
KEGGihsa:390081.
UCSCiuc010qzs.3. human.

Organism-specific databases

CTDi390081.
GeneCardsiOR52E4.
HGNCiHGNC:15213. OR52E4.
neXtProtiNX_Q8NGH9.
PharmGKBiPA32405.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIR5. Eukaryota.
ENOG411157P. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGH9.
KOiK04257.
OMAiCAPIKIN.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGH9.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52E4.
GenomeRNAii390081.
NextBioi103371.
PROiQ8NGH9.

Gene expression databases

CleanExiHS_OR52E4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52E4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGH9
Secondary accession number(s): Q6IFG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.