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Protein

Olfactory receptor 56A4

Gene

OR56A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31371-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56A4
Alternative name(s):
Olfactory receptor OR11-49
Gene namesi
Name:OR56A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14791. OR56A4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 102ExtracellularSequence analysisAdd BLAST24
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 142CytoplasmicSequence analysisAdd BLAST19
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 199ExtracellularSequence analysisAdd BLAST36
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 240CytoplasmicSequence analysisAdd BLAST20
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 276ExtracellularSequence analysisAdd BLAST15
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 313CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32446.

Polymorphism and mutation databases

BioMutaiOR56A4.
DMDMi259016292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507951 – 313Olfactory receptor 56A4Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NGH8.
PaxDbiQ8NGH8.
PeptideAtlasiQ8NGH8.
PRIDEiQ8NGH8.

Expressioni

Gene expression databases

CleanExiHS_OR56A4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328215.

Structurei

3D structure databases

ProteinModelPortaliQ8NGH8.
SMRiQ8NGH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II2D. Eukaryota.
ENOG410YAIE. LUCA.
HOVERGENiHBG017625.
InParanoidiQ8NGH8.
KOiK04257.
OrthoDBiEOG091G0H8A.
PhylomeDBiQ8NGH8.
TreeFamiTF344049.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPSNDSTA PVSEFLLICF PNFQSWQHWL SLPLSLLFLL AMGANTTLLI
60 70 80 90 100
TIQLEASLHQ PLYYLLSLLS LLDIVLCLTV IPKVLAIFWF DLRSISFPAC
110 120 130 140 150
FLQMFIMNSF LTMESCTFMV MAYDRYVAIC HPLRYPSIIT DQFVARAVVF
160 170 180 190 200
VIARNAFVSL PVPMLSARLR YCAGNIIKNC ICSNLSVSKL SCDDITFNQL
210 220 230 240 250
YQFVAGWTLL GSDLILIVIS YSFILKVVLR IKAEGAVAKA LSTCGSHFIL
260 270 280 290 300
ILFFSTVLLV LVITNLARKR IPPDVPILLN ILHHLIPPAL NPIVYGVRTK
310
EIKQGIQNLL KRL
Length:313
Mass (Da):35,116
Last modified:September 22, 2009 - v2
Checksum:i5DC90F4F796373FE
GO

Sequence cautioni

The sequence AAI36987 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5S → N in BAC06037 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065818 Genomic DNA. Translation: BAC06037.1.
AC111177 Genomic DNA. No translation available.
BC136986 mRNA. Translation: AAI36987.1. Different initiation.
RefSeqiNP_001005179.2. NM_001005179.2.
UniGeneiHs.553571.

Genome annotation databases

EnsembliENST00000330728; ENSP00000328215; ENSG00000183389.
GeneIDi120793.
KEGGihsa:120793.
UCSCiuc010qzv.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065818 Genomic DNA. Translation: BAC06037.1.
AC111177 Genomic DNA. No translation available.
BC136986 mRNA. Translation: AAI36987.1. Different initiation.
RefSeqiNP_001005179.2. NM_001005179.2.
UniGeneiHs.553571.

3D structure databases

ProteinModelPortaliQ8NGH8.
SMRiQ8NGH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328215.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR56A4.
DMDMi259016292.

Proteomic databases

EPDiQ8NGH8.
PaxDbiQ8NGH8.
PeptideAtlasiQ8NGH8.
PRIDEiQ8NGH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330728; ENSP00000328215; ENSG00000183389.
GeneIDi120793.
KEGGihsa:120793.
UCSCiuc010qzv.3. human.

Organism-specific databases

CTDi120793.
GeneCardsiOR56A4.
HGNCiHGNC:14791. OR56A4.
neXtProtiNX_Q8NGH8.
PharmGKBiPA32446.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II2D. Eukaryota.
ENOG410YAIE. LUCA.
HOVERGENiHBG017625.
InParanoidiQ8NGH8.
KOiK04257.
OrthoDBiEOG091G0H8A.
PhylomeDBiQ8NGH8.
TreeFamiTF344049.

Enzyme and pathway databases

BioCyciZFISH:G66-31371-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR56A4.
GenomeRNAii120793.
PROiQ8NGH8.

Gene expression databases

CleanExiHS_OR56A4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO56A4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGH8
Secondary accession number(s): B9EH17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.