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Protein

Olfactory receptor 56A4

Gene

OR56A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56A4
Alternative name(s):
Olfactory receptor OR11-49
Gene namesi
Name:OR56A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14791. OR56A4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence analysisAdd
BLAST
Transmembranei29 – 4921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 10224ExtracellularSequence analysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini124 – 14219CytoplasmicSequence analysisAdd
BLAST
Transmembranei143 – 16321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini164 – 19936ExtracellularSequence analysisAdd
BLAST
Transmembranei200 – 22021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini221 – 24020CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini262 – 27615ExtracellularSequence analysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 31316CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32446.

Polymorphism and mutation databases

BioMutaiOR56A4.
DMDMi259016292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 56A4PRO_0000150795Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGH8.
PRIDEiQ8NGH8.

Expressioni

Gene expression databases

CleanExiHS_OR56A4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328215.

Structurei

3D structure databases

ProteinModelPortaliQ8NGH8.
SMRiQ8NGH8. Positions 24-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II2D. Eukaryota.
ENOG410YAIE. LUCA.
HOVERGENiHBG017625.
InParanoidiQ8NGH8.
KOiK04257.
OrthoDBiEOG7Q5HDX.
PhylomeDBiQ8NGH8.
TreeFamiTF344049.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPSNDSTA PVSEFLLICF PNFQSWQHWL SLPLSLLFLL AMGANTTLLI
60 70 80 90 100
TIQLEASLHQ PLYYLLSLLS LLDIVLCLTV IPKVLAIFWF DLRSISFPAC
110 120 130 140 150
FLQMFIMNSF LTMESCTFMV MAYDRYVAIC HPLRYPSIIT DQFVARAVVF
160 170 180 190 200
VIARNAFVSL PVPMLSARLR YCAGNIIKNC ICSNLSVSKL SCDDITFNQL
210 220 230 240 250
YQFVAGWTLL GSDLILIVIS YSFILKVVLR IKAEGAVAKA LSTCGSHFIL
260 270 280 290 300
ILFFSTVLLV LVITNLARKR IPPDVPILLN ILHHLIPPAL NPIVYGVRTK
310
EIKQGIQNLL KRL
Length:313
Mass (Da):35,116
Last modified:September 22, 2009 - v2
Checksum:i5DC90F4F796373FE
GO

Sequence cautioni

The sequence AAI36987.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51S → N in BAC06037 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065818 Genomic DNA. Translation: BAC06037.1.
AC111177 Genomic DNA. No translation available.
BC136986 mRNA. Translation: AAI36987.1. Different initiation.
RefSeqiNP_001005179.2. NM_001005179.2.
UniGeneiHs.553571.

Genome annotation databases

EnsembliENST00000330728; ENSP00000328215; ENSG00000183389.
GeneIDi120793.
KEGGihsa:120793.
UCSCiuc010qzv.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065818 Genomic DNA. Translation: BAC06037.1.
AC111177 Genomic DNA. No translation available.
BC136986 mRNA. Translation: AAI36987.1. Different initiation.
RefSeqiNP_001005179.2. NM_001005179.2.
UniGeneiHs.553571.

3D structure databases

ProteinModelPortaliQ8NGH8.
SMRiQ8NGH8. Positions 24-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328215.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR56A4.
DMDMi259016292.

Proteomic databases

PaxDbiQ8NGH8.
PRIDEiQ8NGH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330728; ENSP00000328215; ENSG00000183389.
GeneIDi120793.
KEGGihsa:120793.
UCSCiuc010qzv.3. human.

Organism-specific databases

CTDi120793.
GeneCardsiOR56A4.
HGNCiHGNC:14791. OR56A4.
neXtProtiNX_Q8NGH8.
PharmGKBiPA32446.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II2D. Eukaryota.
ENOG410YAIE. LUCA.
HOVERGENiHBG017625.
InParanoidiQ8NGH8.
KOiK04257.
OrthoDBiEOG7Q5HDX.
PhylomeDBiQ8NGH8.
TreeFamiTF344049.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR56A4.
GenomeRNAii120793.
NextBioi80623.
PROiQ8NGH8.

Gene expression databases

CleanExiHS_OR56A4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiO56A4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGH8
Secondary accession number(s): B9EH17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: September 22, 2009
Last modified: March 16, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.