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Protein

Olfactory receptor 52L1

Gene

OR52L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52L1
Alternative name(s):
Olfactory receptor OR11-50
Gene namesi
Name:OR52L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14785. OR52L1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 72CytoplasmicSequence analysis8
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 117ExtracellularSequence analysisAdd BLAST24
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini139 – 157CytoplasmicSequence analysisAdd BLAST19
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 214ExtracellularSequence analysisAdd BLAST36
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini236 – 255CytoplasmicSequence analysisAdd BLAST20
Transmembranei256 – 276Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini277 – 291ExtracellularSequence analysisAdd BLAST15
Transmembranei292 – 312Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini313 – 329CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32420.

Polymorphism and mutation databases

BioMutaiOR52L1.
DMDMi296439491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507831 – 329Olfactory receptor 52L1Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGH7.
PeptideAtlasiQ8NGH7.
PRIDEiQ8NGH7.

Expressioni

Gene expression databases

BgeeiENSG00000183313.
CleanExiHS_OR52L1.

Interactioni

Protein-protein interaction databases

IntActiQ8NGH7. 1 interactor.
STRINGi9606.ENSP00000330338.

Structurei

3D structure databases

ProteinModelPortaliQ8NGH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH9X. Eukaryota.
ENOG410YB92. LUCA.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGH7.
KOiK04257.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGH7.
TreeFamiTF343679.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NGH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLVSFFSFL SKPLIMLLSN SSWRLSQPSF LLVGIPGLEE SQHWIALPLG
60 70 80 90 100
ILYLLALVGN VTILFIIWMD PSLHQSMYLF LSMLAAIDLV LASSTAPKAL
110 120 130 140 150
AVLLVHAHEI GYIVCLIQMF FIHAFSSMES GVLVAMALDC YVAICHPLHH
160 170 180 190 200
STILHPGVIG CIGMVVLVRG LLLLIPFPIL LGKLIFCQAT IIGHAYCEHM
210 220 230 240 250
AVVKLACSET TVNRAYGLTM ALLVIGLDVL AIGVSYAHIL QAVLKVPGSE
260 270 280 290 300
ARLKAFSTCG SHICVILVFY VPGIFSFLTH RFGHHVPHHV HVLLATWYLL
310 320
MPPALNPLVY GVKTQQIRQR VLRVFTQKD
Length:329
Mass (Da):36,221
Last modified:May 18, 2010 - v4
Checksum:iB3EE384D7B548940
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05507888D → N1 PublicationCorresponds to variant dbSNP:rs4501959Ensembl.1
Natural variantiVAR_055079140C → R3 PublicationsCorresponds to variant dbSNP:rs4436525Ensembl.1
Natural variantiVAR_055080161C → R3 PublicationsCorresponds to variant dbSNP:rs4436524Ensembl.1
Natural variantiVAR_055081183K → T3 PublicationsCorresponds to variant dbSNP:rs4354673Ensembl.1
Natural variantiVAR_055082297W → R3 PublicationsCorresponds to variant dbSNP:rs4237768Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065819 Genomic DNA. Translation: BAC06038.1.
AC025016 Genomic DNA. No translation available.
AC111177 Genomic DNA. No translation available.
AC131574 Genomic DNA. No translation available.
BC137343 mRNA. Translation: AAI37344.1.
BK004253 Genomic DNA. Translation: DAA04651.1.
CCDSiCCDS44529.1.
RefSeqiNP_001005173.3. NM_001005173.3.
UniGeneiHs.553703.

Genome annotation databases

EnsembliENST00000332249; ENSP00000330338; ENSG00000183313.
GeneIDi338751.
KEGGihsa:338751.
UCSCiuc001mcd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO52L1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGH7
Secondary accession number(s): B2RPA6, Q6IFK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: August 30, 2017
This is version 119 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families