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Q8NGH7

- O52L1_HUMAN

UniProt

Q8NGH7 - O52L1_HUMAN

Protein

Olfactory receptor 52L1

Gene

OR52L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 4 (18 May 2010)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 52L1
    Alternative name(s):
    Olfactory receptor OR11-50
    Gene namesi
    Name:OR52L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14785. OR52L1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32420.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329Olfactory receptor 52L1PRO_0000150783Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGH7.
    PRIDEiQ8NGH7.

    Expressioni

    Gene expression databases

    CleanExiHS_OR52L1.
    GenevestigatoriQ8NGH7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000330338.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGH7.
    SMRiQ8NGH7. Positions 51-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 728CytoplasmicSequence Analysis
    Topological domaini94 – 11724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 15719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 21436ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 25520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 29115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini313 – 32917CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42004.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NGH7.
    KOiK04257.
    OMAiYIVCLIQ.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ8NGH7.
    TreeFamiTF343679.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLVSFFSFL SKPLIMLLSN SSWRLSQPSF LLVGIPGLEE SQHWIALPLG    50
    ILYLLALVGN VTILFIIWMD PSLHQSMYLF LSMLAAIDLV LASSTAPKAL 100
    AVLLVHAHEI GYIVCLIQMF FIHAFSSMES GVLVAMALDC YVAICHPLHH 150
    STILHPGVIG CIGMVVLVRG LLLLIPFPIL LGKLIFCQAT IIGHAYCEHM 200
    AVVKLACSET TVNRAYGLTM ALLVIGLDVL AIGVSYAHIL QAVLKVPGSE 250
    ARLKAFSTCG SHICVILVFY VPGIFSFLTH RFGHHVPHHV HVLLATWYLL 300
    MPPALNPLVY GVKTQQIRQR VLRVFTQKD 329
    Length:329
    Mass (Da):36,221
    Last modified:May 18, 2010 - v4
    Checksum:iB3EE384D7B548940
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti88 – 881D → N.1 Publication
    Corresponds to variant rs4501959 [ dbSNP | Ensembl ].
    VAR_055078
    Natural varianti140 – 1401C → R.3 Publications
    Corresponds to variant rs4436525 [ dbSNP | Ensembl ].
    VAR_055079
    Natural varianti161 – 1611C → R.3 Publications
    Corresponds to variant rs4436524 [ dbSNP | Ensembl ].
    VAR_055080
    Natural varianti183 – 1831K → T.3 Publications
    Corresponds to variant rs4354673 [ dbSNP | Ensembl ].
    VAR_055081
    Natural varianti297 – 2971W → R.3 Publications
    Corresponds to variant rs4237768 [ dbSNP | Ensembl ].
    VAR_055082

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065819 Genomic DNA. Translation: BAC06038.1.
    AC025016 Genomic DNA. No translation available.
    AC111177 Genomic DNA. No translation available.
    AC131574 Genomic DNA. No translation available.
    BC137343 mRNA. Translation: AAI37344.1.
    BK004253 Genomic DNA. Translation: DAA04651.1.
    CCDSiCCDS44529.1.
    RefSeqiNP_001005173.3. NM_001005173.3.
    UniGeneiHs.553703.

    Genome annotation databases

    EnsembliENST00000332249; ENSP00000330338; ENSG00000183313.
    GeneIDi338751.
    KEGGihsa:338751.
    UCSCiuc001mcd.2. human.

    Polymorphism databases

    DMDMi296439491.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065819 Genomic DNA. Translation: BAC06038.1 .
    AC025016 Genomic DNA. No translation available.
    AC111177 Genomic DNA. No translation available.
    AC131574 Genomic DNA. No translation available.
    BC137343 mRNA. Translation: AAI37344.1 .
    BK004253 Genomic DNA. Translation: DAA04651.1 .
    CCDSi CCDS44529.1.
    RefSeqi NP_001005173.3. NM_001005173.3.
    UniGenei Hs.553703.

    3D structure databases

    ProteinModelPortali Q8NGH7.
    SMRi Q8NGH7. Positions 51-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000330338.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 296439491.

    Proteomic databases

    PaxDbi Q8NGH7.
    PRIDEi Q8NGH7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332249 ; ENSP00000330338 ; ENSG00000183313 .
    GeneIDi 338751.
    KEGGi hsa:338751.
    UCSCi uc001mcd.2. human.

    Organism-specific databases

    CTDi 338751.
    GeneCardsi GC11M006008.
    HGNCi HGNC:14785. OR52L1.
    neXtProti NX_Q8NGH7.
    PharmGKBi PA32420.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42004.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NGH7.
    KOi K04257.
    OMAi YIVCLIQ.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q8NGH7.
    TreeFami TF343679.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR52L1.
    GenomeRNAii 338751.
    NextBioi 97129.
    PROi Q8NGH7.

    Gene expression databases

    CleanExi HS_OR52L1.
    Genevestigatori Q8NGH7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-140; ARG-161; THR-183 AND ARG-297.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-88; ARG-140; ARG-161; THR-183 AND ARG-297.
    4. Cited for: IDENTIFICATION, VARIANTS ARG-140; ARG-161; THR-183 AND ARG-297.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO52L1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGH7
    Secondary accession number(s): B2RPA6, Q6IFK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 100 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-16 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3