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Q8NGH7 (O52L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 52L1
Alternative name(s):
Olfactory receptor OR11-50
Gene names
Name:OR52L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329Olfactory receptor 52L1
PRO_0000150783

Regions

Topological domain1 – 4343Extracellular Potential
Transmembrane44 – 6421Helical; Name=1; Potential
Topological domain65 – 728Cytoplasmic Potential
Transmembrane73 – 9321Helical; Name=2; Potential
Topological domain94 – 11724Extracellular Potential
Transmembrane118 – 13821Helical; Name=3; Potential
Topological domain139 – 15719Cytoplasmic Potential
Transmembrane158 – 17821Helical; Name=4; Potential
Topological domain179 – 21436Extracellular Potential
Transmembrane215 – 23521Helical; Name=5; Potential
Topological domain236 – 25520Cytoplasmic Potential
Transmembrane256 – 27621Helical; Name=6; Potential
Topological domain277 – 29115Extracellular Potential
Transmembrane292 – 31221Helical; Name=7; Potential
Topological domain313 – 32917Cytoplasmic Potential

Amino acid modifications

Glycosylation201N-linked (GlcNAc...) Potential
Disulfide bond115 ↔ 207 By similarity

Natural variations

Natural variant881D → N. Ref.3
Corresponds to variant rs4501959 [ dbSNP | Ensembl ].
VAR_055078
Natural variant1401C → R. Ref.1 Ref.3 Ref.4
Corresponds to variant rs4436525 [ dbSNP | Ensembl ].
VAR_055079
Natural variant1611C → R. Ref.1 Ref.3 Ref.4
Corresponds to variant rs4436524 [ dbSNP | Ensembl ].
VAR_055080
Natural variant1831K → T. Ref.1 Ref.3 Ref.4
Corresponds to variant rs4354673 [ dbSNP | Ensembl ].
VAR_055081
Natural variant2971W → R. Ref.1 Ref.3 Ref.4
Corresponds to variant rs4237768 [ dbSNP | Ensembl ].
VAR_055082

Sequences

Sequence LengthMass (Da)Tools
Q8NGH7 [UniParc].

Last modified May 18, 2010. Version 4.
Checksum: B3EE384D7B548940

FASTA32936,221
        10         20         30         40         50         60 
MTLVSFFSFL SKPLIMLLSN SSWRLSQPSF LLVGIPGLEE SQHWIALPLG ILYLLALVGN 

        70         80         90        100        110        120 
VTILFIIWMD PSLHQSMYLF LSMLAAIDLV LASSTAPKAL AVLLVHAHEI GYIVCLIQMF 

       130        140        150        160        170        180 
FIHAFSSMES GVLVAMALDC YVAICHPLHH STILHPGVIG CIGMVVLVRG LLLLIPFPIL 

       190        200        210        220        230        240 
LGKLIFCQAT IIGHAYCEHM AVVKLACSET TVNRAYGLTM ALLVIGLDVL AIGVSYAHIL 

       250        260        270        280        290        300 
QAVLKVPGSE ARLKAFSTCG SHICVILVFY VPGIFSFLTH RFGHHVPHHV HVLLATWYLL 

       310        320 
MPPALNPLVY GVKTQQIRQR VLRVFTQKD 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-140; ARG-161; THR-183 AND ARG-297.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-88; ARG-140; ARG-161; THR-183 AND ARG-297.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, VARIANTS ARG-140; ARG-161; THR-183 AND ARG-297.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065819 Genomic DNA. Translation: BAC06038.1.
AC025016 Genomic DNA. No translation available.
AC111177 Genomic DNA. No translation available.
AC131574 Genomic DNA. No translation available.
BC137343 mRNA. Translation: AAI37344.1.
BK004253 Genomic DNA. Translation: DAA04651.1.
RefSeqNP_001005173.3. NM_001005173.3.
UniGeneHs.553703.

3D structure databases

ProteinModelPortalQ8NGH7.
SMRQ8NGH7. Positions 51-148.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000330338.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM296439491.

Proteomic databases

PaxDbQ8NGH7.
PRIDEQ8NGH7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332249; ENSP00000330338; ENSG00000183313.
GeneID338751.
KEGGhsa:338751.
UCSCuc001mcd.2. human.

Organism-specific databases

CTD338751.
GeneCardsGC11M006008.
HGNCHGNC:14785. OR52L1.
neXtProtNX_Q8NGH7.
PharmGKBPA32420.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42004.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ8NGH7.
KOK04257.
OMAYIVCLIQ.
OrthoDBEOG754HPV.
PhylomeDBQ8NGH7.
TreeFamTF343679.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR52L1.
GenevestigatorQ8NGH7.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR52L1.
GenomeRNAi338751.
NextBio97129.
PROQ8NGH7.

Entry information

Entry nameO52L1_HUMAN
AccessionPrimary (citable) accession number: Q8NGH7
Secondary accession number(s): B2RPA6, Q6IFK9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 98 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries