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Q8NGH7

- O52L1_HUMAN

UniProt

Q8NGH7 - O52L1_HUMAN

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Protein

Olfactory receptor 52L1

Gene

OR52L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52L1
Alternative name(s):
Olfactory receptor OR11-50
Gene namesi
Name:OR52L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14785. OR52L1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini65 – 728CytoplasmicSequence Analysis
Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini94 – 11724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini139 – 15719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini179 – 21436ExtracellularSequence AnalysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini236 – 25520CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini277 – 29115ExtracellularSequence AnalysisAdd
BLAST
Transmembranei292 – 31221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini313 – 32917CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Olfactory receptor 52L1PRO_0000150783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGH7.
PRIDEiQ8NGH7.

Expressioni

Gene expression databases

CleanExiHS_OR52L1.
GenevestigatoriQ8NGH7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330338.

Structurei

3D structure databases

ProteinModelPortaliQ8NGH7.
SMRiQ8NGH7. Positions 51-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42004.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGH7.
KOiK04257.
OMAiYIVCLIQ.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGH7.
TreeFamiTF343679.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGH7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLVSFFSFL SKPLIMLLSN SSWRLSQPSF LLVGIPGLEE SQHWIALPLG
60 70 80 90 100
ILYLLALVGN VTILFIIWMD PSLHQSMYLF LSMLAAIDLV LASSTAPKAL
110 120 130 140 150
AVLLVHAHEI GYIVCLIQMF FIHAFSSMES GVLVAMALDC YVAICHPLHH
160 170 180 190 200
STILHPGVIG CIGMVVLVRG LLLLIPFPIL LGKLIFCQAT IIGHAYCEHM
210 220 230 240 250
AVVKLACSET TVNRAYGLTM ALLVIGLDVL AIGVSYAHIL QAVLKVPGSE
260 270 280 290 300
ARLKAFSTCG SHICVILVFY VPGIFSFLTH RFGHHVPHHV HVLLATWYLL
310 320
MPPALNPLVY GVKTQQIRQR VLRVFTQKD
Length:329
Mass (Da):36,221
Last modified:May 18, 2010 - v4
Checksum:iB3EE384D7B548940
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti88 – 881D → N.1 Publication
Corresponds to variant rs4501959 [ dbSNP | Ensembl ].
VAR_055078
Natural varianti140 – 1401C → R.3 Publications
Corresponds to variant rs4436525 [ dbSNP | Ensembl ].
VAR_055079
Natural varianti161 – 1611C → R.3 Publications
Corresponds to variant rs4436524 [ dbSNP | Ensembl ].
VAR_055080
Natural varianti183 – 1831K → T.3 Publications
Corresponds to variant rs4354673 [ dbSNP | Ensembl ].
VAR_055081
Natural varianti297 – 2971W → R.3 Publications
Corresponds to variant rs4237768 [ dbSNP | Ensembl ].
VAR_055082

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065819 Genomic DNA. Translation: BAC06038.1.
AC025016 Genomic DNA. No translation available.
AC111177 Genomic DNA. No translation available.
AC131574 Genomic DNA. No translation available.
BC137343 mRNA. Translation: AAI37344.1.
BK004253 Genomic DNA. Translation: DAA04651.1.
CCDSiCCDS44529.1.
RefSeqiNP_001005173.3. NM_001005173.3.
UniGeneiHs.553703.

Genome annotation databases

EnsembliENST00000332249; ENSP00000330338; ENSG00000183313.
GeneIDi338751.
KEGGihsa:338751.
UCSCiuc001mcd.2. human.

Polymorphism databases

DMDMi296439491.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065819 Genomic DNA. Translation: BAC06038.1 .
AC025016 Genomic DNA. No translation available.
AC111177 Genomic DNA. No translation available.
AC131574 Genomic DNA. No translation available.
BC137343 mRNA. Translation: AAI37344.1 .
BK004253 Genomic DNA. Translation: DAA04651.1 .
CCDSi CCDS44529.1.
RefSeqi NP_001005173.3. NM_001005173.3.
UniGenei Hs.553703.

3D structure databases

ProteinModelPortali Q8NGH7.
SMRi Q8NGH7. Positions 51-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000330338.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 296439491.

Proteomic databases

PaxDbi Q8NGH7.
PRIDEi Q8NGH7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332249 ; ENSP00000330338 ; ENSG00000183313 .
GeneIDi 338751.
KEGGi hsa:338751.
UCSCi uc001mcd.2. human.

Organism-specific databases

CTDi 338751.
GeneCardsi GC11M006008.
HGNCi HGNC:14785. OR52L1.
neXtProti NX_Q8NGH7.
PharmGKBi PA32420.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42004.
GeneTreei ENSGT00760000118843.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q8NGH7.
KOi K04257.
OMAi YIVCLIQ.
OrthoDBi EOG754HPV.
PhylomeDBi Q8NGH7.
TreeFami TF343679.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR52L1.
GenomeRNAii 338751.
NextBioi 97129.
PROi Q8NGH7.

Gene expression databases

CleanExi HS_OR52L1.
Genevestigatori Q8NGH7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-140; ARG-161; THR-183 AND ARG-297.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-88; ARG-140; ARG-161; THR-183 AND ARG-297.
  4. Cited for: IDENTIFICATION, VARIANTS ARG-140; ARG-161; THR-183 AND ARG-297.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52L1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGH7
Secondary accession number(s): B2RPA6, Q6IFK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 101 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3