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Q8NGH5

- O56A1_HUMAN

UniProt

Q8NGH5 - O56A1_HUMAN

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Protein
Olfactory receptor 56A1
Gene
OR56A1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56A1
Alternative name(s):
Olfactory receptor OR11-75
Gene namesi
Name:OR56A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14781. OR56A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Extracellular Reviewed prediction
Add
BLAST
Transmembranei33 – 5321Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini54 – 618Cytoplasmic Reviewed prediction
Transmembranei62 – 8221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini83 – 10624Extracellular Reviewed prediction
Add
BLAST
Transmembranei107 – 12721Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini128 – 14619Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei147 – 16721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini168 – 20336Extracellular Reviewed prediction
Add
BLAST
Transmembranei204 – 22421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini225 – 24420Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei245 – 26521Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini266 – 28015Extracellular Reviewed prediction
Add
BLAST
Transmembranei281 – 30121Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini302 – 31817Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 56A1
PRO_0000150793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi104 ↔ 196 By similarity
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi198 – 1981N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGH5.

Expressioni

Gene expression databases

CleanExiHS_OR56A1.
GenevestigatoriQ8NGH5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321246.

Structurei

3D structure databases

ProteinModelPortaliQ8NGH5.
SMRiQ8NGH5. Positions 28-313.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25303.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGH5.
KOiK04257.
OMAiRVPMDIL.
OrthoDBiEOG7Q5HDX.
PhylomeDBiQ8NGH5.
TreeFamiTF344049.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGH5-1 [UniParc]FASTAAdd to Basket

« Hide

MIQPMASPSN SSTVPVSEFL LICFPNFQSW QHWLSLPLSL LFLLAMGANT    50
TLLITIQLEA SLHQPLYYLL SLLSLLDIVL CLTVIPKVLA IFWYDLRSIS 100
FPACFLQMFI MNSFLPMESC TFMVMAYDRY VAICHPLRYP SIITNQFVAK 150
ASVFIVVRNA LLTAPIPILT SLLHYCGENV IENCICANLS VSRLSCDNFT 200
LNRIYQFVAG WTLLGSDLFL IFLSYTFILR AVLRFKAEGA AVKALSTCGS 250
HFILILFFST ILLVVVLTNV ARKKVPMDIL ILLNVLHHLI PPALNPIVYG 300
VRTKEIKQGI QKLLQRGR 318
Length:318
Mass (Da):35,823
Last modified:May 5, 2009 - v3
Checksum:iD0174EFA5005C677
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221I → T in BAC06040. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065821 Genomic DNA. Translation: BAC06040.1.
AC111177 Genomic DNA. No translation available.
BC136904 mRNA. Translation: AAI36905.1.
BC136911 mRNA. Translation: AAI36912.1.
BK004252 Genomic DNA. Translation: DAA04650.1.
CCDSiCCDS31405.1.
RefSeqiNP_001001917.2. NM_001001917.2.
UniGeneiHs.553543.

Genome annotation databases

EnsembliENST00000316650; ENSP00000321246; ENSG00000180934.
GeneIDi120796.
KEGGihsa:120796.
UCSCiuc010qzw.2. human.

Polymorphism databases

DMDMi229462958.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065821 Genomic DNA. Translation: BAC06040.1 .
AC111177 Genomic DNA. No translation available.
BC136904 mRNA. Translation: AAI36905.1 .
BC136911 mRNA. Translation: AAI36912.1 .
BK004252 Genomic DNA. Translation: DAA04650.1 .
CCDSi CCDS31405.1.
RefSeqi NP_001001917.2. NM_001001917.2.
UniGenei Hs.553543.

3D structure databases

ProteinModelPortali Q8NGH5.
SMRi Q8NGH5. Positions 28-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000321246.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 229462958.

Proteomic databases

PRIDEi Q8NGH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316650 ; ENSP00000321246 ; ENSG00000180934 .
GeneIDi 120796.
KEGGi hsa:120796.
UCSCi uc010qzw.2. human.

Organism-specific databases

CTDi 120796.
GeneCardsi GC11M006048.
H-InvDB HIX0036119.
HGNCi HGNC:14781. OR56A1.
neXtProti NX_Q8NGH5.
PharmGKBi PA32443.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25303.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q8NGH5.
KOi K04257.
OMAi RVPMDIL.
OrthoDBi EOG7Q5HDX.
PhylomeDBi Q8NGH5.
TreeFami TF344049.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR56A1.
GenomeRNAii 120796.
NextBioi 80627.
PROi Q8NGH5.

Gene expression databases

CleanExi HS_OR56A1.
Genevestigatori Q8NGH5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO56A1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGH5
Secondary accession number(s): B2RNI2, Q6IFL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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