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Protein

Olfactory receptor 56A1

Gene

OR56A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56A1
Alternative name(s):
Olfactory receptor OR11-75
Gene namesi
Name:OR56A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000180934.5
HGNCiHGNC:14781 OR56A1
neXtProtiNX_Q8NGH5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini54 – 61CytoplasmicSequence analysis8
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 106ExtracellularSequence analysisAdd BLAST24
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 146CytoplasmicSequence analysisAdd BLAST19
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 203ExtracellularSequence analysisAdd BLAST36
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 244CytoplasmicSequence analysisAdd BLAST20
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 280ExtracellularSequence analysisAdd BLAST15
Transmembranei281 – 301Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini302 – 318CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32443

Polymorphism and mutation databases

BioMutaiOR56A1
DMDMi229462958

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507931 – 318Olfactory receptor 56A1Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 196PROSITE-ProRule annotation
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGH5
PeptideAtlasiQ8NGH5
PRIDEiQ8NGH5

PTM databases

iPTMnetiQ8NGH5
PhosphoSitePlusiQ8NGH5

Expressioni

Gene expression databases

BgeeiENSG00000180934
CleanExiHS_OR56A1
ExpressionAtlasiQ8NGH5 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321246

Structurei

3D structure databases

ProteinModelPortaliQ8NGH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II2D Eukaryota
ENOG410YAIE LUCA
GeneTreeiENSGT00550000074576
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NGH5
KOiK04257
OMAiRFKAEGA
OrthoDBiEOG091G0H8A
PhylomeDBiQ8NGH5
TreeFamiTF344049

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQPMASPSN SSTVPVSEFL LICFPNFQSW QHWLSLPLSL LFLLAMGANT
60 70 80 90 100
TLLITIQLEA SLHQPLYYLL SLLSLLDIVL CLTVIPKVLA IFWYDLRSIS
110 120 130 140 150
FPACFLQMFI MNSFLPMESC TFMVMAYDRY VAICHPLRYP SIITNQFVAK
160 170 180 190 200
ASVFIVVRNA LLTAPIPILT SLLHYCGENV IENCICANLS VSRLSCDNFT
210 220 230 240 250
LNRIYQFVAG WTLLGSDLFL IFLSYTFILR AVLRFKAEGA AVKALSTCGS
260 270 280 290 300
HFILILFFST ILLVVVLTNV ARKKVPMDIL ILLNVLHHLI PPALNPIVYG
310
VRTKEIKQGI QKLLQRGR
Length:318
Mass (Da):35,823
Last modified:May 5, 2009 - v3
Checksum:iD0174EFA5005C677
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22I → T in BAC06040 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065821 Genomic DNA Translation: BAC06040.1
AC111177 Genomic DNA No translation available.
BC136904 mRNA Translation: AAI36905.1
BC136911 mRNA Translation: AAI36912.1
BK004252 Genomic DNA Translation: DAA04650.1
CCDSiCCDS31405.1
RefSeqiNP_001001917.2, NM_001001917.2
UniGeneiHs.553543

Genome annotation databases

EnsembliENST00000316650; ENSP00000321246; ENSG00000180934
GeneIDi120796
KEGGihsa:120796
UCSCiuc010qzw.2 human

Similar proteinsi

Entry informationi

Entry nameiO56A1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGH5
Secondary accession number(s): B2RNI2, Q6IFL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: February 28, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health