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Q8NGH5

- O56A1_HUMAN

UniProt

Q8NGH5 - O56A1_HUMAN

Protein

Olfactory receptor 56A1

Gene

OR56A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 56A1
    Alternative name(s):
    Olfactory receptor OR11-75
    Gene namesi
    Name:OR56A1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14781. OR56A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32443.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Olfactory receptor 56A1PRO_0000150793Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 196PROSITE-ProRule annotation
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGH5.

    Expressioni

    Gene expression databases

    CleanExiHS_OR56A1.
    GenevestigatoriQ8NGH5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000321246.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGH5.
    SMRiQ8NGH5. Positions 28-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini54 – 618CytoplasmicSequence Analysis
    Topological domaini83 – 10624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini128 – 14619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini168 – 20336ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 24420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 28015ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini302 – 31817CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25303.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NGH5.
    KOiK04257.
    OMAiRVPMDIL.
    OrthoDBiEOG7Q5HDX.
    PhylomeDBiQ8NGH5.
    TreeFamiTF344049.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGH5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIQPMASPSN SSTVPVSEFL LICFPNFQSW QHWLSLPLSL LFLLAMGANT    50
    TLLITIQLEA SLHQPLYYLL SLLSLLDIVL CLTVIPKVLA IFWYDLRSIS 100
    FPACFLQMFI MNSFLPMESC TFMVMAYDRY VAICHPLRYP SIITNQFVAK 150
    ASVFIVVRNA LLTAPIPILT SLLHYCGENV IENCICANLS VSRLSCDNFT 200
    LNRIYQFVAG WTLLGSDLFL IFLSYTFILR AVLRFKAEGA AVKALSTCGS 250
    HFILILFFST ILLVVVLTNV ARKKVPMDIL ILLNVLHHLI PPALNPIVYG 300
    VRTKEIKQGI QKLLQRGR 318
    Length:318
    Mass (Da):35,823
    Last modified:May 5, 2009 - v3
    Checksum:iD0174EFA5005C677
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221I → T in BAC06040. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065821 Genomic DNA. Translation: BAC06040.1.
    AC111177 Genomic DNA. No translation available.
    BC136904 mRNA. Translation: AAI36905.1.
    BC136911 mRNA. Translation: AAI36912.1.
    BK004252 Genomic DNA. Translation: DAA04650.1.
    CCDSiCCDS31405.1.
    RefSeqiNP_001001917.2. NM_001001917.2.
    UniGeneiHs.553543.

    Genome annotation databases

    EnsembliENST00000316650; ENSP00000321246; ENSG00000180934.
    GeneIDi120796.
    KEGGihsa:120796.
    UCSCiuc010qzw.2. human.

    Polymorphism databases

    DMDMi229462958.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065821 Genomic DNA. Translation: BAC06040.1 .
    AC111177 Genomic DNA. No translation available.
    BC136904 mRNA. Translation: AAI36905.1 .
    BC136911 mRNA. Translation: AAI36912.1 .
    BK004252 Genomic DNA. Translation: DAA04650.1 .
    CCDSi CCDS31405.1.
    RefSeqi NP_001001917.2. NM_001001917.2.
    UniGenei Hs.553543.

    3D structure databases

    ProteinModelPortali Q8NGH5.
    SMRi Q8NGH5. Positions 28-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000321246.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 229462958.

    Proteomic databases

    PRIDEi Q8NGH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316650 ; ENSP00000321246 ; ENSG00000180934 .
    GeneIDi 120796.
    KEGGi hsa:120796.
    UCSCi uc010qzw.2. human.

    Organism-specific databases

    CTDi 120796.
    GeneCardsi GC11M006048.
    H-InvDB HIX0036119.
    HGNCi HGNC:14781. OR56A1.
    neXtProti NX_Q8NGH5.
    PharmGKBi PA32443.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25303.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NGH5.
    KOi K04257.
    OMAi RVPMDIL.
    OrthoDBi EOG7Q5HDX.
    PhylomeDBi Q8NGH5.
    TreeFami TF344049.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR56A1.
    GenomeRNAii 120796.
    NextBioi 80627.
    PROi Q8NGH5.

    Gene expression databases

    CleanExi HS_OR56A1.
    Genevestigatori Q8NGH5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO56A1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGH5
    Secondary accession number(s): B2RNI2, Q6IFL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-5 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3