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Q8NGH5

- O56A1_HUMAN

UniProt

Q8NGH5 - O56A1_HUMAN

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Protein

Olfactory receptor 56A1

Gene

OR56A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56A1
Alternative name(s):
Olfactory receptor OR11-75
Gene namesi
Name:OR56A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14781. OR56A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 5321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini54 – 618CytoplasmicSequence Analysis
Transmembranei62 – 8221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini83 – 10624ExtracellularSequence AnalysisAdd
BLAST
Transmembranei107 – 12721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini128 – 14619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini168 – 20336ExtracellularSequence AnalysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini225 – 24420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini266 – 28015ExtracellularSequence AnalysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini302 – 31817CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 56A1PRO_0000150793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 196PROSITE-ProRule annotation
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGH5.

Expressioni

Gene expression databases

CleanExiHS_OR56A1.
GenevestigatoriQ8NGH5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321246.

Structurei

3D structure databases

ProteinModelPortaliQ8NGH5.
SMRiQ8NGH5. Positions 28-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25303.
GeneTreeiENSGT00550000074576.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGH5.
KOiK04257.
OMAiRVPMDIL.
OrthoDBiEOG7Q5HDX.
PhylomeDBiQ8NGH5.
TreeFamiTF344049.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGH5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQPMASPSN SSTVPVSEFL LICFPNFQSW QHWLSLPLSL LFLLAMGANT
60 70 80 90 100
TLLITIQLEA SLHQPLYYLL SLLSLLDIVL CLTVIPKVLA IFWYDLRSIS
110 120 130 140 150
FPACFLQMFI MNSFLPMESC TFMVMAYDRY VAICHPLRYP SIITNQFVAK
160 170 180 190 200
ASVFIVVRNA LLTAPIPILT SLLHYCGENV IENCICANLS VSRLSCDNFT
210 220 230 240 250
LNRIYQFVAG WTLLGSDLFL IFLSYTFILR AVLRFKAEGA AVKALSTCGS
260 270 280 290 300
HFILILFFST ILLVVVLTNV ARKKVPMDIL ILLNVLHHLI PPALNPIVYG
310
VRTKEIKQGI QKLLQRGR
Length:318
Mass (Da):35,823
Last modified:May 5, 2009 - v3
Checksum:iD0174EFA5005C677
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221I → T in BAC06040. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065821 Genomic DNA. Translation: BAC06040.1.
AC111177 Genomic DNA. No translation available.
BC136904 mRNA. Translation: AAI36905.1.
BC136911 mRNA. Translation: AAI36912.1.
BK004252 Genomic DNA. Translation: DAA04650.1.
CCDSiCCDS31405.1.
RefSeqiNP_001001917.2. NM_001001917.2.
UniGeneiHs.553543.

Genome annotation databases

EnsembliENST00000316650; ENSP00000321246; ENSG00000180934.
GeneIDi120796.
KEGGihsa:120796.
UCSCiuc010qzw.2. human.

Polymorphism databases

DMDMi229462958.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065821 Genomic DNA. Translation: BAC06040.1 .
AC111177 Genomic DNA. No translation available.
BC136904 mRNA. Translation: AAI36905.1 .
BC136911 mRNA. Translation: AAI36912.1 .
BK004252 Genomic DNA. Translation: DAA04650.1 .
CCDSi CCDS31405.1.
RefSeqi NP_001001917.2. NM_001001917.2.
UniGenei Hs.553543.

3D structure databases

ProteinModelPortali Q8NGH5.
SMRi Q8NGH5. Positions 28-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000321246.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 229462958.

Proteomic databases

PRIDEi Q8NGH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316650 ; ENSP00000321246 ; ENSG00000180934 .
GeneIDi 120796.
KEGGi hsa:120796.
UCSCi uc010qzw.2. human.

Organism-specific databases

CTDi 120796.
GeneCardsi GC11M006048.
H-InvDB HIX0036119.
HGNCi HGNC:14781. OR56A1.
neXtProti NX_Q8NGH5.
PharmGKBi PA32443.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25303.
GeneTreei ENSGT00550000074576.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q8NGH5.
KOi K04257.
OMAi RVPMDIL.
OrthoDBi EOG7Q5HDX.
PhylomeDBi Q8NGH5.
TreeFami TF344049.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR56A1.
GenomeRNAii 120796.
NextBioi 80627.
PROi Q8NGH5.

Gene expression databases

CleanExi HS_OR56A1.
Genevestigatori Q8NGH5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO56A1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGH5
Secondary accession number(s): B2RNI2, Q6IFL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3