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Protein

Olfactory receptor 2D3

Gene

OR2D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2D3
Alternative name(s):
Olfactory receptor OR11-89
Gene namesi
Name:OR2D3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15146. OR2D3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei42 – 6524Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini66 – 738CytoplasmicSequence Analysis
Transmembranei74 – 9522Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini96 – 11621ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13620Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 15519CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei156 – 17419Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini175 – 21137ExtracellularSequence AnalysisAdd
BLAST
Transmembranei212 – 23524Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini236 – 25217CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27523Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini276 – 28813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei289 – 30820Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 33022CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Olfactory receptor 2D3PRO_0000150468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGH3.
PRIDEiQ8NGH3.

PTM databases

PhosphoSiteiQ8NGH3.

Expressioni

Gene expression databases

BgeeiQ8NGH3.
CleanExiHS_OR2D3.
GenevestigatoriQ8NGH3.

Organism-specific databases

HPAiHPA052551.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320560.

Structurei

3D structure databases

ProteinModelPortaliQ8NGH3.
SMRiQ8NGH3. Positions 42-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74246.
GeneTreeiENSGT00760000119029.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGH3.
KOiK04257.
OMAiISMGEEN.
OrthoDBiEOG70PBZ3.
PhylomeDBiQ8NGH3.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGH3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCSFFLCQTG KQAKISMGEE NQTFVSKFIF LGLSQDLQTQ ILLFILFLII
60 70 80 90 100
YLLTVLGNQL IIILIFLDSR LHTPMYFFLR NLSFADLCFS TSIVPQVLVH
110 120 130 140 150
FLVKRKTISF YGCMTQIIVF LLVGCTECAL LAVMSYDRYV AVCKPLYYST
160 170 180 190 200
IMTQRVCLWL SFRSWASGAL VSLVDTSFTF HLPYWGQNII NHYFCEPPAL
210 220 230 240 250
LKLASIDTYS TEMAIFSMGV VILLAPVSLI LGSYWNIIST VIQMQSGEGR
260 270 280 290 300
LKAFSTCGSH LIVVVLFYGS GIFTYMRPNS KTTKELDKMI SVFYTAVTPM
310 320 330
LNPIIYSLRN KDVKGALRKL VGRKCFSHRQ
Length:330
Mass (Da):37,489
Last modified:February 10, 2009 - v2
Checksum:iA829F400F34E3DEB
GO

Sequence cautioni

The sequence BAC06044.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821L → I.
Corresponds to variant rs10839658 [ dbSNP | Ensembl ].
VAR_057537
Natural varianti155 – 1551R → W.1 Publication
Corresponds to variant rs12806437 [ dbSNP | Ensembl ].
VAR_057538
Natural varianti165 – 1651W → S.
Corresponds to variant rs10839659 [ dbSNP | Ensembl ].
VAR_057539

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065825 Genomic DNA. Translation: BAC06044.1. Different initiation.
BC137208 mRNA. Translation: AAI37209.1.
BC137209 mRNA. Translation: AAI37210.1.
AF399592 Genomic DNA. Translation: AAK95077.1.
BK004294 Genomic DNA. Translation: DAA04692.1.
CCDSiCCDS31417.1.
RefSeqiNP_001004684.1. NM_001004684.1.
UniGeneiHs.446766.

Genome annotation databases

EnsembliENST00000317834; ENSP00000320560; ENSG00000178358.
GeneIDi120775.
KEGGihsa:120775.
UCSCiuc010rav.2. human.

Polymorphism databases

DMDMi223590116.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065825 Genomic DNA. Translation: BAC06044.1. Different initiation.
BC137208 mRNA. Translation: AAI37209.1.
BC137209 mRNA. Translation: AAI37210.1.
AF399592 Genomic DNA. Translation: AAK95077.1.
BK004294 Genomic DNA. Translation: DAA04692.1.
CCDSiCCDS31417.1.
RefSeqiNP_001004684.1. NM_001004684.1.
UniGeneiHs.446766.

3D structure databases

ProteinModelPortaliQ8NGH3.
SMRiQ8NGH3. Positions 42-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000320560.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGH3.

Polymorphism databases

DMDMi223590116.

Proteomic databases

PaxDbiQ8NGH3.
PRIDEiQ8NGH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317834; ENSP00000320560; ENSG00000178358.
GeneIDi120775.
KEGGihsa:120775.
UCSCiuc010rav.2. human.

Organism-specific databases

CTDi120775.
GeneCardsiGC11P006942.
HGNCiHGNC:15146. OR2D3.
HPAiHPA052551.
neXtProtiNX_Q8NGH3.
PharmGKBiPA32153.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG74246.
GeneTreeiENSGT00760000119029.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGH3.
KOiK04257.
OMAiISMGEEN.
OrthoDBiEOG70PBZ3.
PhylomeDBiQ8NGH3.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2D3.
GenomeRNAii120775.
NextBioi80611.
PROiQ8NGH3.

Gene expression databases

BgeeiQ8NGH3.
CleanExiHS_OR2D3.
GenevestigatoriQ8NGH3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TRP-155.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-299.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2D3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGH3
Secondary accession number(s): B2RP06, Q6IFG8, Q96R51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: January 7, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.