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Protein

Olfactory receptor 2D3

Gene

OR2D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178358-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2D3
Alternative name(s):
Olfactory receptor OR11-89
Gene namesi
Name:OR2D3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15146. OR2D3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 65Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini66 – 73CytoplasmicSequence analysis8
Transmembranei74 – 95Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini96 – 116ExtracellularSequence analysisAdd BLAST21
Transmembranei117 – 136Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini137 – 155CytoplasmicSequence analysisAdd BLAST19
Transmembranei156 – 174Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini175 – 211ExtracellularSequence analysisAdd BLAST37
Transmembranei212 – 235Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini236 – 252CytoplasmicSequence analysisAdd BLAST17
Transmembranei253 – 275Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini276 – 288ExtracellularSequence analysisAdd BLAST13
Transmembranei289 – 308Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini309 – 330CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178358.
PharmGKBiPA32153.

Polymorphism and mutation databases

BioMutaiOR2D3.
DMDMi223590116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504681 – 330Olfactory receptor 2D3Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGH3.
PeptideAtlasiQ8NGH3.
PRIDEiQ8NGH3.

PTM databases

iPTMnetiQ8NGH3.
PhosphoSitePlusiQ8NGH3.

Expressioni

Gene expression databases

BgeeiENSG00000178358.
CleanExiHS_OR2D3.

Organism-specific databases

HPAiHPA052551.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320560.

Structurei

3D structure databases

ProteinModelPortaliQ8NGH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVFF. Eukaryota.
ENOG41114MT. LUCA.
GeneTreeiENSGT00820000126998.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGH3.
KOiK04257.
OMAiMAIFSMG.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGH3.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSFFLCQTG KQAKISMGEE NQTFVSKFIF LGLSQDLQTQ ILLFILFLII
60 70 80 90 100
YLLTVLGNQL IIILIFLDSR LHTPMYFFLR NLSFADLCFS TSIVPQVLVH
110 120 130 140 150
FLVKRKTISF YGCMTQIIVF LLVGCTECAL LAVMSYDRYV AVCKPLYYST
160 170 180 190 200
IMTQRVCLWL SFRSWASGAL VSLVDTSFTF HLPYWGQNII NHYFCEPPAL
210 220 230 240 250
LKLASIDTYS TEMAIFSMGV VILLAPVSLI LGSYWNIIST VIQMQSGEGR
260 270 280 290 300
LKAFSTCGSH LIVVVLFYGS GIFTYMRPNS KTTKELDKMI SVFYTAVTPM
310 320 330
LNPIIYSLRN KDVKGALRKL VGRKCFSHRQ
Length:330
Mass (Da):37,489
Last modified:February 10, 2009 - v2
Checksum:iA829F400F34E3DEB
GO

Sequence cautioni

The sequence BAC06044 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05753782L → I.Corresponds to variant rs10839658dbSNPEnsembl.1
Natural variantiVAR_057538155R → W.1 PublicationCorresponds to variant rs12806437dbSNPEnsembl.1
Natural variantiVAR_057539165W → S.Corresponds to variant rs10839659dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065825 Genomic DNA. Translation: BAC06044.1. Different initiation.
BC137208 mRNA. Translation: AAI37209.1.
BC137209 mRNA. Translation: AAI37210.1.
AF399592 Genomic DNA. Translation: AAK95077.1.
BK004294 Genomic DNA. Translation: DAA04692.1.
CCDSiCCDS31417.1.
RefSeqiNP_001004684.1. NM_001004684.1.
UniGeneiHs.446766.

Genome annotation databases

EnsembliENST00000317834; ENSP00000320560; ENSG00000178358.
GeneIDi120775.
KEGGihsa:120775.
UCSCiuc010rav.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065825 Genomic DNA. Translation: BAC06044.1. Different initiation.
BC137208 mRNA. Translation: AAI37209.1.
BC137209 mRNA. Translation: AAI37210.1.
AF399592 Genomic DNA. Translation: AAK95077.1.
BK004294 Genomic DNA. Translation: DAA04692.1.
CCDSiCCDS31417.1.
RefSeqiNP_001004684.1. NM_001004684.1.
UniGeneiHs.446766.

3D structure databases

ProteinModelPortaliQ8NGH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000320560.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGH3.
PhosphoSitePlusiQ8NGH3.

Polymorphism and mutation databases

BioMutaiOR2D3.
DMDMi223590116.

Proteomic databases

PaxDbiQ8NGH3.
PeptideAtlasiQ8NGH3.
PRIDEiQ8NGH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317834; ENSP00000320560; ENSG00000178358.
GeneIDi120775.
KEGGihsa:120775.
UCSCiuc010rav.3. human.

Organism-specific databases

CTDi120775.
GeneCardsiOR2D3.
HGNCiHGNC:15146. OR2D3.
HPAiHPA052551.
neXtProtiNX_Q8NGH3.
OpenTargetsiENSG00000178358.
PharmGKBiPA32153.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVFF. Eukaryota.
ENOG41114MT. LUCA.
GeneTreeiENSGT00820000126998.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGH3.
KOiK04257.
OMAiMAIFSMG.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGH3.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178358-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2D3.
GenomeRNAii120775.
PROiQ8NGH3.

Gene expression databases

BgeeiENSG00000178358.
CleanExiHS_OR2D3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2D3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGH3
Secondary accession number(s): B2RP06, Q6IFG8, Q96R51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.