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Q8NGH3 (OR2D3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2D3
Alternative name(s):
Olfactory receptor OR11-89
Gene names
Name:OR2D3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.

Sequence caution

The sequence BAC06044.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Olfactory receptor 2D3
PRO_0000150468

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6524Helical; Name=1; Potential
Topological domain66 – 738Cytoplasmic Potential
Transmembrane74 – 9522Helical; Name=2; Potential
Topological domain96 – 11621Extracellular Potential
Transmembrane117 – 13620Helical; Name=3; Potential
Topological domain137 – 15519Cytoplasmic Potential
Transmembrane156 – 17419Helical; Name=4; Potential
Topological domain175 – 21137Extracellular Potential
Transmembrane212 – 23524Helical; Name=5; Potential
Topological domain236 – 25217Cytoplasmic Potential
Transmembrane253 – 27523Helical; Name=6; Potential
Topological domain276 – 28813Extracellular Potential
Transmembrane289 – 30820Helical; Name=7; Potential
Topological domain309 – 33022Cytoplasmic Potential

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential

Natural variations

Natural variant821L → I.
Corresponds to variant rs10839658 [ dbSNP | Ensembl ].
VAR_057537
Natural variant1551R → W. Ref.2
Corresponds to variant rs12806437 [ dbSNP | Ensembl ].
VAR_057538
Natural variant1651W → S.
Corresponds to variant rs10839659 [ dbSNP | Ensembl ].
VAR_057539

Sequences

Sequence LengthMass (Da)Tools
Q8NGH3 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: A829F400F34E3DEB

FASTA33037,489
        10         20         30         40         50         60 
MCSFFLCQTG KQAKISMGEE NQTFVSKFIF LGLSQDLQTQ ILLFILFLII YLLTVLGNQL 

        70         80         90        100        110        120 
IIILIFLDSR LHTPMYFFLR NLSFADLCFS TSIVPQVLVH FLVKRKTISF YGCMTQIIVF 

       130        140        150        160        170        180 
LLVGCTECAL LAVMSYDRYV AVCKPLYYST IMTQRVCLWL SFRSWASGAL VSLVDTSFTF 

       190        200        210        220        230        240 
HLPYWGQNII NHYFCEPPAL LKLASIDTYS TEMAIFSMGV VILLAPVSLI LGSYWNIIST 

       250        260        270        280        290        300 
VIQMQSGEGR LKAFSTCGSH LIVVVLFYGS GIFTYMRPNS KTTKELDKMI SVFYTAVTPM 

       310        320        330 
LNPIIYSLRN KDVKGALRKL VGRKCFSHRQ 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TRP-155.
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-299.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065825 Genomic DNA. Translation: BAC06044.1. Different initiation.
BC137208 mRNA. Translation: AAI37209.1.
BC137209 mRNA. Translation: AAI37210.1.
AF399592 Genomic DNA. Translation: AAK95077.1.
BK004294 Genomic DNA. Translation: DAA04692.1.
RefSeqNP_001004684.1. NM_001004684.1.
UniGeneHs.446766.

3D structure databases

ProteinModelPortalQ8NGH3.
SMRQ8NGH3. Positions 24-323.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000320560.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGH3.

Polymorphism databases

DMDM223590116.

Proteomic databases

PaxDbQ8NGH3.
PRIDEQ8NGH3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317834; ENSP00000320560; ENSG00000178358.
GeneID120775.
KEGGhsa:120775.
UCSCuc010rav.2. human.

Organism-specific databases

CTD120775.
GeneCardsGC11P006942.
HGNCHGNC:15146. OR2D3.
HPAHPA052551.
neXtProtNX_Q8NGH3.
PharmGKBPA32153.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG74246.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGH3.
KOK04257.
OMAISMGEEN.
OrthoDBEOG70PBZ3.
PhylomeDBQ8NGH3.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8NGH3.
CleanExHS_OR2D3.
GenevestigatorQ8NGH3.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2D3.
GenomeRNAi120775.
NextBio80611.
PROQ8NGH3.

Entry information

Entry nameOR2D3_HUMAN
AccessionPrimary (citable) accession number: Q8NGH3
Secondary accession number(s): B2RP06, Q6IFG8, Q96R51
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: April 16, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries