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Q8NGH3

- OR2D3_HUMAN

UniProt

Q8NGH3 - OR2D3_HUMAN

Protein

Olfactory receptor 2D3

Gene

OR2D3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2D3
    Alternative name(s):
    Olfactory receptor OR11-89
    Gene namesi
    Name:OR2D3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15146. OR2D3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32153.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Olfactory receptor 2D3PRO_0000150468Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8NGH3.
    PRIDEiQ8NGH3.

    PTM databases

    PhosphoSiteiQ8NGH3.

    Expressioni

    Gene expression databases

    BgeeiQ8NGH3.
    CleanExiHS_OR2D3.
    GenevestigatoriQ8NGH3.

    Organism-specific databases

    HPAiHPA052551.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000320560.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGH3.
    SMRiQ8NGH3. Positions 42-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini66 – 738CytoplasmicSequence Analysis
    Topological domaini96 – 11621ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 21137ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 25217CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini276 – 28813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 33022CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6524Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9522Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13620Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17419Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei212 – 23524Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27523Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei289 – 30820Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74246.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGH3.
    KOiK04257.
    OMAiISMGEEN.
    OrthoDBiEOG70PBZ3.
    PhylomeDBiQ8NGH3.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGH3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCSFFLCQTG KQAKISMGEE NQTFVSKFIF LGLSQDLQTQ ILLFILFLII    50
    YLLTVLGNQL IIILIFLDSR LHTPMYFFLR NLSFADLCFS TSIVPQVLVH 100
    FLVKRKTISF YGCMTQIIVF LLVGCTECAL LAVMSYDRYV AVCKPLYYST 150
    IMTQRVCLWL SFRSWASGAL VSLVDTSFTF HLPYWGQNII NHYFCEPPAL 200
    LKLASIDTYS TEMAIFSMGV VILLAPVSLI LGSYWNIIST VIQMQSGEGR 250
    LKAFSTCGSH LIVVVLFYGS GIFTYMRPNS KTTKELDKMI SVFYTAVTPM 300
    LNPIIYSLRN KDVKGALRKL VGRKCFSHRQ 330
    Length:330
    Mass (Da):37,489
    Last modified:February 10, 2009 - v2
    Checksum:iA829F400F34E3DEB
    GO

    Sequence cautioni

    The sequence BAC06044.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821L → I.
    Corresponds to variant rs10839658 [ dbSNP | Ensembl ].
    VAR_057537
    Natural varianti155 – 1551R → W.1 Publication
    Corresponds to variant rs12806437 [ dbSNP | Ensembl ].
    VAR_057538
    Natural varianti165 – 1651W → S.
    Corresponds to variant rs10839659 [ dbSNP | Ensembl ].
    VAR_057539

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065825 Genomic DNA. Translation: BAC06044.1. Different initiation.
    BC137208 mRNA. Translation: AAI37209.1.
    BC137209 mRNA. Translation: AAI37210.1.
    AF399592 Genomic DNA. Translation: AAK95077.1.
    BK004294 Genomic DNA. Translation: DAA04692.1.
    CCDSiCCDS31417.1.
    RefSeqiNP_001004684.1. NM_001004684.1.
    UniGeneiHs.446766.

    Genome annotation databases

    EnsembliENST00000317834; ENSP00000320560; ENSG00000178358.
    GeneIDi120775.
    KEGGihsa:120775.
    UCSCiuc010rav.2. human.

    Polymorphism databases

    DMDMi223590116.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065825 Genomic DNA. Translation: BAC06044.1 . Different initiation.
    BC137208 mRNA. Translation: AAI37209.1 .
    BC137209 mRNA. Translation: AAI37210.1 .
    AF399592 Genomic DNA. Translation: AAK95077.1 .
    BK004294 Genomic DNA. Translation: DAA04692.1 .
    CCDSi CCDS31417.1.
    RefSeqi NP_001004684.1. NM_001004684.1.
    UniGenei Hs.446766.

    3D structure databases

    ProteinModelPortali Q8NGH3.
    SMRi Q8NGH3. Positions 42-321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000320560.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGH3.

    Polymorphism databases

    DMDMi 223590116.

    Proteomic databases

    PaxDbi Q8NGH3.
    PRIDEi Q8NGH3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317834 ; ENSP00000320560 ; ENSG00000178358 .
    GeneIDi 120775.
    KEGGi hsa:120775.
    UCSCi uc010rav.2. human.

    Organism-specific databases

    CTDi 120775.
    GeneCardsi GC11P006942.
    HGNCi HGNC:15146. OR2D3.
    HPAi HPA052551.
    neXtProti NX_Q8NGH3.
    PharmGKBi PA32153.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74246.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGH3.
    KOi K04257.
    OMAi ISMGEEN.
    OrthoDBi EOG70PBZ3.
    PhylomeDBi Q8NGH3.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2D3.
    GenomeRNAii 120775.
    NextBioi 80611.
    PROi Q8NGH3.

    Gene expression databases

    Bgeei Q8NGH3.
    CleanExi HS_OR2D3.
    Genevestigatori Q8NGH3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TRP-155.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-299.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2D3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGH3
    Secondary accession number(s): B2RP06, Q6IFG8, Q96R51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-17 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3