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Protein

Olfactory receptor 8A1

Gene

OR8A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8A1
Alternative name(s):
OST025
Olfactory receptor OR11-318
Gene namesi
Name:OR8A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8469. OR8A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence analysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini67 – 7711CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 10023Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini101 – 11616ExtracellularSequence analysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 15013CytoplasmicSequence analysisAdd
BLAST
Transmembranei151 – 17121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini172 – 22251ExtracellularSequence analysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini244 – 26017CytoplasmicSequence analysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini282 – 2876ExtracellularSequence analysis
Transmembranei288 – 30821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini309 – 32618CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32744.

Polymorphism and mutation databases

BioMutaiOR8A1.
DMDMi212276454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Olfactory receptor 8A1PRO_0000150653Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGG7.
PRIDEiQ8NGG7.

PTM databases

PhosphoSiteiQ8NGG7.

Expressioni

Gene expression databases

BgeeiENSG00000196119.
CleanExiHS_OR8A1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000284287.

Structurei

3D structure databases

ProteinModelPortaliQ8NGG7.
SMRiQ8NGG7. Positions 48-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHGI. Eukaryota.
ENOG41117G7. LUCA.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG7.
KOiK04257.
OMAiNIIMSHH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGG7.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLSPMHPC RPPTQRRMAA GNHSTVTEFI LKGLTKRADL QLPLFLLFLG
60 70 80 90 100
IYLVTIVGNL GMITLICLNS QLHTPMYYFL SNLSLMDLCY SSVITPKMLV
110 120 130 140 150
NFVSEKNIIS YAGCMSQLYF FLVFVIAECY MLTVMAYDRY VAICHPLLYN
160 170 180 190 200
IIMSHHTCLL LVAVVYAIGL IGSTIETGLM LKLPYCEHLI SHYFCDILPL
210 220 230 240 250
MKLSCSSTYD VEMTVFFSAG FNIIVTSLTV LVSYTFILSS ILGISTTEGR
260 270 280 290 300
SKAFSTCSSH LAAVGMFYGS TAFMYLKPST ISSLTQENVA SVFYTTVIPM
310 320
LNPLIYSLRN KEVKAAVQKT LRGKLF
Length:326
Mass (Da):36,388
Last modified:November 4, 2008 - v2
Checksum:iB939AB0E17796279
GO

Sequence cautioni

The sequence BAC06052 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331T → R.
Corresponds to variant rs55861866 [ dbSNP | Ensembl ].
VAR_062057
Natural varianti218 – 2181S → L.
Corresponds to variant rs12792184 [ dbSNP | Ensembl ].
VAR_053238

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065833 Genomic DNA. Translation: BAC06052.1. Different initiation.
AP000916 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67586.1.
BC137194 mRNA. Translation: AAI37195.1.
BC137197 mRNA. Translation: AAI37198.1.
AF399512 Genomic DNA. Translation: AAK94997.1.
BK004495 Genomic DNA. Translation: DAA04893.1.
CCDSiCCDS31712.1.
RefSeqiNP_001005194.1. NM_001005194.1.
UniGeneiHs.632104.

Genome annotation databases

EnsembliENST00000284287; ENSP00000284287; ENSG00000196119.
GeneIDi390275.
KEGGihsa:390275.
UCSCiuc010san.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065833 Genomic DNA. Translation: BAC06052.1. Different initiation.
AP000916 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67586.1.
BC137194 mRNA. Translation: AAI37195.1.
BC137197 mRNA. Translation: AAI37198.1.
AF399512 Genomic DNA. Translation: AAK94997.1.
BK004495 Genomic DNA. Translation: DAA04893.1.
CCDSiCCDS31712.1.
RefSeqiNP_001005194.1. NM_001005194.1.
UniGeneiHs.632104.

3D structure databases

ProteinModelPortaliQ8NGG7.
SMRiQ8NGG7. Positions 48-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000284287.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGG7.

Polymorphism and mutation databases

BioMutaiOR8A1.
DMDMi212276454.

Proteomic databases

PaxDbiQ8NGG7.
PRIDEiQ8NGG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284287; ENSP00000284287; ENSG00000196119.
GeneIDi390275.
KEGGihsa:390275.
UCSCiuc010san.3. human.

Organism-specific databases

CTDi390275.
GeneCardsiOR8A1.
HGNCiHGNC:8469. OR8A1.
neXtProtiNX_Q8NGG7.
PharmGKBiPA32744.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHGI. Eukaryota.
ENOG41117G7. LUCA.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG7.
KOiK04257.
OMAiNIIMSHH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGG7.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8A1.
GenomeRNAii390275.
PROiQ8NGG7.

Gene expression databases

BgeeiENSG00000196119.
CleanExiHS_OR8A1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR8A1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG7
Secondary accession number(s): Q6IEW7, Q96RC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.