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Q8NGG6

- OR8BC_HUMAN

UniProt

Q8NGG6 - OR8BC_HUMAN

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Protein

Olfactory receptor 8B12

Gene

OR8B12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8B12
Alternative name(s):
Olfactory receptor OR11-317
Gene namesi
Name:OR8B12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15307. OR8B12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini46 – 538CytoplasmicSequence Analysis
Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini75 – 9824ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32748.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 8B12PRO_0000150658Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGG6.

Expressioni

Gene expression databases

BgeeiQ8NGG6.
CleanExiHS_OR8B12.
GenevestigatoriQ8NGG6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307159.

Structurei

3D structure databases

ProteinModelPortaliQ8NGG6.
SMRiQ8NGG6. Positions 21-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44152.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG6.
KOiK04257.
OMAiSCNSSYM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGG6.
TreeFamiTF352753.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGG6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAKNSSVTE FILEGLTHQP GLRIPLFFLF LGFYTVTVVG NLGLITLIGL
60 70 80 90 100
NSHLHTPMYF FLFNLSLIDF CFSTTITPKM LMSFVSRKNI ISFTGCMTQL
110 120 130 140 150
FFFCFFVVSE SFILSAMAYD RYVAICNPLL YTVTMSCQVC LLLLLGAYGM
160 170 180 190 200
GFAGAMAHTG SIMNLTFCAD NLVNHFMCDI LPLLELSCNS SYMNELVVFI
210 220 230 240 250
VVAVDVGMPI VTVFISYALI LSSILHNSST EGRSKAFSTC SSHIIVVSLF
260 270 280 290 300
FGSGAFMYLK PLSILPLEQG KVSSLFYTII VPVLNPLIYS LRNKDVKVAL
310
RRTLGRKIFS
Length:310
Mass (Da):34,372
Last modified:October 1, 2002 - v1
Checksum:i5035D547E91CDB3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065834 Genomic DNA. Translation: BAC06053.1.
CH471065 Genomic DNA. Translation: EAW67585.1.
BC136863 mRNA. Translation: AAI36864.1.
BC136864 mRNA. Translation: AAI36865.1.
AF399511 Genomic DNA. Translation: AAK94996.1.
BK004494 Genomic DNA. Translation: DAA04892.1.
CCDSiCCDS31711.1.
RefSeqiNP_001005195.1. NM_001005195.1.
UniGeneiHs.553634.

Genome annotation databases

EnsembliENST00000306842; ENSP00000307159; ENSG00000170953.
GeneIDi219858.
KEGGihsa:219858.
UCSCiuc010sam.2. human.

Polymorphism databases

DMDMi38372689.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065834 Genomic DNA. Translation: BAC06053.1 .
CH471065 Genomic DNA. Translation: EAW67585.1 .
BC136863 mRNA. Translation: AAI36864.1 .
BC136864 mRNA. Translation: AAI36865.1 .
AF399511 Genomic DNA. Translation: AAK94996.1 .
BK004494 Genomic DNA. Translation: DAA04892.1 .
CCDSi CCDS31711.1.
RefSeqi NP_001005195.1. NM_001005195.1.
UniGenei Hs.553634.

3D structure databases

ProteinModelPortali Q8NGG6.
SMRi Q8NGG6. Positions 21-129.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000307159.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372689.

Proteomic databases

PRIDEi Q8NGG6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306842 ; ENSP00000307159 ; ENSG00000170953 .
GeneIDi 219858.
KEGGi hsa:219858.
UCSCi uc010sam.2. human.

Organism-specific databases

CTDi 219858.
GeneCardsi GC11M124412.
HGNCi HGNC:15307. OR8B12.
neXtProti NX_Q8NGG6.
PharmGKBi PA32748.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44152.
GeneTreei ENSGT00760000118817.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGG6.
KOi K04257.
OMAi SCNSSYM.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGG6.
TreeFami TF352753.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR8B12.
GenomeRNAii 219858.
NextBioi 90810.
PROi Q8NGG6.

Gene expression databases

Bgeei Q8NGG6.
CleanExi HS_OR8B12.
Genevestigatori Q8NGG6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR8BC_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG6
Secondary accession number(s): B2RNF6, Q6IEW8, Q96RC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3