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Protein

Olfactory receptor 8B12

Gene

OR8B12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8B12
Alternative name(s):
Olfactory receptor OR11-317
Gene namesi
Name:OR8B12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15307. OR8B12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini46 – 538CytoplasmicSequence Analysis
Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini75 – 9824ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32748.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 8B12PRO_0000150658Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGG6.

Expressioni

Gene expression databases

BgeeiQ8NGG6.
CleanExiHS_OR8B12.
GenevestigatoriQ8NGG6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307159.

Structurei

3D structure databases

ProteinModelPortaliQ8NGG6.
SMRiQ8NGG6. Positions 21-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44152.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG6.
KOiK04257.
OMAiSCNSSYM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGG6.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGG6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAKNSSVTE FILEGLTHQP GLRIPLFFLF LGFYTVTVVG NLGLITLIGL
60 70 80 90 100
NSHLHTPMYF FLFNLSLIDF CFSTTITPKM LMSFVSRKNI ISFTGCMTQL
110 120 130 140 150
FFFCFFVVSE SFILSAMAYD RYVAICNPLL YTVTMSCQVC LLLLLGAYGM
160 170 180 190 200
GFAGAMAHTG SIMNLTFCAD NLVNHFMCDI LPLLELSCNS SYMNELVVFI
210 220 230 240 250
VVAVDVGMPI VTVFISYALI LSSILHNSST EGRSKAFSTC SSHIIVVSLF
260 270 280 290 300
FGSGAFMYLK PLSILPLEQG KVSSLFYTII VPVLNPLIYS LRNKDVKVAL
310
RRTLGRKIFS
Length:310
Mass (Da):34,372
Last modified:October 1, 2002 - v1
Checksum:i5035D547E91CDB3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065834 Genomic DNA. Translation: BAC06053.1.
CH471065 Genomic DNA. Translation: EAW67585.1.
BC136863 mRNA. Translation: AAI36864.1.
BC136864 mRNA. Translation: AAI36865.1.
AF399511 Genomic DNA. Translation: AAK94996.1.
BK004494 Genomic DNA. Translation: DAA04892.1.
CCDSiCCDS31711.1.
RefSeqiNP_001005195.1. NM_001005195.1.
UniGeneiHs.553634.

Genome annotation databases

EnsembliENST00000306842; ENSP00000307159; ENSG00000170953.
GeneIDi219858.
KEGGihsa:219858.
UCSCiuc010sam.2. human.

Polymorphism databases

DMDMi38372689.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065834 Genomic DNA. Translation: BAC06053.1.
CH471065 Genomic DNA. Translation: EAW67585.1.
BC136863 mRNA. Translation: AAI36864.1.
BC136864 mRNA. Translation: AAI36865.1.
AF399511 Genomic DNA. Translation: AAK94996.1.
BK004494 Genomic DNA. Translation: DAA04892.1.
CCDSiCCDS31711.1.
RefSeqiNP_001005195.1. NM_001005195.1.
UniGeneiHs.553634.

3D structure databases

ProteinModelPortaliQ8NGG6.
SMRiQ8NGG6. Positions 21-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000307159.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi38372689.

Proteomic databases

PRIDEiQ8NGG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306842; ENSP00000307159; ENSG00000170953.
GeneIDi219858.
KEGGihsa:219858.
UCSCiuc010sam.2. human.

Organism-specific databases

CTDi219858.
GeneCardsiGC11M124412.
HGNCiHGNC:15307. OR8B12.
neXtProtiNX_Q8NGG6.
PharmGKBiPA32748.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44152.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG6.
KOiK04257.
OMAiSCNSSYM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGG6.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8B12.
GenomeRNAii219858.
NextBioi90810.
PROiQ8NGG6.

Gene expression databases

BgeeiQ8NGG6.
CleanExiHS_OR8B12.
GenevestigatoriQ8NGG6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR8BC_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG6
Secondary accession number(s): B2RNF6, Q6IEW8, Q96RC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.