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Q8NGG6

- OR8BC_HUMAN

UniProt

Q8NGG6 - OR8BC_HUMAN

Protein

Olfactory receptor 8B12

Gene

OR8B12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 8B12
    Alternative name(s):
    Olfactory receptor OR11-317
    Gene namesi
    Name:OR8B12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15307. OR8B12.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32748.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Olfactory receptor 8B12PRO_0000150658Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGG6.

    Expressioni

    Gene expression databases

    BgeeiQ8NGG6.
    CleanExiHS_OR8B12.
    GenevestigatoriQ8NGG6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000307159.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGG6.
    SMRiQ8NGG6. Positions 21-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini46 – 538CytoplasmicSequence Analysis
    Topological domaini75 – 9824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44152.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGG6.
    KOiK04257.
    OMAiSCNSSYM.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGG6.
    TreeFamiTF352753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGG6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAKNSSVTE FILEGLTHQP GLRIPLFFLF LGFYTVTVVG NLGLITLIGL    50
    NSHLHTPMYF FLFNLSLIDF CFSTTITPKM LMSFVSRKNI ISFTGCMTQL 100
    FFFCFFVVSE SFILSAMAYD RYVAICNPLL YTVTMSCQVC LLLLLGAYGM 150
    GFAGAMAHTG SIMNLTFCAD NLVNHFMCDI LPLLELSCNS SYMNELVVFI 200
    VVAVDVGMPI VTVFISYALI LSSILHNSST EGRSKAFSTC SSHIIVVSLF 250
    FGSGAFMYLK PLSILPLEQG KVSSLFYTII VPVLNPLIYS LRNKDVKVAL 300
    RRTLGRKIFS 310
    Length:310
    Mass (Da):34,372
    Last modified:October 1, 2002 - v1
    Checksum:i5035D547E91CDB3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065834 Genomic DNA. Translation: BAC06053.1.
    CH471065 Genomic DNA. Translation: EAW67585.1.
    BC136863 mRNA. Translation: AAI36864.1.
    BC136864 mRNA. Translation: AAI36865.1.
    AF399511 Genomic DNA. Translation: AAK94996.1.
    BK004494 Genomic DNA. Translation: DAA04892.1.
    CCDSiCCDS31711.1.
    RefSeqiNP_001005195.1. NM_001005195.1.
    UniGeneiHs.553634.

    Genome annotation databases

    EnsembliENST00000306842; ENSP00000307159; ENSG00000170953.
    GeneIDi219858.
    KEGGihsa:219858.
    UCSCiuc010sam.2. human.

    Polymorphism databases

    DMDMi38372689.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065834 Genomic DNA. Translation: BAC06053.1 .
    CH471065 Genomic DNA. Translation: EAW67585.1 .
    BC136863 mRNA. Translation: AAI36864.1 .
    BC136864 mRNA. Translation: AAI36865.1 .
    AF399511 Genomic DNA. Translation: AAK94996.1 .
    BK004494 Genomic DNA. Translation: DAA04892.1 .
    CCDSi CCDS31711.1.
    RefSeqi NP_001005195.1. NM_001005195.1.
    UniGenei Hs.553634.

    3D structure databases

    ProteinModelPortali Q8NGG6.
    SMRi Q8NGG6. Positions 21-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000307159.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372689.

    Proteomic databases

    PRIDEi Q8NGG6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306842 ; ENSP00000307159 ; ENSG00000170953 .
    GeneIDi 219858.
    KEGGi hsa:219858.
    UCSCi uc010sam.2. human.

    Organism-specific databases

    CTDi 219858.
    GeneCardsi GC11M124412.
    HGNCi HGNC:15307. OR8B12.
    neXtProti NX_Q8NGG6.
    PharmGKBi PA32748.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44152.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGG6.
    KOi K04257.
    OMAi SCNSSYM.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGG6.
    TreeFami TF352753.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR8B12.
    GenomeRNAii 219858.
    NextBioi 90810.
    PROi Q8NGG6.

    Gene expression databases

    Bgeei Q8NGG6.
    CleanExi HS_OR8B12.
    Genevestigatori Q8NGG6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR8BC_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGG6
    Secondary accession number(s): B2RNF6, Q6IEW8, Q96RC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3