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Q8NGG6 (OR8BC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 8B12
Alternative name(s):
Olfactory receptor OR11-317
Gene names
Name:OR8B12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Olfactory receptor 8B12
PRO_0000150658

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4521Helical; Name=1; Potential
Topological domain46 – 538Cytoplasmic Potential
Transmembrane54 – 7421Helical; Name=2; Potential
Topological domain75 – 9824Extracellular Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 21620Helical; Name=5; Potential
Topological domain217 – 23620Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 27013Extracellular Potential
Transmembrane271 – 29121Helical; Name=7; Potential
Topological domain292 – 31019Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation1641N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 188 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NGG6 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 5035D547E91CDB3F

FASTA31034,372
        10         20         30         40         50         60 
MAAKNSSVTE FILEGLTHQP GLRIPLFFLF LGFYTVTVVG NLGLITLIGL NSHLHTPMYF 

        70         80         90        100        110        120 
FLFNLSLIDF CFSTTITPKM LMSFVSRKNI ISFTGCMTQL FFFCFFVVSE SFILSAMAYD 

       130        140        150        160        170        180 
RYVAICNPLL YTVTMSCQVC LLLLLGAYGM GFAGAMAHTG SIMNLTFCAD NLVNHFMCDI 

       190        200        210        220        230        240 
LPLLELSCNS SYMNELVVFI VVAVDVGMPI VTVFISYALI LSSILHNSST EGRSKAFSTC 

       250        260        270        280        290        300 
SSHIIVVSLF FGSGAFMYLK PLSILPLEQG KVSSLFYTII VPVLNPLIYS LRNKDVKVAL 

       310 
RRTLGRKIFS 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065834 Genomic DNA. Translation: BAC06053.1.
CH471065 Genomic DNA. Translation: EAW67585.1.
BC136863 mRNA. Translation: AAI36864.1.
BC136864 mRNA. Translation: AAI36865.1.
AF399511 Genomic DNA. Translation: AAK94996.1.
BK004494 Genomic DNA. Translation: DAA04892.1.
RefSeqNP_001005195.1. NM_001005195.1.
UniGeneHs.553634.

3D structure databases

ProteinModelPortalQ8NGG6.
SMRQ8NGG6. Positions 21-129, 277-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000307159.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372689.

Proteomic databases

PRIDEQ8NGG6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306842; ENSP00000307159; ENSG00000170953.
GeneID219858.
KEGGhsa:219858.
UCSCuc010sam.2. human.

Organism-specific databases

CTD219858.
GeneCardsGC11M124412.
HGNCHGNC:15307. OR8B12.
neXtProtNX_Q8NGG6.
PharmGKBPA32748.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44152.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGG6.
KOK04257.
OMANSSYMNE.
OrthoDBEOG71K63J.
PhylomeDBQ8NGG6.
TreeFamTF352753.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8NGG6.
CleanExHS_OR8B12.
GenevestigatorQ8NGG6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR8B12.
GenomeRNAi219858.
NextBio90810.
PROQ8NGG6.

Entry information

Entry nameOR8BC_HUMAN
AccessionPrimary (citable) accession number: Q8NGG6
Secondary accession number(s): B2RNF6, Q6IEW8, Q96RC7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries