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Protein

Olfactory receptor 8K1

Gene

OR8K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150261-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8K1
Alternative name(s):
Olfactory receptor OR11-182
Gene namesi
Name:OR8K1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14831. OR8K1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 105ExtracellularSequence analysisAdd BLAST24
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 145CytoplasmicSequence analysisAdd BLAST19
Transmembranei146 – 166Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini167 – 203ExtracellularSequence analysisAdd BLAST37
Transmembranei204 – 223Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini224 – 243CytoplasmicSequence analysisAdd BLAST20
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 277ExtracellularSequence analysisAdd BLAST13
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 319CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150261.
ENSG00000263328.
PharmGKBiPA32775.

Polymorphism and mutation databases

BioMutaiOR8K1.
DMDMi38372688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506711 – 319Olfactory receptor 8K1Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGG5.
PeptideAtlasiQ8NGG5.
PRIDEiQ8NGG5.

Expressioni

Gene expression databases

CleanExiHS_OR8K1.
ExpressionAtlasiQ8NGG5. baseline and differential.

Organism-specific databases

HPAiHPA055233.

Structurei

3D structure databases

ProteinModelPortaliQ8NGG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK5R. Eukaryota.
ENOG4111AZY. LUCA.
GeneTreeiENSGT00810000125371.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG5.
KOiK04257.
OMAiHMEKHNH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGG5.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHVVKHNHT AVTKVTEFIL MGITDNPGLQ APLFGLFLII YLVTVIGNLG
60 70 80 90 100
MVILTYLDSK LHTPMYFFLR HLSITDLGYS TVIAPKMLVN FIVHKNTISY
110 120 130 140 150
NWYATQLAFF EIFIISELFI LSAMAYDRYV AICKPLLYVI IMAEKVLWVL
160 170 180 190 200
VIVPYLYSTF VSLFLTIKLF KLSFCGSNII SYFYCDCIPL MSILCSDTNE
210 220 230 240 250
LELIILIFSG CNLLFSLSIV LISYMFILVA ILRMNSRKGR YKAFSTCSSH
260 270 280 290 300
LTVVIMFYGT LLFIYLQPKS SHTLAIDKMA SVFYTLLIPM LNPLIYSLRN
310
KEVKDALKRT LTNRFKIPI
Length:319
Mass (Da):36,581
Last modified:October 1, 2002 - v1
Checksum:i9CB4F7F94917E9D5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03427021M → V.Corresponds to variant rs10896271dbSNPEnsembl.1
Natural variantiVAR_03427127P → T.Corresponds to variant rs10896272dbSNPEnsembl.1
Natural variantiVAR_03427284A → T.1 PublicationCorresponds to variant rs17614327dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065835 Genomic DNA. Translation: BAC06054.1.
BC146844 mRNA. Translation: AAI46845.1.
AF399517 Genomic DNA. Translation: AAK95002.1.
BK004339 Genomic DNA. Translation: DAA04737.1.
CCDSiCCDS31528.1.
RefSeqiNP_001002907.1. NM_001002907.1.
UniGeneiHs.553748.

Genome annotation databases

EnsembliENST00000279783; ENSP00000279783; ENSG00000150261.
ENST00000574800; ENSP00000461384; ENSG00000263328.
GeneIDi390157.
KEGGihsa:390157.
UCSCiuc010rjg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065835 Genomic DNA. Translation: BAC06054.1.
BC146844 mRNA. Translation: AAI46845.1.
AF399517 Genomic DNA. Translation: AAK95002.1.
BK004339 Genomic DNA. Translation: DAA04737.1.
CCDSiCCDS31528.1.
RefSeqiNP_001002907.1. NM_001002907.1.
UniGeneiHs.553748.

3D structure databases

ProteinModelPortaliQ8NGG5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR8K1.
DMDMi38372688.

Proteomic databases

PaxDbiQ8NGG5.
PeptideAtlasiQ8NGG5.
PRIDEiQ8NGG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279783; ENSP00000279783; ENSG00000150261.
ENST00000574800; ENSP00000461384; ENSG00000263328.
GeneIDi390157.
KEGGihsa:390157.
UCSCiuc010rjg.2. human.

Organism-specific databases

CTDi390157.
GeneCardsiOR8K1.
HGNCiHGNC:14831. OR8K1.
HPAiHPA055233.
neXtProtiNX_Q8NGG5.
OpenTargetsiENSG00000150261.
ENSG00000263328.
PharmGKBiPA32775.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK5R. Eukaryota.
ENOG4111AZY. LUCA.
GeneTreeiENSGT00810000125371.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG5.
KOiK04257.
OMAiHMEKHNH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGG5.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150261-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8K1.
GenomeRNAii390157.
PROiQ8NGG5.

Gene expression databases

CleanExiHS_OR8K1.
ExpressionAtlasiQ8NGG5. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR8K1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG5
Secondary accession number(s): B9EJB1, Q6IFC3, Q96RC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.