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Protein

Olfactory receptor 8H1

Gene

OR8H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8H1
Alternative name(s):
Olfactory receptor OR11-180
Gene namesi
Name:OR8H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14824. OR8H1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9823ExtracellularSequence analysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 23620CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence analysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 31120CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32767.

Polymorphism and mutation databases

BioMutaiOR8H1.
DMDMi38372687.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 8H1PRO_0000150665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGG4.
PRIDEiQ8NGG4.

PTM databases

iPTMnetiQ8NGG4.
PhosphoSiteiQ8NGG4.

Expressioni

Gene expression databases

CleanExiHS_OR8H1.
ExpressionAtlasiQ8NGG4. differential.

Structurei

3D structure databases

ProteinModelPortaliQ8NGG4.
SMRiQ8NGG4. Positions 29-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIPE. Eukaryota.
ENOG4111C57. LUCA.
GeneTreeiENSGT00840000129818.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG4.
KOiK04257.
OMAiGPYVISF.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGG4.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRNNTNVP DFILTGLSDS EEVQMALFIL FLLIYLITML GNVGMILIIR
60 70 80 90 100
LDLQLHTPMY FFLTHLSFID LSYSTVITPK TLANLLTSNY ISFMGCFAQM
110 120 130 140 150
FFFVFLGAAE CFLLSSMAYD RYVAICSPLR YPVIMSKRLC CALVTGPYVI
160 170 180 190 200
SFINSFVNVV WMSRLHFCDS NVVRHFFCDT SPILALSCMD TYDIEIMIHI
210 220 230 240 250
LAGSTLMVSL ITISASYVSI LSTILKINST SGKQKALSTC ASHLLGVTIF
260 270 280 290 300
YGTMIFTYLK PRKSYSLGRD QVASVFYTIV IPMLNPLIYS LRNKEVKNAL
310
IRVMQRRQDS R
Length:311
Mass (Da):35,228
Last modified:October 1, 2002 - v1
Checksum:iB2E5484AE80C2BB2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21G → S.
Corresponds to variant rs11600896 [ dbSNP | Ensembl ].
VAR_053246
Natural varianti22 – 221E → V.
Corresponds to variant rs17540861 [ dbSNP | Ensembl ].
VAR_034261

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065836 Genomic DNA. Translation: BAC06055.1.
CH471076 Genomic DNA. Translation: EAW73707.1.
BC136909 mRNA. Translation: AAI36910.1.
BC136910 mRNA. Translation: AAI36911.1.
BK004337 Genomic DNA. Translation: DAA04735.1.
CCDSiCCDS31526.1.
RefSeqiNP_001005199.1. NM_001005199.1.
UniGeneiHs.553628.

Genome annotation databases

EnsembliENST00000313022; ENSP00000323595; ENSG00000181693.
ENST00000626711; ENSP00000486842; ENSG00000262611.
GeneIDi219469.
KEGGihsa:219469.
UCSCiuc010rje.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065836 Genomic DNA. Translation: BAC06055.1.
CH471076 Genomic DNA. Translation: EAW73707.1.
BC136909 mRNA. Translation: AAI36910.1.
BC136910 mRNA. Translation: AAI36911.1.
BK004337 Genomic DNA. Translation: DAA04735.1.
CCDSiCCDS31526.1.
RefSeqiNP_001005199.1. NM_001005199.1.
UniGeneiHs.553628.

3D structure databases

ProteinModelPortaliQ8NGG4.
SMRiQ8NGG4. Positions 29-159.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGG4.
PhosphoSiteiQ8NGG4.

Polymorphism and mutation databases

BioMutaiOR8H1.
DMDMi38372687.

Proteomic databases

PaxDbiQ8NGG4.
PRIDEiQ8NGG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313022; ENSP00000323595; ENSG00000181693.
ENST00000626711; ENSP00000486842; ENSG00000262611.
GeneIDi219469.
KEGGihsa:219469.
UCSCiuc010rje.3. human.

Organism-specific databases

CTDi219469.
GeneCardsiOR8H1.
HGNCiHGNC:14824. OR8H1.
neXtProtiNX_Q8NGG4.
PharmGKBiPA32767.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIPE. Eukaryota.
ENOG4111C57. LUCA.
GeneTreeiENSGT00840000129818.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG4.
KOiK04257.
OMAiGPYVISF.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGG4.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8H1.
GenomeRNAii219469.
PROiQ8NGG4.

Gene expression databases

CleanExiHS_OR8H1.
ExpressionAtlasiQ8NGG4. differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR8H1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG4
Secondary accession number(s): B2RNI7, Q6IFC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.