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Q8NGG3

- OR5T3_HUMAN

UniProt

Q8NGG3 - OR5T3_HUMAN

Protein

Olfactory receptor 5T3

Gene

OR5T3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 3 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5T3
    Alternative name(s):
    Olfactory receptor OR11-178
    Gene namesi
    Name:OR5T3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15297. OR5T3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32568.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Olfactory receptor 5T3PRO_0000150615Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi127 ↔ 219PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGG3.
    PRIDEiQ8NGG3.

    PTM databases

    PhosphoSiteiQ8NGG3.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5T3.
    GenevestigatoriQ8NGG3.

    Organism-specific databases

    HPAiHPA044986.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000305403.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGG3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 848CytoplasmicSequence Analysis
    Topological domaini106 – 12924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini151 – 16919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 22636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini289 – 30113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini323 – 34018CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 7621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40304.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGG3.
    KOiK04257.
    OMAiILFIYMR.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGG3.
    TreeFamiTF352753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGG3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSTFTGYNL YNLQVKTEMD KLSSGLDIYR NPLKNKTEVT MFILTGFTDD    50
    FELQVFLFLL FFAIYLFTLI GNLGLVVLVI EDSWLHNPMY YFLSVLSFLD 100
    ACYSTVVTPK MLVNFLAKNK SISFIGCATQ MLLFVTFGTT ECFLLAAMAY 150
    DHYVAIYNPL LYSVSMSPRV YVPLITASYV AGILHATIHI VATFSLSFCG 200
    SNEIRHVFCD MPPLLAISCS DTHTNQLLLF YFVGSIEIVT ILIVLISCDF 250
    ILLSILKMHS AKGRQKAFST CGSHLTGVTI YHGTILVSYM RPSSSYASDH 300
    DIIVSIFYTI VIPKLNPIIY SLRNKEVKKA VKKMLKLVYK 340
    Length:340
    Mass (Da):38,346
    Last modified:December 16, 2008 - v3
    Checksum:iC2CD1CC3A28FB246
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti84 – 841W → G.
    Corresponds to variant rs17150243 [ dbSNP | Ensembl ].
    VAR_047836

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065837 Genomic DNA. Translation: BAC06056.1.
    AC022882 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73705.1.
    BK004335 Genomic DNA. Translation: DAA04733.1.
    CCDSiCCDS31524.1.
    RefSeqiNP_001004747.1. NM_001004747.1.
    UniGeneiHs.553746.

    Genome annotation databases

    EnsembliENST00000303059; ENSP00000305403; ENSG00000172489.
    GeneIDi390154.
    KEGGihsa:390154.
    UCSCiuc010rjd.2. human.

    Polymorphism databases

    DMDMi218512125.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065837 Genomic DNA. Translation: BAC06056.1 .
    AC022882 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73705.1 .
    BK004335 Genomic DNA. Translation: DAA04733.1 .
    CCDSi CCDS31524.1.
    RefSeqi NP_001004747.1. NM_001004747.1.
    UniGenei Hs.553746.

    3D structure databases

    ProteinModelPortali Q8NGG3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000305403.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGG3.

    Polymorphism databases

    DMDMi 218512125.

    Proteomic databases

    PaxDbi Q8NGG3.
    PRIDEi Q8NGG3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303059 ; ENSP00000305403 ; ENSG00000172489 .
    GeneIDi 390154.
    KEGGi hsa:390154.
    UCSCi uc010rjd.2. human.

    Organism-specific databases

    CTDi 390154.
    GeneCardsi GC11P056015.
    HGNCi HGNC:15297. OR5T3.
    HPAi HPA044986.
    neXtProti NX_Q8NGG3.
    PharmGKBi PA32568.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40304.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGG3.
    KOi K04257.
    OMAi ILFIYMR.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGG3.
    TreeFami TF352753.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5T3.
    NextBioi 103453.
    PROi Q8NGG3.

    Gene expression databases

    CleanExi HS_OR5T3.
    Genevestigatori Q8NGG3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR5T3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGG3
    Secondary accession number(s): Q6IFC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 108 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-19 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3