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Q8NGG3

- OR5T3_HUMAN

UniProt

Q8NGG3 - OR5T3_HUMAN

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Protein

Olfactory receptor 5T3

Gene

OR5T3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5T3
Alternative name(s):
Olfactory receptor OR11-178
Gene namesi
Name:OR5T3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15297. OR5T3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32568.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Olfactory receptor 5T3PRO_0000150615Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi127 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGG3.
PRIDEiQ8NGG3.

PTM databases

PhosphoSiteiQ8NGG3.

Expressioni

Gene expression databases

CleanExiHS_OR5T3.
GenevestigatoriQ8NGG3.

Organism-specific databases

HPAiHPA044986.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305403.

Structurei

3D structure databases

ProteinModelPortaliQ8NGG3.
SMRiQ8NGG3. Positions 139-170.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
BLAST
Topological domaini77 – 848CytoplasmicSequence Analysis
Topological domaini106 – 12924ExtracellularSequence AnalysisAdd
BLAST
Topological domaini151 – 16919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini191 – 22636ExtracellularSequence AnalysisAdd
BLAST
Topological domaini248 – 26720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini289 – 30113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini323 – 34018CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei130 – 15021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40304.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG3.
KOiK04257.
OMAiILFIYMR.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGG3.
TreeFamiTF352753.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGG3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSTFTGYNL YNLQVKTEMD KLSSGLDIYR NPLKNKTEVT MFILTGFTDD
60 70 80 90 100
FELQVFLFLL FFAIYLFTLI GNLGLVVLVI EDSWLHNPMY YFLSVLSFLD
110 120 130 140 150
ACYSTVVTPK MLVNFLAKNK SISFIGCATQ MLLFVTFGTT ECFLLAAMAY
160 170 180 190 200
DHYVAIYNPL LYSVSMSPRV YVPLITASYV AGILHATIHI VATFSLSFCG
210 220 230 240 250
SNEIRHVFCD MPPLLAISCS DTHTNQLLLF YFVGSIEIVT ILIVLISCDF
260 270 280 290 300
ILLSILKMHS AKGRQKAFST CGSHLTGVTI YHGTILVSYM RPSSSYASDH
310 320 330 340
DIIVSIFYTI VIPKLNPIIY SLRNKEVKKA VKKMLKLVYK
Length:340
Mass (Da):38,346
Last modified:December 16, 2008 - v3
Checksum:iC2CD1CC3A28FB246
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841W → G.
Corresponds to variant rs17150243 [ dbSNP | Ensembl ].
VAR_047836

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065837 Genomic DNA. Translation: BAC06056.1.
AC022882 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73705.1.
BK004335 Genomic DNA. Translation: DAA04733.1.
CCDSiCCDS31524.1.
RefSeqiNP_001004747.1. NM_001004747.1.
UniGeneiHs.553746.

Genome annotation databases

EnsembliENST00000303059; ENSP00000305403; ENSG00000172489.
GeneIDi390154.
KEGGihsa:390154.
UCSCiuc010rjd.2. human.

Polymorphism databases

DMDMi218512125.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065837 Genomic DNA. Translation: BAC06056.1 .
AC022882 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73705.1 .
BK004335 Genomic DNA. Translation: DAA04733.1 .
CCDSi CCDS31524.1.
RefSeqi NP_001004747.1. NM_001004747.1.
UniGenei Hs.553746.

3D structure databases

ProteinModelPortali Q8NGG3.
SMRi Q8NGG3. Positions 139-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000305403.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGG3.

Polymorphism databases

DMDMi 218512125.

Proteomic databases

PaxDbi Q8NGG3.
PRIDEi Q8NGG3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303059 ; ENSP00000305403 ; ENSG00000172489 .
GeneIDi 390154.
KEGGi hsa:390154.
UCSCi uc010rjd.2. human.

Organism-specific databases

CTDi 390154.
GeneCardsi GC11P056015.
HGNCi HGNC:15297. OR5T3.
HPAi HPA044986.
neXtProti NX_Q8NGG3.
PharmGKBi PA32568.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40304.
GeneTreei ENSGT00760000118942.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGG3.
KOi K04257.
OMAi ILFIYMR.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGG3.
TreeFami TF352753.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR5T3.
GenomeRNAii 390154.
NextBioi 103453.
PROi Q8NGG3.

Gene expression databases

CleanExi HS_OR5T3.
Genevestigatori Q8NGG3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5T3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG3
Secondary accession number(s): Q6IFC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-19 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3