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Q8NGG3 (OR5T3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5T3
Alternative name(s):
Olfactory receptor OR11-178
Gene names
Name:OR5T3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-19 is the initiator.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Olfactory receptor 5T3
PRO_0000150615

Regions

Topological domain1 – 5555Extracellular Potential
Transmembrane56 – 7621Helical; Name=1; Potential
Topological domain77 – 848Cytoplasmic Potential
Transmembrane85 – 10521Helical; Name=2; Potential
Topological domain106 – 12924Extracellular Potential
Transmembrane130 – 15021Helical; Name=3; Potential
Topological domain151 – 16919Cytoplasmic Potential
Transmembrane170 – 19021Helical; Name=4; Potential
Topological domain191 – 22636Extracellular Potential
Transmembrane227 – 24721Helical; Name=5; Potential
Topological domain248 – 26720Cytoplasmic Potential
Transmembrane268 – 28821Helical; Name=6; Potential
Topological domain289 – 30113Extracellular Potential
Transmembrane302 – 32221Helical; Name=7; Potential
Topological domain323 – 34018Cytoplasmic Potential

Amino acid modifications

Glycosylation351N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential
Disulfide bond127 ↔ 219 By similarity

Natural variations

Natural variant841W → G.
Corresponds to variant rs17150243 [ dbSNP | Ensembl ].
VAR_047836

Sequences

Sequence LengthMass (Da)Tools
Q8NGG3 [UniParc].

Last modified December 16, 2008. Version 3.
Checksum: C2CD1CC3A28FB246

FASTA34038,346
        10         20         30         40         50         60 
MDSTFTGYNL YNLQVKTEMD KLSSGLDIYR NPLKNKTEVT MFILTGFTDD FELQVFLFLL 

        70         80         90        100        110        120 
FFAIYLFTLI GNLGLVVLVI EDSWLHNPMY YFLSVLSFLD ACYSTVVTPK MLVNFLAKNK 

       130        140        150        160        170        180 
SISFIGCATQ MLLFVTFGTT ECFLLAAMAY DHYVAIYNPL LYSVSMSPRV YVPLITASYV 

       190        200        210        220        230        240 
AGILHATIHI VATFSLSFCG SNEIRHVFCD MPPLLAISCS DTHTNQLLLF YFVGSIEIVT 

       250        260        270        280        290        300 
ILIVLISCDF ILLSILKMHS AKGRQKAFST CGSHLTGVTI YHGTILVSYM RPSSSYASDH 

       310        320        330        340 
DIIVSIFYTI VIPKLNPIIY SLRNKEVKKA VKKMLKLVYK 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065837 Genomic DNA. Translation: BAC06056.1.
AC022882 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73705.1.
BK004335 Genomic DNA. Translation: DAA04733.1.
RefSeqNP_001004747.1. NM_001004747.1.
UniGeneHs.553746.

3D structure databases

ProteinModelPortalQ8NGG3.
SMRQ8NGG3. Positions 139-170, 308-338.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000305403.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGG3.

Polymorphism databases

DMDM218512125.

Proteomic databases

PaxDbQ8NGG3.
PRIDEQ8NGG3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303059; ENSP00000305403; ENSG00000172489.
ENST00000575738; ENSP00000459586; ENSG00000261897.
GeneID390154.
KEGGhsa:390154.
UCSCuc010rjd.2. human.

Organism-specific databases

CTD390154.
GeneCardsGC11P056015.
HGNCHGNC:15297. OR5T3.
HPAHPA044986.
neXtProtNX_Q8NGG3.
PharmGKBPA32568.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40304.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGG3.
KOK04257.
OMAILFIYMR.
OrthoDBEOG71K63J.
PhylomeDBQ8NGG3.
TreeFamTF352753.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5T3.
GenevestigatorQ8NGG3.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR5T3.
NextBio103453.
PROQ8NGG3.

Entry information

Entry nameOR5T3_HUMAN
AccessionPrimary (citable) accession number: Q8NGG3
Secondary accession number(s): Q6IFC7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries