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Protein

Olfactory receptor 5T3

Gene

OR5T3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172489-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5T3
Alternative name(s):
Olfactory receptor OR11-178
Gene namesi
Name:OR5T3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15297. OR5T3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55ExtracellularSequence analysisAdd BLAST55
Transmembranei56 – 76Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini77 – 84CytoplasmicSequence analysis8
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini106 – 129ExtracellularSequence analysisAdd BLAST24
Transmembranei130 – 150Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini151 – 169CytoplasmicSequence analysisAdd BLAST19
Transmembranei170 – 190Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini191 – 226ExtracellularSequence analysisAdd BLAST36
Transmembranei227 – 247Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini248 – 267CytoplasmicSequence analysisAdd BLAST20
Transmembranei268 – 288Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini289 – 301ExtracellularSequence analysisAdd BLAST13
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 340CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172489.
ENSG00000261897.
PharmGKBiPA32568.

Polymorphism and mutation databases

BioMutaiOR5T3.
DMDMi218512125.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506151 – 340Olfactory receptor 5T3Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...)Sequence analysis1
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi127 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGG3.
PeptideAtlasiQ8NGG3.
PRIDEiQ8NGG3.

PTM databases

iPTMnetiQ8NGG3.
PhosphoSitePlusiQ8NGG3.

Expressioni

Gene expression databases

CleanExiHS_OR5T3.

Organism-specific databases

HPAiHPA044986.

Structurei

3D structure databases

ProteinModelPortaliQ8NGG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410III0. Eukaryota.
ENOG4111ADU. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG3.
KOiK04257.
OMAiEMPGFPS.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGG3.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTFTGYNL YNLQVKTEMD KLSSGLDIYR NPLKNKTEVT MFILTGFTDD
60 70 80 90 100
FELQVFLFLL FFAIYLFTLI GNLGLVVLVI EDSWLHNPMY YFLSVLSFLD
110 120 130 140 150
ACYSTVVTPK MLVNFLAKNK SISFIGCATQ MLLFVTFGTT ECFLLAAMAY
160 170 180 190 200
DHYVAIYNPL LYSVSMSPRV YVPLITASYV AGILHATIHI VATFSLSFCG
210 220 230 240 250
SNEIRHVFCD MPPLLAISCS DTHTNQLLLF YFVGSIEIVT ILIVLISCDF
260 270 280 290 300
ILLSILKMHS AKGRQKAFST CGSHLTGVTI YHGTILVSYM RPSSSYASDH
310 320 330 340
DIIVSIFYTI VIPKLNPIIY SLRNKEVKKA VKKMLKLVYK
Length:340
Mass (Da):38,346
Last modified:December 16, 2008 - v3
Checksum:iC2CD1CC3A28FB246
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04783684W → G.Corresponds to variant rs17150243dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065837 Genomic DNA. Translation: BAC06056.1.
AC022882 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73705.1.
BK004335 Genomic DNA. Translation: DAA04733.1.
CCDSiCCDS31524.1.
RefSeqiNP_001004747.1. NM_001004747.1.
UniGeneiHs.553746.

Genome annotation databases

EnsembliENST00000303059; ENSP00000305403; ENSG00000172489.
ENST00000575738; ENSP00000459586; ENSG00000261897.
GeneIDi390154.
KEGGihsa:390154.
UCSCiuc010rjd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065837 Genomic DNA. Translation: BAC06056.1.
AC022882 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73705.1.
BK004335 Genomic DNA. Translation: DAA04733.1.
CCDSiCCDS31524.1.
RefSeqiNP_001004747.1. NM_001004747.1.
UniGeneiHs.553746.

3D structure databases

ProteinModelPortaliQ8NGG3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGG3.
PhosphoSitePlusiQ8NGG3.

Polymorphism and mutation databases

BioMutaiOR5T3.
DMDMi218512125.

Proteomic databases

PaxDbiQ8NGG3.
PeptideAtlasiQ8NGG3.
PRIDEiQ8NGG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303059; ENSP00000305403; ENSG00000172489.
ENST00000575738; ENSP00000459586; ENSG00000261897.
GeneIDi390154.
KEGGihsa:390154.
UCSCiuc010rjd.2. human.

Organism-specific databases

CTDi390154.
GeneCardsiOR5T3.
HGNCiHGNC:15297. OR5T3.
HPAiHPA044986.
neXtProtiNX_Q8NGG3.
OpenTargetsiENSG00000172489.
ENSG00000261897.
PharmGKBiPA32568.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410III0. Eukaryota.
ENOG4111ADU. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG3.
KOiK04257.
OMAiEMPGFPS.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGG3.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172489-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5T3.
GenomeRNAii390154.
PROiQ8NGG3.

Gene expression databases

CleanExiHS_OR5T3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5T3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG3
Secondary accession number(s): Q6IFC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: November 2, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-19 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.