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Protein

Olfactory receptor 5T2

Gene

OR5T2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5T2
Alternative name(s):
Olfactory receptor OR11-177
Gene namesi
Name:OR5T2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15296. OR5T2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464ExtracellularSequence analysisAdd
BLAST
Transmembranei65 – 8521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini86 – 938CytoplasmicSequence analysis
Transmembranei94 – 11421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini115 – 13824ExtracellularSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini160 – 17819CytoplasmicSequence analysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini200 – 23536ExtracellularSequence analysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini257 – 27620CytoplasmicSequence analysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini298 – 31013ExtracellularSequence analysisAdd
BLAST
Transmembranei311 – 33121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini332 – 35928CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32567.

Polymorphism and mutation databases

BioMutaiOR5T2.
DMDMi223590250.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Olfactory receptor 5T2PRO_0000150614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGG2.
PeptideAtlasiQ8NGG2.
PRIDEiQ8NGG2.

PTM databases

iPTMnetiQ8NGG2.
PhosphoSiteiQ8NGG2.

Expressioni

Gene expression databases

CleanExiHS_OR5T2.

Structurei

3D structure databases

ProteinModelPortaliQ8NGG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410III0. Eukaryota.
ENOG4111ADU. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG2.
KOiK04257.
OMAiFLACSFG.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGG2.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSIYKSTV NIPLSHGVVH SFCHNMNCNF MHIFKFVLDF NMKNVTEVTL
60 70 80 90 100
FVLKGFTDNL ELQTIFFFLF LAIYLFTLMG NLGLILVVIR DSQLHKPMYY
110 120 130 140 150
FLSMLSSVDA CYSSVITPNM LVDFTTKNKV ISFLGCVAQV FLACSFGTTE
160 170 180 190 200
CFLLAAMAYD RYVAIYNPLL YSVSMSPRVY MPLINASYVA GILHATIHTV
210 220 230 240 250
ATFSLSFCGA NEIRRVFCDI PPLLAISYSD THTNQLLLFY FVGSIELVTI
260 270 280 290 300
LIVLISYGLI LLAILKMYSA EGRRKVFSTC GAHLTGVSIY YGTILFMYVR
310 320 330 340 350
PSSSYASDHD MIVSIFYTIV IPLLNPVIYS LRNKDVKDSM KKMFGKNQVI

NKVYFHTKK
Length:359
Mass (Da):40,696
Last modified:February 10, 2009 - v3
Checksum:i5A89383A21841F73
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211S → Y.
Corresponds to variant rs3919907 [ dbSNP | Ensembl ].
VAR_054349
Natural varianti64 – 641T → I.
Corresponds to variant rs11227599 [ dbSNP | Ensembl ].
VAR_054350
Natural varianti87 – 871V → L.1 Publication
Corresponds to variant rs10791893 [ dbSNP | Ensembl ].
VAR_054351
Natural varianti125 – 1251T → M.
Corresponds to variant rs7122514 [ dbSNP | Ensembl ].
VAR_054352
Natural varianti238 – 2381L → V.
Corresponds to variant rs12221615 [ dbSNP | Ensembl ].
VAR_054353
Natural varianti309 – 3091H → D.
Corresponds to variant rs7121880 [ dbSNP | Ensembl ].
VAR_054354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065838 Genomic DNA. Translation: BAC06057.1.
AC022882 Genomic DNA. No translation available.
BC136876 mRNA. Translation: AAI36877.1.
BK004334 Genomic DNA. Translation: DAA04732.1.
CCDSiCCDS31523.1.
RefSeqiNP_001004746.1. NM_001004746.1.
UniGeneiHs.553627.

Genome annotation databases

EnsembliENST00000313264; ENSP00000323688; ENSG00000181718.
ENST00000573647; ENSP00000460931; ENSG00000262851.
GeneIDi219464.
KEGGihsa:219464.
UCSCiuc010rjc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065838 Genomic DNA. Translation: BAC06057.1.
AC022882 Genomic DNA. No translation available.
BC136876 mRNA. Translation: AAI36877.1.
BK004334 Genomic DNA. Translation: DAA04732.1.
CCDSiCCDS31523.1.
RefSeqiNP_001004746.1. NM_001004746.1.
UniGeneiHs.553627.

3D structure databases

ProteinModelPortaliQ8NGG2.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGG2.
PhosphoSiteiQ8NGG2.

Polymorphism and mutation databases

BioMutaiOR5T2.
DMDMi223590250.

Proteomic databases

PaxDbiQ8NGG2.
PeptideAtlasiQ8NGG2.
PRIDEiQ8NGG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313264; ENSP00000323688; ENSG00000181718.
ENST00000573647; ENSP00000460931; ENSG00000262851.
GeneIDi219464.
KEGGihsa:219464.
UCSCiuc010rjc.2. human.

Organism-specific databases

CTDi219464.
GeneCardsiOR5T2.
HGNCiHGNC:15296. OR5T2.
neXtProtiNX_Q8NGG2.
PharmGKBiPA32567.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410III0. Eukaryota.
ENOG4111ADU. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG2.
KOiK04257.
OMAiFLACSFG.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGG2.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5T2.
GenomeRNAii219464.
PROiQ8NGG2.

Gene expression databases

CleanExiHS_OR5T2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5T2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG2
Secondary accession number(s): B9EGX5, Q6IFC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: September 7, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-31 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.