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Q8NGG0

- OR8J3_HUMAN

UniProt

Q8NGG0 - OR8J3_HUMAN

Protein

Olfactory receptor 8J3

Gene

OR8J3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 8J3
    Alternative name(s):
    Olfactory receptor OR11-173
    Gene namesi
    Name:OR8J3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15312. OR8J3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32774.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Olfactory receptor 8J3PRO_0000150670Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGG0.
    PRIDEiQ8NGG0.

    PTM databases

    PhosphoSiteiQ8NGG0.

    Expressioni

    Gene expression databases

    CleanExiHS_OR8J3.
    GenevestigatoriQ8NGG0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000301529.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGG0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31523CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40548.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGG0.
    KOiK04257.
    OMAiIVVSPCI.
    OrthoDBiEOG783MVW.
    PhylomeDBiQ8NGG0.
    TreeFamiTF352753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGG0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPENFTRVT EFILTGVSSC PELQIPLFLV FLVLYVLTMA GNLGIITLTS    50
    VDSRLQNPMY FFLRHLAIIN LGNSTVIAPK MLMNFLVKKK TTSFYECATQ 100
    LGGFLFFIVS EVMMLAVMAY DRYVAICNPL LYMVVVSRRL CLLLVSLTYL 150
    YGFSTAIVVS PCIFSVSYCS SNIINHFYCD IAPLLALSCS DTYIPETIVF 200
    ISAATNLVFS MITVLVSYFN IVLSILRIRS PEGRKKAFST CASHMIAVTV 250
    FYGTMLFMYL QPQTNHSLDT DKMASVFYTL VIPMLNPLIY SLRNNDVNVA 300
    LKKFMENPCY SFKSM 315
    Length:315
    Mass (Da):35,481
    Last modified:October 1, 2002 - v1
    Checksum:iEBC2E1724FCC4D2E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571N → T.
    Corresponds to variant rs1947924 [ dbSNP | Ensembl ].
    VAR_048052
    Natural varianti87 – 871V → I.
    Corresponds to variant rs7937461 [ dbSNP | Ensembl ].
    VAR_048053
    Natural varianti208 – 2081V → F.1 Publication
    Corresponds to variant rs1384094 [ dbSNP | Ensembl ].
    VAR_048054
    Natural varianti271 – 2711D → E.
    Corresponds to variant rs17150102 [ dbSNP | Ensembl ].
    VAR_048055

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065841 Genomic DNA. Translation: BAC06060.1.
    AF399516 Genomic DNA. Translation: AAK95001.1.
    BK004346 Genomic DNA. Translation: DAA04744.1.
    CCDSiCCDS31520.1.
    RefSeqiNP_001004064.1. NM_001004064.1.
    UniGeneiHs.554523.

    Genome annotation databases

    EnsembliENST00000301529; ENSP00000301529; ENSG00000167822.
    GeneIDi81168.
    KEGGihsa:81168.
    UCSCiuc010riz.2. human.

    Polymorphism databases

    DMDMi38372684.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065841 Genomic DNA. Translation: BAC06060.1 .
    AF399516 Genomic DNA. Translation: AAK95001.1 .
    BK004346 Genomic DNA. Translation: DAA04744.1 .
    CCDSi CCDS31520.1.
    RefSeqi NP_001004064.1. NM_001004064.1.
    UniGenei Hs.554523.

    3D structure databases

    ProteinModelPortali Q8NGG0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000301529.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGG0.

    Polymorphism databases

    DMDMi 38372684.

    Proteomic databases

    PaxDbi Q8NGG0.
    PRIDEi Q8NGG0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301529 ; ENSP00000301529 ; ENSG00000167822 .
    GeneIDi 81168.
    KEGGi hsa:81168.
    UCSCi uc010riz.2. human.

    Organism-specific databases

    CTDi 81168.
    GeneCardsi GC11M055904.
    HGNCi HGNC:15312. OR8J3.
    neXtProti NX_Q8NGG0.
    PharmGKBi PA32774.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40548.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGG0.
    KOi K04257.
    OMAi IVVSPCI.
    OrthoDBi EOG783MVW.
    PhylomeDBi Q8NGG0.
    TreeFami TF352753.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR8J3.
    GenomeRNAii 81168.
    NextBioi 71462.
    PROi Q8NGG0.

    Gene expression databases

    CleanExi HS_OR8J3.
    Genevestigatori Q8NGG0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, VARIANT PHE-208.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR8J3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGG0
    Secondary accession number(s): Q6IFB6, Q96RC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3