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Protein

Olfactory receptor 8J3

Gene

OR8J3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167822-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8J3
Alternative name(s):
Olfactory receptor OR11-173
Gene namesi
Name:OR8J3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15312. OR8J3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 315CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167822.
PharmGKBiPA32774.

Polymorphism and mutation databases

BioMutaiOR8J3.
DMDMi38372684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506701 – 315Olfactory receptor 8J3Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGG0.
PRIDEiQ8NGG0.

PTM databases

iPTMnetiQ8NGG0.
PhosphoSitePlusiQ8NGG0.

Expressioni

Gene expression databases

CleanExiHS_OR8J3.
ExpressionAtlasiQ8NGG0. differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301529.

Structurei

3D structure databases

ProteinModelPortaliQ8NGG0.
SMRiQ8NGG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF11. Eukaryota.
ENOG411183X. LUCA.
GeneTreeiENSGT00810000125371.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG0.
KOiK04257.
OMAiYGTMLFM.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGG0.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPENFTRVT EFILTGVSSC PELQIPLFLV FLVLYVLTMA GNLGIITLTS
60 70 80 90 100
VDSRLQNPMY FFLRHLAIIN LGNSTVIAPK MLMNFLVKKK TTSFYECATQ
110 120 130 140 150
LGGFLFFIVS EVMMLAVMAY DRYVAICNPL LYMVVVSRRL CLLLVSLTYL
160 170 180 190 200
YGFSTAIVVS PCIFSVSYCS SNIINHFYCD IAPLLALSCS DTYIPETIVF
210 220 230 240 250
ISAATNLVFS MITVLVSYFN IVLSILRIRS PEGRKKAFST CASHMIAVTV
260 270 280 290 300
FYGTMLFMYL QPQTNHSLDT DKMASVFYTL VIPMLNPLIY SLRNNDVNVA
310
LKKFMENPCY SFKSM
Length:315
Mass (Da):35,481
Last modified:October 1, 2002 - v1
Checksum:iEBC2E1724FCC4D2E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04805257N → T.Corresponds to variant rs1947924dbSNPEnsembl.1
Natural variantiVAR_04805387V → I.Corresponds to variant rs7937461dbSNPEnsembl.1
Natural variantiVAR_048054208V → F.1 PublicationCorresponds to variant rs1384094dbSNPEnsembl.1
Natural variantiVAR_048055271D → E.Corresponds to variant rs17150102dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065841 Genomic DNA. Translation: BAC06060.1.
AF399516 Genomic DNA. Translation: AAK95001.1.
BK004346 Genomic DNA. Translation: DAA04744.1.
CCDSiCCDS31520.1.
RefSeqiNP_001004064.1. NM_001004064.1.
UniGeneiHs.554523.

Genome annotation databases

EnsembliENST00000301529; ENSP00000301529; ENSG00000167822.
GeneIDi81168.
KEGGihsa:81168.
UCSCiuc010riz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065841 Genomic DNA. Translation: BAC06060.1.
AF399516 Genomic DNA. Translation: AAK95001.1.
BK004346 Genomic DNA. Translation: DAA04744.1.
CCDSiCCDS31520.1.
RefSeqiNP_001004064.1. NM_001004064.1.
UniGeneiHs.554523.

3D structure databases

ProteinModelPortaliQ8NGG0.
SMRiQ8NGG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301529.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGG0.
PhosphoSitePlusiQ8NGG0.

Polymorphism and mutation databases

BioMutaiOR8J3.
DMDMi38372684.

Proteomic databases

PaxDbiQ8NGG0.
PRIDEiQ8NGG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301529; ENSP00000301529; ENSG00000167822.
GeneIDi81168.
KEGGihsa:81168.
UCSCiuc010riz.2. human.

Organism-specific databases

CTDi81168.
GeneCardsiOR8J3.
HGNCiHGNC:15312. OR8J3.
neXtProtiNX_Q8NGG0.
OpenTargetsiENSG00000167822.
PharmGKBiPA32774.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF11. Eukaryota.
ENOG411183X. LUCA.
GeneTreeiENSGT00810000125371.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG0.
KOiK04257.
OMAiYGTMLFM.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGG0.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167822-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8J3.
GenomeRNAii81168.
PROiQ8NGG0.

Gene expression databases

CleanExiHS_OR8J3.
ExpressionAtlasiQ8NGG0. differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR8J3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG0
Secondary accession number(s): Q6IFB6, Q96RC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.