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Q8NGG0

- OR8J3_HUMAN

UniProt

Q8NGG0 - OR8J3_HUMAN

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Protein

Olfactory receptor 8J3

Gene

OR8J3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8J3
Alternative name(s):
Olfactory receptor OR11-173
Gene namesi
Name:OR8J3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15312. OR8J3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31523CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32774.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 8J3PRO_0000150670Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGG0.
PRIDEiQ8NGG0.

PTM databases

PhosphoSiteiQ8NGG0.

Expressioni

Gene expression databases

CleanExiHS_OR8J3.
GenevestigatoriQ8NGG0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301529.

Structurei

3D structure databases

ProteinModelPortaliQ8NGG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40548.
GeneTreeiENSGT00760000118826.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGG0.
KOiK04257.
OMAiIVVSPCI.
OrthoDBiEOG783MVW.
PhylomeDBiQ8NGG0.
TreeFamiTF352753.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPENFTRVT EFILTGVSSC PELQIPLFLV FLVLYVLTMA GNLGIITLTS
60 70 80 90 100
VDSRLQNPMY FFLRHLAIIN LGNSTVIAPK MLMNFLVKKK TTSFYECATQ
110 120 130 140 150
LGGFLFFIVS EVMMLAVMAY DRYVAICNPL LYMVVVSRRL CLLLVSLTYL
160 170 180 190 200
YGFSTAIVVS PCIFSVSYCS SNIINHFYCD IAPLLALSCS DTYIPETIVF
210 220 230 240 250
ISAATNLVFS MITVLVSYFN IVLSILRIRS PEGRKKAFST CASHMIAVTV
260 270 280 290 300
FYGTMLFMYL QPQTNHSLDT DKMASVFYTL VIPMLNPLIY SLRNNDVNVA
310
LKKFMENPCY SFKSM
Length:315
Mass (Da):35,481
Last modified:October 1, 2002 - v1
Checksum:iEBC2E1724FCC4D2E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571N → T.
Corresponds to variant rs1947924 [ dbSNP | Ensembl ].
VAR_048052
Natural varianti87 – 871V → I.
Corresponds to variant rs7937461 [ dbSNP | Ensembl ].
VAR_048053
Natural varianti208 – 2081V → F.1 Publication
Corresponds to variant rs1384094 [ dbSNP | Ensembl ].
VAR_048054
Natural varianti271 – 2711D → E.
Corresponds to variant rs17150102 [ dbSNP | Ensembl ].
VAR_048055

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065841 Genomic DNA. Translation: BAC06060.1.
AF399516 Genomic DNA. Translation: AAK95001.1.
BK004346 Genomic DNA. Translation: DAA04744.1.
CCDSiCCDS31520.1.
RefSeqiNP_001004064.1. NM_001004064.1.
UniGeneiHs.554523.

Genome annotation databases

EnsembliENST00000301529; ENSP00000301529; ENSG00000167822.
GeneIDi81168.
KEGGihsa:81168.
UCSCiuc010riz.2. human.

Polymorphism databases

DMDMi38372684.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065841 Genomic DNA. Translation: BAC06060.1 .
AF399516 Genomic DNA. Translation: AAK95001.1 .
BK004346 Genomic DNA. Translation: DAA04744.1 .
CCDSi CCDS31520.1.
RefSeqi NP_001004064.1. NM_001004064.1.
UniGenei Hs.554523.

3D structure databases

ProteinModelPortali Q8NGG0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000301529.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGG0.

Polymorphism databases

DMDMi 38372684.

Proteomic databases

PaxDbi Q8NGG0.
PRIDEi Q8NGG0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301529 ; ENSP00000301529 ; ENSG00000167822 .
GeneIDi 81168.
KEGGi hsa:81168.
UCSCi uc010riz.2. human.

Organism-specific databases

CTDi 81168.
GeneCardsi GC11M055904.
HGNCi HGNC:15312. OR8J3.
neXtProti NX_Q8NGG0.
PharmGKBi PA32774.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40548.
GeneTreei ENSGT00760000118826.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGG0.
KOi K04257.
OMAi IVVSPCI.
OrthoDBi EOG783MVW.
PhylomeDBi Q8NGG0.
TreeFami TF352753.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR8J3.
GenomeRNAii 81168.
NextBioi 71462.
PROi Q8NGG0.

Gene expression databases

CleanExi HS_OR8J3.
Genevestigatori Q8NGG0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, VARIANT PHE-208.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR8J3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG0
Secondary accession number(s): Q6IFB6, Q96RC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3