Q8NGG0 (OR8J3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 8J3

Alternative name(s):
Olfactory receptor OR11-173

Gene names

Name:

OR8J3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Olfactory receptor 8J3		PRO_0000150670
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 217	20	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 315	23	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	265	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	57	1	N → T. Corresponds to variant rs1947924 [ dbSNP | Ensembl ].		VAR_048052
	Natural variant	87	1	V → I. Corresponds to variant rs7937461 [ dbSNP | Ensembl ].		VAR_048053
	Natural variant	208	1	V → F. Ref.2 Corresponds to variant rs1384094 [ dbSNP | Ensembl ].		VAR_048054
	Natural variant	271	1	D → E. Corresponds to variant rs17150102 [ dbSNP | Ensembl ].		VAR_048055

Sequences

	Sequence		Length	Mass (Da)
	Q8NGG0 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: EBC2E1724FCC4D2E	FASTA	315	35,481
	10 20 30 40 50 60 MAPENFTRVT EFILTGVSSC PELQIPLFLV FLVLYVLTMA GNLGIITLTS VDSRLQNPMY 70 80 90 100 110 120 FFLRHLAIIN LGNSTVIAPK MLMNFLVKKK TTSFYECATQ LGGFLFFIVS EVMMLAVMAY 130 140 150 160 170 180 DRYVAICNPL LYMVVVSRRL CLLLVSLTYL YGFSTAIVVS PCIFSVSYCS SNIINHFYCD 190 200 210 220 230 240 IAPLLALSCS DTYIPETIVF ISAATNLVFS MITVLVSYFN IVLSILRIRS PEGRKKAFST 250 260 270 280 290 300 CASHMIAVTV FYGTMLFMYL QPQTNHSLDT DKMASVFYTL VIPMLNPLIY SLRNNDVNVA 310 LKKFMENPCY SFKSM

References

[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, VARIANT PHE-208.
[3]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065841 Genomic DNA. Translation: BAC06060.1. AF399516 Genomic DNA. Translation: AAK95001.1. BK004346 Genomic DNA. Translation: DAA04744.1.
IPI	IPI00169005.
RefSeq	NP_001004064.1. NM_001004064.1.
UniGene	Hs.554523.
3D structure databases
ProteinModelPortal	Q8NGG0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000301529.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NGG0.
Polymorphism databases
DMDM	38372684.
Proteomic databases
PaxDb	Q8NGG0.
PRIDE	Q8NGG0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301529; ENSP00000301529; ENSG00000167822.
GeneID	81168.
KEGG	hsa:81168.
UCSC	uc010riz.2. human.
Organism-specific databases
CTD	81168.
GeneCards	GC11M055904.
HGNC	HGNC:15312. OR8J3.
neXtProt	NX_Q8NGG0.
PharmGKB	PA32774.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40548.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q8NGG0.
KO	K04257.
OMA	MITVLVS.
OrthoDB	EOG4X3H21.
PhylomeDB	Q8NGG0.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR8J3.
Genevestigator	Q8NGG0.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	81168.
NextBio	71462.

Entry information

Entry name

OR8J3_HUMAN

Accession

Primary (citable) accession number: Q8NGG0
Secondary accession number(s): Q6IFB6, Q96RC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.