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Q8NGG0 (OR8J3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 8J3
Alternative name(s):
Olfactory receptor OR11-173
Gene names
Name:OR8J3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Olfactory receptor 8J3
PRO_0000150670

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31523Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant571N → T.
Corresponds to variant rs1947924 [ dbSNP | Ensembl ].
VAR_048052
Natural variant871V → I.
Corresponds to variant rs7937461 [ dbSNP | Ensembl ].
VAR_048053
Natural variant2081V → F. Ref.2
Corresponds to variant rs1384094 [ dbSNP | Ensembl ].
VAR_048054
Natural variant2711D → E.
Corresponds to variant rs17150102 [ dbSNP | Ensembl ].
VAR_048055

Sequences

Sequence LengthMass (Da)Tools
Q8NGG0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: EBC2E1724FCC4D2E

FASTA31535,481
        10         20         30         40         50         60 
MAPENFTRVT EFILTGVSSC PELQIPLFLV FLVLYVLTMA GNLGIITLTS VDSRLQNPMY 

        70         80         90        100        110        120 
FFLRHLAIIN LGNSTVIAPK MLMNFLVKKK TTSFYECATQ LGGFLFFIVS EVMMLAVMAY 

       130        140        150        160        170        180 
DRYVAICNPL LYMVVVSRRL CLLLVSLTYL YGFSTAIVVS PCIFSVSYCS SNIINHFYCD 

       190        200        210        220        230        240 
IAPLLALSCS DTYIPETIVF ISAATNLVFS MITVLVSYFN IVLSILRIRS PEGRKKAFST 

       250        260        270        280        290        300 
CASHMIAVTV FYGTMLFMYL QPQTNHSLDT DKMASVFYTL VIPMLNPLIY SLRNNDVNVA 

       310 
LKKFMENPCY SFKSM 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, VARIANT PHE-208.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065841 Genomic DNA. Translation: BAC06060.1.
AF399516 Genomic DNA. Translation: AAK95001.1.
BK004346 Genomic DNA. Translation: DAA04744.1.
RefSeqNP_001004064.1. NM_001004064.1.
UniGeneHs.554523.

3D structure databases

ProteinModelPortalQ8NGG0.
SMRQ8NGG0. Positions 109-140, 278-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000301529.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGG0.

Polymorphism databases

DMDM38372684.

Proteomic databases

PaxDbQ8NGG0.
PRIDEQ8NGG0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301529; ENSP00000301529; ENSG00000167822.
GeneID81168.
KEGGhsa:81168.
UCSCuc010riz.2. human.

Organism-specific databases

CTD81168.
GeneCardsGC11M055904.
HGNCHGNC:15312. OR8J3.
neXtProtNX_Q8NGG0.
PharmGKBPA32774.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40548.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGG0.
KOK04257.
OMAMITVLVS.
OrthoDBEOG783MVW.
PhylomeDBQ8NGG0.
TreeFamTF352753.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR8J3.
GenevestigatorQ8NGG0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR8J3.
GenomeRNAi81168.
NextBio71462.
PROQ8NGG0.

Entry information

Entry nameOR8J3_HUMAN
AccessionPrimary (citable) accession number: Q8NGG0
Secondary accession number(s): Q6IFB6, Q96RC2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries