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Protein

Olfactory receptor 4X2

Gene

OR4X2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4X2
Alternative name(s):
Olfactory receptor OR11-105
Gene namesi
Name:OR4X2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15184. OR4X2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717ExtracellularSequence analysisAdd
BLAST
Transmembranei18 – 4124Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini42 – 498CytoplasmicSequence analysis
Transmembranei50 – 7122Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini72 – 9221ExtracellularSequence analysisAdd
BLAST
Transmembranei93 – 11220Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini113 – 13119CytoplasmicSequence analysisAdd
BLAST
Transmembranei132 – 15019Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini151 – 18737ExtracellularSequence analysisAdd
BLAST
Transmembranei188 – 21124Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini212 – 22716CytoplasmicSequence analysisAdd
BLAST
Transmembranei228 – 25023Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini251 – 26111ExtracellularSequence analysisAdd
BLAST
Transmembranei262 – 28120Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini282 – 30322CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32351.

Polymorphism and mutation databases

BioMutaiOR4X2.
DMDMi38372683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Olfactory receptor 4X2PRO_0000150571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi89 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NGF9.
PRIDEiQ8NGF9.

PTM databases

iPTMnetiQ8NGF9.
PhosphoSiteiQ8NGF9.

Expressioni

Gene expression databases

CleanExiHS_OR4X2.

Organism-specific databases

HPAiHPA060249.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307751.

Structurei

3D structure databases

ProteinModelPortaliQ8NGF9.
SMRiQ8NGF9. Positions 15-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVIK. Eukaryota.
ENOG410YB9C. LUCA.
GeneTreeiENSGT00840000129716.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGF9.
KOiK04257.
OMAiCLSFVEI.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NGF9.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFIFLVLS PNQEVQRVCF VIFLFLYTAI VLGNFLIVLT VMTSRSLGSP
60 70 80 90 100
MYFFLSYLSF MEICYSSATA PKLISDLLAE RKVISWWGCM AQLFFLHFFG
110 120 130 140 150
GTEIFLLTVM AYDHYVAICK PLSYTTIMNW QVCTVLVGIA WVGGFMHSFA
160 170 180 190 200
QILLIFHLLF CGPNVINHYF CDLVPLLKLA CSDTFLIGLL IVANGGTLSV
210 220 230 240 250
ISFGVLLASY MVILLHLRTW SSEGWCKALS TCGSHFAVVI LFFGPCVFNS
260 270 280 290 300
LRPSTTLPID KMVAVFYTVI TAILNPVIYS LRNAEMRKAM KRLWIRTLRL

NEK
Length:303
Mass (Da):34,289
Last modified:October 1, 2002 - v1
Checksum:i4C4C934B7C6FBFCF
GO

Polymorphismi

A stop codon in the gene coding for this protein at position Tyr-27 is responsible for functional diversity thus producing a pseudogene.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065847 Genomic DNA. Translation: BAC06065.1.
CH471064 Genomic DNA. Translation: EAW67871.1.
BC136935 mRNA. Translation: AAI36936.1.
BC136936 mRNA. Translation: AAI36937.1.
AF399580 Genomic DNA. Translation: AAK95065.1.
BK004389 Genomic DNA. Translation: DAA04787.1.
CCDSiCCDS31486.1.
RefSeqiNP_001004727.1. NM_001004727.1.
UniGeneiHs.553565.

Genome annotation databases

EnsembliENST00000623137; ENSP00000485191; ENSG00000279556.
GeneIDi119764.
KEGGihsa:119764.
UCSCiuc001ngs.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065847 Genomic DNA. Translation: BAC06065.1.
CH471064 Genomic DNA. Translation: EAW67871.1.
BC136935 mRNA. Translation: AAI36936.1.
BC136936 mRNA. Translation: AAI36937.1.
AF399580 Genomic DNA. Translation: AAK95065.1.
BK004389 Genomic DNA. Translation: DAA04787.1.
CCDSiCCDS31486.1.
RefSeqiNP_001004727.1. NM_001004727.1.
UniGeneiHs.553565.

3D structure databases

ProteinModelPortaliQ8NGF9.
SMRiQ8NGF9. Positions 15-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000307751.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGF9.
PhosphoSiteiQ8NGF9.

Polymorphism and mutation databases

BioMutaiOR4X2.
DMDMi38372683.

Proteomic databases

PaxDbiQ8NGF9.
PRIDEiQ8NGF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000623137; ENSP00000485191; ENSG00000279556.
GeneIDi119764.
KEGGihsa:119764.
UCSCiuc001ngs.1. human.

Organism-specific databases

CTDi119764.
GeneCardsiOR4X2.
HGNCiHGNC:15184. OR4X2.
HPAiHPA060249.
neXtProtiNX_Q8NGF9.
PharmGKBiPA32351.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVIK. Eukaryota.
ENOG410YB9C. LUCA.
GeneTreeiENSGT00840000129716.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGF9.
KOiK04257.
OMAiCLSFVEI.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NGF9.
TreeFamiTF337350.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4X2.
GenomeRNAii119764.
PROiQ8NGF9.

Gene expression databases

CleanExiHS_OR4X2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-272.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  7. "Genetic elucidation of human hyperosmia to isovaleric acid."
    Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W., Lancet D.
    PLoS Biol. 5:2462-2468(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.

Entry informationi

Entry nameiOR4X2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGF9
Secondary accession number(s): B2RNK3, Q6IF73, Q96R63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.