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Protein

Olfactory receptor 4B1

Gene

OR4B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4B1
Alternative name(s):
OST208
Olfactory receptor OR11-106
Gene namesi
Name:OR4B1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175619.2
HGNCiHGNC:8290 OR4B1
neXtProtiNX_Q8NGF8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 287Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini288 – 309CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175619
PharmGKBiPA32250

Polymorphism and mutation databases

BioMutaiOR4B1
DMDMi38372682

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505281 – 309Olfactory receptor 4B1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGF8
PeptideAtlasiQ8NGF8
PRIDEiQ8NGF8
ProteomicsDBi73500

Expressioni

Gene expression databases

CleanExiHS_OR4B1
ExpressionAtlasiQ8NGF8 baseline and differential

Organism-specific databases

HPAiHPA059443

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311605

Structurei

3D structure databases

ProteinModelPortaliQ8NGF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVIK Eukaryota
ENOG410YB9C LUCA
GeneTreeiENSGT00920000148993
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGF8
KOiK04257
OMAiHYMNIIS
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NGF8
TreeFamiTF337350

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTSNVTEL IFTGLFQDPA VQSVCFVVFL PVYLATVVGN GLIVLTVSIS
60 70 80 90 100
KSLDSPMYFF LSCLSLVEIS YSSTIAPKFI IDLLAKIKTI SLEGCLTQIF
110 120 130 140 150
FFHFFGVAEI LLIVVMAYDC YVAICKPLHY MNIISRQLCH LLVAGSWLGG
160 170 180 190 200
FCHSIIQILV IIQLPFCGPN VIDHYFCDLQ PLFKLACTDT FMEGVIVLAN
210 220 230 240 250
SGLFSVFSFL ILVSSYIVIL VNLRNHSAEG RHKALSTCAS HITVVILFFG
260 270 280 290 300
PAIFLYMRPS STFTEDKLVA VFYTVITPML NPIIYTLRNA EVKIAIRRLW

SKKENPGRE
Length:309
Mass (Da):34,456
Last modified:October 1, 2002 - v1
Checksum:iAD37FF9C88549964
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03418963C → Y. Corresponds to variant dbSNP:rs11606506Ensembl.1
Natural variantiVAR_034190237T → N. Corresponds to variant dbSNP:rs12292056Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065848 Genomic DNA Translation: BAC06066.1
AF399579 Genomic DNA Translation: AAK95064.1
BK004387 Genomic DNA Translation: DAA04785.1
CCDSiCCDS31485.1
RefSeqiNP_001005470.1, NM_001005470.1
UniGeneiHs.553566

Genome annotation databases

EnsembliENST00000309562; ENSP00000311605; ENSG00000175619
GeneIDi119765
KEGGihsa:119765
UCSCiuc010rhs.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4B1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGF8
Secondary accession number(s): Q6IF75, Q96R64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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