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Protein

Olfactory receptor 5B17

Gene

OR5B17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31059-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5B17
Alternative name(s):
Olfactory receptor 5B20
Olfactory receptor OR11-237
Gene namesi
Name:OR5B17
Synonyms:OR5B20P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15267. OR5B17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 314CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197786.
PharmGKBiPA32486.

Polymorphism and mutation databases

BioMutaiOR5B17.
DMDMi38372681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505881 – 314Olfactory receptor 5B17Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGF7.
PeptideAtlasiQ8NGF7.
PRIDEiQ8NGF7.

PTM databases

PhosphoSitePlusiQ8NGF7.

Expressioni

Gene expression databases

CleanExiHS_OR5B17.
ExpressionAtlasiQ8NGF7. baseline.

Organism-specific databases

HPAiCAB004647.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349945.

Structurei

3D structure databases

ProteinModelPortaliQ8NGF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAFE. Eukaryota.
ENOG4111CJ0. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGF7.
KOiK04257.
OMAiHTGKGYQ.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGF7.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENNTEVSEF ILLGLTNAPE LQVPLFIMFT LIYLITLTGN LGMIILILLD
60 70 80 90 100
SHLHTPMYFF LSNLSLAGIG YSSAVTPKVL TGLLIEDKAI SYSACAAQMF
110 120 130 140 150
FCAVFATVEN YLLSSMAYDR YAAVCNPLHY TTTMTTRVCA CLAIGCYVIG
160 170 180 190 200
FLNASIQIGD TFRLSFCMSN VIHHFFCDKP AVITLTCSEK HISELILVLI
210 220 230 240 250
SSFNVFFALL VTLISYLFIL ITILKRHTGK GYQKPLSTCG SHLIAIFLFY
260 270 280 290 300
ITVIIMYIRP SSSHSMDTDK IASVFYTMII PMLSPIVYTL RNKDVKNAFM
310
KVVEKAKYSL DSVF
Length:314
Mass (Da):35,091
Last modified:October 1, 2002 - v1
Checksum:i952366E31FFD7C52
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03421980L → I.Corresponds to variant rs4939208dbSNPEnsembl.1
Natural variantiVAR_053193308Y → C.Corresponds to variant rs4127353dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065849 Genomic DNA. Translation: BAC06067.1.
BK004491 Genomic DNA. Translation: DAA04889.1.
CCDSiCCDS31548.1.
RefSeqiNP_001005489.1. NM_001005489.1.
UniGeneiHs.554517.

Genome annotation databases

EnsembliENST00000357377; ENSP00000349945; ENSG00000197786.
GeneIDi219965.
KEGGihsa:219965.
UCSCiuc010rke.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065849 Genomic DNA. Translation: BAC06067.1.
BK004491 Genomic DNA. Translation: DAA04889.1.
CCDSiCCDS31548.1.
RefSeqiNP_001005489.1. NM_001005489.1.
UniGeneiHs.554517.

3D structure databases

ProteinModelPortaliQ8NGF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349945.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8NGF7.

Polymorphism and mutation databases

BioMutaiOR5B17.
DMDMi38372681.

Proteomic databases

PaxDbiQ8NGF7.
PeptideAtlasiQ8NGF7.
PRIDEiQ8NGF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357377; ENSP00000349945; ENSG00000197786.
GeneIDi219965.
KEGGihsa:219965.
UCSCiuc010rke.3. human.

Organism-specific databases

CTDi219965.
GeneCardsiOR5B17.
HGNCiHGNC:15267. OR5B17.
HPAiCAB004647.
neXtProtiNX_Q8NGF7.
OpenTargetsiENSG00000197786.
PharmGKBiPA32486.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAFE. Eukaryota.
ENOG4111CJ0. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGF7.
KOiK04257.
OMAiHTGKGYQ.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGF7.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:G66-31059-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5B17.
GenomeRNAii219965.
PROiQ8NGF7.

Gene expression databases

CleanExiHS_OR5B17.
ExpressionAtlasiQ8NGF7. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5BH_HUMAN
AccessioniPrimary (citable) accession number: Q8NGF7
Secondary accession number(s): Q6IEX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.