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Q8NGF7

- OR5BH_HUMAN

UniProt

Q8NGF7 - OR5BH_HUMAN

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Protein

Olfactory receptor 5B17

Gene

OR5B17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5B17
Alternative name(s):
Olfactory receptor 5B20
Olfactory receptor OR11-237
Gene namesi
Name:OR5B17
Synonyms:OR5B20P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15267. OR5B17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence Analysis
Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19436ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini216 – 23520CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini257 – 26913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini291 – 31424CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 5B17PRO_0000150588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGF7.
PRIDEiQ8NGF7.

Expressioni

Gene expression databases

CleanExiHS_OR5B17.
GenevestigatoriQ8NGF7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349945.

Structurei

3D structure databases

ProteinModelPortaliQ8NGF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45899.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGF7.
KOiK04257.
OMAiDVKNAFM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGF7.
TreeFamiTF352753.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGF7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENNTEVSEF ILLGLTNAPE LQVPLFIMFT LIYLITLTGN LGMIILILLD
60 70 80 90 100
SHLHTPMYFF LSNLSLAGIG YSSAVTPKVL TGLLIEDKAI SYSACAAQMF
110 120 130 140 150
FCAVFATVEN YLLSSMAYDR YAAVCNPLHY TTTMTTRVCA CLAIGCYVIG
160 170 180 190 200
FLNASIQIGD TFRLSFCMSN VIHHFFCDKP AVITLTCSEK HISELILVLI
210 220 230 240 250
SSFNVFFALL VTLISYLFIL ITILKRHTGK GYQKPLSTCG SHLIAIFLFY
260 270 280 290 300
ITVIIMYIRP SSSHSMDTDK IASVFYTMII PMLSPIVYTL RNKDVKNAFM
310
KVVEKAKYSL DSVF
Length:314
Mass (Da):35,091
Last modified:October 1, 2002 - v1
Checksum:i952366E31FFD7C52
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801L → I.
Corresponds to variant rs4939208 [ dbSNP | Ensembl ].
VAR_034219
Natural varianti308 – 3081Y → C.
Corresponds to variant rs4127353 [ dbSNP | Ensembl ].
VAR_053193

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065849 Genomic DNA. Translation: BAC06067.1.
BK004491 Genomic DNA. Translation: DAA04889.1.
CCDSiCCDS31548.1.
RefSeqiNP_001005489.1. NM_001005489.1.
UniGeneiHs.554517.

Genome annotation databases

EnsembliENST00000357377; ENSP00000349945; ENSG00000197786.
GeneIDi219965.
KEGGihsa:219965.
UCSCiuc010rke.2. human.

Polymorphism databases

DMDMi38372681.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065849 Genomic DNA. Translation: BAC06067.1 .
BK004491 Genomic DNA. Translation: DAA04889.1 .
CCDSi CCDS31548.1.
RefSeqi NP_001005489.1. NM_001005489.1.
UniGenei Hs.554517.

3D structure databases

ProteinModelPortali Q8NGF7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000349945.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372681.

Proteomic databases

PaxDbi Q8NGF7.
PRIDEi Q8NGF7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357377 ; ENSP00000349945 ; ENSG00000197786 .
GeneIDi 219965.
KEGGi hsa:219965.
UCSCi uc010rke.2. human.

Organism-specific databases

CTDi 219965.
GeneCardsi GC11M058125.
HGNCi HGNC:15267. OR5B17.
neXtProti NX_Q8NGF7.
PharmGKBi PA32486.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45899.
GeneTreei ENSGT00760000118941.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGF7.
KOi K04257.
OMAi DVKNAFM.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGF7.
TreeFami TF352753.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR5B17.
GenomeRNAii 219965.
NextBioi 90894.
PROi Q8NGF7.

Gene expression databases

CleanExi HS_OR5B17.
Genevestigatori Q8NGF7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5BH_HUMAN
AccessioniPrimary (citable) accession number: Q8NGF7
Secondary accession number(s): Q6IEX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3