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Q8NGF7

- OR5BH_HUMAN

UniProt

Q8NGF7 - OR5BH_HUMAN

Protein

Olfactory receptor 5B17

Gene

OR5B17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5B17
    Alternative name(s):
    Olfactory receptor 5B20
    Olfactory receptor OR11-237
    Gene namesi
    Name:OR5B17
    Synonyms:OR5B20P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15267. OR5B17.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32486.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 5B17PRO_0000150588Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGF7.
    PRIDEiQ8NGF7.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5B17.
    GenevestigatoriQ8NGF7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000349945.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGF7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 528CytoplasmicSequence Analysis
    Topological domaini74 – 9724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19436ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 23520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 26913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini291 – 31424CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45899.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGF7.
    KOiK04257.
    OMAiDVKNAFM.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGF7.
    TreeFamiTF352753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGF7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENNTEVSEF ILLGLTNAPE LQVPLFIMFT LIYLITLTGN LGMIILILLD    50
    SHLHTPMYFF LSNLSLAGIG YSSAVTPKVL TGLLIEDKAI SYSACAAQMF 100
    FCAVFATVEN YLLSSMAYDR YAAVCNPLHY TTTMTTRVCA CLAIGCYVIG 150
    FLNASIQIGD TFRLSFCMSN VIHHFFCDKP AVITLTCSEK HISELILVLI 200
    SSFNVFFALL VTLISYLFIL ITILKRHTGK GYQKPLSTCG SHLIAIFLFY 250
    ITVIIMYIRP SSSHSMDTDK IASVFYTMII PMLSPIVYTL RNKDVKNAFM 300
    KVVEKAKYSL DSVF 314
    Length:314
    Mass (Da):35,091
    Last modified:October 1, 2002 - v1
    Checksum:i952366E31FFD7C52
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti80 – 801L → I.
    Corresponds to variant rs4939208 [ dbSNP | Ensembl ].
    VAR_034219
    Natural varianti308 – 3081Y → C.
    Corresponds to variant rs4127353 [ dbSNP | Ensembl ].
    VAR_053193

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065849 Genomic DNA. Translation: BAC06067.1.
    BK004491 Genomic DNA. Translation: DAA04889.1.
    CCDSiCCDS31548.1.
    RefSeqiNP_001005489.1. NM_001005489.1.
    UniGeneiHs.554517.

    Genome annotation databases

    EnsembliENST00000357377; ENSP00000349945; ENSG00000197786.
    GeneIDi219965.
    KEGGihsa:219965.
    UCSCiuc010rke.2. human.

    Polymorphism databases

    DMDMi38372681.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065849 Genomic DNA. Translation: BAC06067.1 .
    BK004491 Genomic DNA. Translation: DAA04889.1 .
    CCDSi CCDS31548.1.
    RefSeqi NP_001005489.1. NM_001005489.1.
    UniGenei Hs.554517.

    3D structure databases

    ProteinModelPortali Q8NGF7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000349945.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372681.

    Proteomic databases

    PaxDbi Q8NGF7.
    PRIDEi Q8NGF7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357377 ; ENSP00000349945 ; ENSG00000197786 .
    GeneIDi 219965.
    KEGGi hsa:219965.
    UCSCi uc010rke.2. human.

    Organism-specific databases

    CTDi 219965.
    GeneCardsi GC11M058125.
    HGNCi HGNC:15267. OR5B17.
    neXtProti NX_Q8NGF7.
    PharmGKBi PA32486.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45899.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGF7.
    KOi K04257.
    OMAi DVKNAFM.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGF7.
    TreeFami TF352753.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5B17.
    GenomeRNAii 219965.
    NextBioi 90894.
    PROi Q8NGF7.

    Gene expression databases

    CleanExi HS_OR5B17.
    Genevestigatori Q8NGF7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR5BH_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGF7
    Secondary accession number(s): Q6IEX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3