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Protein

Olfactory receptor 10W1

Gene

OR10W1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10W1
Alternative name(s):
Olfactory receptor OR11-236
Gene namesi
Name:OR10W1
Synonyms:OR10W1P
ORF Names:UNQ6469/PRO34070
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15139. OR10W1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei17 – 3721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini38 – 458CytoplasmicSequence Analysis
Transmembranei46 – 6621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini67 – 9024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei91 – 11121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini112 – 13019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei131 – 15121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini152 – 18837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei189 – 20820Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 22820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei229 – 24921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini250 – 26213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini284 – 30522CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Olfactory receptor 10W1PRO_0000150719Add
BLAST

Proteomic databases

PRIDEiQ8NGF6.

Expressioni

Gene expression databases

GenevestigatoriQ8NGF6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000378516.

Structurei

3D structure databases

ProteinModelPortaliQ8NGF6.
SMRiQ8NGF6. Positions 28-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42006.
GeneTreeiENSGT00710000106401.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGF6.
KOiK04257.
OMAiMTWENHS.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGF6.
TreeFamiTF352734.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVFLAYPS CPELHILSFL GVSLVYGLII TGNILIVVSI HTETCLCTSM
60 70 80 90 100
YYFLGSLSGI EICYTAVVVP HILANTLQSE KTITLLGCAT QMAFFIALGS
110 120 130 140 150
ADCFLLAAMA YDRYVAICHP LQYPLLMTLT LCVHLVVASV ISGLFLSLQL
160 170 180 190 200
VAFIFSLPFC QAQGIEHFFC DVPPVMHVVC AQSHIHEQSV LVAAILAIAV
210 220 230 240 250
PFFLITTSYT FIVAALLKIH SAAGRHRAFS TCSSHLTVVL LQYGCCAFMY
260 270 280 290 300
LCPSSSYNPK QDRFISLVYT LGTPLLNPLI YALRNSEMKG AVGRVLTRNC

LSQNS
Length:305
Mass (Da):33,376
Last modified:October 1, 2002 - v1
Checksum:i07D612EFA3044A82
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti263 – 2631R → Q.3 Publications
Corresponds to variant rs10792156 [ dbSNP | Ensembl ].
VAR_057568

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065850 Genomic DNA. Translation: BAC06068.1.
AY358251 mRNA. Translation: AAQ88618.1.
AP000435 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73802.1.
BC132848 mRNA. Translation: AAI32849.1.
BC132850 mRNA. Translation: AAI32851.1.
BK004490 Genomic DNA. Translation: DAA04888.1.
CCDSiCCDS7968.1.
RefSeqiNP_997257.2. NM_207374.3.
UniGeneiHs.531507.

Genome annotation databases

EnsembliENST00000395079; ENSP00000378516; ENSG00000172772.
GeneIDi81341.
KEGGihsa:81341.
UCSCiuc001nmq.1. human.

Polymorphism databases

DMDMi51316487.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065850 Genomic DNA. Translation: BAC06068.1.
AY358251 mRNA. Translation: AAQ88618.1.
AP000435 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73802.1.
BC132848 mRNA. Translation: AAI32849.1.
BC132850 mRNA. Translation: AAI32851.1.
BK004490 Genomic DNA. Translation: DAA04888.1.
CCDSiCCDS7968.1.
RefSeqiNP_997257.2. NM_207374.3.
UniGeneiHs.531507.

3D structure databases

ProteinModelPortaliQ8NGF6.
SMRiQ8NGF6. Positions 28-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000378516.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi51316487.

Proteomic databases

PRIDEiQ8NGF6.

Protocols and materials databases

DNASUi81341.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395079; ENSP00000378516; ENSG00000172772.
GeneIDi81341.
KEGGihsa:81341.
UCSCiuc001nmq.1. human.

Organism-specific databases

CTDi81341.
GeneCardsiGC11M058035.
HGNCiHGNC:15139. OR10W1.
neXtProtiNX_Q8NGF6.
PharmGKBiPA32006.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42006.
GeneTreeiENSGT00710000106401.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGF6.
KOiK04257.
OMAiMTWENHS.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGF6.
TreeFamiTF352734.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10W1.
GenomeRNAii81341.
NextBioi71612.
PROiQ8NGF6.

Gene expression databases

GenevestigatoriQ8NGF6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-263.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-263.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-263.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiO10W1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGF6
Secondary accession number(s): A2RUD2, A8MTE1, Q6UXQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.