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Q8NGF6

- O10W1_HUMAN

UniProt

Q8NGF6 - O10W1_HUMAN

Protein

Olfactory receptor 10W1

Gene

OR10W1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10W1
    Alternative name(s):
    Olfactory receptor OR11-236
    Gene namesi
    Name:OR10W1
    Synonyms:OR10W1P
    ORF Names:UNQ6469/PRO34070
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15139. OR10W1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32006.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Olfactory receptor 10W1PRO_0000150719Add
    BLAST

    Proteomic databases

    PRIDEiQ8NGF6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8NGF6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000378516.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGF6.
    SMRiQ8NGF6. Positions 28-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini38 – 458CytoplasmicSequence Analysis
    Topological domaini67 – 9024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini112 – 13019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini152 – 18837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 22820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini250 – 26213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini284 – 30522CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei46 – 6621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 20820Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42006.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    KOiK04257.
    OMAiMTWENHS.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGF6.
    TreeFamiTF352734.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGF6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFVFLAYPS CPELHILSFL GVSLVYGLII TGNILIVVSI HTETCLCTSM    50
    YYFLGSLSGI EICYTAVVVP HILANTLQSE KTITLLGCAT QMAFFIALGS 100
    ADCFLLAAMA YDRYVAICHP LQYPLLMTLT LCVHLVVASV ISGLFLSLQL 150
    VAFIFSLPFC QAQGIEHFFC DVPPVMHVVC AQSHIHEQSV LVAAILAIAV 200
    PFFLITTSYT FIVAALLKIH SAAGRHRAFS TCSSHLTVVL LQYGCCAFMY 250
    LCPSSSYNPK QDRFISLVYT LGTPLLNPLI YALRNSEMKG AVGRVLTRNC 300
    LSQNS 305
    Length:305
    Mass (Da):33,376
    Last modified:October 1, 2002 - v1
    Checksum:i07D612EFA3044A82
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti263 – 2631R → Q.3 Publications
    Corresponds to variant rs10792156 [ dbSNP | Ensembl ].
    VAR_057568

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065850 Genomic DNA. Translation: BAC06068.1.
    AY358251 mRNA. Translation: AAQ88618.1.
    AP000435 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73802.1.
    BC132848 mRNA. Translation: AAI32849.1.
    BC132850 mRNA. Translation: AAI32851.1.
    BK004490 Genomic DNA. Translation: DAA04888.1.
    CCDSiCCDS7968.1.
    RefSeqiNP_997257.2. NM_207374.3.
    UniGeneiHs.531507.

    Genome annotation databases

    EnsembliENST00000395079; ENSP00000378516; ENSG00000172772.
    GeneIDi81341.
    KEGGihsa:81341.
    UCSCiuc001nmq.1. human.

    Polymorphism databases

    DMDMi51316487.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065850 Genomic DNA. Translation: BAC06068.1 .
    AY358251 mRNA. Translation: AAQ88618.1 .
    AP000435 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73802.1 .
    BC132848 mRNA. Translation: AAI32849.1 .
    BC132850 mRNA. Translation: AAI32851.1 .
    BK004490 Genomic DNA. Translation: DAA04888.1 .
    CCDSi CCDS7968.1.
    RefSeqi NP_997257.2. NM_207374.3.
    UniGenei Hs.531507.

    3D structure databases

    ProteinModelPortali Q8NGF6.
    SMRi Q8NGF6. Positions 28-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000378516.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 51316487.

    Proteomic databases

    PRIDEi Q8NGF6.

    Protocols and materials databases

    DNASUi 81341.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395079 ; ENSP00000378516 ; ENSG00000172772 .
    GeneIDi 81341.
    KEGGi hsa:81341.
    UCSCi uc001nmq.1. human.

    Organism-specific databases

    CTDi 81341.
    GeneCardsi GC11M058035.
    HGNCi HGNC:15139. OR10W1.
    neXtProti NX_Q8NGF6.
    PharmGKBi PA32006.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42006.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    KOi K04257.
    OMAi MTWENHS.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGF6.
    TreeFami TF352734.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10W1.
    GenomeRNAii 81341.
    NextBioi 71612.
    PROi Q8NGF6.

    Gene expression databases

    Genevestigatori Q8NGF6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-263.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-263.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-263.
    6. Cited for: IDENTIFICATION.
    7. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10W1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGF6
    Secondary accession number(s): A2RUD2, A8MTE1, Q6UXQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3