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Q8NGF6 (O10W1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10W1
Alternative name(s):
Olfactory receptor OR11-236
Gene names
Name:OR10W1
Synonyms:OR10W1P
ORF Names:UNQ6469/PRO34070
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Olfactory receptor 10W1
PRO_0000150719

Regions

Topological domain1 – 1616Extracellular Potential
Transmembrane17 – 3721Helical; Name=1; Potential
Topological domain38 – 458Cytoplasmic Potential
Transmembrane46 – 6621Helical; Name=2; Potential
Topological domain67 – 9024Extracellular Potential
Transmembrane91 – 11121Helical; Name=3; Potential
Topological domain112 – 13019Cytoplasmic Potential
Transmembrane131 – 15121Helical; Name=4; Potential
Topological domain152 – 18837Extracellular Potential
Transmembrane189 – 20820Helical; Name=5; Potential
Topological domain209 – 22820Cytoplasmic Potential
Transmembrane229 – 24921Helical; Name=6; Potential
Topological domain250 – 26213Extracellular Potential
Transmembrane263 – 28321Helical; Name=7; Potential
Topological domain284 – 30522Cytoplasmic Potential

Natural variations

Natural variant2631R → Q. Ref.2 Ref.4 Ref.5
Corresponds to variant rs10792156 [ dbSNP | Ensembl ].
VAR_057568

Sequences

Sequence LengthMass (Da)Tools
Q8NGF6 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 07D612EFA3044A82

FASTA30533,376
        10         20         30         40         50         60 
MEFVFLAYPS CPELHILSFL GVSLVYGLII TGNILIVVSI HTETCLCTSM YYFLGSLSGI 

        70         80         90        100        110        120 
EICYTAVVVP HILANTLQSE KTITLLGCAT QMAFFIALGS ADCFLLAAMA YDRYVAICHP 

       130        140        150        160        170        180 
LQYPLLMTLT LCVHLVVASV ISGLFLSLQL VAFIFSLPFC QAQGIEHFFC DVPPVMHVVC 

       190        200        210        220        230        240 
AQSHIHEQSV LVAAILAIAV PFFLITTSYT FIVAALLKIH SAAGRHRAFS TCSSHLTVVL 

       250        260        270        280        290        300 
LQYGCCAFMY LCPSSSYNPK QDRFISLVYT LGTPLLNPLI YALRNSEMKG AVGRVLTRNC 


LSQNS 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-263.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-263.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-263.
[6]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065850 Genomic DNA. Translation: BAC06068.1.
AY358251 mRNA. Translation: AAQ88618.1.
AP000435 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73802.1.
BC132848 mRNA. Translation: AAI32849.1.
BC132850 mRNA. Translation: AAI32851.1.
BK004490 Genomic DNA. Translation: DAA04888.1.
RefSeqNP_997257.2. NM_207374.3.
UniGeneHs.531507.

3D structure databases

ProteinModelPortalQ8NGF6.
SMRQ8NGF6. Positions 28-298.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000378516.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM51316487.

Proteomic databases

PRIDEQ8NGF6.

Protocols and materials databases

DNASU81341.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395079; ENSP00000378516; ENSG00000172772.
GeneID81341.
KEGGhsa:81341.
UCSCuc001nmq.1. human.

Organism-specific databases

CTD81341.
GeneCardsGC11M058035.
HGNCHGNC:15139. OR10W1.
neXtProtNX_Q8NGF6.
PharmGKBPA32006.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42006.
HOGENOMHOG000041365.
HOVERGENHBG017625.
KOK04257.
OMAMTWENHS.
OrthoDBEOG71K63J.
PhylomeDBQ8NGF6.
TreeFamTF352734.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

GenevestigatorQ8NGF6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10W1.
GenomeRNAi81341.
NextBio71612.
PROQ8NGF6.

Entry information

Entry nameO10W1_HUMAN
AccessionPrimary (citable) accession number: Q8NGF6
Secondary accession number(s): A2RUD2, A8MTE1, Q6UXQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries