Q8NGF4 (O5AP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 5AP2

Gene names

Name:

OR5AP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Olfactory receptor 5AP2		PRO_0000150578
Regions
	Topological domain	1 – 34	34	Extracellular Potential
	Transmembrane	35 – 55	21	Helical; Name=1; Potential
	Topological domain	56	1	Cytoplasmic Potential
	Transmembrane	57 – 77	21	Helical; Name=2; Potential
	Topological domain	78 – 104	27	Extracellular Potential
	Transmembrane	105 – 125	21	Helical; Name=3; Potential
	Topological domain	126 – 135	10	Cytoplasmic Potential
	Transmembrane	136 – 156	21	Helical; Name=4; Potential
	Topological domain	157 – 210	54	Extracellular Potential
	Transmembrane	211 – 231	21	Helical; Name=5; Potential
	Topological domain	232 – 245	14	Cytoplasmic Potential
	Transmembrane	246 – 266	21	Helical; Name=6; Potential
	Topological domain	267 – 278	12	Extracellular Potential
	Transmembrane	279 – 299	21	Helical; Name=7; Potential
	Topological domain	300 – 316	17	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	11	1	N-linked (GlcNAc...) Potential
	Disulfide bond	103 ↔ 195		By similarity
Natural variations
	Natural variant	105	1	A → T. Corresponds to variant rs11606499 [ dbSNP | Ensembl ].		VAR_053180

Sequences

	Sequence		Length	Mass (Da)
	Q8NGF4 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 5C2A3D9B7482400C	FASTA	316	35,508
	10 20 30 40 50 60 MRLMKEVRGR NQTEVTEFLL LGLSDNPDLQ GVLFALFLLI YMANMVGNLG MIVLIKIDLC 70 80 90 100 110 120 LHTPMYFFLS SLSFVDASYS SSVTPKMLVN LMAENKAISF HGCAAQFYFF GSFLGTECFL 130 140 150 160 170 180 LAMMAYDRYA AIWNPLLYPV LVSGRICFLL IATSFLAGCG NAAIHTGMTF RLSFCGSNRI 190 200 210 220 230 240 NHFYCDTPPL LKLSCSDTHF NGIVIMAFSS FIVISCVMIV LISYLCIFIA VLKMPSLEGR 250 260 270 280 290 300 HKAFSTCASY LMAVTIFFGT ILFMYLRPTS SYSMEQDKVV SVFYTVIIPV LNPLIYSLKN 310 KDVKKALKKI LWKHIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065854 Genomic DNA. Translation: BAC06072.1. CH471076 Genomic DNA. Translation: EAW73720.1. BC136989 mRNA. Translation: AAI36990.1.
IPI	IPI01013000.
RefSeq	NP_001002925.1. NM_001002925.1.
UniGene	Hs.449692.
3D structure databases
ProteinModelPortal	Q8NGF4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000303111.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NGF4.
Polymorphism databases
DMDM	37081351.
Proteomic databases
PaxDb	Q8NGF4.
PRIDE	Q8NGF4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302981; ENSP00000303111; ENSG00000172464.
GeneID	338675.
KEGG	hsa:338675.
UCSC	uc001njb.1. human.
Organism-specific databases
CTD	338675.
GeneCards	GC11M056408.
HGNC	HGNC:15258. OR5AP2.
neXtProt	NX_Q8NGF4.
PharmGKB	PA32469.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47896.
HOVERGEN	HBG017625.
InParanoid	Q8NGF4.
KO	K04257.
OMA	KEVRGRN.
OrthoDB	EOG4RXZ0N.
PhylomeDB	Q8NGF4.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q8NGF4.
CleanEx	HS_OR5AP2.
Genevestigator	Q8NGF4.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	338675.
NextBio	97099.

Entry information

Entry name

O5AP2_HUMAN

Accession

Primary (citable) accession number: Q8NGF4
Secondary accession number(s): B2RNM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.