OR5AP2

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW
odorant binding Source: GO_Central
olfactory receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 5AP2
Gene namesⁱ	Name:OR5AP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172464.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15258 OR5AP2
neXtProtⁱ	NX_Q8NGF4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 34	ExtracellularSequence analysisAdd BLAST	34
Transmembraneⁱ	35 – 55	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	56	CytoplasmicSequence analysis	1
Transmembraneⁱ	57 – 77	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	78 – 104	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	105 – 125	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	126 – 135	CytoplasmicSequence analysis	10
Transmembraneⁱ	136 – 156	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	157 – 210	ExtracellularSequence analysisAdd BLAST	54
Transmembraneⁱ	211 – 231	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	232 – 245	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	246 – 266	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	267 – 278	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	279 – 299	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	300 – 316	CytoplasmicSequence analysisAdd BLAST	17

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA32469

PharmGKBⁱ

PA32469

Polymorphism and mutation databases

BioMutaⁱ	OR5AP2
DMDMⁱ	37081351

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150578	1 – 316	Olfactory receptor 5AP2Add BLAST		316

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	11	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	103 ↔ 195	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGF4
PeptideAtlas More...PeptideAtlasⁱ	Q8NGF4
PRIDEⁱ	Q8NGF4
ProteomicsDBⁱ	73497

PTM databases

PhosphoSitePlusⁱ	Q8NGF4

PhosphoSitePlusⁱ

Q8NGF4

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_OR5AP2
ExpressionAtlasⁱ	Q8NGF4 baseline and differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000303111

STRINGⁱ

9606.ENSP00000303111

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGF4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJJ3 Eukaryota ENOG4111D9W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144101
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGF4
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	KEVRGRN
PhylomeDBⁱ	Q8NGF4
TreeFamⁱ	TF352753

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGF4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLMKEVRGR NQTEVTEFLL LGLSDNPDLQ GVLFALFLLI YMANMVGNLG 
        60         70         80         90        100
MIVLIKIDLC LHTPMYFFLS SLSFVDASYS SSVTPKMLVN LMAENKAISF 
       110        120        130        140        150
HGCAAQFYFF GSFLGTECFL LAMMAYDRYA AIWNPLLYPV LVSGRICFLL 
       160        170        180        190        200
IATSFLAGCG NAAIHTGMTF RLSFCGSNRI NHFYCDTPPL LKLSCSDTHF 
       210        220        230        240        250
NGIVIMAFSS FIVISCVMIV LISYLCIFIA VLKMPSLEGR HKAFSTCASY 
       260        270        280        290        300
LMAVTIFFGT ILFMYLRPTS SYSMEQDKVV SVFYTVIIPV LNPLIYSLKN 
       310 
KDVKKALKKI LWKHIL

Length:316

Mass (Da):35,508

Last modified:October 1, 2002 - v1

Checksum:ⁱ5C2A3D9B7482400C

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053180	105	A → T. Corresponds to variant dbSNP:rs11606499Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065854 Genomic DNA Translation: BAC06072.1 CH471076 Genomic DNA Translation: EAW73720.1 BC136989 mRNA Translation: AAI36990.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31534.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001002925.1, NM_001002925.1
UniGeneⁱ	Hs.449692

Genome annotation databases

Ensemblⁱ	ENST00000544374; ENSP00000442701; ENSG00000172464
GeneIDⁱ	338675
KEGGⁱ	hsa:338675
UCSC genome browser More...UCSCⁱ	uc001njb.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8NGF4	Olfactory receptor		HUMAN		317
Olfactory receptor		MYOBR		334
UPI0004BD5D3B		EQUPR		321
Olfactory receptor		PROCO		317
Olfactory receptor		TUPCH		317
+61

Protein	Similar proteins		Species	Score	Length
Q8NGF4	Olfactory receptor 8D4		HUMAN		314
UPI0005F55B60		CERAT		336
Olfactory receptor		PANTR		314
Olfactory receptor family 8 subfamily D member 4		PANPA		314
Olfactory receptor		GORGO		314
+502

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065854 Genomic DNA Translation: BAC06072.1 CH471076 Genomic DNA Translation: EAW73720.1 BC136989 mRNA Translation: AAI36990.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31534.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001002925.1, NM_001002925.1
UniGeneⁱ	Hs.449692

3D structure databases

ProteinModelPortalⁱ	Q8NGF4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000303111

STRINGⁱ

9606.ENSP00000303111

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	Q8NGF4

PhosphoSitePlusⁱ

Q8NGF4

Polymorphism and mutation databases

BioMutaⁱ	OR5AP2
DMDMⁱ	37081351

Proteomic databases

PaxDbⁱ	Q8NGF4
PeptideAtlas More...PeptideAtlasⁱ	Q8NGF4
PRIDEⁱ	Q8NGF4
ProteomicsDBⁱ	73497

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000544374; ENSP00000442701; ENSG00000172464
GeneIDⁱ	338675
KEGGⁱ	hsa:338675
UCSC genome browser More...UCSCⁱ	uc001njb.1 human

Organism-specific databases

CTDⁱ	338675
EuPathDBⁱ	HostDB:ENSG00000172464.2
GeneCardsⁱ	OR5AP2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15258 OR5AP2
neXtProtⁱ	NX_Q8NGF4
PharmGKBⁱ	PA32469
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJJ3 Eukaryota ENOG4111D9W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144101
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGF4
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	KEVRGRN
PhylomeDBⁱ	Q8NGF4
TreeFamⁱ	TF352753

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAiⁱ	338675
Protein Ontology More...PROⁱ	PR:Q8NGF4

Gene expression databases

CleanExⁱ	HS_OR5AP2
ExpressionAtlasⁱ	Q8NGF4 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O5AP2_HUMAN
Accessionⁱ	Q8NGF4Primary (citable) accession number: Q8NGF4 Secondary accession number(s): B2RNM8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
	Last sequence update:	October 1, 2002
	Last modified:	June 20, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q8NGF4 (O5AP2_HUMAN)

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Olfactory receptor 5AP2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ