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Protein

Olfactory receptor 5AP2

Gene

OR5AP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AP2
Gene namesi
Name:OR5AP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15258. OR5AP2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 5521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini56 – 561CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 10427ExtracellularSequence analysisAdd
BLAST
Transmembranei105 – 12521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini126 – 13510CytoplasmicSequence analysis
Transmembranei136 – 15621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini157 – 21054ExtracellularSequence analysisAdd
BLAST
Transmembranei211 – 23121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini232 – 24514CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini267 – 27812ExtracellularSequence analysisAdd
BLAST
Transmembranei279 – 29921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini300 – 31617CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32469.

Polymorphism and mutation databases

BioMutaiOR5AP2.
DMDMi37081351.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 5AP2PRO_0000150578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi103 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGF4.
PRIDEiQ8NGF4.

PTM databases

PhosphoSiteiQ8NGF4.

Expressioni

Gene expression databases

CleanExiHS_OR5AP2.
ExpressionAtlasiQ8NGF4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303111.

Structurei

3D structure databases

ProteinModelPortaliQ8NGF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJJ3. Eukaryota.
ENOG4111D9W. LUCA.
GeneTreeiENSGT00760000118941.
HOVERGENiHBG017625.
InParanoidiQ8NGF4.
KOiK04257.
OMAiNSDLQIV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGF4.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLMKEVRGR NQTEVTEFLL LGLSDNPDLQ GVLFALFLLI YMANMVGNLG
60 70 80 90 100
MIVLIKIDLC LHTPMYFFLS SLSFVDASYS SSVTPKMLVN LMAENKAISF
110 120 130 140 150
HGCAAQFYFF GSFLGTECFL LAMMAYDRYA AIWNPLLYPV LVSGRICFLL
160 170 180 190 200
IATSFLAGCG NAAIHTGMTF RLSFCGSNRI NHFYCDTPPL LKLSCSDTHF
210 220 230 240 250
NGIVIMAFSS FIVISCVMIV LISYLCIFIA VLKMPSLEGR HKAFSTCASY
260 270 280 290 300
LMAVTIFFGT ILFMYLRPTS SYSMEQDKVV SVFYTVIIPV LNPLIYSLKN
310
KDVKKALKKI LWKHIL
Length:316
Mass (Da):35,508
Last modified:October 1, 2002 - v1
Checksum:i5C2A3D9B7482400C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti105 – 1051A → T.
Corresponds to variant rs11606499 [ dbSNP | Ensembl ].
VAR_053180

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065854 Genomic DNA. Translation: BAC06072.1.
CH471076 Genomic DNA. Translation: EAW73720.1.
BC136989 mRNA. Translation: AAI36990.1.
CCDSiCCDS31534.1.
RefSeqiNP_001002925.1. NM_001002925.1.
UniGeneiHs.449692.

Genome annotation databases

EnsembliENST00000302981; ENSP00000303111; ENSG00000172464.
GeneIDi338675.
KEGGihsa:338675.
UCSCiuc001njb.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065854 Genomic DNA. Translation: BAC06072.1.
CH471076 Genomic DNA. Translation: EAW73720.1.
BC136989 mRNA. Translation: AAI36990.1.
CCDSiCCDS31534.1.
RefSeqiNP_001002925.1. NM_001002925.1.
UniGeneiHs.449692.

3D structure databases

ProteinModelPortaliQ8NGF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303111.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGF4.

Polymorphism and mutation databases

BioMutaiOR5AP2.
DMDMi37081351.

Proteomic databases

PaxDbiQ8NGF4.
PRIDEiQ8NGF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302981; ENSP00000303111; ENSG00000172464.
GeneIDi338675.
KEGGihsa:338675.
UCSCiuc001njb.1. human.

Organism-specific databases

CTDi338675.
GeneCardsiOR5AP2.
HGNCiHGNC:15258. OR5AP2.
neXtProtiNX_Q8NGF4.
PharmGKBiPA32469.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJJ3. Eukaryota.
ENOG4111D9W. LUCA.
GeneTreeiENSGT00760000118941.
HOVERGENiHBG017625.
InParanoidiQ8NGF4.
KOiK04257.
OMAiNSDLQIV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGF4.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii338675.
NextBioi97099.
PROiQ8NGF4.

Gene expression databases

CleanExiHS_OR5AP2.
ExpressionAtlasiQ8NGF4. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiO5AP2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGF4
Secondary accession number(s): B2RNM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2002
Last modified: February 17, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.