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Protein

Olfactory receptor 5AP2

Gene

OR5AP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AP2
Gene namesi
Name:OR5AP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172464.2
HGNCiHGNC:15258 OR5AP2
neXtProtiNX_Q8NGF4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini56CytoplasmicSequence analysis1
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 104ExtracellularSequence analysisAdd BLAST27
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 135CytoplasmicSequence analysis10
Transmembranei136 – 156Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini157 – 210ExtracellularSequence analysisAdd BLAST54
Transmembranei211 – 231Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini232 – 245CytoplasmicSequence analysisAdd BLAST14
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 278ExtracellularSequence analysisAdd BLAST12
Transmembranei279 – 299Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini300 – 316CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32469

Polymorphism and mutation databases

BioMutaiOR5AP2
DMDMi37081351

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505781 – 316Olfactory receptor 5AP2Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGF4
PeptideAtlasiQ8NGF4
PRIDEiQ8NGF4
ProteomicsDBi73497

PTM databases

PhosphoSitePlusiQ8NGF4

Expressioni

Gene expression databases

CleanExiHS_OR5AP2
ExpressionAtlasiQ8NGF4 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303111

Structurei

3D structure databases

ProteinModelPortaliQ8NGF4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJJ3 Eukaryota
ENOG4111D9W LUCA
GeneTreeiENSGT00910000144101
HOVERGENiHBG017625
InParanoidiQ8NGF4
KOiK04257
OMAiKEVRGRN
PhylomeDBiQ8NGF4
TreeFamiTF352753

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLMKEVRGR NQTEVTEFLL LGLSDNPDLQ GVLFALFLLI YMANMVGNLG
60 70 80 90 100
MIVLIKIDLC LHTPMYFFLS SLSFVDASYS SSVTPKMLVN LMAENKAISF
110 120 130 140 150
HGCAAQFYFF GSFLGTECFL LAMMAYDRYA AIWNPLLYPV LVSGRICFLL
160 170 180 190 200
IATSFLAGCG NAAIHTGMTF RLSFCGSNRI NHFYCDTPPL LKLSCSDTHF
210 220 230 240 250
NGIVIMAFSS FIVISCVMIV LISYLCIFIA VLKMPSLEGR HKAFSTCASY
260 270 280 290 300
LMAVTIFFGT ILFMYLRPTS SYSMEQDKVV SVFYTVIIPV LNPLIYSLKN
310
KDVKKALKKI LWKHIL
Length:316
Mass (Da):35,508
Last modified:October 1, 2002 - v1
Checksum:i5C2A3D9B7482400C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053180105A → T. Corresponds to variant dbSNP:rs11606499Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065854 Genomic DNA Translation: BAC06072.1
CH471076 Genomic DNA Translation: EAW73720.1
BC136989 mRNA Translation: AAI36990.1
CCDSiCCDS31534.1
RefSeqiNP_001002925.1, NM_001002925.1
UniGeneiHs.449692

Genome annotation databases

EnsembliENST00000544374; ENSP00000442701; ENSG00000172464
GeneIDi338675
KEGGihsa:338675
UCSCiuc001njb.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO5AP2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGF4
Secondary accession number(s): B2RNM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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