UniProtKB - Q8NGF4 (O5AP2_HUMAN)
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Protein
Olfactory receptor 5AP2
Gene
OR5AP2
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G-protein coupled receptor activity Source: UniProtKB-KW
- odorant binding Source: GO_Central
- olfactory receptor activity Source: GO_Central
GO - Biological processi
- G-protein coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753. Olfactory Signaling Pathway. |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 5AP2 |
Gene namesi | Name:OR5AP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172464.2. |
HGNCi | HGNC:15258. OR5AP2. |
neXtProti | NX_Q8NGF4. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 34 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 35 – 55 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 56 | CytoplasmicSequence analysis | 1 | |
Transmembranei | 57 – 77 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 104 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 105 – 125 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 126 – 135 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 136 – 156 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 157 – 210 | ExtracellularSequence analysisAdd BLAST | 54 | |
Transmembranei | 211 – 231 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 232 – 245 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 246 – 266 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 267 – 278 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 279 – 299 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 300 – 316 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA32469. |
Polymorphism and mutation databases
BioMutai | OR5AP2. |
DMDMi | 37081351. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150578 | 1 – 316 | Olfactory receptor 5AP2Add BLAST | 316 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 103 ↔ 195 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGF4. |
PeptideAtlasi | Q8NGF4. |
PRIDEi | Q8NGF4. |
PTM databases
PhosphoSitePlusi | Q8NGF4. |
Expressioni
Gene expression databases
CleanExi | HS_OR5AP2. |
ExpressionAtlasi | Q8NGF4. baseline and differential. |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IJJ3. Eukaryota. ENOG4111D9W. LUCA. |
GeneTreei | ENSGT00910000144101. |
HOVERGENi | HBG017625. |
InParanoidi | Q8NGF4. |
KOi | K04257. |
OMAi | KEVRGRN. |
PhylomeDBi | Q8NGF4. |
TreeFami | TF352753. |
Family and domain databases
InterProi | View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. |
Pfami | View protein in Pfam PF13853. 7tm_4. 1 hit. |
PRINTSi | PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR. |
PROSITEi | View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8NGF4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLMKEVRGR NQTEVTEFLL LGLSDNPDLQ GVLFALFLLI YMANMVGNLG
60 70 80 90 100
MIVLIKIDLC LHTPMYFFLS SLSFVDASYS SSVTPKMLVN LMAENKAISF
110 120 130 140 150
HGCAAQFYFF GSFLGTECFL LAMMAYDRYA AIWNPLLYPV LVSGRICFLL
160 170 180 190 200
IATSFLAGCG NAAIHTGMTF RLSFCGSNRI NHFYCDTPPL LKLSCSDTHF
210 220 230 240 250
NGIVIMAFSS FIVISCVMIV LISYLCIFIA VLKMPSLEGR HKAFSTCASY
260 270 280 290 300
LMAVTIFFGT ILFMYLRPTS SYSMEQDKVV SVFYTVIIPV LNPLIYSLKN
310
KDVKKALKKI LWKHIL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053180 | 105 | A → T. Corresponds to variant dbSNP:rs11606499Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065854 Genomic DNA. Translation: BAC06072.1. CH471076 Genomic DNA. Translation: EAW73720.1. BC136989 mRNA. Translation: AAI36990.1. |
CCDSi | CCDS31534.1. |
RefSeqi | NP_001002925.1. NM_001002925.1. |
UniGenei | Hs.449692. |
Genome annotation databases
Ensembli | ENST00000544374; ENSP00000442701; ENSG00000172464. |
GeneIDi | 338675. |
KEGGi | hsa:338675. |
UCSCi | uc001njb.1. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | O5AP2_HUMAN | |
Accessioni | Q8NGF4Primary (citable) accession number: Q8NGF4 Secondary accession number(s): B2RNM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 28, 2018 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |