OR5AP2

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW
odorant binding Source: GO_Central
olfactory receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 5AP2
Gene namesⁱ	Name:OR5AP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172464.2.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15258. OR5AP2.
neXtProtⁱ	NX_Q8NGF4.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 34	ExtracellularSequence analysisAdd BLAST	34
Transmembraneⁱ	35 – 55	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	56	CytoplasmicSequence analysis	1
Transmembraneⁱ	57 – 77	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	78 – 104	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	105 – 125	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	126 – 135	CytoplasmicSequence analysis	10
Transmembraneⁱ	136 – 156	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	157 – 210	ExtracellularSequence analysisAdd BLAST	54
Transmembraneⁱ	211 – 231	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	232 – 245	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	246 – 266	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	267 – 278	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	279 – 299	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	300 – 316	CytoplasmicSequence analysisAdd BLAST	17

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA32469.

PharmGKBⁱ

PA32469.

Polymorphism and mutation databases

BioMutaⁱ	OR5AP2.
DMDMⁱ	37081351.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150578	1 – 316	Olfactory receptor 5AP2Add BLAST		316

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	11	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	103 ↔ 195	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGF4.
PeptideAtlas More...PeptideAtlasⁱ	Q8NGF4.
PRIDEⁱ	Q8NGF4.

PTM databases

PhosphoSitePlusⁱ	Q8NGF4.

PhosphoSitePlusⁱ

Q8NGF4.

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_OR5AP2.
ExpressionAtlasⁱ	Q8NGF4. baseline and differential.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000303111.

STRINGⁱ

9606.ENSP00000303111.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGF4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJJ3. Eukaryota. ENOG4111D9W. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144101.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	Q8NGF4.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	KEVRGRN.
PhylomeDBⁱ	Q8NGF4.
TreeFamⁱ	TF352753.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853. 7tm_4. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGF4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLMKEVRGR NQTEVTEFLL LGLSDNPDLQ GVLFALFLLI YMANMVGNLG 
        60         70         80         90        100
MIVLIKIDLC LHTPMYFFLS SLSFVDASYS SSVTPKMLVN LMAENKAISF 
       110        120        130        140        150
HGCAAQFYFF GSFLGTECFL LAMMAYDRYA AIWNPLLYPV LVSGRICFLL 
       160        170        180        190        200
IATSFLAGCG NAAIHTGMTF RLSFCGSNRI NHFYCDTPPL LKLSCSDTHF 
       210        220        230        240        250
NGIVIMAFSS FIVISCVMIV LISYLCIFIA VLKMPSLEGR HKAFSTCASY 
       260        270        280        290        300
LMAVTIFFGT ILFMYLRPTS SYSMEQDKVV SVFYTVIIPV LNPLIYSLKN 
       310 
KDVKKALKKI LWKHIL

Length:316

Mass (Da):35,508

Last modified:October 1, 2002 - v1

Checksum:ⁱ5C2A3D9B7482400C

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053180	105	A → T. Corresponds to variant dbSNP:rs11606499Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065854 Genomic DNA. Translation: BAC06072.1. CH471076 Genomic DNA. Translation: EAW73720.1. BC136989 mRNA. Translation: AAI36990.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31534.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001002925.1. NM_001002925.1.
UniGeneⁱ	Hs.449692.

Genome annotation databases

Ensemblⁱ	ENST00000544374; ENSP00000442701; ENSG00000172464.
GeneIDⁱ	338675.
KEGGⁱ	hsa:338675.
UCSC genome browser More...UCSCⁱ	uc001njb.1. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8NGF4	B9EH20	Homo sapiens (Human)	316	UniRef100_Q8NGF4	Cluster: Olfactory receptor 5AP2	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8NGF4	B9EH20 S7NP71 UPI0003BBD5BE UPI0004BD5D3B A0A2K6GIW9 UPI0007A6F50B UPI000C9E7533 H0XNQ0 G1NTL3 M3Z545 +55	Homo sapiens (Human) Myotis brandtii (Brandt's bat) Equus przewalskii (Przewalski's horse) (Equus caballus przewalskii) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Miniopterus natalensis (Natal long-fingered bat) (Miniopterus schreibersii natalensis) Equus caballus (Horse) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Myotis lucifugus (Little brown bat) Mustela putorius furo (European domestic ferret) (Mustela furo) Acinonyx jubatus (Cheetah) And more	316	UniRef90_Q8NGF4	Cluster: Olfactory receptor 5AP2	66

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8NGF4	Q8NGM9 UPI0005F55B60 H2Q505 UPI0002745258 A0A126GV90 G3QQ68 UPI0003AB7EC6 UPI0006250B08 A0A0D9S977 A0A2J8X056 +486	Homo sapiens (Human) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pan troglodytes (Chimpanzee) Pan paniscus (Pygmy chimpanzee) (Bonobo) Gorilla gorilla gorilla (Western lowland gorilla) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Aotus nancymaae (Ma's night monkey) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Macaca nemestrina (Pig-tailed macaque) And more	314	UniRef50_Q8NGM9	Cluster: Olfactory receptor 8D4	497

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065854 Genomic DNA. Translation: BAC06072.1. CH471076 Genomic DNA. Translation: EAW73720.1. BC136989 mRNA. Translation: AAI36990.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31534.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001002925.1. NM_001002925.1.
UniGeneⁱ	Hs.449692.

3D structure databases

ProteinModelPortalⁱ	Q8NGF4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000303111.

STRINGⁱ

9606.ENSP00000303111.

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	Q8NGF4.

PhosphoSitePlusⁱ

Q8NGF4.

Polymorphism and mutation databases

BioMutaⁱ	OR5AP2.
DMDMⁱ	37081351.

Proteomic databases

PaxDbⁱ	Q8NGF4.
PeptideAtlas More...PeptideAtlasⁱ	Q8NGF4.
PRIDEⁱ	Q8NGF4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000544374; ENSP00000442701; ENSG00000172464.
GeneIDⁱ	338675.
KEGGⁱ	hsa:338675.
UCSC genome browser More...UCSCⁱ	uc001njb.1. human.

Organism-specific databases

CTDⁱ	338675.
EuPathDBⁱ	HostDB:ENSG00000172464.2.
GeneCardsⁱ	OR5AP2.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15258. OR5AP2.
neXtProtⁱ	NX_Q8NGF4.
PharmGKBⁱ	PA32469.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJJ3. Eukaryota. ENOG4111D9W. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144101.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	Q8NGF4.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	KEVRGRN.
PhylomeDBⁱ	Q8NGF4.
TreeFamⁱ	TF352753.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAiⁱ	338675.
Protein Ontology More...PROⁱ	PR:Q8NGF4.

Gene expression databases

CleanExⁱ	HS_OR5AP2.
ExpressionAtlasⁱ	Q8NGF4. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853. 7tm_4. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O5AP2_HUMAN
Accessionⁱ	Q8NGF4Primary (citable) accession number: Q8NGF4 Secondary accession number(s): B2RNM8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
	Last sequence update:	October 1, 2002
	Last modified:	February 28, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NGF4 (O5AP2_HUMAN)

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Olfactory receptor 5AP2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ