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Q8NGF0 (O52B6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 52B6
Alternative name(s):
Olfactory receptor OR11-47
Gene names
Name:OR52B6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-22 is the initiator.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Olfactory receptor 52B6
PRO_0000150769

Regions

Topological domain1 – 4545Extracellular Potential
Transmembrane46 – 6621Helical; Name=1; Potential
Topological domain67 – 748Cytoplasmic Potential
Transmembrane75 – 9521Helical; Name=2; Potential
Topological domain96 – 11924Extracellular Potential
Transmembrane120 – 13920Helical; Name=3; Potential
Topological domain140 – 15819Cytoplasmic Potential
Transmembrane159 – 17921Helical; Name=4; Potential
Topological domain180 – 21536Extracellular Potential
Transmembrane216 – 23621Helical; Name=5; Potential
Topological domain237 – 25620Cytoplasmic Potential
Transmembrane257 – 27721Helical; Name=6; Potential
Topological domain278 – 29316Extracellular Potential
Transmembrane294 – 31421Helical; Name=7; Potential
Topological domain315 – 33521Cytoplasmic Potential

Amino acid modifications

Glycosylation231N-linked (GlcNAc...) Potential
Disulfide bond117 ↔ 208 By similarity

Natural variations

Natural variant571T → A.
Corresponds to variant rs1077126 [ dbSNP | Ensembl ].
VAR_048077
Natural variant1111L → H.
Corresponds to variant rs2341432 [ dbSNP | Ensembl ].
VAR_048078
Natural variant1671A → T.
Corresponds to variant rs2341433 [ dbSNP | Ensembl ].
VAR_048079
Natural variant1701H → R.
Corresponds to variant rs2341434 [ dbSNP | Ensembl ].
VAR_048080
Natural variant2881V → I.
Corresponds to variant rs10769086 [ dbSNP | Ensembl ].
VAR_048081

Sequences

Sequence LengthMass (Da)Tools
Q8NGF0 [UniParc].

Last modified December 16, 2008. Version 3.
Checksum: F1F3458611158252

FASTA33536,963
        10         20         30         40         50         60 
MAQVRALHKI MALFSANSIG AMNNSDTRIA GCFLTGIPGL EQLHIWLSIP FCIMYITALE 

        70         80         90        100        110        120 
GNGILICVIL SQAILHEPMY IFLSMLASAD VLLSTTTMPK ALANLWLGYS LISFDGCLTQ 

       130        140        150        160        170        180 
MFFIHFLFIH SAVLLAMAFD RYVAICSPLR YVTILTSKVI GKIVTAALSH SFIIMFPSIF 

       190        200        210        220        230        240 
LLEHLHYCQI NIIAHTFCEH MGIAHLSCSD ISINVWYGLA AALLSTGLDI MLITVSYIHI 

       250        260        270        280        290        300 
LQAVFRLLSQ DARSKALSTC GSHICVILLF YVPALFSVFA YRFGGRSVPC YVHILLASLY 

       310        320        330 
VVIPPMLNPV IYGVRTKPIL EGAKQMFSNL AKGSK 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065858 Genomic DNA. Translation: BAC06076.1.
AC015691 Genomic DNA. No translation available.
BK004275 Genomic DNA. Translation: DAA04673.1.
CCDSCCDS41611.1.
RefSeqNP_001005162.2. NM_001005162.2.
UniGeneHs.553704.

3D structure databases

ProteinModelPortalQ8NGF0.
SMRQ8NGF0. Positions 39-177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000341581.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGF0.

Polymorphism databases

DMDM218512128.

Proteomic databases

PaxDbQ8NGF0.
PRIDEQ8NGF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000345043; ENSP00000341581; ENSG00000187747.
GeneID340980.
KEGGhsa:340980.
UCSCuc010qzi.2. human.

Organism-specific databases

CTD340980.
GeneCardsGC11P005604.
HGNCHGNC:15211. OR52B6.
neXtProtNX_Q8NGF0.
PharmGKBPA32400.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG147576.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ8NGF0.
KOK04257.
OMAKQMFSNL.
OrthoDBEOG754HPV.
PhylomeDBQ8NGF0.
TreeFamTF343679.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR52B6.
GenevestigatorQ8NGF0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR52B6.
GenomeRNAi340980.
NextBio98050.
PROQ8NGF0.

Entry information

Entry nameO52B6_HUMAN
AccessionPrimary (citable) accession number: Q8NGF0
Secondary accession number(s): Q6IFI7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: July 9, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries