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Protein

Olfactory receptor 52B6

Gene

OR52B6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181609-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52B6
Alternative name(s):
Olfactory receptor OR11-47
Gene namesi
Name:OR52B6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15211. OR52B6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini67 – 74CytoplasmicSequence analysis8
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 119ExtracellularSequence analysisAdd BLAST24
Transmembranei120 – 139Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini140 – 158CytoplasmicSequence analysisAdd BLAST19
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 215ExtracellularSequence analysisAdd BLAST36
Transmembranei216 – 236Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini237 – 256CytoplasmicSequence analysisAdd BLAST20
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 293ExtracellularSequence analysisAdd BLAST16
Transmembranei294 – 314Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini315 – 335CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187747.
PharmGKBiPA32400.

Polymorphism and mutation databases

BioMutaiOR52B6.
DMDMi218512128.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507691 – 335Olfactory receptor 52B6Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi117 ↔ 208PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGF0.
PRIDEiQ8NGF0.

PTM databases

iPTMnetiQ8NGF0.
PhosphoSitePlusiQ8NGF0.

Expressioni

Gene expression databases

CleanExiHS_OR52B6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341581.

Structurei

3D structure databases

ProteinModelPortaliQ8NGF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II1I. Eukaryota.
ENOG410YB92. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGF0.
KOiK04257.
OMAiFSANSIG.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGF0.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVRALHKI MALFSANSIG AMNNSDTRIA GCFLTGIPGL EQLHIWLSIP
60 70 80 90 100
FCIMYITALE GNGILICVIL SQAILHEPMY IFLSMLASAD VLLSTTTMPK
110 120 130 140 150
ALANLWLGYS LISFDGCLTQ MFFIHFLFIH SAVLLAMAFD RYVAICSPLR
160 170 180 190 200
YVTILTSKVI GKIVTAALSH SFIIMFPSIF LLEHLHYCQI NIIAHTFCEH
210 220 230 240 250
MGIAHLSCSD ISINVWYGLA AALLSTGLDI MLITVSYIHI LQAVFRLLSQ
260 270 280 290 300
DARSKALSTC GSHICVILLF YVPALFSVFA YRFGGRSVPC YVHILLASLY
310 320 330
VVIPPMLNPV IYGVRTKPIL EGAKQMFSNL AKGSK
Length:335
Mass (Da):36,963
Last modified:December 16, 2008 - v3
Checksum:iF1F3458611158252
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04807757T → A.Corresponds to variant rs1077126dbSNPEnsembl.1
Natural variantiVAR_048078111L → H.Corresponds to variant rs2341432dbSNPEnsembl.1
Natural variantiVAR_048079167A → T.Corresponds to variant rs2341433dbSNPEnsembl.1
Natural variantiVAR_048080170H → R.Corresponds to variant rs2341434dbSNPEnsembl.1
Natural variantiVAR_048081288V → I.Corresponds to variant rs10769086dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065858 Genomic DNA. Translation: BAC06076.1.
AC015691 Genomic DNA. No translation available.
BK004275 Genomic DNA. Translation: DAA04673.1.
CCDSiCCDS41611.1.
RefSeqiNP_001005162.2. NM_001005162.2.
UniGeneiHs.553704.

Genome annotation databases

EnsembliENST00000345043; ENSP00000341581; ENSG00000187747.
GeneIDi340980.
KEGGihsa:340980.
UCSCiuc010qzi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065858 Genomic DNA. Translation: BAC06076.1.
AC015691 Genomic DNA. No translation available.
BK004275 Genomic DNA. Translation: DAA04673.1.
CCDSiCCDS41611.1.
RefSeqiNP_001005162.2. NM_001005162.2.
UniGeneiHs.553704.

3D structure databases

ProteinModelPortaliQ8NGF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341581.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGF0.
PhosphoSitePlusiQ8NGF0.

Polymorphism and mutation databases

BioMutaiOR52B6.
DMDMi218512128.

Proteomic databases

PaxDbiQ8NGF0.
PRIDEiQ8NGF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345043; ENSP00000341581; ENSG00000187747.
GeneIDi340980.
KEGGihsa:340980.
UCSCiuc010qzi.2. human.

Organism-specific databases

CTDi340980.
GeneCardsiOR52B6.
HGNCiHGNC:15211. OR52B6.
neXtProtiNX_Q8NGF0.
OpenTargetsiENSG00000187747.
PharmGKBiPA32400.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II1I. Eukaryota.
ENOG410YB92. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGF0.
KOiK04257.
OMAiFSANSIG.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGF0.
TreeFamiTF343679.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181609-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52B6.
GenomeRNAii340980.
PROiQ8NGF0.

Gene expression databases

CleanExiHS_OR52B6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52B6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGF0
Secondary accession number(s): Q6IFI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: November 2, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-22 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.