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Protein

Olfactory receptor 52B6

Gene

OR52B6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52B6
Alternative name(s):
Olfactory receptor OR11-47
Gene namesi
Name:OR52B6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15211. OR52B6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini67 – 748CytoplasmicSequence Analysis
Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini96 – 11924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei120 – 13920Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini140 – 15819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 21536ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 23621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini237 – 25620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini278 – 29316ExtracellularSequence AnalysisAdd
BLAST
Transmembranei294 – 31421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini315 – 33521CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32400.

Polymorphism and mutation databases

BioMutaiOR52B6.
DMDMi218512128.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Olfactory receptor 52B6PRO_0000150769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 208PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGF0.
PRIDEiQ8NGF0.

PTM databases

PhosphoSiteiQ8NGF0.

Expressioni

Gene expression databases

CleanExiHS_OR52B6.
GenevestigatoriQ8NGF0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341581.

Structurei

3D structure databases

ProteinModelPortaliQ8NGF0.
SMRiQ8NGF0. Positions 39-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147576.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGF0.
KOiK04257.
OMAiAVSYIHI.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGF0.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVRALHKI MALFSANSIG AMNNSDTRIA GCFLTGIPGL EQLHIWLSIP
60 70 80 90 100
FCIMYITALE GNGILICVIL SQAILHEPMY IFLSMLASAD VLLSTTTMPK
110 120 130 140 150
ALANLWLGYS LISFDGCLTQ MFFIHFLFIH SAVLLAMAFD RYVAICSPLR
160 170 180 190 200
YVTILTSKVI GKIVTAALSH SFIIMFPSIF LLEHLHYCQI NIIAHTFCEH
210 220 230 240 250
MGIAHLSCSD ISINVWYGLA AALLSTGLDI MLITVSYIHI LQAVFRLLSQ
260 270 280 290 300
DARSKALSTC GSHICVILLF YVPALFSVFA YRFGGRSVPC YVHILLASLY
310 320 330
VVIPPMLNPV IYGVRTKPIL EGAKQMFSNL AKGSK
Length:335
Mass (Da):36,963
Last modified:December 16, 2008 - v3
Checksum:iF1F3458611158252
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571T → A.
Corresponds to variant rs1077126 [ dbSNP | Ensembl ].
VAR_048077
Natural varianti111 – 1111L → H.
Corresponds to variant rs2341432 [ dbSNP | Ensembl ].
VAR_048078
Natural varianti167 – 1671A → T.
Corresponds to variant rs2341433 [ dbSNP | Ensembl ].
VAR_048079
Natural varianti170 – 1701H → R.
Corresponds to variant rs2341434 [ dbSNP | Ensembl ].
VAR_048080
Natural varianti288 – 2881V → I.
Corresponds to variant rs10769086 [ dbSNP | Ensembl ].
VAR_048081

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065858 Genomic DNA. Translation: BAC06076.1.
AC015691 Genomic DNA. No translation available.
BK004275 Genomic DNA. Translation: DAA04673.1.
CCDSiCCDS41611.1.
RefSeqiNP_001005162.2. NM_001005162.2.
UniGeneiHs.553704.

Genome annotation databases

EnsembliENST00000345043; ENSP00000341581; ENSG00000187747.
GeneIDi340980.
KEGGihsa:340980.
UCSCiuc010qzi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065858 Genomic DNA. Translation: BAC06076.1.
AC015691 Genomic DNA. No translation available.
BK004275 Genomic DNA. Translation: DAA04673.1.
CCDSiCCDS41611.1.
RefSeqiNP_001005162.2. NM_001005162.2.
UniGeneiHs.553704.

3D structure databases

ProteinModelPortaliQ8NGF0.
SMRiQ8NGF0. Positions 39-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341581.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGF0.

Polymorphism and mutation databases

BioMutaiOR52B6.
DMDMi218512128.

Proteomic databases

PaxDbiQ8NGF0.
PRIDEiQ8NGF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345043; ENSP00000341581; ENSG00000187747.
GeneIDi340980.
KEGGihsa:340980.
UCSCiuc010qzi.2. human.

Organism-specific databases

CTDi340980.
GeneCardsiGC11P005604.
HGNCiHGNC:15211. OR52B6.
neXtProtiNX_Q8NGF0.
PharmGKBiPA32400.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147576.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NGF0.
KOiK04257.
OMAiAVSYIHI.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NGF0.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52B6.
GenomeRNAii340980.
NextBioi98050.
PROiQ8NGF0.

Gene expression databases

CleanExiHS_OR52B6.
GenevestigatoriQ8NGF0.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52B6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGF0
Secondary accession number(s): Q6IFI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: May 27, 2015
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-22 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.