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Q8NGF0

- O52B6_HUMAN

UniProt

Q8NGF0 - O52B6_HUMAN

Protein

Olfactory receptor 52B6

Gene

OR52B6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 3 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 52B6
    Alternative name(s):
    Olfactory receptor OR11-47
    Gene namesi
    Name:OR52B6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15211. OR52B6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32400.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Olfactory receptor 52B6PRO_0000150769Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 208PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGF0.
    PRIDEiQ8NGF0.

    PTM databases

    PhosphoSiteiQ8NGF0.

    Expressioni

    Gene expression databases

    CleanExiHS_OR52B6.
    GenevestigatoriQ8NGF0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000341581.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGF0.
    SMRiQ8NGF0. Positions 39-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 748CytoplasmicSequence Analysis
    Topological domaini96 – 11924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini140 – 15819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 21536ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini237 – 25620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini278 – 29316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini315 – 33521CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 13920Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147576.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NGF0.
    KOiK04257.
    OMAiKQMFSNL.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ8NGF0.
    TreeFamiTF343679.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQVRALHKI MALFSANSIG AMNNSDTRIA GCFLTGIPGL EQLHIWLSIP    50
    FCIMYITALE GNGILICVIL SQAILHEPMY IFLSMLASAD VLLSTTTMPK 100
    ALANLWLGYS LISFDGCLTQ MFFIHFLFIH SAVLLAMAFD RYVAICSPLR 150
    YVTILTSKVI GKIVTAALSH SFIIMFPSIF LLEHLHYCQI NIIAHTFCEH 200
    MGIAHLSCSD ISINVWYGLA AALLSTGLDI MLITVSYIHI LQAVFRLLSQ 250
    DARSKALSTC GSHICVILLF YVPALFSVFA YRFGGRSVPC YVHILLASLY 300
    VVIPPMLNPV IYGVRTKPIL EGAKQMFSNL AKGSK 335
    Length:335
    Mass (Da):36,963
    Last modified:December 16, 2008 - v3
    Checksum:iF1F3458611158252
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571T → A.
    Corresponds to variant rs1077126 [ dbSNP | Ensembl ].
    VAR_048077
    Natural varianti111 – 1111L → H.
    Corresponds to variant rs2341432 [ dbSNP | Ensembl ].
    VAR_048078
    Natural varianti167 – 1671A → T.
    Corresponds to variant rs2341433 [ dbSNP | Ensembl ].
    VAR_048079
    Natural varianti170 – 1701H → R.
    Corresponds to variant rs2341434 [ dbSNP | Ensembl ].
    VAR_048080
    Natural varianti288 – 2881V → I.
    Corresponds to variant rs10769086 [ dbSNP | Ensembl ].
    VAR_048081

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065858 Genomic DNA. Translation: BAC06076.1.
    AC015691 Genomic DNA. No translation available.
    BK004275 Genomic DNA. Translation: DAA04673.1.
    CCDSiCCDS41611.1.
    RefSeqiNP_001005162.2. NM_001005162.2.
    UniGeneiHs.553704.

    Genome annotation databases

    EnsembliENST00000345043; ENSP00000341581; ENSG00000187747.
    GeneIDi340980.
    KEGGihsa:340980.
    UCSCiuc010qzi.2. human.

    Polymorphism databases

    DMDMi218512128.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065858 Genomic DNA. Translation: BAC06076.1 .
    AC015691 Genomic DNA. No translation available.
    BK004275 Genomic DNA. Translation: DAA04673.1 .
    CCDSi CCDS41611.1.
    RefSeqi NP_001005162.2. NM_001005162.2.
    UniGenei Hs.553704.

    3D structure databases

    ProteinModelPortali Q8NGF0.
    SMRi Q8NGF0. Positions 39-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000341581.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGF0.

    Polymorphism databases

    DMDMi 218512128.

    Proteomic databases

    PaxDbi Q8NGF0.
    PRIDEi Q8NGF0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345043 ; ENSP00000341581 ; ENSG00000187747 .
    GeneIDi 340980.
    KEGGi hsa:340980.
    UCSCi uc010qzi.2. human.

    Organism-specific databases

    CTDi 340980.
    GeneCardsi GC11P005604.
    HGNCi HGNC:15211. OR52B6.
    neXtProti NX_Q8NGF0.
    PharmGKBi PA32400.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147576.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NGF0.
    KOi K04257.
    OMAi KQMFSNL.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q8NGF0.
    TreeFami TF343679.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR52B6.
    GenomeRNAii 340980.
    NextBioi 98050.
    PROi Q8NGF0.

    Gene expression databases

    CleanExi HS_OR52B6.
    Genevestigatori Q8NGF0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO52B6_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGF0
    Secondary accession number(s): Q6IFI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-22 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3