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Q8NGE9

- OR9Q2_HUMAN

UniProt

Q8NGE9 - OR9Q2_HUMAN

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Protein

Olfactory receptor 9Q2

Gene

OR9Q2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9Q2
Gene namesi
Name:OR9Q2
Synonyms:OR9Q2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15328. OR9Q2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 9Q2PRO_0000150684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGE9.

Expressioni

Gene expression databases

BgeeiQ8NGE9.
CleanExiHS_OR9Q2.
GenevestigatoriQ8NGE9.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308714.

Structurei

3D structure databases

ProteinModelPortaliQ8NGE9.
SMRiQ8NGE9. Positions 21-220.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47340.
GeneTreeiENSGT00750000117548.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGE9.
KOiK04257.
OMAiMAERNYT.
OrthoDBiEOG7MPRF7.
PhylomeDBiQ8NGE9.
TreeFamiTF337111.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGE9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAERNYTVVT EFFLTAFTEH LQWRVPLFLI FLSFYLATML GNTGMILLIR
60 70 80 90 100
GDRRLHTPMY FFLSHLSLVD ICYSSAIIPQ MLAVLWEHGT TISQARCAAQ
110 120 130 140 150
FFLFTFFASI DCYLLAIMAY DRYTAVCQPL LYVTIITEKA RWGLVTGAYV
160 170 180 190 200
AGFFSAFVRT VTAFTLSFCG NNEINFIFCD LPPLLKLSCG DSYTQEVVII
210 220 230 240 250
VFALFVMPAC ILVILVSYLF IIVAILQIHS AGGRAKTFST CASHLTAVAL
260 270 280 290 300
FFGTLIFMYL RDNTGQSSEG DRVVSVLYTV VTPMLNPLIY SLRNKEVKEA
310
TRKALSKSKP ARRP
Length:314
Mass (Da):35,363
Last modified:October 1, 2002 - v1
Checksum:iEFD847443D8FDFD4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791C → R.
Corresponds to variant rs34337292 [ dbSNP | Ensembl ].
VAR_062061

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065859 Genomic DNA. Translation: BAC06077.1.
CCDSiCCDS31544.1.
RefSeqiNP_001005283.1. NM_001005283.2.
UniGeneiHs.553643.

Genome annotation databases

EnsembliENST00000311591; ENSP00000308714; ENSG00000186513.
GeneIDi219957.
KEGGihsa:219957.
UCSCiuc010rka.2. human.

Polymorphism databases

DMDMi74762579.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065859 Genomic DNA. Translation: BAC06077.1 .
CCDSi CCDS31544.1.
RefSeqi NP_001005283.1. NM_001005283.2.
UniGenei Hs.553643.

3D structure databases

ProteinModelPortali Q8NGE9.
SMRi Q8NGE9. Positions 21-220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000308714.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 74762579.

Proteomic databases

PRIDEi Q8NGE9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311591 ; ENSP00000308714 ; ENSG00000186513 .
GeneIDi 219957.
KEGGi hsa:219957.
UCSCi uc010rka.2. human.

Organism-specific databases

CTDi 219957.
GeneCardsi GC11P057957.
HGNCi HGNC:15328. OR9Q2.
neXtProti NX_Q8NGE9.
PharmGKBi PA32806.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47340.
GeneTreei ENSGT00750000117548.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGE9.
KOi K04257.
OMAi MAERNYT.
OrthoDBi EOG7MPRF7.
PhylomeDBi Q8NGE9.
TreeFami TF337111.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii 219957.
NextBioi 90878.
PROi Q8NGE9.

Gene expression databases

Bgeei Q8NGE9.
CleanExi HS_OR9Q2.
Genevestigatori Q8NGE9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiOR9Q2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3