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Protein

Olfactory receptor 9Q2

Gene

OR9Q2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9Q2
Gene namesi
Name:OR9Q2
Synonyms:OR9Q2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15328. OR9Q2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 9Q2PRO_0000150684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGE9.

Expressioni

Gene expression databases

BgeeiQ8NGE9.
CleanExiHS_OR9Q2.
GenevestigatoriQ8NGE9.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308714.

Structurei

3D structure databases

ProteinModelPortaliQ8NGE9.
SMRiQ8NGE9. Positions 21-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47340.
GeneTreeiENSGT00780000121955.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGE9.
KOiK04257.
OMAiMAERNYT.
OrthoDBiEOG7MPRF7.
PhylomeDBiQ8NGE9.
TreeFamiTF337111.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERNYTVVT EFFLTAFTEH LQWRVPLFLI FLSFYLATML GNTGMILLIR
60 70 80 90 100
GDRRLHTPMY FFLSHLSLVD ICYSSAIIPQ MLAVLWEHGT TISQARCAAQ
110 120 130 140 150
FFLFTFFASI DCYLLAIMAY DRYTAVCQPL LYVTIITEKA RWGLVTGAYV
160 170 180 190 200
AGFFSAFVRT VTAFTLSFCG NNEINFIFCD LPPLLKLSCG DSYTQEVVII
210 220 230 240 250
VFALFVMPAC ILVILVSYLF IIVAILQIHS AGGRAKTFST CASHLTAVAL
260 270 280 290 300
FFGTLIFMYL RDNTGQSSEG DRVVSVLYTV VTPMLNPLIY SLRNKEVKEA
310
TRKALSKSKP ARRP
Length:314
Mass (Da):35,363
Last modified:October 1, 2002 - v1
Checksum:iEFD847443D8FDFD4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791C → R.
Corresponds to variant rs34337292 [ dbSNP | Ensembl ].
VAR_062061

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065859 Genomic DNA. Translation: BAC06077.1.
CCDSiCCDS31544.1.
RefSeqiNP_001005283.1. NM_001005283.2.
UniGeneiHs.553643.

Genome annotation databases

EnsembliENST00000311591; ENSP00000308714; ENSG00000186513.
GeneIDi219957.
KEGGihsa:219957.
UCSCiuc010rka.2. human.

Polymorphism databases

DMDMi74762579.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065859 Genomic DNA. Translation: BAC06077.1.
CCDSiCCDS31544.1.
RefSeqiNP_001005283.1. NM_001005283.2.
UniGeneiHs.553643.

3D structure databases

ProteinModelPortaliQ8NGE9.
SMRiQ8NGE9. Positions 21-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308714.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi74762579.

Proteomic databases

PRIDEiQ8NGE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311591; ENSP00000308714; ENSG00000186513.
GeneIDi219957.
KEGGihsa:219957.
UCSCiuc010rka.2. human.

Organism-specific databases

CTDi219957.
GeneCardsiGC11P057957.
HGNCiHGNC:15328. OR9Q2.
neXtProtiNX_Q8NGE9.
PharmGKBiPA32806.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47340.
GeneTreeiENSGT00780000121955.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGE9.
KOiK04257.
OMAiMAERNYT.
OrthoDBiEOG7MPRF7.
PhylomeDBiQ8NGE9.
TreeFamiTF337111.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii219957.
NextBioi90878.
PROiQ8NGE9.

Gene expression databases

BgeeiQ8NGE9.
CleanExiHS_OR9Q2.
GenevestigatoriQ8NGE9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiOR9Q2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.