Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NGE9 (OR9Q2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 9Q2
Gene names
Name:OR9Q2
Synonyms:OR9Q2P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Olfactory receptor 9Q2
PRO_0000150684

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31422Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant1791C → R.
Corresponds to variant rs34337292 [ dbSNP | Ensembl ].
VAR_062061

Sequences

Sequence LengthMass (Da)Tools
Q8NGE9 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: EFD847443D8FDFD4

FASTA31435,363
        10         20         30         40         50         60 
MAERNYTVVT EFFLTAFTEH LQWRVPLFLI FLSFYLATML GNTGMILLIR GDRRLHTPMY 

        70         80         90        100        110        120 
FFLSHLSLVD ICYSSAIIPQ MLAVLWEHGT TISQARCAAQ FFLFTFFASI DCYLLAIMAY 

       130        140        150        160        170        180 
DRYTAVCQPL LYVTIITEKA RWGLVTGAYV AGFFSAFVRT VTAFTLSFCG NNEINFIFCD 

       190        200        210        220        230        240 
LPPLLKLSCG DSYTQEVVII VFALFVMPAC ILVILVSYLF IIVAILQIHS AGGRAKTFST 

       250        260        270        280        290        300 
CASHLTAVAL FFGTLIFMYL RDNTGQSSEG DRVVSVLYTV VTPMLNPLIY SLRNKEVKEA 

       310 
TRKALSKSKP ARRP 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065859 Genomic DNA. Translation: BAC06077.1.
CCDSCCDS31544.1.
RefSeqNP_001005283.1. NM_001005283.2.
UniGeneHs.553643.

3D structure databases

ProteinModelPortalQ8NGE9.
SMRQ8NGE9. Positions 21-220.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308714.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM74762579.

Proteomic databases

PRIDEQ8NGE9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311591; ENSP00000308714; ENSG00000186513.
GeneID219957.
KEGGhsa:219957.
UCSCuc010rka.2. human.

Organism-specific databases

CTD219957.
GeneCardsGC11P057957.
HGNCHGNC:15328. OR9Q2.
neXtProtNX_Q8NGE9.
PharmGKBPA32806.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47340.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGE9.
KOK04257.
OMAMAERNYT.
OrthoDBEOG7MPRF7.
PhylomeDBQ8NGE9.
TreeFamTF337111.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8NGE9.
CleanExHS_OR9Q2.
GenevestigatorQ8NGE9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio90878.
PROQ8NGE9.

Entry information

Entry nameOR9Q2_HUMAN
AccessionPrimary (citable) accession number: Q8NGE9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries