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Q8NGE9

- OR9Q2_HUMAN

UniProt

Q8NGE9 - OR9Q2_HUMAN

Protein

Olfactory receptor 9Q2

Gene

OR9Q2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 9Q2
    Gene namesi
    Name:OR9Q2
    Synonyms:OR9Q2P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15328. OR9Q2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32806.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 9Q2PRO_0000150684Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGE9.

    Expressioni

    Gene expression databases

    BgeeiQ8NGE9.
    CleanExiHS_OR9Q2.
    GenevestigatoriQ8NGE9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308714.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGE9.
    SMRiQ8NGE9. Positions 21-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47340.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGE9.
    KOiK04257.
    OMAiMAERNYT.
    OrthoDBiEOG7MPRF7.
    PhylomeDBiQ8NGE9.
    TreeFamiTF337111.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGE9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAERNYTVVT EFFLTAFTEH LQWRVPLFLI FLSFYLATML GNTGMILLIR    50
    GDRRLHTPMY FFLSHLSLVD ICYSSAIIPQ MLAVLWEHGT TISQARCAAQ 100
    FFLFTFFASI DCYLLAIMAY DRYTAVCQPL LYVTIITEKA RWGLVTGAYV 150
    AGFFSAFVRT VTAFTLSFCG NNEINFIFCD LPPLLKLSCG DSYTQEVVII 200
    VFALFVMPAC ILVILVSYLF IIVAILQIHS AGGRAKTFST CASHLTAVAL 250
    FFGTLIFMYL RDNTGQSSEG DRVVSVLYTV VTPMLNPLIY SLRNKEVKEA 300
    TRKALSKSKP ARRP 314
    Length:314
    Mass (Da):35,363
    Last modified:October 1, 2002 - v1
    Checksum:iEFD847443D8FDFD4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti179 – 1791C → R.
    Corresponds to variant rs34337292 [ dbSNP | Ensembl ].
    VAR_062061

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065859 Genomic DNA. Translation: BAC06077.1.
    CCDSiCCDS31544.1.
    RefSeqiNP_001005283.1. NM_001005283.2.
    UniGeneiHs.553643.

    Genome annotation databases

    EnsembliENST00000311591; ENSP00000308714; ENSG00000186513.
    GeneIDi219957.
    KEGGihsa:219957.
    UCSCiuc010rka.2. human.

    Polymorphism databases

    DMDMi74762579.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065859 Genomic DNA. Translation: BAC06077.1 .
    CCDSi CCDS31544.1.
    RefSeqi NP_001005283.1. NM_001005283.2.
    UniGenei Hs.553643.

    3D structure databases

    ProteinModelPortali Q8NGE9.
    SMRi Q8NGE9. Positions 21-220.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308714.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 74762579.

    Proteomic databases

    PRIDEi Q8NGE9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311591 ; ENSP00000308714 ; ENSG00000186513 .
    GeneIDi 219957.
    KEGGi hsa:219957.
    UCSCi uc010rka.2. human.

    Organism-specific databases

    CTDi 219957.
    GeneCardsi GC11P057957.
    HGNCi HGNC:15328. OR9Q2.
    neXtProti NX_Q8NGE9.
    PharmGKBi PA32806.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47340.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGE9.
    KOi K04257.
    OMAi MAERNYT.
    OrthoDBi EOG7MPRF7.
    PhylomeDBi Q8NGE9.
    TreeFami TF337111.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    NextBioi 90878.
    PROi Q8NGE9.

    Gene expression databases

    Bgeei Q8NGE9.
    CleanExi HS_OR9Q2.
    Genevestigatori Q8NGE9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiOR9Q2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3