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Q8NGE7 (OR9K2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 9K2
Alternative name(s):
Olfactory receptor OR12-2
Gene names
Name:OR9K2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.

Sequence caution

The sequence BAC06080.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Olfactory receptor 9K2
PRO_0000150682

Regions

Topological domain1 – 5050Extracellular Potential
Transmembrane51 – 7121Helical; Name=1; Potential
Topological domain72 – 798Cytoplasmic Potential
Transmembrane80 – 10021Helical; Name=2; Potential
Topological domain101 – 12424Extracellular Potential
Transmembrane125 – 14521Helical; Name=3; Potential
Topological domain146 – 16419Cytoplasmic Potential
Transmembrane165 – 18521Helical; Name=4; Potential
Topological domain186 – 22237Extracellular Potential
Transmembrane223 – 24220Helical; Name=5; Potential
Topological domain243 – 26220Cytoplasmic Potential
Transmembrane263 – 28321Helical; Name=6; Potential
Topological domain284 – 29613Extracellular Potential
Topological domain316 – 33520Cytoplasmic Potential

Amino acid modifications

Glycosylation301N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Disulfide bond122 ↔ 214 By similarity

Natural variations

Natural variant451R → C.
Corresponds to variant rs12303066 [ dbSNP | Ensembl ].
VAR_048057
Natural variant1031E → A.
Corresponds to variant rs7305779 [ dbSNP | Ensembl ].
VAR_048058
Natural variant2071R → H.
Corresponds to variant rs7306491 [ dbSNP | Ensembl ].
VAR_048059

Sequences

Sequence LengthMass (Da)Tools
Q8NGE7 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 90454BC59D32F5F3

FASTA33537,746
        10         20         30         40         50         60 
MLGSKPRVHL YILPCASQQV STMGDRGTSN HSEMTDFILA GFRVRPELHI LLFLLFLFVY 

        70         80         90        100        110        120 
AMILLGNVGM MTIIMTDPRL NTPMYFFLGN LSFIDLFYSS VIEPKAMINF WSENKSISFA 

       130        140        150        160        170        180 
GCVAQLFLFA LLIVTEGFLL AAMAYDRFIA ICNPLLYSVQ MSTRLCTQLV AGSYFCGCIS 

       190        200        210        220        230        240 
SVIQTSMTFT LSFCASRAVD HFYCDSRPLQ RLSCSDLFIH RMISFSLSCI IILPTIIVII 

       250        260        270        280        290        300 
VSYMYIVSTV LKIHSTEGHK KAFSTCSSHL GVVSVLYGAV FFMYLTPDRF PELSKVASLC 

       310        320        330 
YSLVTPMLNP LIYSLRNKDV QEALKKFLEK KNIIL 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065862 Genomic DNA. Translation: BAC06080.1. Different initiation.
BC136988 mRNA. Translation: AAI36989.1.
BK004326 Genomic DNA. Translation: DAA04724.1.
RefSeqNP_001005243.1. NM_001005243.1.
UniGeneHs.553827.

3D structure databases

ProteinModelPortalQ8NGE7.
SMRQ8NGE7. Positions 49-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000307598.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGE7.

Polymorphism databases

DMDM218511732.

Proteomic databases

PaxDbQ8NGE7.
PRIDEQ8NGE7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305377; ENSP00000307598; ENSG00000170605.
GeneID441639.
KEGGhsa:441639.
UCSCuc010spe.2. human.

Organism-specific databases

CTD441639.
GeneCardsGC12P055523.
HGNCHGNC:15339. OR9K2.
HPAHPA015808.
neXtProtNX_Q8NGE7.
PharmGKBPA32799.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39616.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGE7.
KOK04257.
OMASCIIILP.
OrthoDBEOG7QG44P.
PhylomeDBQ8NGE7.
TreeFamTF352758.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR9K2.
GenevestigatorQ8NGE7.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR9K2.
GenomeRNAi441639.
NextBio110363.
PROQ8NGE7.

Entry information

Entry nameOR9K2_HUMAN
AccessionPrimary (citable) accession number: Q8NGE7
Secondary accession number(s): B9EH19, Q6IFD6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries