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Q8NGE7

- OR9K2_HUMAN

UniProt

Q8NGE7 - OR9K2_HUMAN

Protein

Olfactory receptor 9K2

Gene

OR9K2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 9K2
    Alternative name(s):
    Olfactory receptor OR12-2
    Gene namesi
    Name:OR9K2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:15339. OR9K2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32799.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Olfactory receptor 9K2PRO_0000150682Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi122 ↔ 214PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGE7.
    PRIDEiQ8NGE7.

    PTM databases

    PhosphoSiteiQ8NGE7.

    Expressioni

    Gene expression databases

    CleanExiHS_OR9K2.
    GenevestigatoriQ8NGE7.

    Organism-specific databases

    HPAiHPA015808.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000307598.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGE7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5050ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini72 – 798CytoplasmicSequence Analysis
    Topological domaini101 – 12424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini146 – 16419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini186 – 22237ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini243 – 26220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini284 – 29613ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini316 – 33520CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei223 – 24220Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39616.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGE7.
    KOiK04257.
    OMAiSCIIILP.
    OrthoDBiEOG7QG44P.
    PhylomeDBiQ8NGE7.
    TreeFamiTF352758.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGSKPRVHL YILPCASQQV STMGDRGTSN HSEMTDFILA GFRVRPELHI    50
    LLFLLFLFVY AMILLGNVGM MTIIMTDPRL NTPMYFFLGN LSFIDLFYSS 100
    VIEPKAMINF WSENKSISFA GCVAQLFLFA LLIVTEGFLL AAMAYDRFIA 150
    ICNPLLYSVQ MSTRLCTQLV AGSYFCGCIS SVIQTSMTFT LSFCASRAVD 200
    HFYCDSRPLQ RLSCSDLFIH RMISFSLSCI IILPTIIVII VSYMYIVSTV 250
    LKIHSTEGHK KAFSTCSSHL GVVSVLYGAV FFMYLTPDRF PELSKVASLC 300
    YSLVTPMLNP LIYSLRNKDV QEALKKFLEK KNIIL 335
    Length:335
    Mass (Da):37,746
    Last modified:December 16, 2008 - v2
    Checksum:i90454BC59D32F5F3
    GO

    Sequence cautioni

    The sequence BAC06080.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451R → C.
    Corresponds to variant rs12303066 [ dbSNP | Ensembl ].
    VAR_048057
    Natural varianti103 – 1031E → A.
    Corresponds to variant rs7305779 [ dbSNP | Ensembl ].
    VAR_048058
    Natural varianti207 – 2071R → H.
    Corresponds to variant rs7306491 [ dbSNP | Ensembl ].
    VAR_048059

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065862 Genomic DNA. Translation: BAC06080.1. Different initiation.
    BC136988 mRNA. Translation: AAI36989.1.
    BK004326 Genomic DNA. Translation: DAA04724.1.
    CCDSiCCDS31814.1.
    RefSeqiNP_001005243.1. NM_001005243.1.
    UniGeneiHs.553827.

    Genome annotation databases

    GeneIDi441639.
    KEGGihsa:441639.
    UCSCiuc010spe.2. human.

    Polymorphism databases

    DMDMi218511732.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065862 Genomic DNA. Translation: BAC06080.1 . Different initiation.
    BC136988 mRNA. Translation: AAI36989.1 .
    BK004326 Genomic DNA. Translation: DAA04724.1 .
    CCDSi CCDS31814.1.
    RefSeqi NP_001005243.1. NM_001005243.1.
    UniGenei Hs.553827.

    3D structure databases

    ProteinModelPortali Q8NGE7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000307598.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGE7.

    Polymorphism databases

    DMDMi 218511732.

    Proteomic databases

    PaxDbi Q8NGE7.
    PRIDEi Q8NGE7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 441639.
    KEGGi hsa:441639.
    UCSCi uc010spe.2. human.

    Organism-specific databases

    CTDi 441639.
    GeneCardsi GC12P055523.
    HGNCi HGNC:15339. OR9K2.
    HPAi HPA015808.
    neXtProti NX_Q8NGE7.
    PharmGKBi PA32799.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39616.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGE7.
    KOi K04257.
    OMAi SCIIILP.
    OrthoDBi EOG7QG44P.
    PhylomeDBi Q8NGE7.
    TreeFami TF352758.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR9K2.
    GenomeRNAii 441639.
    NextBioi 110363.
    PROi Q8NGE7.

    Gene expression databases

    CleanExi HS_OR9K2.
    Genevestigatori Q8NGE7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR9K2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGE7
    Secondary accession number(s): B9EH19, Q6IFD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-23 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3