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Protein

Olfactory receptor 9K2

Gene

OR9K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9K2
Alternative name(s):
Olfactory receptor OR12-2
Gene namesi
Name:OR9K2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:15339. OR9K2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050ExtracellularSequence AnalysisAdd
BLAST
Transmembranei51 – 7121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini72 – 798CytoplasmicSequence Analysis
Transmembranei80 – 10021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini101 – 12424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei125 – 14521Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini146 – 16419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini186 – 22237ExtracellularSequence AnalysisAdd
BLAST
Transmembranei223 – 24220Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini243 – 26220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini284 – 29613ExtracellularSequence AnalysisAdd
BLAST
Topological domaini316 – 33520CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32799.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Olfactory receptor 9K2PRO_0000150682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi122 ↔ 214PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGE7.
PRIDEiQ8NGE7.

PTM databases

PhosphoSiteiQ8NGE7.

Expressioni

Gene expression databases

CleanExiHS_OR9K2.
GenevestigatoriQ8NGE7.

Organism-specific databases

HPAiHPA015808.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307598.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39616.
GeneTreeiENSGT00530000062998.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGE7.
KOiK04257.
OMAiDLFIHRM.
OrthoDBiEOG7QG44P.
PhylomeDBiQ8NGE7.
TreeFamiTF352758.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSKPRVHL YILPCASQQV STMGDRGTSN HSEMTDFILA GFRVRPELHI
60 70 80 90 100
LLFLLFLFVY AMILLGNVGM MTIIMTDPRL NTPMYFFLGN LSFIDLFYSS
110 120 130 140 150
VIEPKAMINF WSENKSISFA GCVAQLFLFA LLIVTEGFLL AAMAYDRFIA
160 170 180 190 200
ICNPLLYSVQ MSTRLCTQLV AGSYFCGCIS SVIQTSMTFT LSFCASRAVD
210 220 230 240 250
HFYCDSRPLQ RLSCSDLFIH RMISFSLSCI IILPTIIVII VSYMYIVSTV
260 270 280 290 300
LKIHSTEGHK KAFSTCSSHL GVVSVLYGAV FFMYLTPDRF PELSKVASLC
310 320 330
YSLVTPMLNP LIYSLRNKDV QEALKKFLEK KNIIL
Length:335
Mass (Da):37,746
Last modified:December 16, 2008 - v2
Checksum:i90454BC59D32F5F3
GO

Sequence cautioni

The sequence BAC06080.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451R → C.
Corresponds to variant rs12303066 [ dbSNP | Ensembl ].
VAR_048057
Natural varianti103 – 1031E → A.
Corresponds to variant rs7305779 [ dbSNP | Ensembl ].
VAR_048058
Natural varianti207 – 2071R → H.
Corresponds to variant rs7306491 [ dbSNP | Ensembl ].
VAR_048059

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065862 Genomic DNA. Translation: BAC06080.1. Different initiation.
BC136988 mRNA. Translation: AAI36989.1.
BK004326 Genomic DNA. Translation: DAA04724.1.
CCDSiCCDS31814.1.
RefSeqiNP_001005243.1. NM_001005243.1.
UniGeneiHs.553827.

Genome annotation databases

EnsembliENST00000305377; ENSP00000307598; ENSG00000170605.
GeneIDi441639.
KEGGihsa:441639.
UCSCiuc010spe.2. human.

Polymorphism databases

DMDMi218511732.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065862 Genomic DNA. Translation: BAC06080.1. Different initiation.
BC136988 mRNA. Translation: AAI36989.1.
BK004326 Genomic DNA. Translation: DAA04724.1.
CCDSiCCDS31814.1.
RefSeqiNP_001005243.1. NM_001005243.1.
UniGeneiHs.553827.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000307598.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGE7.

Polymorphism databases

DMDMi218511732.

Proteomic databases

PaxDbiQ8NGE7.
PRIDEiQ8NGE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305377; ENSP00000307598; ENSG00000170605.
GeneIDi441639.
KEGGihsa:441639.
UCSCiuc010spe.2. human.

Organism-specific databases

CTDi441639.
GeneCardsiGC12P055523.
HGNCiHGNC:15339. OR9K2.
HPAiHPA015808.
neXtProtiNX_Q8NGE7.
PharmGKBiPA32799.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39616.
GeneTreeiENSGT00530000062998.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGE7.
KOiK04257.
OMAiDLFIHRM.
OrthoDBiEOG7QG44P.
PhylomeDBiQ8NGE7.
TreeFamiTF352758.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR9K2.
GenomeRNAii441639.
NextBioi110363.
PROiQ8NGE7.

Gene expression databases

CleanExiHS_OR9K2.
GenevestigatoriQ8NGE7.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiOR9K2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGE7
Secondary accession number(s): B9EH19, Q6IFD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: April 1, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.