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Q8NGE5 (O10A7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10A7
Alternative name(s):
Olfactory receptor OR12-6
Gene names
Name:OR10A7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Olfactory receptor 10A7
PRO_0000150690

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31624Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential

Natural variations

Natural variant961G → S.
Corresponds to variant rs12578318 [ dbSNP | Ensembl ].
VAR_053266

Sequences

Sequence LengthMass (Da)Tools
Q8NGE5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: A01AA01481C7FBBE

FASTA31635,695
        10         20         30         40         50         60 
MICENHTRVT EFILLGFTNN PEMQVSLFIF FLAIYTVTLL GNFLIVTVTS VDLALQTPMY 

        70         80         90        100        110        120 
FFLQNLSLLE VCFTLVMVPK MLVDLVSPRK IISFVGCGTQ MYFFFFFGSS ECFLLSMMAY 

       130        140        150        160        170        180 
DRFVAICNPL HYSVIMNRSL CLWMAIGSWM SGVPVSMLQT AWMMALPFCG PNAVDHFFCD 

       190        200        210        220        230        240 
GPPVLKLVTV DTTMYEMQAL ASTLLFIMFP FCLILVSYTR IIITILRMSS ATGRQKAFST 

       250        260        270        280        290        300 
CSSHLIVVSL FYGTASLTYL RPKSNQSPES KKLVSLSYTV ITPMLNPIIY GLRNNEVKGA 

       310 
VKRTITQKVL QKLDVF 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065864 Genomic DNA. Translation: BAC06082.1.
AF399626 Genomic DNA. Translation: AAK95111.1.
BK004327 Genomic DNA. Translation: DAA04725.1.
CCDSCCDS31815.1.
RefSeqNP_001005280.1. NM_001005280.1.
UniGeneHs.554557.

3D structure databases

ProteinModelPortalQ8NGE5.
SMRQ8NGE5. Positions 23-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000326718.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372676.

Proteomic databases

PaxDbQ8NGE5.
PRIDEQ8NGE5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326258; ENSP00000326718; ENSG00000179919.
GeneID121364.
KEGGhsa:121364.
UCSCuc010spf.2. human.

Organism-specific databases

CTD121364.
GeneCardsGC12P055614.
H-InvDBHIX0171658.
HGNCHGNC:15329. OR10A7.
HPAHPA055111.
neXtProtNX_Q8NGE5.
PharmGKBPA31955.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG38940.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGE5.
KOK04257.
OMAMFPFSLI.
OrthoDBEOG7X9G79.
PhylomeDBQ8NGE5.
TreeFamTF337350.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10A7.
GenevestigatorQ8NGE5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10A7.
GenomeRNAi121364.
NextBio80728.
PROQ8NGE5.

Entry information

Entry nameO10A7_HUMAN
AccessionPrimary (citable) accession number: Q8NGE5
Secondary accession number(s): Q6IFD5, Q96R19
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries