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Q8NGE5

- O10A7_HUMAN

UniProt

Q8NGE5 - O10A7_HUMAN

Protein

Olfactory receptor 10A7

Gene

OR10A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10A7
    Alternative name(s):
    Olfactory receptor OR12-6
    Gene namesi
    Name:OR10A7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:15329. OR10A7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31955.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Olfactory receptor 10A7PRO_0000150690Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8NGE5.
    PRIDEiQ8NGE5.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10A7.
    GenevestigatoriQ8NGE5.

    Organism-specific databases

    HPAiHPA055111.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000326718.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGE5.
    SMRiQ8NGE5. Positions 23-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31624CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG38940.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGE5.
    KOiK04257.
    OMAiMFPFSLI.
    OrthoDBiEOG7X9G79.
    PhylomeDBiQ8NGE5.
    TreeFamiTF337350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MICENHTRVT EFILLGFTNN PEMQVSLFIF FLAIYTVTLL GNFLIVTVTS    50
    VDLALQTPMY FFLQNLSLLE VCFTLVMVPK MLVDLVSPRK IISFVGCGTQ 100
    MYFFFFFGSS ECFLLSMMAY DRFVAICNPL HYSVIMNRSL CLWMAIGSWM 150
    SGVPVSMLQT AWMMALPFCG PNAVDHFFCD GPPVLKLVTV DTTMYEMQAL 200
    ASTLLFIMFP FCLILVSYTR IIITILRMSS ATGRQKAFST CSSHLIVVSL 250
    FYGTASLTYL RPKSNQSPES KKLVSLSYTV ITPMLNPIIY GLRNNEVKGA 300
    VKRTITQKVL QKLDVF 316
    Length:316
    Mass (Da):35,695
    Last modified:October 1, 2002 - v1
    Checksum:iA01AA01481C7FBBE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti96 – 961G → S.
    Corresponds to variant rs12578318 [ dbSNP | Ensembl ].
    VAR_053266

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065864 Genomic DNA. Translation: BAC06082.1.
    AF399626 Genomic DNA. Translation: AAK95111.1.
    BK004327 Genomic DNA. Translation: DAA04725.1.
    CCDSiCCDS31815.1.
    RefSeqiNP_001005280.1. NM_001005280.1.
    UniGeneiHs.554557.

    Genome annotation databases

    EnsembliENST00000326258; ENSP00000326718; ENSG00000179919.
    GeneIDi121364.
    KEGGihsa:121364.
    UCSCiuc010spf.2. human.

    Polymorphism databases

    DMDMi38372676.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065864 Genomic DNA. Translation: BAC06082.1 .
    AF399626 Genomic DNA. Translation: AAK95111.1 .
    BK004327 Genomic DNA. Translation: DAA04725.1 .
    CCDSi CCDS31815.1.
    RefSeqi NP_001005280.1. NM_001005280.1.
    UniGenei Hs.554557.

    3D structure databases

    ProteinModelPortali Q8NGE5.
    SMRi Q8NGE5. Positions 23-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000326718.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372676.

    Proteomic databases

    PaxDbi Q8NGE5.
    PRIDEi Q8NGE5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326258 ; ENSP00000326718 ; ENSG00000179919 .
    GeneIDi 121364.
    KEGGi hsa:121364.
    UCSCi uc010spf.2. human.

    Organism-specific databases

    CTDi 121364.
    GeneCardsi GC12P055614.
    H-InvDB HIX0171658.
    HGNCi HGNC:15329. OR10A7.
    HPAi HPA055111.
    neXtProti NX_Q8NGE5.
    PharmGKBi PA31955.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG38940.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGE5.
    KOi K04257.
    OMAi MFPFSLI.
    OrthoDBi EOG7X9G79.
    PhylomeDBi Q8NGE5.
    TreeFami TF337350.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10A7.
    GenomeRNAii 121364.
    NextBioi 80728.
    PROi Q8NGE5.

    Gene expression databases

    CleanExi HS_OR10A7.
    Genevestigatori Q8NGE5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10A7_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGE5
    Secondary accession number(s): Q6IFD5, Q96R19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3