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Protein

Olfactory receptor 2AP1

Gene

OR2AP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AP1
Alternative name(s):
Olfactory receptor OR12-9
Gene namesi
Name:OR2AP1
Synonyms:OR2AP1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:15335. OR2AP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21724Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23417CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei235 – 25723Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29020Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini291 – 30919CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 2AP1PRO_0000150475Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGE2.

Expressioni

Gene expression databases

GenevestigatoriQ8NGE2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323423.

Structurei

3D structure databases

ProteinModelPortaliQ8NGE2.
SMRiQ8NGE2. Positions 34-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41315.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGE2.
KOiK04257.
OMAiMAIIPPI.
OrthoDBiEOG75MVWN.
PhylomeDBiQ8NGE2.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGE2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNKTVLTEF ILLGLTDVPE LQVAVFTFLF LAYLLSILGN LTILILTLLD
60 70 80 90 100
SHLQTPMYFF LRNFSFLEIS FTNIFIPRVL ISITTGNKSI SFAGCFTQYF
110 120 130 140 150
FAMFLGATEF YLLAAMSYDR YVAICKPLHY TTIMSSRICI QLIFCSWLGG
160 170 180 190 200
LMAIIPTITL MSQQDFCASN RLNHYFCDYE PLLELSCSDT SLIEKVVFLV
210 220 230 240 250
ASVTLVVTLV LVILSYAFII KTILKLPSAQ QRTKAFSTCS SHMIVISLSY
260 270 280 290 300
GSCMFMYINP SAKEGDTFNK GVALLITSVA PLLNPFIYTL RNQQVKQPFK

DMVKKLLNL
Length:309
Mass (Da):34,902
Last modified:October 1, 2002 - v1
Checksum:i0BD7AFFEA740CA12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065868 Genomic DNA. Translation: BAC06086.1.
BK004260 Genomic DNA. Translation: DAA04658.1.
CCDSiCCDS58241.1.
RefSeqiNP_001245214.1. NM_001258285.1.
UniGeneiHs.742584.

Genome annotation databases

EnsembliENST00000321688; ENSP00000323423; ENSG00000179615.
GeneIDi121129.
KEGGihsa:121129.
UCSCiuc031qhr.1. human.

Polymorphism databases

DMDMi74760248.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065868 Genomic DNA. Translation: BAC06086.1.
BK004260 Genomic DNA. Translation: DAA04658.1.
CCDSiCCDS58241.1.
RefSeqiNP_001245214.1. NM_001258285.1.
UniGeneiHs.742584.

3D structure databases

ProteinModelPortaliQ8NGE2.
SMRiQ8NGE2. Positions 34-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323423.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi74760248.

Proteomic databases

PRIDEiQ8NGE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321688; ENSP00000323423; ENSG00000179615.
GeneIDi121129.
KEGGihsa:121129.
UCSCiuc031qhr.1. human.

Organism-specific databases

CTDi121129.
GeneCardsiGC12P055968.
H-InvDBHIX0201932.
HGNCiHGNC:15335. OR2AP1.
neXtProtiNX_Q8NGE2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41315.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGE2.
KOiK04257.
OMAiMAIIPPI.
OrthoDBiEOG75MVWN.
PhylomeDBiQ8NGE2.
TreeFamiTF336833.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2AP1.
GenomeRNAii121129.
NextBioi80669.
PROiQ8NGE2.

Gene expression databases

GenevestigatoriQ8NGE2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO2AP1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.