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Q8NGE2 (O2AP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2AP1
Alternative name(s):
Olfactory receptor OR12-9
Gene names
Name:OR2AP1
Synonyms:OR2AP1P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Olfactory receptor 2AP1
PRO_0000150475

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4724Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7722Helical; Name=2; Potential
Topological domain78 – 9821Extracellular Potential
Transmembrane99 – 11820Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 15619Helical; Name=4; Potential
Topological domain157 – 19337Extracellular Potential
Transmembrane194 – 21724Helical; Name=5; Potential
Topological domain218 – 23417Cytoplasmic Potential
Transmembrane235 – 25723Helical; Name=6; Potential
Topological domain258 – 27013Extracellular Potential
Transmembrane271 – 29020Helical; Name=7; Potential
Topological domain291 – 30919Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NGE2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0BD7AFFEA740CA12

FASTA30934,902
        10         20         30         40         50         60 
MKNKTVLTEF ILLGLTDVPE LQVAVFTFLF LAYLLSILGN LTILILTLLD SHLQTPMYFF 

        70         80         90        100        110        120 
LRNFSFLEIS FTNIFIPRVL ISITTGNKSI SFAGCFTQYF FAMFLGATEF YLLAAMSYDR 

       130        140        150        160        170        180 
YVAICKPLHY TTIMSSRICI QLIFCSWLGG LMAIIPTITL MSQQDFCASN RLNHYFCDYE 

       190        200        210        220        230        240 
PLLELSCSDT SLIEKVVFLV ASVTLVVTLV LVILSYAFII KTILKLPSAQ QRTKAFSTCS 

       250        260        270        280        290        300 
SHMIVISLSY GSCMFMYINP SAKEGDTFNK GVALLITSVA PLLNPFIYTL RNQQVKQPFK 


DMVKKLLNL 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065868 Genomic DNA. Translation: BAC06086.1.
BK004260 Genomic DNA. Translation: DAA04658.1.
RefSeqNP_001245214.1. NM_001258285.1.
UniGeneHs.742584.

3D structure databases

ProteinModelPortalQ8NGE2.
SMRQ8NGE2. Positions 34-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000323423.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM74760248.

Proteomic databases

PRIDEQ8NGE2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321688; ENSP00000323423; ENSG00000179615.
GeneID121129.
KEGGhsa:121129.
UCSCuc031qhr.1. human.

Organism-specific databases

CTD121129.
GeneCardsGC12P055968.
H-InvDBHIX0201932.
HGNCHGNC:15335. OR2AP1.
neXtProtNX_Q8NGE2.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41315.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGE2.
KOK04257.
OMAMAIIPPI.
OrthoDBEOG75MVWN.
PhylomeDBQ8NGE2.
TreeFamTF336833.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

GenevestigatorQ8NGE2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2AP1.
GenomeRNAi121129.
NextBio80669.
PROQ8NGE2.

Entry information

Entry nameO2AP1_HUMAN
AccessionPrimary (citable) accession number: Q8NGE2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries