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Q8NGE2

- O2AP1_HUMAN

UniProt

Q8NGE2 - O2AP1_HUMAN

Protein

Olfactory receptor 2AP1

Gene

OR2AP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2AP1
    Alternative name(s):
    Olfactory receptor OR12-9
    Gene namesi
    Name:OR2AP1
    Synonyms:OR2AP1P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:15335. OR2AP1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Olfactory receptor 2AP1PRO_0000150475Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGE2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8NGE2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000323423.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGE2.
    SMRiQ8NGE2. Positions 34-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini291 – 30919CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21724Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25723Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41315.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGE2.
    KOiK04257.
    OMAiMAIIPPI.
    OrthoDBiEOG75MVWN.
    PhylomeDBiQ8NGE2.
    TreeFamiTF336833.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNKTVLTEF ILLGLTDVPE LQVAVFTFLF LAYLLSILGN LTILILTLLD    50
    SHLQTPMYFF LRNFSFLEIS FTNIFIPRVL ISITTGNKSI SFAGCFTQYF 100
    FAMFLGATEF YLLAAMSYDR YVAICKPLHY TTIMSSRICI QLIFCSWLGG 150
    LMAIIPTITL MSQQDFCASN RLNHYFCDYE PLLELSCSDT SLIEKVVFLV 200
    ASVTLVVTLV LVILSYAFII KTILKLPSAQ QRTKAFSTCS SHMIVISLSY 250
    GSCMFMYINP SAKEGDTFNK GVALLITSVA PLLNPFIYTL RNQQVKQPFK 300
    DMVKKLLNL 309
    Length:309
    Mass (Da):34,902
    Last modified:October 1, 2002 - v1
    Checksum:i0BD7AFFEA740CA12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065868 Genomic DNA. Translation: BAC06086.1.
    BK004260 Genomic DNA. Translation: DAA04658.1.
    CCDSiCCDS58241.1.
    RefSeqiNP_001245214.1. NM_001258285.1.
    UniGeneiHs.742584.

    Genome annotation databases

    EnsembliENST00000321688; ENSP00000323423; ENSG00000179615.
    GeneIDi121129.
    KEGGihsa:121129.
    UCSCiuc031qhr.1. human.

    Polymorphism databases

    DMDMi74760248.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065868 Genomic DNA. Translation: BAC06086.1 .
    BK004260 Genomic DNA. Translation: DAA04658.1 .
    CCDSi CCDS58241.1.
    RefSeqi NP_001245214.1. NM_001258285.1.
    UniGenei Hs.742584.

    3D structure databases

    ProteinModelPortali Q8NGE2.
    SMRi Q8NGE2. Positions 34-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000323423.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 74760248.

    Proteomic databases

    PRIDEi Q8NGE2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321688 ; ENSP00000323423 ; ENSG00000179615 .
    GeneIDi 121129.
    KEGGi hsa:121129.
    UCSCi uc031qhr.1. human.

    Organism-specific databases

    CTDi 121129.
    GeneCardsi GC12P055968.
    H-InvDB HIX0201932.
    HGNCi HGNC:15335. OR2AP1.
    neXtProti NX_Q8NGE2.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41315.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGE2.
    KOi K04257.
    OMAi MAIIPPI.
    OrthoDBi EOG75MVWN.
    PhylomeDBi Q8NGE2.
    TreeFami TF336833.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2AP1.
    GenomeRNAii 121129.
    NextBioi 80669.
    PROi Q8NGE2.

    Gene expression databases

    Genevestigatori Q8NGE2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO2AP1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3