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Protein

Olfactory receptor 2AP1

Gene

OR2AP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AP1
Alternative name(s):
Olfactory receptor OR12-9
Gene namesi
Name:OR2AP1
Synonyms:OR2AP1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000179615.1
HGNCiHGNC:15335 OR2AP1
neXtProtiNX_Q8NGE2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 234CytoplasmicSequence analysisAdd BLAST17
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 309CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179615

Polymorphism and mutation databases

BioMutaiOR2AP1
DMDMi74760248

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504751 – 309Olfactory receptor 2AP1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGE2
PeptideAtlasiQ8NGE2
PRIDEiQ8NGE2
ProteomicsDBi73488

Expressioni

Gene expression databases

BgeeiENSG00000179615
ExpressionAtlasiQ8NGE2 differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323423

Structurei

3D structure databases

ProteinModelPortaliQ8NGE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGX Eukaryota
ENOG41116WS LUCA
GeneTreeiENSGT00900000140821
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGE2
KOiK04257
OMAiMAIIPPI
OrthoDBiEOG091G0EL1
PhylomeDBiQ8NGE2
TreeFamiTF336833

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKTVLTEF ILLGLTDVPE LQVAVFTFLF LAYLLSILGN LTILILTLLD
60 70 80 90 100
SHLQTPMYFF LRNFSFLEIS FTNIFIPRVL ISITTGNKSI SFAGCFTQYF
110 120 130 140 150
FAMFLGATEF YLLAAMSYDR YVAICKPLHY TTIMSSRICI QLIFCSWLGG
160 170 180 190 200
LMAIIPTITL MSQQDFCASN RLNHYFCDYE PLLELSCSDT SLIEKVVFLV
210 220 230 240 250
ASVTLVVTLV LVILSYAFII KTILKLPSAQ QRTKAFSTCS SHMIVISLSY
260 270 280 290 300
GSCMFMYINP SAKEGDTFNK GVALLITSVA PLLNPFIYTL RNQQVKQPFK

DMVKKLLNL
Length:309
Mass (Da):34,902
Last modified:October 1, 2002 - v1
Checksum:i0BD7AFFEA740CA12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065868 Genomic DNA Translation: BAC06086.1
BK004260 Genomic DNA Translation: DAA04658.1
CCDSiCCDS58241.1
RefSeqiNP_001245214.1, NM_001258285.1
UniGeneiHs.742584

Genome annotation databases

EnsembliENST00000321688; ENSP00000323423; ENSG00000179615
ENST00000641114; ENSP00000493043; ENSG00000179615
GeneIDi121129
KEGGihsa:121129
UCSCiuc031qhr.1 human

Similar proteinsi

Entry informationi

Entry nameiO2AP1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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