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Protein

Olfactory receptor 2AP1

Gene

OR2AP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179615-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AP1
Alternative name(s):
Olfactory receptor OR12-9
Gene namesi
Name:OR2AP1
Synonyms:OR2AP1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:15335. OR2AP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 234CytoplasmicSequence analysisAdd BLAST17
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 309CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179615.

Polymorphism and mutation databases

BioMutaiOR2AP1.
DMDMi74760248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504751 – 309Olfactory receptor 2AP1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGE2.
PRIDEiQ8NGE2.

Expressioni

Gene expression databases

ExpressionAtlasiQ8NGE2. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323423.

Structurei

3D structure databases

ProteinModelPortaliQ8NGE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGX. Eukaryota.
ENOG41116WS. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGE2.
KOiK04257.
OMAiMAIIPPI.
OrthoDBiEOG091G0EL1.
PhylomeDBiQ8NGE2.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKTVLTEF ILLGLTDVPE LQVAVFTFLF LAYLLSILGN LTILILTLLD
60 70 80 90 100
SHLQTPMYFF LRNFSFLEIS FTNIFIPRVL ISITTGNKSI SFAGCFTQYF
110 120 130 140 150
FAMFLGATEF YLLAAMSYDR YVAICKPLHY TTIMSSRICI QLIFCSWLGG
160 170 180 190 200
LMAIIPTITL MSQQDFCASN RLNHYFCDYE PLLELSCSDT SLIEKVVFLV
210 220 230 240 250
ASVTLVVTLV LVILSYAFII KTILKLPSAQ QRTKAFSTCS SHMIVISLSY
260 270 280 290 300
GSCMFMYINP SAKEGDTFNK GVALLITSVA PLLNPFIYTL RNQQVKQPFK

DMVKKLLNL
Length:309
Mass (Da):34,902
Last modified:October 1, 2002 - v1
Checksum:i0BD7AFFEA740CA12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065868 Genomic DNA. Translation: BAC06086.1.
BK004260 Genomic DNA. Translation: DAA04658.1.
CCDSiCCDS58241.1.
RefSeqiNP_001245214.1. NM_001258285.1.
UniGeneiHs.742584.

Genome annotation databases

EnsembliENST00000321688; ENSP00000323423; ENSG00000179615.
GeneIDi121129.
KEGGihsa:121129.
UCSCiuc031qhr.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065868 Genomic DNA. Translation: BAC06086.1.
BK004260 Genomic DNA. Translation: DAA04658.1.
CCDSiCCDS58241.1.
RefSeqiNP_001245214.1. NM_001258285.1.
UniGeneiHs.742584.

3D structure databases

ProteinModelPortaliQ8NGE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323423.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2AP1.
DMDMi74760248.

Proteomic databases

PaxDbiQ8NGE2.
PRIDEiQ8NGE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321688; ENSP00000323423; ENSG00000179615.
GeneIDi121129.
KEGGihsa:121129.
UCSCiuc031qhr.1. human.

Organism-specific databases

CTDi121129.
GeneCardsiOR2AP1.
H-InvDBHIX0201932.
HGNCiHGNC:15335. OR2AP1.
neXtProtiNX_Q8NGE2.
OpenTargetsiENSG00000179615.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEGX. Eukaryota.
ENOG41116WS. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGE2.
KOiK04257.
OMAiMAIIPPI.
OrthoDBiEOG091G0EL1.
PhylomeDBiQ8NGE2.
TreeFamiTF336833.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179615-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2AP1.
GenomeRNAii121129.
PROiQ8NGE2.

Gene expression databases

ExpressionAtlasiQ8NGE2. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO2AP1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.