Q8NGE1 (OR6C4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 6C4

Alternative name(s):
Olfactory receptor OR12-10

Gene names

Name:

OR6C4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Olfactory receptor 6C4		PRO_0000150626
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 44	21	Helical; Name=1; Potential
	Topological domain	45 – 52	8	Cytoplasmic Potential
	Transmembrane	53 – 73	21	Helical; Name=2; Potential
	Topological domain	74 – 97	24	Extracellular Potential
	Transmembrane	98 – 118	21	Helical; Name=3; Potential
	Topological domain	119 – 137	19	Cytoplasmic Potential
	Transmembrane	138 – 158	21	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 215	20	Helical; Name=5; Potential
	Topological domain	216 – 235	20	Cytoplasmic Potential
	Transmembrane	236 – 256	21	Helical; Name=6; Potential
	Topological domain	257 – 269	13	Extracellular Potential
	Transmembrane	270 – 290	21	Helical; Name=7; Potential
	Topological domain	291 – 309	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 187		By similarity
Natural variations
	Natural variant	37	1	I → V. Ref.3 Ref.4 Corresponds to variant rs7313899 [ dbSNP | Ensembl ].		VAR_034246
	Natural variant	83	1	M → T. Corresponds to variant rs11835716 [ dbSNP | Ensembl ].		VAR_053220

Sequences

	Sequence		Length	Mass (Da)
	Q8NGE1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 49BC9CE718DDB950	FASTA	309	35,010
	10 20 30 40 50 60 MKNRTMFGEF ILLGLTNQPE LQVMIFIFLF LTYMLSILGN LTIITLTLLD PHLQTPMYFF 70 80 90 100 110 120 LRNFSFLEIS FTSIFIPRFL TSMTTGNKVI SFAGCLTQYF FAIFLGATEF YLLASMSYDR 130 140 150 160 170 180 YVAICKPLHY LTIMSSRVCI QLVFCSWLGG FLAILPPIIL MTQVDFCVSN ILNHYYCDYG 190 200 210 220 230 240 PLVELACSDT SLLELMVILL AVVTLMVTLV LVTLSYTYII RTILRIPSAQ QRTKAFSTCS 250 260 270 280 290 300 SHMIVISLSY GSCMFMYINP SAKEGGAFNK GIAVLITSVT PLLNPFIYTL RNQQVKQAFK DSVKKIVKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-37.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-37.
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065869 Genomic DNA. Translation: BAC06087.1. AC009779 Genomic DNA. No translation available. CH471054 Genomic DNA. Translation: EAW96815.1. BC137000 mRNA. Translation: AAI37001.1. BC137001 mRNA. Translation: AAI37002.1. BK004261 Genomic DNA. Translation: DAA04659.1.
IPI	IPI00303374.
RefSeq	NP_001005494.1. NM_001005494.1.
UniGene	Hs.495021. Hs.554552.
3D structure databases
ProteinModelPortal	Q8NGE1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000377799.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38258178.
Proteomic databases
PaxDb	Q8NGE1.
PRIDE	Q8NGE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000394256; ENSP00000377799; ENSG00000179626.
GeneID	341418.
KEGG	hsa:341418.
UCSC	uc010spp.2. human.
Organism-specific databases
CTD	341418.
GeneCards	GC12P055946.
HGNC	HGNC:19632. OR6C4.
neXtProt	NX_Q8NGE1.
PharmGKB	PA134970819.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG305803.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
KO	K04257.
OMA	MKNRTMF.
OrthoDB	EOG4K6G4T.
PhylomeDB	Q8NGE1.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR6C4.
Genevestigator	Q8NGE1.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	341418.
NextBio	98150.

Entry information

Entry name

OR6C4_HUMAN

Accession

Primary (citable) accession number: Q8NGE1
Secondary accession number(s): A8MZG7, B2RNN2, Q6IFK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.