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Protein

Olfactory receptor 6C4

Gene

OR6C4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6C4
Alternative name(s):
Olfactory receptor OR12-10
Gene namesi
Name:OR6C4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:19632. OR6C4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence analysis
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21520Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 23520CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini257 – 26913ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 30919CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134970819.

Polymorphism and mutation databases

BioMutaiOR6C4.
DMDMi38258178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 6C4PRO_0000150626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGE1.
PRIDEiQ8NGE1.

Expressioni

Gene expression databases

CleanExiHS_OR6C4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000377799.

Structurei

3D structure databases

ProteinModelPortaliQ8NGE1.
SMRiQ8NGE1. Positions 34-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGX. Eukaryota.
ENOG41116WS. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGE1.
KOiK04257.
OMAiMKNRTMF.
OrthoDBiEOG75MVWN.
PhylomeDBiQ8NGE1.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNRTMFGEF ILLGLTNQPE LQVMIFIFLF LTYMLSILGN LTIITLTLLD
60 70 80 90 100
PHLQTPMYFF LRNFSFLEIS FTSIFIPRFL TSMTTGNKVI SFAGCLTQYF
110 120 130 140 150
FAIFLGATEF YLLASMSYDR YVAICKPLHY LTIMSSRVCI QLVFCSWLGG
160 170 180 190 200
FLAILPPIIL MTQVDFCVSN ILNHYYCDYG PLVELACSDT SLLELMVILL
210 220 230 240 250
AVVTLMVTLV LVTLSYTYII RTILRIPSAQ QRTKAFSTCS SHMIVISLSY
260 270 280 290 300
GSCMFMYINP SAKEGGAFNK GIAVLITSVT PLLNPFIYTL RNQQVKQAFK

DSVKKIVKL
Length:309
Mass (Da):35,010
Last modified:October 1, 2002 - v1
Checksum:i49BC9CE718DDB950
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371I → V.2 Publications
Corresponds to variant rs7313899 [ dbSNP | Ensembl ].
VAR_034246
Natural varianti83 – 831M → T.
Corresponds to variant rs11835716 [ dbSNP | Ensembl ].
VAR_053220

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065869 Genomic DNA. Translation: BAC06087.1.
AC009779 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96815.1.
BC137000 mRNA. Translation: AAI37001.1.
BC137001 mRNA. Translation: AAI37002.1.
BK004261 Genomic DNA. Translation: DAA04659.1.
CCDSiCCDS31827.1.
RefSeqiNP_001005494.1. NM_001005494.1.
UniGeneiHs.495021.
Hs.554552.

Genome annotation databases

EnsembliENST00000394256; ENSP00000377799; ENSG00000179626.
GeneIDi341418.
KEGGihsa:341418.
UCSCiuc010spp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065869 Genomic DNA. Translation: BAC06087.1.
AC009779 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96815.1.
BC137000 mRNA. Translation: AAI37001.1.
BC137001 mRNA. Translation: AAI37002.1.
BK004261 Genomic DNA. Translation: DAA04659.1.
CCDSiCCDS31827.1.
RefSeqiNP_001005494.1. NM_001005494.1.
UniGeneiHs.495021.
Hs.554552.

3D structure databases

ProteinModelPortaliQ8NGE1.
SMRiQ8NGE1. Positions 34-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000377799.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR6C4.
DMDMi38258178.

Proteomic databases

PaxDbiQ8NGE1.
PRIDEiQ8NGE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394256; ENSP00000377799; ENSG00000179626.
GeneIDi341418.
KEGGihsa:341418.
UCSCiuc010spp.3. human.

Organism-specific databases

CTDi341418.
GeneCardsiOR6C4.
HGNCiHGNC:19632. OR6C4.
neXtProtiNX_Q8NGE1.
PharmGKBiPA134970819.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEGX. Eukaryota.
ENOG41116WS. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGE1.
KOiK04257.
OMAiMKNRTMF.
OrthoDBiEOG75MVWN.
PhylomeDBiQ8NGE1.
TreeFamiTF336833.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6C4.
GenomeRNAii341418.
PROiQ8NGE1.

Gene expression databases

CleanExiHS_OR6C4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-37.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-37.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR6C4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGE1
Secondary accession number(s): A8MZG7, B2RNN2, Q6IFK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.