ID   O10AD_HUMAN             Reviewed;         317 AA.
AC   Q8NGE0; B9EGT9; Q6IFA8;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 149.
DE   RecName: Full=Olfactory receptor 10AD1;
DE   AltName: Full=Olfactory receptor OR12-1;
GN   Name=OR10AD1; Synonyms=OR10AD1P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10AD1";
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DR   EMBL; AB065872; BAC06090.1; -; Genomic_DNA.
DR   EMBL; BC136757; AAI36758.1; -; mRNA.
DR   EMBL; BC136758; AAI36759.1; -; mRNA.
DR   EMBL; BK004354; DAA04752.1; -; Genomic_DNA.
DR   CCDS; CCDS31787.1; -.
DR   RefSeq; NP_001004134.1; NM_001004134.1.
DR   AlphaFoldDB; Q8NGE0; -.
DR   SMR; Q8NGE0; -.
DR   BioGRID; 125719; 1.
DR   STRING; 9606.ENSP00000308689; -.
DR   GlyCosmos; Q8NGE0; 1 site, No reported glycans.
DR   GlyGen; Q8NGE0; 1 site.
DR   BioMuta; OR10AD1; -.
DR   DMDM; 38258177; -.
DR   PaxDb; 9606-ENSP00000308689; -.
DR   Antibodypedia; 57040; 113 antibodies from 23 providers.
DR   DNASU; 121275; -.
DR   Ensembl; ENST00000310248.4; ENSP00000308689.2; ENSG00000172640.4.
DR   GeneID; 121275; -.
DR   KEGG; hsa:121275; -.
DR   MANE-Select; ENST00000310248.4; ENSP00000308689.2; NM_001004134.1; NP_001004134.1.
DR   UCSC; uc001rrl.2; human.
DR   AGR; HGNC:14819; -.
DR   CTD; 121275; -.
DR   DisGeNET; 121275; -.
DR   GeneCards; OR10AD1; -.
DR   HGNC; HGNC:14819; OR10AD1.
DR   HPA; ENSG00000172640; Tissue enhanced (retina).
DR   neXtProt; NX_Q8NGE0; -.
DR   PharmGKB; PA31959; -.
DR   VEuPathDB; HostDB:ENSG00000172640; -.
DR   eggNOG; ENOG502QVH7; Eukaryota.
DR   GeneTree; ENSGT01100000263574; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGE0; -.
DR   OMA; QMYFVFC; -.
DR   OrthoDB; 4825386at2759; -.
DR   PhylomeDB; Q8NGE0; -.
DR   TreeFam; TF338235; -.
DR   PathwayCommons; Q8NGE0; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 121275; 14 hits in 746 CRISPR screens.
DR   GeneWiki; OR10AD1; -.
DR   GenomeRNAi; 121275; -.
DR   Pharos; Q8NGE0; Tdark.
DR   PRO; PR:Q8NGE0; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8NGE0; Protein.
DR   Bgee; ENSG00000172640; Expressed in sural nerve and 79 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15237; 7tmA_OR2-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF215; OLFACTORY RECEPTOR 10AD1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..317
FT                   /note="Olfactory receptor 10AD1"
FT                   /id="PRO_0000150691"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..317
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         8
FT                   /note="V -> A (in dbSNP:rs17122812)"
FT                   /id="VAR_053267"
FT   VARIANT         166
FT                   /note="R -> Q (in dbSNP:rs17224674)"
FT                   /id="VAR_053268"
FT   VARIANT         275
FT                   /note="F -> V (in dbSNP:rs11830378)"
FT                   /id="VAR_053269"
FT   VARIANT         279
FT                   /note="Y -> H (in dbSNP:rs11168459)"
FT                   /id="VAR_024125"
SQ   SEQUENCE   317 AA;  35698 MW;  72D856594467060F CRC64;
     MLRNGSIVTE FILVGFQQSS TSTRALLFAL FLALYSLTMA MNGLIIFITS WTDPKLNSPM
     YFFLGHLSLL DVCFITTTIP QMLIHLVVRD HIVSFVCCMT QMYFVFCVGV AECILLAFMA
     YDRYVAICYP LNYVPIISQK VCVRLVGTAW FFGLINGIFL EYISFREPFR RDNHIESFFC
     EAPIVIGLSC GDPQFSLWAI FADAIVVILS PMVLTVTSYV HILATILSKA SSSGRGKTFS
     TCASHLTVVI FLYTSAMFSY MNPHSTHGPD KDKPFSLLYT IITPMCNPII YSFRNKEIKE
     AMVRALGRTR LAQPQSV
//