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Protein

Olfactory receptor 10AD1

Gene

OR10AD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172640-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10AD1
Alternative name(s):
Olfactory receptor OR12-1
Gene namesi
Name:OR10AD1
Synonyms:OR10AD1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14819. OR10AD1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 55CytoplasmicSequence analysis9
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 100ExtracellularSequence analysisAdd BLAST24
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 317CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172640.
PharmGKBiPA31959.

Polymorphism and mutation databases

BioMutaiOR10AD1.
DMDMi38258177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506911 – 317Olfactory receptor 10AD1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGE0.
PRIDEiQ8NGE0.

Expressioni

Gene expression databases

BgeeiENSG00000172640.

Organism-specific databases

HPAiHPA049913.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308689.

Structurei

3D structure databases

ProteinModelPortaliQ8NGE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHT0. Eukaryota.
ENOG4111C5C. LUCA.
GeneTreeiENSGT00390000018918.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGE0.
KOiK04257.
OMAiRDSHIEN.
OrthoDBiEOG091G0DBL.
PhylomeDBiQ8NGE0.
TreeFamiTF338235.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNGSIVTE FILVGFQQSS TSTRALLFAL FLALYSLTMA MNGLIIFITS
60 70 80 90 100
WTDPKLNSPM YFFLGHLSLL DVCFITTTIP QMLIHLVVRD HIVSFVCCMT
110 120 130 140 150
QMYFVFCVGV AECILLAFMA YDRYVAICYP LNYVPIISQK VCVRLVGTAW
160 170 180 190 200
FFGLINGIFL EYISFREPFR RDNHIESFFC EAPIVIGLSC GDPQFSLWAI
210 220 230 240 250
FADAIVVILS PMVLTVTSYV HILATILSKA SSSGRGKTFS TCASHLTVVI
260 270 280 290 300
FLYTSAMFSY MNPHSTHGPD KDKPFSLLYT IITPMCNPII YSFRNKEIKE
310
AMVRALGRTR LAQPQSV
Length:317
Mass (Da):35,698
Last modified:October 1, 2002 - v1
Checksum:i72D856594467060F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0532678V → A.Corresponds to variant rs17122812dbSNPEnsembl.1
Natural variantiVAR_053268166R → Q.Corresponds to variant rs17224674dbSNPEnsembl.1
Natural variantiVAR_053269275F → V.Corresponds to variant rs11830378dbSNPEnsembl.1
Natural variantiVAR_024125279Y → H.Corresponds to variant rs11168459dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065872 Genomic DNA. Translation: BAC06090.1.
BC136757 mRNA. Translation: AAI36758.1.
BC136758 mRNA. Translation: AAI36759.1.
BK004354 Genomic DNA. Translation: DAA04752.1.
CCDSiCCDS31787.1.
RefSeqiNP_001004134.1. NM_001004134.1.
UniGeneiHs.446790.

Genome annotation databases

EnsembliENST00000310248; ENSP00000308689; ENSG00000172640.
GeneIDi121275.
KEGGihsa:121275.
UCSCiuc001rrl.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065872 Genomic DNA. Translation: BAC06090.1.
BC136757 mRNA. Translation: AAI36758.1.
BC136758 mRNA. Translation: AAI36759.1.
BK004354 Genomic DNA. Translation: DAA04752.1.
CCDSiCCDS31787.1.
RefSeqiNP_001004134.1. NM_001004134.1.
UniGeneiHs.446790.

3D structure databases

ProteinModelPortaliQ8NGE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308689.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR10AD1.
DMDMi38258177.

Proteomic databases

PaxDbiQ8NGE0.
PRIDEiQ8NGE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310248; ENSP00000308689; ENSG00000172640.
GeneIDi121275.
KEGGihsa:121275.
UCSCiuc001rrl.2. human.

Organism-specific databases

CTDi121275.
GeneCardsiOR10AD1.
HGNCiHGNC:14819. OR10AD1.
HPAiHPA049913.
neXtProtiNX_Q8NGE0.
OpenTargetsiENSG00000172640.
PharmGKBiPA31959.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHT0. Eukaryota.
ENOG4111C5C. LUCA.
GeneTreeiENSGT00390000018918.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGE0.
KOiK04257.
OMAiRDSHIEN.
OrthoDBiEOG091G0DBL.
PhylomeDBiQ8NGE0.
TreeFamiTF338235.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172640-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10AD1.
GenomeRNAii121275.
PROiQ8NGE0.

Gene expression databases

BgeeiENSG00000172640.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10AD_HUMAN
AccessioniPrimary (citable) accession number: Q8NGE0
Secondary accession number(s): B9EGT9, Q6IFA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.