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Q8NGE0

- O10AD_HUMAN

UniProt

Q8NGE0 - O10AD_HUMAN

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Protein

Olfactory receptor 10AD1

Gene

OR10AD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10AD1
Alternative name(s):
Olfactory receptor OR12-1
Gene namesi
Name:OR10AD1
Synonyms:OR10AD1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:14819. OR10AD1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 559CytoplasmicSequence Analysis
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 31724CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Olfactory receptor 10AD1PRO_0000150691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGE0.
PRIDEiQ8NGE0.

Expressioni

Gene expression databases

BgeeiQ8NGE0.
GenevestigatoriQ8NGE0.

Organism-specific databases

HPAiHPA049913.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308689.

Structurei

3D structure databases

ProteinModelPortaliQ8NGE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45259.
GeneTreeiENSGT00390000018918.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGE0.
KOiK04257.
OMAiWAIFADA.
OrthoDBiEOG75B85P.
PhylomeDBiQ8NGE0.
TreeFamiTF338235.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRNGSIVTE FILVGFQQSS TSTRALLFAL FLALYSLTMA MNGLIIFITS
60 70 80 90 100
WTDPKLNSPM YFFLGHLSLL DVCFITTTIP QMLIHLVVRD HIVSFVCCMT
110 120 130 140 150
QMYFVFCVGV AECILLAFMA YDRYVAICYP LNYVPIISQK VCVRLVGTAW
160 170 180 190 200
FFGLINGIFL EYISFREPFR RDNHIESFFC EAPIVIGLSC GDPQFSLWAI
210 220 230 240 250
FADAIVVILS PMVLTVTSYV HILATILSKA SSSGRGKTFS TCASHLTVVI
260 270 280 290 300
FLYTSAMFSY MNPHSTHGPD KDKPFSLLYT IITPMCNPII YSFRNKEIKE
310
AMVRALGRTR LAQPQSV
Length:317
Mass (Da):35,698
Last modified:October 1, 2002 - v1
Checksum:i72D856594467060F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81V → A.
Corresponds to variant rs17122812 [ dbSNP | Ensembl ].
VAR_053267
Natural varianti166 – 1661R → Q.
Corresponds to variant rs17224674 [ dbSNP | Ensembl ].
VAR_053268
Natural varianti275 – 2751F → V.
Corresponds to variant rs11830378 [ dbSNP | Ensembl ].
VAR_053269
Natural varianti279 – 2791Y → H.
Corresponds to variant rs11168459 [ dbSNP | Ensembl ].
VAR_024125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065872 Genomic DNA. Translation: BAC06090.1.
BC136757 mRNA. Translation: AAI36758.1.
BC136758 mRNA. Translation: AAI36759.1.
BK004354 Genomic DNA. Translation: DAA04752.1.
CCDSiCCDS31787.1.
RefSeqiNP_001004134.1. NM_001004134.1.
UniGeneiHs.446790.

Genome annotation databases

EnsembliENST00000310248; ENSP00000308689; ENSG00000172640.
GeneIDi121275.
KEGGihsa:121275.
UCSCiuc001rrl.1. human.

Polymorphism databases

DMDMi38258177.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065872 Genomic DNA. Translation: BAC06090.1 .
BC136757 mRNA. Translation: AAI36758.1 .
BC136758 mRNA. Translation: AAI36759.1 .
BK004354 Genomic DNA. Translation: DAA04752.1 .
CCDSi CCDS31787.1.
RefSeqi NP_001004134.1. NM_001004134.1.
UniGenei Hs.446790.

3D structure databases

ProteinModelPortali Q8NGE0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000308689.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38258177.

Proteomic databases

PaxDbi Q8NGE0.
PRIDEi Q8NGE0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310248 ; ENSP00000308689 ; ENSG00000172640 .
GeneIDi 121275.
KEGGi hsa:121275.
UCSCi uc001rrl.1. human.

Organism-specific databases

CTDi 121275.
GeneCardsi GC12M048596.
HGNCi HGNC:14819. OR10AD1.
HPAi HPA049913.
neXtProti NX_Q8NGE0.
PharmGKBi PA31959.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45259.
GeneTreei ENSGT00390000018918.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGE0.
KOi K04257.
OMAi WAIFADA.
OrthoDBi EOG75B85P.
PhylomeDBi Q8NGE0.
TreeFami TF338235.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10AD1.
GenomeRNAii 121275.
NextBioi 80706.
PROi Q8NGE0.

Gene expression databases

Bgeei Q8NGE0.
Genevestigatori Q8NGE0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10AD_HUMAN
AccessioniPrimary (citable) accession number: Q8NGE0
Secondary accession number(s): B9EGT9, Q6IFA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3