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Q8NGE0 (O10AD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10AD1
Alternative name(s):
Olfactory receptor OR12-1
Gene names
Name:OR10AD1
Synonyms:OR10AD1P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Olfactory receptor 10AD1
PRO_0000150691

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 559Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 10024Extracellular Potential
Transmembrane101 – 12121Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 16121Helical; Name=4; Potential
Topological domain162 – 19837Extracellular Potential
Transmembrane199 – 21820Helical; Name=5; Potential
Topological domain219 – 23820Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29321Helical; Name=7; Potential
Topological domain294 – 31724Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant81V → A.
Corresponds to variant rs17122812 [ dbSNP | Ensembl ].
VAR_053267
Natural variant1661R → Q.
Corresponds to variant rs17224674 [ dbSNP | Ensembl ].
VAR_053268
Natural variant2751F → V.
Corresponds to variant rs11830378 [ dbSNP | Ensembl ].
VAR_053269
Natural variant2791Y → H.
Corresponds to variant rs11168459 [ dbSNP | Ensembl ].
VAR_024125

Sequences

Sequence LengthMass (Da)Tools
Q8NGE0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 72D856594467060F

FASTA31735,698
        10         20         30         40         50         60 
MLRNGSIVTE FILVGFQQSS TSTRALLFAL FLALYSLTMA MNGLIIFITS WTDPKLNSPM 

        70         80         90        100        110        120 
YFFLGHLSLL DVCFITTTIP QMLIHLVVRD HIVSFVCCMT QMYFVFCVGV AECILLAFMA 

       130        140        150        160        170        180 
YDRYVAICYP LNYVPIISQK VCVRLVGTAW FFGLINGIFL EYISFREPFR RDNHIESFFC 

       190        200        210        220        230        240 
EAPIVIGLSC GDPQFSLWAI FADAIVVILS PMVLTVTSYV HILATILSKA SSSGRGKTFS 

       250        260        270        280        290        300 
TCASHLTVVI FLYTSAMFSY MNPHSTHGPD KDKPFSLLYT IITPMCNPII YSFRNKEIKE 

       310 
AMVRALGRTR LAQPQSV 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Testis.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065872 Genomic DNA. Translation: BAC06090.1.
BC136757 mRNA. Translation: AAI36758.1.
BC136758 mRNA. Translation: AAI36759.1.
BK004354 Genomic DNA. Translation: DAA04752.1.
RefSeqNP_001004134.1. NM_001004134.1.
UniGeneHs.446790.

3D structure databases

ProteinModelPortalQ8NGE0.
SMRQ8NGE0. Positions 280-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308689.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38258177.

Proteomic databases

PaxDbQ8NGE0.
PRIDEQ8NGE0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310248; ENSP00000308689; ENSG00000172640.
GeneID121275.
KEGGhsa:121275.
UCSCuc001rrl.1. human.

Organism-specific databases

CTD121275.
GeneCardsGC12M048596.
HGNCHGNC:14819. OR10AD1.
HPAHPA049913.
neXtProtNX_Q8NGE0.
PharmGKBPA31959.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45259.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGE0.
KOK04257.
OrthoDBEOG75B85P.
PhylomeDBQ8NGE0.
TreeFamTF338235.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8NGE0.
GenevestigatorQ8NGE0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10AD1.
GenomeRNAi121275.
NextBio80706.
PROQ8NGE0.

Entry information

Entry nameO10AD_HUMAN
AccessionPrimary (citable) accession number: Q8NGE0
Secondary accession number(s): B9EGT9, Q6IFA8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries