SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8NGE0

- O10AD_HUMAN

UniProt

Q8NGE0 - O10AD_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Olfactory receptor 10AD1
Gene
OR10AD1, OR10AD1P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10AD1
    Alternative name(s):
    Olfactory receptor OR12-1
    Gene namesi
    Name:OR10AD1
    Synonyms:OR10AD1P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14819. OR10AD1.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei26 – 4621Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini47 – 559Cytoplasmic Reviewed prediction
    Transmembranei56 – 7621Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini77 – 10024Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei101 – 12121Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini122 – 14019Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei141 – 16121Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini162 – 19837Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei199 – 21820Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini219 – 23820Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei239 – 25921Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini260 – 27213Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei273 – 29321Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini294 – 31724Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31959.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Olfactory receptor 10AD1
    PRO_0000150691Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi98 ↔ 190 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGE0.
    PRIDEiQ8NGE0.

    Expressioni

    Gene expression databases

    BgeeiQ8NGE0.
    GenevestigatoriQ8NGE0.

    Organism-specific databases

    HPAiHPA049913.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308689.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGE0.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45259.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGE0.
    KOiK04257.
    OMAiWAIFADA.
    OrthoDBiEOG75B85P.
    PhylomeDBiQ8NGE0.
    TreeFamiTF338235.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRNGSIVTE FILVGFQQSS TSTRALLFAL FLALYSLTMA MNGLIIFITS    50
    WTDPKLNSPM YFFLGHLSLL DVCFITTTIP QMLIHLVVRD HIVSFVCCMT 100
    QMYFVFCVGV AECILLAFMA YDRYVAICYP LNYVPIISQK VCVRLVGTAW 150
    FFGLINGIFL EYISFREPFR RDNHIESFFC EAPIVIGLSC GDPQFSLWAI 200
    FADAIVVILS PMVLTVTSYV HILATILSKA SSSGRGKTFS TCASHLTVVI 250
    FLYTSAMFSY MNPHSTHGPD KDKPFSLLYT IITPMCNPII YSFRNKEIKE 300
    AMVRALGRTR LAQPQSV 317
    Length:317
    Mass (Da):35,698
    Last modified:October 1, 2002 - v1
    Checksum:i72D856594467060F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81V → A.
    Corresponds to variant rs17122812 [ dbSNP | Ensembl ].
    VAR_053267
    Natural varianti166 – 1661R → Q.
    Corresponds to variant rs17224674 [ dbSNP | Ensembl ].
    VAR_053268
    Natural varianti275 – 2751F → V.
    Corresponds to variant rs11830378 [ dbSNP | Ensembl ].
    VAR_053269
    Natural varianti279 – 2791Y → H.
    Corresponds to variant rs11168459 [ dbSNP | Ensembl ].
    VAR_024125

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065872 Genomic DNA. Translation: BAC06090.1.
    BC136757 mRNA. Translation: AAI36758.1.
    BC136758 mRNA. Translation: AAI36759.1.
    BK004354 Genomic DNA. Translation: DAA04752.1.
    CCDSiCCDS31787.1.
    RefSeqiNP_001004134.1. NM_001004134.1.
    UniGeneiHs.446790.

    Genome annotation databases

    EnsembliENST00000310248; ENSP00000308689; ENSG00000172640.
    GeneIDi121275.
    KEGGihsa:121275.
    UCSCiuc001rrl.1. human.

    Polymorphism databases

    DMDMi38258177.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065872 Genomic DNA. Translation: BAC06090.1 .
    BC136757 mRNA. Translation: AAI36758.1 .
    BC136758 mRNA. Translation: AAI36759.1 .
    BK004354 Genomic DNA. Translation: DAA04752.1 .
    CCDSi CCDS31787.1.
    RefSeqi NP_001004134.1. NM_001004134.1.
    UniGenei Hs.446790.

    3D structure databases

    ProteinModelPortali Q8NGE0.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308689.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38258177.

    Proteomic databases

    PaxDbi Q8NGE0.
    PRIDEi Q8NGE0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310248 ; ENSP00000308689 ; ENSG00000172640 .
    GeneIDi 121275.
    KEGGi hsa:121275.
    UCSCi uc001rrl.1. human.

    Organism-specific databases

    CTDi 121275.
    GeneCardsi GC12M048596.
    HGNCi HGNC:14819. OR10AD1.
    HPAi HPA049913.
    neXtProti NX_Q8NGE0.
    PharmGKBi PA31959.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45259.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGE0.
    KOi K04257.
    OMAi WAIFADA.
    OrthoDBi EOG75B85P.
    PhylomeDBi Q8NGE0.
    TreeFami TF338235.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10AD1.
    GenomeRNAii 121275.
    NextBioi 80706.
    PROi Q8NGE0.

    Gene expression databases

    Bgeei Q8NGE0.
    Genevestigatori Q8NGE0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Testis.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10AD_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGE0
    Secondary accession number(s): B9EGT9, Q6IFA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: October 1, 2002
    Last modified: September 3, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi