Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 4K1

Gene

OR4K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155249-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4K1
Alternative name(s):
Olfactory receptor OR14-19
Gene namesi
Name:OR4K1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:14726. OR4K1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 311CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155249.
PharmGKBiPA32308.

Polymorphism and mutation databases

BioMutaiOR4K1.
DMDMi38372674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505521 – 311Olfactory receptor 4K1Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGD4.
PeptideAtlasiQ8NGD4.
PRIDEiQ8NGD4.

Expressioni

Gene expression databases

CleanExiHS_OR4K1.

Organism-specific databases

HPAiHPA028877.

Interactioni

Protein-protein interaction databases

BioGridi122709. 1 interactor.
STRINGi9606.ENSP00000285600.

Structurei

3D structure databases

ProteinModelPortaliQ8NGD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG6X. Eukaryota.
ENOG4111BJZ. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGD4.
KOiK04257.
OMAiRHVNSWK.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NGD4.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHTNESMVS EFVLLGLSNS WGLQLFFFAI FSIVYVTSVL GNVLIIVIIS
60 70 80 90 100
FDSHLNSPMY FLLSNLSFID ICQSNFATPK MLVDFFIERK TISFEGCMAQ
110 120 130 140 150
IFVLHSFVGS EMMLLVAMAY DRFIAICKPL HYSTIMNRRL CVIFVSISWA
160 170 180 190 200
VGVLHSVSHL AFTVDLPFCG PNEVDSFFCD LPLVIELACM DTYEMEIMTL
210 220 230 240 250
TNSGLISLSC FLALIISYTI ILIGVRCRSS SGSSKALSTL TAHITVVILF
260 270 280 290 300
FGPCIYFYIW PFSRLPVDKF LSVFYTVCTP LLNPIIYSLR NEDVKAAMWK
310
LRNRHVNSWK N
Length:311
Mass (Da):35,201
Last modified:October 1, 2002 - v1
Checksum:i97C9A3B6DC91A063
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05412189R → H.Corresponds to variant rs12885778dbSNPEnsembl.1
Natural variantiVAR_054122138R → Q.Corresponds to variant rs3916626dbSNPEnsembl.1
Natural variantiVAR_054123304R → H.3 PublicationsCorresponds to variant rs2792146dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065879 Genomic DNA. Translation: BAC06097.1.
AB065881 Genomic DNA. Translation: BAC06099.1.
CH471078 Genomic DNA. Translation: EAW66494.1.
BC151145 mRNA. Translation: AAI51146.1.
AF399570 Genomic DNA. Translation: AAK95055.1.
BK004356 Genomic DNA. Translation: DAA04754.1.
CCDSiCCDS32025.1.
RefSeqiNP_001004063.2. NM_001004063.2.
XP_011535455.1. XM_011537153.2.
UniGeneiHs.554584.

Genome annotation databases

EnsembliENST00000285600; ENSP00000285600; ENSG00000155249.
GeneIDi79544.
KEGGihsa:79544.
UCSCiuc001vwj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065879 Genomic DNA. Translation: BAC06097.1.
AB065881 Genomic DNA. Translation: BAC06099.1.
CH471078 Genomic DNA. Translation: EAW66494.1.
BC151145 mRNA. Translation: AAI51146.1.
AF399570 Genomic DNA. Translation: AAK95055.1.
BK004356 Genomic DNA. Translation: DAA04754.1.
CCDSiCCDS32025.1.
RefSeqiNP_001004063.2. NM_001004063.2.
XP_011535455.1. XM_011537153.2.
UniGeneiHs.554584.

3D structure databases

ProteinModelPortaliQ8NGD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122709. 1 interactor.
STRINGi9606.ENSP00000285600.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR4K1.
DMDMi38372674.

Proteomic databases

PaxDbiQ8NGD4.
PeptideAtlasiQ8NGD4.
PRIDEiQ8NGD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285600; ENSP00000285600; ENSG00000155249.
GeneIDi79544.
KEGGihsa:79544.
UCSCiuc001vwj.2. human.

Organism-specific databases

CTDi79544.
GeneCardsiOR4K1.
HGNCiHGNC:14726. OR4K1.
HPAiHPA028877.
neXtProtiNX_Q8NGD4.
OpenTargetsiENSG00000155249.
PharmGKBiPA32308.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG6X. Eukaryota.
ENOG4111BJZ. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGD4.
KOiK04257.
OMAiRHVNSWK.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NGD4.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155249-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4K1.
GenomeRNAii79544.
PROiQ8NGD4.

Gene expression databases

CleanExiHS_OR4K1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4K1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGD4
Secondary accession number(s): B9EKV9, Q8NGD6, Q96R73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.