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Q8NGD1

- OR4N2_HUMAN

UniProt

Q8NGD1 - OR4N2_HUMAN

Protein

Olfactory receptor 4N2

Gene

OR4N2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 4N2
    Alternative name(s):
    Olfactory receptor OR14-13
    Olfactory receptor OR14-8
    Gene namesi
    Name:OR4N2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:14742. OR4N2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32330.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Olfactory receptor 4N2PRO_0000150563Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGD1.
    PRIDEiQ8NGD1.

    PTM databases

    PhosphoSiteiQ8NGD1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NGD1.
    BgeeiQ8NGD1.
    CleanExiHS_OR4N2.
    GenevestigatoriQ8NGD1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000319601.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGD1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23516CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 26911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 30718CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43237.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGD1.
    KOiK04257.
    OMAiCRIRGSS.
    PhylomeDBiQ8NGD1.
    TreeFamiTF338273.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGD1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESENRTVIR EFILLGLTQS QDIQLLVFVL VLIFYFIILP GNFLIIFTIK    50
    SDPGLTAPLY FFLGNLAFLD ASYSFIVAPR MLVDFLSAKK IISYRGCITQ 100
    LFFLHFLGGG EGLLLVVMAF DRYIAICRPL HYPTVMNPRT CYAMMLALWL 150
    GGFVHSIIQV VLILRLPFCG PNQLDNFFCD VPQVIKLACT DTFVVELLMV 200
    FNSGLMTLLC FLGLLASYAV ILCRIRGSSS EAKNKAMSTC ITHIIVIFFM 250
    FGPGIFIYTR PFRAFPADKV VSLFHTVIFP LLNPVIYTLR NQEVKASMKK 300
    VFNKHIA 307
    Length:307
    Mass (Da):34,721
    Last modified:October 1, 2002 - v1
    Checksum:i69BB9360CCC590B5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti76 – 761I → T.
    Corresponds to variant rs2801164 [ dbSNP | Ensembl ].
    VAR_048032
    Natural varianti133 – 1331P → S.
    Corresponds to variant rs2318279 [ dbSNP | Ensembl ].
    VAR_048033
    Natural varianti135 – 1351V → L.
    Corresponds to variant rs17114261 [ dbSNP | Ensembl ].
    VAR_034207

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065885 Genomic DNA. Translation: BAC06102.1.
    BK004473 Genomic DNA. Translation: DAA04871.1.
    BK004360 Genomic DNA. Translation: DAA04758.1.
    CCDSiCCDS32022.1.
    RefSeqiNP_001004723.1. NM_001004723.2.
    UniGeneiHs.512490.

    Genome annotation databases

    EnsembliENST00000315947; ENSP00000319601; ENSG00000176294.
    GeneIDi390429.
    KEGGihsa:390429.
    UCSCiuc010tkv.2. human.

    Polymorphism databases

    DMDMi38372671.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065885 Genomic DNA. Translation: BAC06102.1 .
    BK004473 Genomic DNA. Translation: DAA04871.1 .
    BK004360 Genomic DNA. Translation: DAA04758.1 .
    CCDSi CCDS32022.1.
    RefSeqi NP_001004723.1. NM_001004723.2.
    UniGenei Hs.512490.

    3D structure databases

    ProteinModelPortali Q8NGD1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000319601.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGD1.

    Polymorphism databases

    DMDMi 38372671.

    Proteomic databases

    PaxDbi Q8NGD1.
    PRIDEi Q8NGD1.

    Protocols and materials databases

    DNASUi 390429.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315947 ; ENSP00000319601 ; ENSG00000176294 .
    GeneIDi 390429.
    KEGGi hsa:390429.
    UCSCi uc010tkv.2. human.

    Organism-specific databases

    CTDi 390429.
    GeneCardsi GC14P020187.
    H-InvDB HIX0038471.
    HGNCi HGNC:14742. OR4N2.
    neXtProti NX_Q8NGD1.
    PharmGKBi PA32330.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43237.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGD1.
    KOi K04257.
    OMAi CRIRGSS.
    PhylomeDBi Q8NGD1.
    TreeFami TF338273.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR4N2.
    GenomeRNAii 390429.
    NextBioi 103782.
    PROi Q8NGD1.

    Gene expression databases

    ArrayExpressi Q8NGD1.
    Bgeei Q8NGD1.
    CleanExi HS_OR4N2.
    Genevestigatori Q8NGD1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR4N2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGD1
    Secondary accession number(s): Q6IEY9, Q6IFA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3