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Q8NGD1

- OR4N2_HUMAN

UniProt

Q8NGD1 - OR4N2_HUMAN

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Protein

Olfactory receptor 4N2

Gene

OR4N2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4N2
Alternative name(s):
Olfactory receptor OR14-13
Olfactory receptor OR14-8
Gene namesi
Name:OR4N2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:14742. OR4N2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23516CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence AnalysisAdd
BLAST
Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 30718CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Olfactory receptor 4N2PRO_0000150563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGD1.
PRIDEiQ8NGD1.

PTM databases

PhosphoSiteiQ8NGD1.

Expressioni

Gene expression databases

BgeeiQ8NGD1.
CleanExiHS_OR4N2.
ExpressionAtlasiQ8NGD1. baseline.
GenevestigatoriQ8NGD1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319601.

Structurei

3D structure databases

ProteinModelPortaliQ8NGD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43237.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGD1.
KOiK04257.
OMAiCRIRGSS.
PhylomeDBiQ8NGD1.
TreeFamiTF338273.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGD1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESENRTVIR EFILLGLTQS QDIQLLVFVL VLIFYFIILP GNFLIIFTIK
60 70 80 90 100
SDPGLTAPLY FFLGNLAFLD ASYSFIVAPR MLVDFLSAKK IISYRGCITQ
110 120 130 140 150
LFFLHFLGGG EGLLLVVMAF DRYIAICRPL HYPTVMNPRT CYAMMLALWL
160 170 180 190 200
GGFVHSIIQV VLILRLPFCG PNQLDNFFCD VPQVIKLACT DTFVVELLMV
210 220 230 240 250
FNSGLMTLLC FLGLLASYAV ILCRIRGSSS EAKNKAMSTC ITHIIVIFFM
260 270 280 290 300
FGPGIFIYTR PFRAFPADKV VSLFHTVIFP LLNPVIYTLR NQEVKASMKK

VFNKHIA
Length:307
Mass (Da):34,721
Last modified:October 1, 2002 - v1
Checksum:i69BB9360CCC590B5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761I → T.
Corresponds to variant rs2801164 [ dbSNP | Ensembl ].
VAR_048032
Natural varianti133 – 1331P → S.
Corresponds to variant rs2318279 [ dbSNP | Ensembl ].
VAR_048033
Natural varianti135 – 1351V → L.
Corresponds to variant rs17114261 [ dbSNP | Ensembl ].
VAR_034207

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065885 Genomic DNA. Translation: BAC06102.1.
BK004473 Genomic DNA. Translation: DAA04871.1.
BK004360 Genomic DNA. Translation: DAA04758.1.
CCDSiCCDS32022.1.
RefSeqiNP_001004723.1. NM_001004723.2.
UniGeneiHs.512490.

Genome annotation databases

EnsembliENST00000315947; ENSP00000319601; ENSG00000176294.
GeneIDi390429.
KEGGihsa:390429.
UCSCiuc010tkv.2. human.

Polymorphism databases

DMDMi38372671.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065885 Genomic DNA. Translation: BAC06102.1 .
BK004473 Genomic DNA. Translation: DAA04871.1 .
BK004360 Genomic DNA. Translation: DAA04758.1 .
CCDSi CCDS32022.1.
RefSeqi NP_001004723.1. NM_001004723.2.
UniGenei Hs.512490.

3D structure databases

ProteinModelPortali Q8NGD1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000319601.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGD1.

Polymorphism databases

DMDMi 38372671.

Proteomic databases

PaxDbi Q8NGD1.
PRIDEi Q8NGD1.

Protocols and materials databases

DNASUi 390429.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315947 ; ENSP00000319601 ; ENSG00000176294 .
GeneIDi 390429.
KEGGi hsa:390429.
UCSCi uc010tkv.2. human.

Organism-specific databases

CTDi 390429.
GeneCardsi GC14P020187.
H-InvDB HIX0038471.
HGNCi HGNC:14742. OR4N2.
neXtProti NX_Q8NGD1.
PharmGKBi PA32330.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43237.
GeneTreei ENSGT00760000119104.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGD1.
KOi K04257.
OMAi CRIRGSS.
PhylomeDBi Q8NGD1.
TreeFami TF338273.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR4N2.
GenomeRNAii 390429.
NextBioi 103782.
PROi Q8NGD1.

Gene expression databases

Bgeei Q8NGD1.
CleanExi HS_OR4N2.
ExpressionAtlasi Q8NGD1. baseline.
Genevestigatori Q8NGD1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4N2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGD1
Secondary accession number(s): Q6IEY9, Q6IFA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3