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Q8NGD1 (OR4N2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4N2
Alternative name(s):
Olfactory receptor OR14-13
Olfactory receptor OR14-8
Gene names
Name:OR4N2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Olfactory receptor 4N2
PRO_0000150563

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23516Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 26911Extracellular Potential
Transmembrane270 – 28920Helical; Name=7; Potential
Topological domain290 – 30718Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant761I → T.
Corresponds to variant rs2801164 [ dbSNP | Ensembl ].
VAR_048032
Natural variant1331P → S.
Corresponds to variant rs2318279 [ dbSNP | Ensembl ].
VAR_048033
Natural variant1351V → L.
Corresponds to variant rs17114261 [ dbSNP | Ensembl ].
VAR_034207

Sequences

Sequence LengthMass (Da)Tools
Q8NGD1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 69BB9360CCC590B5

FASTA30734,721
        10         20         30         40         50         60 
MESENRTVIR EFILLGLTQS QDIQLLVFVL VLIFYFIILP GNFLIIFTIK SDPGLTAPLY 

        70         80         90        100        110        120 
FFLGNLAFLD ASYSFIVAPR MLVDFLSAKK IISYRGCITQ LFFLHFLGGG EGLLLVVMAF 

       130        140        150        160        170        180 
DRYIAICRPL HYPTVMNPRT CYAMMLALWL GGFVHSIIQV VLILRLPFCG PNQLDNFFCD 

       190        200        210        220        230        240 
VPQVIKLACT DTFVVELLMV FNSGLMTLLC FLGLLASYAV ILCRIRGSSS EAKNKAMSTC 

       250        260        270        280        290        300 
ITHIIVIFFM FGPGIFIYTR PFRAFPADKV VSLFHTVIFP LLNPVIYTLR NQEVKASMKK 


VFNKHIA 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065885 Genomic DNA. Translation: BAC06102.1.
BK004473 Genomic DNA. Translation: DAA04871.1.
BK004360 Genomic DNA. Translation: DAA04758.1.
RefSeqNP_001004723.1. NM_001004723.1.
UniGeneHs.512490.

3D structure databases

ProteinModelPortalQ8NGD1.
SMRQ8NGD1. Positions 109-140, 275-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000319601.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGD1.

Polymorphism databases

DMDM38372671.

Proteomic databases

PaxDbQ8NGD1.
PRIDEQ8NGD1.

Protocols and materials databases

DNASU390429.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315947; ENSP00000319601; ENSG00000176294.
GeneID390429.
KEGGhsa:390429.
UCSCuc010tkv.2. human.

Organism-specific databases

CTD390429.
GeneCardsGC14P020187.
H-InvDBHIX0038471.
HGNCHGNC:14742. OR4N2.
neXtProtNX_Q8NGD1.
PharmGKBPA32330.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43237.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGD1.
KOK04257.
OMACRIRGSS.
PhylomeDBQ8NGD1.
TreeFamTF338273.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ8NGD1.
BgeeQ8NGD1.
CleanExHS_OR4N2.
GenevestigatorQ8NGD1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR4N2.
GenomeRNAi390429.
NextBio103782.
PROQ8NGD1.

Entry information

Entry nameOR4N2_HUMAN
AccessionPrimary (citable) accession number: Q8NGD1
Secondary accession number(s): Q6IEY9, Q6IFA2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries