ID   O11H4_HUMAN             Reviewed;         324 AA.
AC   Q8NGC9; B2RNQ4; Q6IF07;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=Olfactory receptor 11H4;
DE   AltName: Full=Olfactory receptor OR14-36;
GN   Name=OR11H4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR11H4";
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DR   EMBL; AB065887; BAC06104.1; -; Genomic_DNA.
DR   EMBL; CH471078; EAW66484.1; -; Genomic_DNA.
DR   EMBL; BC137054; AAI37055.1; -; mRNA.
DR   EMBL; BC137055; AAI37056.1; -; mRNA.
DR   EMBL; BK004455; DAA04853.1; -; Genomic_DNA.
DR   RefSeq; NP_001004479.1; NM_001004479.1.
DR   AlphaFoldDB; Q8NGC9; -.
DR   SMR; Q8NGC9; -.
DR   STRING; 9606.ENSP00000318997; -.
DR   GlyCosmos; Q8NGC9; 1 site, No reported glycans.
DR   GlyGen; Q8NGC9; 1 site.
DR   iPTMnet; Q8NGC9; -.
DR   PhosphoSitePlus; Q8NGC9; -.
DR   BioMuta; OR11H4; -.
DR   DMDM; 38372669; -.
DR   EPD; Q8NGC9; -.
DR   PaxDb; 9606-ENSP00000318997; -.
DR   PeptideAtlas; Q8NGC9; -.
DR   Antibodypedia; 22003; 31 antibodies from 14 providers.
DR   DNASU; 390442; -.
DR   GeneID; 390442; -.
DR   KEGG; hsa:390442; -.
DR   UCSC; uc010tld.3; human.
DR   AGR; HGNC:15347; -.
DR   GeneCards; OR11H4; -.
DR   HGNC; HGNC:15347; OR11H4.
DR   neXtProt; NX_Q8NGC9; -.
DR   PharmGKB; PA32016; -.
DR   VEuPathDB; HostDB:ENSG00000176198; -.
DR   eggNOG; ENOG502QVH7; Eukaryota.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q8NGC9; -.
DR   OMA; GFPGCWE; -.
DR   OrthoDB; 4314801at2759; -.
DR   PhylomeDB; Q8NGC9; -.
DR   TreeFam; TF338968; -.
DR   PathwayCommons; Q8NGC9; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390442; 29 hits in 755 CRISPR screens.
DR   GeneWiki; OR11H4; -.
DR   GenomeRNAi; 390442; -.
DR   Pharos; Q8NGC9; Tdark.
DR   PRO; PR:Q8NGC9; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; Q8NGC9; Protein.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   CDD; cd15913; 7tmA_OR11G-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR24242; G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24242:SF381; OLFACTORY RECEPTOR 11H4; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..324
FT                   /note="Olfactory receptor 11H4"
FT                   /id="PRO_0000150725"
FT   TOPO_DOM        1..35
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..64
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..109
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..207
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..227
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        228..247
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..281
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..324
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        107..199
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         301
FT                   /note="T -> S (in dbSNP:rs17277270)"
FT                   /id="VAR_034298"
SQ   SEQUENCE   324 AA;  36886 MW;  D556E455336C7DC8 CRC64;
     MSFFFVDLRP MNRSATHIVT EFILLGFPGC WKIQIFLFSL FLVIYVLTLL GNGAIIYAVR
     CNPLLHTPMY FLLGNFAFLE IWYVSSTIPN MLVNILSKTK AISFSGCFLQ FYFFFSLGTT
     ECLFLAVMAY DRYLAICHPL QYPAIMTVRF CGKLVSFCWL IGFLGYPIPI FYISQLPFCG
     PNIIDHFLCD MDPLMALSCA PAPITECIFY TQSSLVLFFT SMYILRSYIL LLTAVFQVPS
     AAGRRKAFST CGSHLVVVSL FYGTVMVMYV SPTYGIPTLL QKILTLVYSV TTPLFNPLIY
     TLRNKDMKLA LRNVLFGMRI RQNS
//