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Q8NGC9

- O11H4_HUMAN

UniProt

Q8NGC9 - O11H4_HUMAN

Protein

Olfactory receptor 11H4

Gene

OR11H4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 11H4
    Alternative name(s):
    Olfactory receptor OR14-36
    Gene namesi
    Name:OR11H4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:15347. OR11H4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32016.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Olfactory receptor 11H4PRO_0000150725Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi107 ↔ 199PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGC9.

    PTM databases

    PhosphoSiteiQ8NGC9.

    Expressioni

    Gene expression databases

    CleanExiHS_OR11H4.
    GenevestigatoriQ8NGC9.

    Organism-specific databases

    HPAiHPA052790.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000318997.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGC9.
    SMRiQ8NGC9. Positions 42-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini57 – 648CytoplasmicSequence Analysis
    Topological domaini86 – 10924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini131 – 14919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 20737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini228 – 24720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 28113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini303 – 32422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei208 – 22720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG75876.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGC9.
    KOiK04257.
    OMAiIHEARGR.
    OrthoDBiEOG7N0C51.
    PhylomeDBiQ8NGC9.
    TreeFamiTF338968.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGC9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFFFVDLRP MNRSATHIVT EFILLGFPGC WKIQIFLFSL FLVIYVLTLL    50
    GNGAIIYAVR CNPLLHTPMY FLLGNFAFLE IWYVSSTIPN MLVNILSKTK 100
    AISFSGCFLQ FYFFFSLGTT ECLFLAVMAY DRYLAICHPL QYPAIMTVRF 150
    CGKLVSFCWL IGFLGYPIPI FYISQLPFCG PNIIDHFLCD MDPLMALSCA 200
    PAPITECIFY TQSSLVLFFT SMYILRSYIL LLTAVFQVPS AAGRRKAFST 250
    CGSHLVVVSL FYGTVMVMYV SPTYGIPTLL QKILTLVYSV TTPLFNPLIY 300
    TLRNKDMKLA LRNVLFGMRI RQNS 324
    Length:324
    Mass (Da):36,886
    Last modified:October 1, 2002 - v1
    Checksum:iD556E455336C7DC8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti301 – 3011T → S.
    Corresponds to variant rs17277270 [ dbSNP | Ensembl ].
    VAR_034298

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065887 Genomic DNA. Translation: BAC06104.1.
    CH471078 Genomic DNA. Translation: EAW66484.1.
    BC137054 mRNA. Translation: AAI37055.1.
    BC137055 mRNA. Translation: AAI37056.1.
    BK004455 Genomic DNA. Translation: DAA04853.1.
    CCDSiCCDS32034.1.
    RefSeqiNP_001004479.1. NM_001004479.1.
    UniGeneiHs.553767.

    Genome annotation databases

    EnsembliENST00000315409; ENSP00000318997; ENSG00000176198.
    GeneIDi390442.
    KEGGihsa:390442.
    UCSCiuc010tld.2. human.

    Polymorphism databases

    DMDMi38372669.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065887 Genomic DNA. Translation: BAC06104.1 .
    CH471078 Genomic DNA. Translation: EAW66484.1 .
    BC137054 mRNA. Translation: AAI37055.1 .
    BC137055 mRNA. Translation: AAI37056.1 .
    BK004455 Genomic DNA. Translation: DAA04853.1 .
    CCDSi CCDS32034.1.
    RefSeqi NP_001004479.1. NM_001004479.1.
    UniGenei Hs.553767.

    3D structure databases

    ProteinModelPortali Q8NGC9.
    SMRi Q8NGC9. Positions 42-322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000318997.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGC9.

    Polymorphism databases

    DMDMi 38372669.

    Proteomic databases

    PRIDEi Q8NGC9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315409 ; ENSP00000318997 ; ENSG00000176198 .
    GeneIDi 390442.
    KEGGi hsa:390442.
    UCSCi uc010tld.2. human.

    Organism-specific databases

    CTDi 390442.
    GeneCardsi GC14P020710.
    HGNCi HGNC:15347. OR11H4.
    HPAi HPA052790.
    neXtProti NX_Q8NGC9.
    PharmGKBi PA32016.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG75876.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGC9.
    KOi K04257.
    OMAi IHEARGR.
    OrthoDBi EOG7N0C51.
    PhylomeDBi Q8NGC9.
    TreeFami TF338968.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR11H4.
    GenomeRNAii 390442.
    NextBioi 103818.
    PROi Q8NGC9.

    Gene expression databases

    CleanExi HS_OR11H4.
    Genevestigatori Q8NGC9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO11H4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGC9
    Secondary accession number(s): B2RNQ4, Q6IF07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3