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Q8NGC9 (O11H4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 11H4
Alternative name(s):
Olfactory receptor OR14-36
Gene names
Name:OR11H4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Olfactory receptor 11H4
PRO_0000150725

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 5621Helical; Name=1; Potential
Topological domain57 – 648Cytoplasmic Potential
Transmembrane65 – 8521Helical; Name=2; Potential
Topological domain86 – 10924Extracellular Potential
Transmembrane110 – 13021Helical; Name=3; Potential
Topological domain131 – 14919Cytoplasmic Potential
Transmembrane150 – 17021Helical; Name=4; Potential
Topological domain171 – 20737Extracellular Potential
Transmembrane208 – 22720Helical; Name=5; Potential
Topological domain228 – 24720Cytoplasmic Potential
Transmembrane248 – 26821Helical; Name=6; Potential
Topological domain269 – 28113Extracellular Potential
Transmembrane282 – 30221Helical; Name=7; Potential
Topological domain303 – 32422Cytoplasmic Potential

Amino acid modifications

Glycosylation121N-linked (GlcNAc...) Potential
Disulfide bond107 ↔ 199 By similarity

Natural variations

Natural variant3011T → S.
Corresponds to variant rs17277270 [ dbSNP | Ensembl ].
VAR_034298

Sequences

Sequence LengthMass (Da)Tools
Q8NGC9 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: D556E455336C7DC8

FASTA32436,886
        10         20         30         40         50         60 
MSFFFVDLRP MNRSATHIVT EFILLGFPGC WKIQIFLFSL FLVIYVLTLL GNGAIIYAVR 

        70         80         90        100        110        120 
CNPLLHTPMY FLLGNFAFLE IWYVSSTIPN MLVNILSKTK AISFSGCFLQ FYFFFSLGTT 

       130        140        150        160        170        180 
ECLFLAVMAY DRYLAICHPL QYPAIMTVRF CGKLVSFCWL IGFLGYPIPI FYISQLPFCG 

       190        200        210        220        230        240 
PNIIDHFLCD MDPLMALSCA PAPITECIFY TQSSLVLFFT SMYILRSYIL LLTAVFQVPS 

       250        260        270        280        290        300 
AAGRRKAFST CGSHLVVVSL FYGTVMVMYV SPTYGIPTLL QKILTLVYSV TTPLFNPLIY 

       310        320 
TLRNKDMKLA LRNVLFGMRI RQNS 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065887 Genomic DNA. Translation: BAC06104.1.
CH471078 Genomic DNA. Translation: EAW66484.1.
BC137054 mRNA. Translation: AAI37055.1.
BC137055 mRNA. Translation: AAI37056.1.
BK004455 Genomic DNA. Translation: DAA04853.1.
RefSeqNP_001004479.1. NM_001004479.1.
UniGeneHs.553767.

3D structure databases

ProteinModelPortalQ8NGC9.
SMRQ8NGC9. Positions 42-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000318997.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGC9.

Polymorphism databases

DMDM38372669.

Proteomic databases

PRIDEQ8NGC9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315409; ENSP00000318997; ENSG00000176198.
GeneID390442.
KEGGhsa:390442.
UCSCuc010tld.2. human.

Organism-specific databases

CTD390442.
GeneCardsGC14P020710.
HGNCHGNC:15347. OR11H4.
HPAHPA052790.
neXtProtNX_Q8NGC9.
PharmGKBPA32016.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG75876.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGC9.
KOK04257.
OMASFCWLIG.
OrthoDBEOG7N0C51.
PhylomeDBQ8NGC9.
TreeFamTF338968.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR11H4.
GenevestigatorQ8NGC9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR11H4.
GenomeRNAi390442.
NextBio103818.
PROQ8NGC9.

Entry information

Entry nameO11H4_HUMAN
AccessionPrimary (citable) accession number: Q8NGC9
Secondary accession number(s): B2RNQ4, Q6IF07
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries