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Q8NGC9

- O11H4_HUMAN

UniProt

Q8NGC9 - O11H4_HUMAN

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Protein
Olfactory receptor 11H4
Gene
OR11H4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H4
Alternative name(s):
Olfactory receptor OR14-36
Gene namesi
Name:OR11H4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:15347. OR11H4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Extracellular Reviewed prediction
Add
BLAST
Transmembranei36 – 5621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini57 – 648Cytoplasmic Reviewed prediction
Transmembranei65 – 8521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini86 – 10924Extracellular Reviewed prediction
Add
BLAST
Transmembranei110 – 13021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini131 – 14919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei150 – 17021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini171 – 20737Extracellular Reviewed prediction
Add
BLAST
Transmembranei208 – 22720Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini228 – 24720Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini269 – 28113Extracellular Reviewed prediction
Add
BLAST
Transmembranei282 – 30221Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini303 – 32422Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Olfactory receptor 11H4
PRO_0000150725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi107 ↔ 199 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGC9.

PTM databases

PhosphoSiteiQ8NGC9.

Expressioni

Gene expression databases

CleanExiHS_OR11H4.
GenevestigatoriQ8NGC9.

Organism-specific databases

HPAiHPA052790.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000318997.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC9.
SMRiQ8NGC9. Positions 42-322.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG75876.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC9.
KOiK04257.
OMAiIHEARGR.
OrthoDBiEOG7N0C51.
PhylomeDBiQ8NGC9.
TreeFamiTF338968.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC9-1 [UniParc]FASTAAdd to Basket

« Hide

MSFFFVDLRP MNRSATHIVT EFILLGFPGC WKIQIFLFSL FLVIYVLTLL    50
GNGAIIYAVR CNPLLHTPMY FLLGNFAFLE IWYVSSTIPN MLVNILSKTK 100
AISFSGCFLQ FYFFFSLGTT ECLFLAVMAY DRYLAICHPL QYPAIMTVRF 150
CGKLVSFCWL IGFLGYPIPI FYISQLPFCG PNIIDHFLCD MDPLMALSCA 200
PAPITECIFY TQSSLVLFFT SMYILRSYIL LLTAVFQVPS AAGRRKAFST 250
CGSHLVVVSL FYGTVMVMYV SPTYGIPTLL QKILTLVYSV TTPLFNPLIY 300
TLRNKDMKLA LRNVLFGMRI RQNS 324
Length:324
Mass (Da):36,886
Last modified:October 1, 2002 - v1
Checksum:iD556E455336C7DC8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti301 – 3011T → S.
Corresponds to variant rs17277270 [ dbSNP | Ensembl ].
VAR_034298

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065887 Genomic DNA. Translation: BAC06104.1.
CH471078 Genomic DNA. Translation: EAW66484.1.
BC137054 mRNA. Translation: AAI37055.1.
BC137055 mRNA. Translation: AAI37056.1.
BK004455 Genomic DNA. Translation: DAA04853.1.
CCDSiCCDS32034.1.
RefSeqiNP_001004479.1. NM_001004479.1.
UniGeneiHs.553767.

Genome annotation databases

EnsembliENST00000315409; ENSP00000318997; ENSG00000176198.
GeneIDi390442.
KEGGihsa:390442.
UCSCiuc010tld.2. human.

Polymorphism databases

DMDMi38372669.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065887 Genomic DNA. Translation: BAC06104.1 .
CH471078 Genomic DNA. Translation: EAW66484.1 .
BC137054 mRNA. Translation: AAI37055.1 .
BC137055 mRNA. Translation: AAI37056.1 .
BK004455 Genomic DNA. Translation: DAA04853.1 .
CCDSi CCDS32034.1.
RefSeqi NP_001004479.1. NM_001004479.1.
UniGenei Hs.553767.

3D structure databases

ProteinModelPortali Q8NGC9.
SMRi Q8NGC9. Positions 42-322.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000318997.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGC9.

Polymorphism databases

DMDMi 38372669.

Proteomic databases

PRIDEi Q8NGC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315409 ; ENSP00000318997 ; ENSG00000176198 .
GeneIDi 390442.
KEGGi hsa:390442.
UCSCi uc010tld.2. human.

Organism-specific databases

CTDi 390442.
GeneCardsi GC14P020710.
HGNCi HGNC:15347. OR11H4.
HPAi HPA052790.
neXtProti NX_Q8NGC9.
PharmGKBi PA32016.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG75876.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGC9.
KOi K04257.
OMAi IHEARGR.
OrthoDBi EOG7N0C51.
PhylomeDBi Q8NGC9.
TreeFami TF338968.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR11H4.
GenomeRNAii 390442.
NextBioi 103818.
PROi Q8NGC9.

Gene expression databases

CleanExi HS_OR11H4.
Genevestigatori Q8NGC9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO11H4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC9
Secondary accession number(s): B2RNQ4, Q6IF07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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