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Protein

Olfactory receptor 11H6

Gene

OR11H6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176219-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H6
Alternative name(s):
Olfactory receptor OR14-35
Gene namesi
Name:OR11H6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15349. OR11H6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 72CytoplasmicSequence analysis8
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 117ExtracellularSequence analysisAdd BLAST24
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini139 – 157CytoplasmicSequence analysisAdd BLAST19
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 215ExtracellularSequence analysisAdd BLAST37
Transmembranei216 – 235Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini236 – 255CytoplasmicSequence analysisAdd BLAST20
Transmembranei256 – 276Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini277 – 289ExtracellularSequence analysisAdd BLAST13
Transmembranei290 – 310Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini311 – 330CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176219.
PharmGKBiPA32018.

Polymorphism and mutation databases

BioMutaiOR11H6.
DMDMi38372668.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507261 – 330Olfactory receptor 11H6Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC7.
PRIDEiQ8NGC7.

Expressioni

Gene expression databases

CleanExiHS_OR11H6.
ExpressionAtlasiQ8NGC7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319071.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFEZ. Eukaryota.
ENOG411183S. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC7.
KOiK04257.
OMAiTMHFVTE.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGC7.
TreeFamiTF338968.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFIIHSLVT SVFLTALGPQ NRTMHFVTEF VLLGFHGQRE MQSCFFSFIL
60 70 80 90 100
VLYLLTLLGN GAIVCAVKLD RRLHTPMYIL LGNFAFLEIW YISSTVPNML
110 120 130 140 150
VNILSEIKTI SFSGCFLQFY FFFSLGTTEC FFLSVMAYDR YLAICRPLHY
160 170 180 190 200
PSIMTGKFCI ILVCVCWVGG FLCYPVPIVL ISQLPFCGPN IIDHLVCDPG
210 220 230 240 250
PLFALACISA PSTELICYTF NSMIIFGPFL SILGSYTLVI RAVLCIPSGA
260 270 280 290 300
GRTKAFSTCG SHLMVVSLFY GTLMVMYVSP TSGNPAGMQK IITLVYTAMT
310 320 330
PFLNPLIYSL RNKDMKDALK RVLGLTVSQN
Length:330
Mass (Da):36,788
Last modified:October 1, 2002 - v1
Checksum:i99014E58C6C57110
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0342997S → Y.Corresponds to variant rs10140652dbSNPEnsembl.1
Natural variantiVAR_02413032L → V.Corresponds to variant rs9323693dbSNPEnsembl.1
Natural variantiVAR_034300107I → T.Corresponds to variant rs12891553dbSNPEnsembl.1
Natural variantiVAR_034301146R → H.Corresponds to variant rs17106351dbSNPEnsembl.1
Natural variantiVAR_034302195L → F.Corresponds to variant rs17211285dbSNPEnsembl.1
Natural variantiVAR_034303236Y → H.Corresponds to variant rs17277221dbSNPEnsembl.1
Natural variantiVAR_034304259C → R.Corresponds to variant rs17277228dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065889 Genomic DNA. Translation: BAC06106.1.
BK004454 Genomic DNA. Translation: DAA04852.1.
CCDSiCCDS32033.1.
RefSeqiNP_001004480.1. NM_001004480.1.
UniGeneiHs.553575.

Genome annotation databases

EnsembliENST00000315519; ENSP00000319071; ENSG00000176219.
GeneIDi122748.
KEGGihsa:122748.
UCSCiuc010tlc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065889 Genomic DNA. Translation: BAC06106.1.
BK004454 Genomic DNA. Translation: DAA04852.1.
CCDSiCCDS32033.1.
RefSeqiNP_001004480.1. NM_001004480.1.
UniGeneiHs.553575.

3D structure databases

ProteinModelPortaliQ8NGC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319071.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR11H6.
DMDMi38372668.

Proteomic databases

PaxDbiQ8NGC7.
PRIDEiQ8NGC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315519; ENSP00000319071; ENSG00000176219.
GeneIDi122748.
KEGGihsa:122748.
UCSCiuc010tlc.3. human.

Organism-specific databases

CTDi122748.
GeneCardsiOR11H6.
HGNCiHGNC:15349. OR11H6.
neXtProtiNX_Q8NGC7.
OpenTargetsiENSG00000176219.
PharmGKBiPA32018.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFEZ. Eukaryota.
ENOG411183S. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC7.
KOiK04257.
OMAiTMHFVTE.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGC7.
TreeFamiTF338968.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176219-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR11H6.
GenomeRNAii122748.
PROiQ8NGC7.

Gene expression databases

CleanExiHS_OR11H6.
ExpressionAtlasiQ8NGC7. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO11H6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC7
Secondary accession number(s): Q6IF08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.