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Q8NGC7

- O11H6_HUMAN

UniProt

Q8NGC7 - O11H6_HUMAN

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Protein

Olfactory receptor 11H6

Gene

OR11H6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H6
Alternative name(s):
Olfactory receptor OR14-35
Gene namesi
Name:OR11H6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:15349. OR11H6.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Olfactory receptor 11H6PRO_0000150726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGC7.

Expressioni

Gene expression databases

CleanExiHS_OR11H6.
GenevestigatoriQ8NGC7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319071.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC7.
SMRiQ8NGC7. Positions 43-323.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
BLAST
Topological domaini65 – 728CytoplasmicSequence Analysis
Topological domaini94 – 11724ExtracellularSequence AnalysisAdd
BLAST
Topological domaini139 – 15719CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini179 – 21537ExtracellularSequence AnalysisAdd
BLAST
Topological domaini236 – 25520CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini277 – 28913ExtracellularSequence AnalysisAdd
BLAST
Topological domaini311 – 33020CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei216 – 23520Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40487.
GeneTreeiENSGT00760000119087.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC7.
KOiK04257.
OMAiNTTMHFV.
OrthoDBiEOG7N0C51.
PhylomeDBiQ8NGC7.
TreeFamiTF338968.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFFIIHSLVT SVFLTALGPQ NRTMHFVTEF VLLGFHGQRE MQSCFFSFIL
60 70 80 90 100
VLYLLTLLGN GAIVCAVKLD RRLHTPMYIL LGNFAFLEIW YISSTVPNML
110 120 130 140 150
VNILSEIKTI SFSGCFLQFY FFFSLGTTEC FFLSVMAYDR YLAICRPLHY
160 170 180 190 200
PSIMTGKFCI ILVCVCWVGG FLCYPVPIVL ISQLPFCGPN IIDHLVCDPG
210 220 230 240 250
PLFALACISA PSTELICYTF NSMIIFGPFL SILGSYTLVI RAVLCIPSGA
260 270 280 290 300
GRTKAFSTCG SHLMVVSLFY GTLMVMYVSP TSGNPAGMQK IITLVYTAMT
310 320 330
PFLNPLIYSL RNKDMKDALK RVLGLTVSQN
Length:330
Mass (Da):36,788
Last modified:October 1, 2002 - v1
Checksum:i99014E58C6C57110
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71S → Y.
Corresponds to variant rs10140652 [ dbSNP | Ensembl ].
VAR_034299
Natural varianti32 – 321L → V.
Corresponds to variant rs9323693 [ dbSNP | Ensembl ].
VAR_024130
Natural varianti107 – 1071I → T.
Corresponds to variant rs12891553 [ dbSNP | Ensembl ].
VAR_034300
Natural varianti146 – 1461R → H.
Corresponds to variant rs17106351 [ dbSNP | Ensembl ].
VAR_034301
Natural varianti195 – 1951L → F.
Corresponds to variant rs17211285 [ dbSNP | Ensembl ].
VAR_034302
Natural varianti236 – 2361Y → H.
Corresponds to variant rs17277221 [ dbSNP | Ensembl ].
VAR_034303
Natural varianti259 – 2591C → R.
Corresponds to variant rs17277228 [ dbSNP | Ensembl ].
VAR_034304

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065889 Genomic DNA. Translation: BAC06106.1.
BK004454 Genomic DNA. Translation: DAA04852.1.
CCDSiCCDS32033.1.
RefSeqiNP_001004480.1. NM_001004480.1.
UniGeneiHs.553575.

Genome annotation databases

EnsembliENST00000315519; ENSP00000319071; ENSG00000176219.
GeneIDi122748.
KEGGihsa:122748.
UCSCiuc010tlc.2. human.

Polymorphism databases

DMDMi38372668.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065889 Genomic DNA. Translation: BAC06106.1 .
BK004454 Genomic DNA. Translation: DAA04852.1 .
CCDSi CCDS32033.1.
RefSeqi NP_001004480.1. NM_001004480.1.
UniGenei Hs.553575.

3D structure databases

ProteinModelPortali Q8NGC7.
SMRi Q8NGC7. Positions 43-323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000319071.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372668.

Proteomic databases

PRIDEi Q8NGC7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315519 ; ENSP00000319071 ; ENSG00000176219 .
GeneIDi 122748.
KEGGi hsa:122748.
UCSCi uc010tlc.2. human.

Organism-specific databases

CTDi 122748.
GeneCardsi GC14P020691.
HGNCi HGNC:15349. OR11H6.
neXtProti NX_Q8NGC7.
PharmGKBi PA32018.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40487.
GeneTreei ENSGT00760000119087.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGC7.
KOi K04257.
OMAi NTTMHFV.
OrthoDBi EOG7N0C51.
PhylomeDBi Q8NGC7.
TreeFami TF338968.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR11H6.
GenomeRNAii 122748.
NextBioi 80987.
PROi Q8NGC7.

Gene expression databases

CleanExi HS_OR11H6.
Genevestigatori Q8NGC7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO11H6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC7
Secondary accession number(s): Q6IF08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3