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Q8NGC7 (O11H6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 11H6
Alternative name(s):
Olfactory receptor OR14-35
Gene names
Name:OR11H6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Olfactory receptor 11H6
PRO_0000150726

Regions

Topological domain1 – 4343Extracellular Potential
Transmembrane44 – 6421Helical; Name=1; Potential
Topological domain65 – 728Cytoplasmic Potential
Transmembrane73 – 9321Helical; Name=2; Potential
Topological domain94 – 11724Extracellular Potential
Transmembrane118 – 13821Helical; Name=3; Potential
Topological domain139 – 15719Cytoplasmic Potential
Transmembrane158 – 17821Helical; Name=4; Potential
Topological domain179 – 21537Extracellular Potential
Transmembrane216 – 23520Helical; Name=5; Potential
Topological domain236 – 25520Cytoplasmic Potential
Transmembrane256 – 27621Helical; Name=6; Potential
Topological domain277 – 28913Extracellular Potential
Transmembrane290 – 31021Helical; Name=7; Potential
Topological domain311 – 33020Cytoplasmic Potential

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond115 ↔ 207 By similarity

Natural variations

Natural variant71S → Y.
Corresponds to variant rs10140652 [ dbSNP | Ensembl ].
VAR_034299
Natural variant321L → V.
Corresponds to variant rs9323693 [ dbSNP | Ensembl ].
VAR_024130
Natural variant1071I → T.
Corresponds to variant rs12891553 [ dbSNP | Ensembl ].
VAR_034300
Natural variant1461R → H.
Corresponds to variant rs17106351 [ dbSNP | Ensembl ].
VAR_034301
Natural variant1951L → F.
Corresponds to variant rs17211285 [ dbSNP | Ensembl ].
VAR_034302
Natural variant2361Y → H.
Corresponds to variant rs17277221 [ dbSNP | Ensembl ].
VAR_034303
Natural variant2591C → R.
Corresponds to variant rs17277228 [ dbSNP | Ensembl ].
VAR_034304

Sequences

Sequence LengthMass (Da)Tools
Q8NGC7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 99014E58C6C57110

FASTA33036,788
        10         20         30         40         50         60 
MFFIIHSLVT SVFLTALGPQ NRTMHFVTEF VLLGFHGQRE MQSCFFSFIL VLYLLTLLGN 

        70         80         90        100        110        120 
GAIVCAVKLD RRLHTPMYIL LGNFAFLEIW YISSTVPNML VNILSEIKTI SFSGCFLQFY 

       130        140        150        160        170        180 
FFFSLGTTEC FFLSVMAYDR YLAICRPLHY PSIMTGKFCI ILVCVCWVGG FLCYPVPIVL 

       190        200        210        220        230        240 
ISQLPFCGPN IIDHLVCDPG PLFALACISA PSTELICYTF NSMIIFGPFL SILGSYTLVI 

       250        260        270        280        290        300 
RAVLCIPSGA GRTKAFSTCG SHLMVVSLFY GTLMVMYVSP TSGNPAGMQK IITLVYTAMT 

       310        320        330 
PFLNPLIYSL RNKDMKDALK RVLGLTVSQN 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065889 Genomic DNA. Translation: BAC06106.1.
BK004454 Genomic DNA. Translation: DAA04852.1.
RefSeqNP_001004480.1. NM_001004480.1.
UniGeneHs.553575.

3D structure databases

ProteinModelPortalQ8NGC7.
SMRQ8NGC7. Positions 43-326.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000319071.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372668.

Proteomic databases

PRIDEQ8NGC7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315519; ENSP00000319071; ENSG00000176219.
GeneID122748.
KEGGhsa:122748.
UCSCuc010tlc.2. human.

Organism-specific databases

CTD122748.
GeneCardsGC14P020691.
HGNCHGNC:15349. OR11H6.
neXtProtNX_Q8NGC7.
PharmGKBPA32018.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40487.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGC7.
KOK04257.
OMANTTMHFV.
OrthoDBEOG7N0C51.
PhylomeDBQ8NGC7.
TreeFamTF338968.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR11H6.
GenevestigatorQ8NGC7.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR11H6.
GenomeRNAi122748.
NextBio80987.
PROQ8NGC7.

Entry information

Entry nameO11H6_HUMAN
AccessionPrimary (citable) accession number: Q8NGC7
Secondary accession number(s): Q6IF08
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries