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Q8NGC7

- O11H6_HUMAN

UniProt

Q8NGC7 - O11H6_HUMAN

Protein

Olfactory receptor 11H6

Gene

OR11H6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 11H6
    Alternative name(s):
    Olfactory receptor OR14-35
    Gene namesi
    Name:OR11H6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:15349. OR11H6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32018.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Olfactory receptor 11H6PRO_0000150726Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGC7.

    Expressioni

    Gene expression databases

    CleanExiHS_OR11H6.
    GenevestigatoriQ8NGC7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000319071.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGC7.
    SMRiQ8NGC7. Positions 43-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 728CytoplasmicSequence Analysis
    Topological domaini94 – 11724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 15719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 21537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 25520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 28913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini311 – 33020CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 23520Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40487.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGC7.
    KOiK04257.
    OMAiNTTMHFV.
    OrthoDBiEOG7N0C51.
    PhylomeDBiQ8NGC7.
    TreeFamiTF338968.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGC7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFFIIHSLVT SVFLTALGPQ NRTMHFVTEF VLLGFHGQRE MQSCFFSFIL    50
    VLYLLTLLGN GAIVCAVKLD RRLHTPMYIL LGNFAFLEIW YISSTVPNML 100
    VNILSEIKTI SFSGCFLQFY FFFSLGTTEC FFLSVMAYDR YLAICRPLHY 150
    PSIMTGKFCI ILVCVCWVGG FLCYPVPIVL ISQLPFCGPN IIDHLVCDPG 200
    PLFALACISA PSTELICYTF NSMIIFGPFL SILGSYTLVI RAVLCIPSGA 250
    GRTKAFSTCG SHLMVVSLFY GTLMVMYVSP TSGNPAGMQK IITLVYTAMT 300
    PFLNPLIYSL RNKDMKDALK RVLGLTVSQN 330
    Length:330
    Mass (Da):36,788
    Last modified:October 1, 2002 - v1
    Checksum:i99014E58C6C57110
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71S → Y.
    Corresponds to variant rs10140652 [ dbSNP | Ensembl ].
    VAR_034299
    Natural varianti32 – 321L → V.
    Corresponds to variant rs9323693 [ dbSNP | Ensembl ].
    VAR_024130
    Natural varianti107 – 1071I → T.
    Corresponds to variant rs12891553 [ dbSNP | Ensembl ].
    VAR_034300
    Natural varianti146 – 1461R → H.
    Corresponds to variant rs17106351 [ dbSNP | Ensembl ].
    VAR_034301
    Natural varianti195 – 1951L → F.
    Corresponds to variant rs17211285 [ dbSNP | Ensembl ].
    VAR_034302
    Natural varianti236 – 2361Y → H.
    Corresponds to variant rs17277221 [ dbSNP | Ensembl ].
    VAR_034303
    Natural varianti259 – 2591C → R.
    Corresponds to variant rs17277228 [ dbSNP | Ensembl ].
    VAR_034304

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065889 Genomic DNA. Translation: BAC06106.1.
    BK004454 Genomic DNA. Translation: DAA04852.1.
    CCDSiCCDS32033.1.
    RefSeqiNP_001004480.1. NM_001004480.1.
    UniGeneiHs.553575.

    Genome annotation databases

    EnsembliENST00000315519; ENSP00000319071; ENSG00000176219.
    GeneIDi122748.
    KEGGihsa:122748.
    UCSCiuc010tlc.2. human.

    Polymorphism databases

    DMDMi38372668.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065889 Genomic DNA. Translation: BAC06106.1 .
    BK004454 Genomic DNA. Translation: DAA04852.1 .
    CCDSi CCDS32033.1.
    RefSeqi NP_001004480.1. NM_001004480.1.
    UniGenei Hs.553575.

    3D structure databases

    ProteinModelPortali Q8NGC7.
    SMRi Q8NGC7. Positions 43-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000319071.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372668.

    Proteomic databases

    PRIDEi Q8NGC7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315519 ; ENSP00000319071 ; ENSG00000176219 .
    GeneIDi 122748.
    KEGGi hsa:122748.
    UCSCi uc010tlc.2. human.

    Organism-specific databases

    CTDi 122748.
    GeneCardsi GC14P020691.
    HGNCi HGNC:15349. OR11H6.
    neXtProti NX_Q8NGC7.
    PharmGKBi PA32018.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40487.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGC7.
    KOi K04257.
    OMAi NTTMHFV.
    OrthoDBi EOG7N0C51.
    PhylomeDBi Q8NGC7.
    TreeFami TF338968.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR11H6.
    GenomeRNAii 122748.
    NextBioi 80987.
    PROi Q8NGC7.

    Gene expression databases

    CleanExi HS_OR11H6.
    Genevestigatori Q8NGC7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO11H6_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGC7
    Secondary accession number(s): Q6IF08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3